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Subproject 2 - Ralf Bartenschlager

OPEN POSITION for a postdoctoral fellow / doctoral student in the research group of Ralf Bartenschlager

The Bartenschlager group is studying the interaction between plus-strand RNA viruses and their host cells. One major focus is the 3D architecture, biogenesis and molecular composition of the membranous replication organelles of hepatitis C virus, flaviviruses (dengue virus, Zika virus) and SARS-CoV-2. We use standard molecular and cell biological methods, -omics based approaches (proteomics, lipidomics), genetic screening as well as cutting-edge light and electron microscopy methods (e.g. Cortese et al., 2020; Cerikan et al., 2020; Romero-Brey et al., 2012; Welsch et al., 2009). To complement our research team and to work on the SARS-CoV-2 replication organelle, we are seeking for a highly motivated postdoctoral fellow / PhD student. Desired qualifications are:

  • A Ph.D. / Master's (or equivalent degree) in biology or related field with an excellent publication record.
  • Strong hands-on experience with cryo-EM, conventional EM and light microscopy.
  • Solid experience in state-of-the-art cell and molecular biology techniques.
  • Profound knowledge in cell biology.
  • Sound knowledge in virology is of advantage.
  • The candidate works accurately, is able to conduct independent research, but also enjoys working in an international and interdisciplinary environment. The candidate is willing to advise students in the lab.
  • Good presentation skills and experience on project management (importance of scheduling, deliverables, reporting) will be highly valued.
  • Fluency in English language (written and spoken) is mandatory. Proficiency in German would be a plus.

Further information about our research can be found at:


  • Cortese et al., 2020. Integrative imaging reveals SARS-CoV-2 induced reshaping of subcellular morphologies. Cell Host & Microbe 28(6):853-866.e5.
  • Cerikan et al., 2020. A Non-Replicative Role of the 3' Terminal Sequence of the Dengue Virus Genome in Membranous Replication Organelle Formation. Cell Reports 7;32(1):107859.
  • Romero-Brey et al., 2012. Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication. PLoS Pathog. 8(12):e1003056.
  • Welsch et al., 2009. Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe 5:365-75.

Subproject 2

2 MD Students per year: Further information on request

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