Open Positions

Master Thesis

We are seeking qualified and highly motivated candidates to join our research team. We offer projects for a Diploma or Master thesis. For informal enquiries please contact Prof. Dr. Hans-Reimer Rodewald (office.rodewald@dkfz.de).

PhD position

“Homeostasis and functions of resident and recruited macrophages under challenge”

 

In the Division of Cellular Immunology, we investigate cell and organ development in the immune system as well as their immunological functions. We are offering a PhD project investigating the roles of ontogenetically distinct macrophage subsets in steady state and under challenging conditions.

 

Description:

 

Tissue macrophages are remarkably heterogeneous cells involved in developmental processes, tissue homeostasis, and immunity. The generation of macrophages from bone marrow-derived monocytes was textbook knowledge of the last decades. However, our traditional view on macrophage biology is currently being redefined. In previous work, we showed that a majority of macrophages in many tissues is derived from yolk sac precursors and is completely independent of the hematopoiesis that takes place in the bone marrow (Gomez Perdiguero E, Klapproth K et al. Nature 2015). In this PhD project, we plan to extent our investigations and to assess the influence of inflammatory diseases and cancer on the homeostasis and composition of certain macrophage populations. Furthermore, we will analyse the influence of ontogenetically distinct macrophage lineages on onset and outcome of different pathological conditions.

The results of our studies will have impact on our understanding on macrophage functions and will help us to develop new strategies of targeting specific macrophage populations for therapeutic applications.

 

For this project, we will apply different mouse models to trace distinct macrophage subsets and elucidate their roles in a variety of disease states. Our investigations will encompass various techniques, e.g. flow cytometry, cell sorting, single cell analyses, cellular barcoding, fluorescence imaging. Experience in any of these methods might be advantageous but are not a prerequisite. We offer a motivating scientific environment and an extensive academic supervision. We are looking for a dedicated, interested, and friendly PhD student with a background in biology or medicine.

 

 

Candidates should send their application as PDF file via e-mail to: k.klapproth@dkfz.de

 

For further information please contact Dr. Kay Klapproth at the Division of Cellular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany

e-mail: k.klapproth@dkfz.de

phone: +49 (0)6221 42 4130

 

PhD position

„In vivo fate mapping of hematopoietic stem cells under steady state and upon challenges“

 

The Division of Cellular Immunology offers a PhD position with the focus on blood cell development from hematopoietic stem cells during normal steady-state hematopoiesis and under challenging conditions.

 

Description:

Our immune system is not only the first barrier against infectious diseases; it is also a key player in cancer development and progression. We still do not fully understand the multifaceted roles that immune cells play in healthy or diseased organisms. The knowledge about origin, development and function of immune cells is crucial to decode the complexity of the immune system under normal conditions but also during cancer, infection or aging. The generation of immune cells, called hematopoiesis, is a tightly coordinated process that is maintained by the life-long function of adult hematopoietic stem cells (HSC). However, very little is known about the function of HSC in their natural bone marrow environment.

We generated a novel fate-mapping mouse that allows in vivo marking and tracing of immature HSC (Busch et al. Nature 2015; Busch and Rodewald Curr. Opin. Hematol. 2016; Höfer et al. Annu. Rev. Immunol. 2016). Together with mathematical modeling our HSC fate-mapping experiments enabled for the first time to quantify the hematopoietic contribution of HSC to immune cell development and revealed as yet unknown facts about HSC biology under normal steady-state conditions. Preliminary data of our fate-mapping mice upon controlled hematopoietic perturbation indicate differential involvement of HSC in response to various challenges. In the future, we will intensify our research to decipher the regulatory architecture of physiological and non-physiological hematopoiesis (e.g. cancer, HSC exhaustion and anemia, infections, aging, immune deficiencies) towards a better understanding of the complex HSC biology.

For this project flow cytometry, cell sorting, single cell analyses, cellular barcoding, fluorescence imaging, molecular and cell biology techniques will be used. We offer a stimulating scientific environment and look for a highly motivated, curious and friendly student who is interested to pursue important and open questions in immunology, stem cell biology and cancer.

 

Candidates should send their application as PDF file via e-mail to: k.busch@dkfz.de

 

For further information please contact Dr. Katrin Busch at the Division of Cellular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany

e-mail: k.busch@dkfz.de

phone: +49 (0)6221 42 4123

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