Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .


These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds

Division of Vascular Signaling and Cancer

Prof. Dr. Andreas Fischer

Fluorescence microscopy image of a tumor. Blood vessels are stained in green (endothelial cells) and red (mural cells), cell nuclei in blue.

Blood vessels supply almost every cell in the human body with oxygen and nutrients. However, blood vessels are not simple, passive tubes enabling the transport of blood, but also instruct tissue regeneration, stem cell renewal and differentiation, as well as tumor progression. In addition, there is increasing evidence that signaling pathways in endothelial cells actively control the transport of nutrients, hormones, immune and cancer cells across the vessel wall. As such, the endothelium appears to act as a communication platform that integrates numerous signals from blood and parenchymal cells to actively maintain homeostasis.

The Division of Vascular Signaling and Cancer studies signaling pathways that control blood vessel growth in cancer and the transport of nutrients, hormones, cancer cells and immune cells across the vessel wall. Our laboratory has identified Delta/Notch and Semaphorin/Neuropilin signaling in the endothelium as key players of angiogenesis, barrier control and metastasis. We aim at understanding how endothelial cells orchestrate the recruitment and differentiation of immune cells and how this alters inflammation and tumor progression. Secondly, we aim at understanding the roles of endothelial cells as organ-specific sensors of nutritional status and analyze how changes in plasma metabolite concentration alter the transcriptional landscape and the functions of the endothelium. We investigate how endothelial signaling pathways affect the transport of plasma metabolites and how this affects organ functions.

Based on this research we will define innovative preclinical therapeutic strategies to interfere with the progression of metabolic diseases and cancer.


Prof. Dr. Andreas Fischer
Vascular Signaling and Cancer (A270)
Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 280
69120 Heidelberg

Selected Publications

  • Wieland*, Rodriguez-Vita*, et al. (2017) Endothelial Notch1 facilitates metastasis. Cancer Cell, (3) 355-367.
  • Jabs, et al. (2018) Inhibition of endothelial Notch signaling impairs fatty acid transport and leads to metabolic and vascular remodeling of the adult heart. Circulation, 137(24):2592-2608.
  • Hasan*, Jabs*, et al. (2020) Endothelial Notch signaling controls insulin transport in muscle. EMBO Mol Med, 12(4):e09271.
  • Weis, et al. (2022) Ketone body oxidation increases cardiac endothelial cell proliferation. EMBO Mol Med. 4(4):e14753.
to top
powered by webEdition CMS