Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .


These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds
Pathogenesis of Virus-Associated Tumors

Division of Pathogenesis of Virus Associated Tumors

Prof. Dr. Dr. Henri-Jacques Delecluse

Primary squamous epithelial cells infected with a recombinant Epstein-Barr virus tagged with a GFP gene.

The Epstein-Barr virus (EBV) infects the large majority of the population and is responsible for 1 to 2% of all cancers. Our projects aim at understanding how the virus induces these tumors and how they can be prevented. We previously found that the multiple microRNAs encoded by the virus modulate its oncogenic properties. More recently, we moved our attention to the contribution of lytic replication, the process that leads to the production of viruses, to cancer development. We showed that the EBV infectious particles can deregulate the centrosome machinery and induce genetic instability. This newly identified cancer risk is independent of the viral genome and could significantly expand the range of diseases caused by the virus. EBV is known to induce Hodgkin’s lymphomas and large cell lymphomas, particularly in immunocompromised patients and a particular type of gastric carcinoma all over the world. However, some EBV-associated tumors such as nasopharyngeal carcinoma and Burkitt’s lymphomas have a strikingly heterogeneous geographic distribution. We have shown that some of these differences can be explained by the infection with particular types of Epstein-Barr viruses. This led to the development of Epstein-Barr virus-like particles (VLPs) from these highly pathogenic strains that can be used as preventative vaccines. We have also designed a new immunotherapeutic approach that uses EBV antigens to induce an immune response against B cell lymphomas.

While we will continue our projects on the molecular mechanisms of EBV-induced cancer, we will focus on the development of clinically relevant projects including the study of EBV strains found in diseased patients, the development of an EBV-specific vaccine and of immunotherapeutic strategies based on antigen-loaded antibodies.


Prof. Dr. Dr. Henri-Jacques Delecluse
Pathogenesis of Virus Associated Tumors (F100)
Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 280
69120 Heidelberg
Tel: +49 6221 42 4870

Selected Publications

  • Shumilov A, Tsai MH, Schlosser YT, Kratz AS, Bernhardt K, Fink S, Mizani T, Lin X, Jauch A, Mautner J, Kopp-Schneider A, Feederle R, Hoffmann I, Delecluse HJ. Epstein-Barr virus particles induce centrosome amplification and chromosomal instability. Nat Commun. 2017 Feb 10;8:14257
  • Li Z, Tsai MH, Shumilov A, Baccianti F, Tsao SW, Poirey R, Delecluse HJ. Epstein-Barr virus ncRNA from a nasopharyngeal carcinoma induces an inflammatory response that promotes virus production. Nat Microbiol. 2019 Sep 9.
  • van Zyl DG, Tsai MH, Shumilov A, Schneidt V, Poirey R, Schlehe B, Fluhr H, Mautner J, Delecluse HJ. Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice. PLoS Pathog. 2018 Dec 6;14(12)
  • Schneidt V, Ilecka M, Dreger P, van Zyl DG, Fink S, Mautner J, Delecluse HJ. Antibodies conjugated with viral antigens elicit a cytotoxic T cell response against primary CLL ex vivo.Leukemia. 2019 Jan;33(1):88-98
to top
powered by webEdition CMS