Peer reviewed publications (since establishment of the group at the DKFZ in 2012)


Kappert L, Ruzicka P, Kutikhin A, Feldner A, Sticht C, Fischer A, Hecker M, Arnold C, Korff T. Loss of Nfat5 promotes lipid accumulation in vascular smooth muscle cells. FASEB. in press 2021

Alsina-Sanchis E, Mülfarth R, Fischer A. Control of Tumor Progression by Angiocrine Factors. Cancers (Basel) 13(11):2610. doi: 10.3390/cancers13112610. [cover story]

Alsina Sanchis E, Mülfarth R, Moll I, Mogler C, Rodriguez-Vita J*, Fischer A*: Intraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages. Mol Cancer Res. 19(2):288-300. doi: 10.1158/1541-7786.MCR-20-0650. [cover story]

Hubert MO, Rodriguez-Vita J, Wiedmann L, Fischer A: Isolation of murine primary aortic smooth muscle cells. BioProtocol. 11(3):e3907. doi: 10.21769/BioProtoc.3907. [cover story]

Morgenstern J, Fleming T, Kliemank E, Brune M, Nawroth PP, Fischer A: Quantification of all-trans retinoic acid by liquid chromatography-tandem mass spectrometry and association with lipid profile in patients with type 2 diabetes. Metabolites. 11(1), 60; 2021.

Hasan SS, Fischer A: The endothelium: an active regulator of lipid and glucose homeostasis. Trends Cell Biol. 31(1):37-49. 2021


Gonzalo-Juan I, Xie F, Becker M, Tulyaganov DU, Ionescu E, Lauterbach S, De Angelis Rigotti F, Fischer A, Riedel R: Synthesis of silver modified bioactive glassy materials with antibacterial properties via facile and low-temperature route. Materials. 13(22):5115. 2020.

Hasan SS, Fischer A: Notch signaling in familial cerebral cavernous malformations and immunohistochemical detection of cleaved Notch intracellular domain. Methods Mol Biol. 2152:427-435, 2020

Hasan SS*, Jabs M*, Taylor J, Wiedmann L, Leibing T, Nordström V, Federico G, Roma LP, Carlein C, Wolff G, Ekim-Üstünel B, Brune M, Moll I, Tetzlaff F, Gröne H-J, Fleming T, Géraud C, Herzig S, Nawroth PP, Fischer A: Endothelial Notch signaling controls insulin transport in muscle. EMBO Mol Med, 12(4):e09271., 2020.


Taylor J, Fischer A: EC dictate cardiac fuel source. Aging, 11: 1083-4, 2019

Goossens P*, Rodriguez-Vita J*, Etzerodt A, Masse M, Rastoin O, Gouirand V, Ulas T, Papantonopoulou O, Van Eck M, Auphan-Anezin N, Bebien M, Verthuy C, Vu Manh TP, Turner M, Dalod M, Schultze JL, Lawrence T. Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression. Cell Metab. 4;29(6):1376-1389.e4. 2019

Ribera J*, Rodríguez-Vita J*, Cordoba B, Portolés I, Casals G, Casals E, Jiménez W, Puntes V, Morales-Ruiz M. Functionalized cerium oxide nanoparticles mitigate the oxidative stress and pro-inflammatory activity associated to the portal vein endothelium of cirrhotic rats. PLoS One. 24;14(6):e0218716. 2019

Klose R, Prinz A, Tetzlaff F, Weis EM, Moll I, Rodriguez-Vita J, Oka C, Korff T, Fischer A: Loss of the serine protease HTRA1 impairs smooth muscle cells maturation. Sci Rep. Dec 3;9(1):18224. 2019


Tetzlaff F and Fischer A: Human EC spheroid-based sprouting angiogenesis assay in collagen. BioProtocol, 8(17), 2018.

Klose R, Adam MG, Weis EM, Moll I, Wüstehube-Lausch J, Tetzlaff F, Oka C, Ehrmann M, Fischer A: Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis. Oncogene, 37: 4260-72, 2018.

Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A. (2018) Inhibition of endothelial Notch signaling impairs fatty acid transport and leads to metabolic and vascular remodeling of the adult heart. Circulation. Jun 12;137(24):2592-2608.

Editorial in Circulation.

Tetzlaff F, Adam MG, Feldner A, Moll I, Menuchin A, Rodriguez-Vita J, Sprinzak D, Fischer A. (2018) MPDZ promotes DLL4-induced Notch signaling during angiogenesis. eLife. Apr 5;7. pii: e32860.


Tetzlaff F, Fischer A: Control of blood vessel formation by Notch signaling. Adv Exp Med Biol, 1066: 319-338, 2018.


Fischer A, Braga VMM: Vascular permeability: Flow-mediated, non-canonical notch signaling promotes barrier integrity. Curr Biol, 28: R119-R121, 2018.


Fischer A, Nawroth PP: Chapters 31, 33, 42,47 and 54 in Kihm L, Kopf S, Nawroth PP (Ed.), Diabetes-Therapie – informiert entscheiden. Patientenzentriertes und fallbasiertes Vorgehen über Leitlinien hinaus. Springer. Berlin Heidelberg. 2018


Feldner A, Adam MG, Tetzlaff F, Moll I, Komljenovic D, Sahm F, Bäuerle T, Ishikawa H, Schroten H, Korff T, Hofmann I, Wolburg H, von Deimling A, Fischer A. Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice. EMBO Mol Med. Jul;9(7):890-905., 2017

Wieland E*, Rodriguez-Vita J*, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A: Endothelial Notch1 activity facilitates metastasis. Cancer Cell, 3: 355-367, 2017.

Editorial in Cancer Cell.

Editorial in Cancer Discovery.

Comment in Science.


Rodriguez Vita JTetzlaff FFischer A (2017) Notch controls endothelial cells. Oncoscience. Jun 25;4(5-6):45-46.


Rodriguez Vita JFischer A (2017) Notch1 induces endothelial senescence and promotes tumor progression. Cell Cycle. May 19;16(10):911-912, 2017


Rodriguez Vita JFischer A (2017) Notch signaling facilitates crossing of endothelial barriers by tumor cells. Mol Cell Oncol. Apr 3;4(3):e1311828.



Spiegler S, Kirchmaier B, Rath M, Korenke GC, Tetzlaff F, van de Vorst M, Neveling K, Acker-Palmer A, Kuss AW, Gilissen C, Fischer A, Schulte-Merker S, Felbor U. (2016) FAM222B is not a likely novel candidate gene for cerebral cavernous malformations. Mol Syndrom. Jul;7(3):144-52.


Herberich SE*, Klose R*, Moll I, Yang W-J, Wüstehube-Lausch J, Fischer A (2015) ANKS1B interacts with the cerebral cavernous malformation protein-1 and controls endothelial permeability but not sprouting angiogenesis. PLoS One.10(12):e0145304.

Yang W-J*, Hu J*, Uemura A, Tetzlaff F, Augustin HG, Fischer A (2015) Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis. EMBO Mol Med. 7 (10):1267-1284.

Editorial in EMBO Mol Med.

Selected as Cover Image.


Fischer A. Physiologie Band 6, Herz und Kreislauf, 7. Auflage, MEDI-LEARN Verlag, Marburg.

Klose R*, Berger C*, Moll I, Adam MG, Schwarz F, Mohr K, Augustin HG, Fischer A (2015) Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis. Cardiovasc Res. 107(1):153-163.

Wöltje K*, Jabs M*, Fischer A (2015) Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS One. 10 (3): e0120547.

Schulz GB, Wieland E, Wüstehube-Lausch J, Boulday G, Moll I, Tournier-Lasserve E, Fischer A (2015) Cerebral cavernous malformation-1 protein controls DLL4-Notch3 signaling between the endothelium and pericytes. Stroke. 46(5):1337-1343.


Adam MGBerger C, Feldner A, Yang W-J, Wüstehube-Lausch J, Herberich SE, Pinder M, Gesierich S, Hammes H-P, Augustin HG, Fischer A (2013) Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res. 113: 1206-1218.

Editorial in Circ Res.

Selected as Cover Image.

Among the 10 most read articles published 2013 in Circ Res.

Schaafhausen MK, Yang WJ, Centanin L, Wittbrodt J, Bosserhoff A, Fischer A, Schartl M, Meierjohann S (2013) Tumor angiogenesis is caused by single melanoma cells in a reactive oxygen species and NF-κB dependent manner. J Cell Sci. 126: 3862-3872.


Fischer A, Zalvide J, Faurobert E, Albiges-Rizo C, Tournier-Lasserve E (2013) Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis. Trends Mol Med 19 (13): 302-308.


Liebler SSFeldner A, Adam MG, Korff T, Augustin HG, Fischer A (2012) No evidence for a functional role of bi-directional Notch signaling during angiogenesis. PLoS One. 7 (12): e53074.

group members are underlined

*, equal contribution


Publications (before establishment of DKFZ group in 2012)

to top
powered by webEdition CMS