Microenvironment and lymphomagenesis

In HE stainings of mouse BL-like tumors multiple tingible macrophages (arrow heads) that engulf and digest apoptotic tumor cells contribute to the BL-characteristic “starry sky” pattern.
© Dr. Sandrine Sander

GCs are complex structures in which B cells interact with a wide variety of specialized cells:

follicular dendritic cells (FDCs), which are essential for affinity maturation of antibody mutants due to antigen presentation, CD4+ T cells (T follicular helper T cells and Foxp3+ regulatory T cells) involved in GC formation and selection processes, and tingible-body macrophages (TBM) that eliminate dying B cells.

As lymphoma cells still share many characteristics with their non-malignant counterparts (e.g. BCR dependency, see project III), the interaction of the malignant cells with GC related immune cells might influence lymphoma development and dissemination. Based on our in vivo models we have the unique opportunity to analyze the impact of these microenvironmental regulators on lymphomagenesis.

FACS analyses reveal different subsets of CD3+T cells (either CD4+ or CD8+) infiltrating the murine lymphomas.
© Dr. Sandrine Sander

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