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NMR Spectroscopy & CEST Imaging

Revealing Cancer Metabolism In Vivo

Our research group develops non-invasive metabolic and molecular MR techniques using 1H and X nuclei, comprising high-resolution NMR spectroscopy (MRS) and MR spectroscopic imaging (MRSI) at ultra-high fields (B0 ≥ 7T), chemical exchange saturation transfer (CEST) MR imaging, and hyperpolarized carbon-13 (HYP 13C). A particular clinical research focus is the molecular tissue characterization of brain tumors for the stratification of genetic subtypes and the assessment of response to therapies. Another focus is the development of novel imaging techniques for the improved molecular characterization of breast cancers.


Research Topics

  • Imaging of physiological parameters, in particular pH values
  • Assessment of tissues' energy metabolism
  • Assessment of changes in tissues' bulk proteome
  • Identification of imaging surrogates for clinical biomarkers using metabolite signals and molecular contrast mechanisms
  • Development of novel molecular imaging techniques
  • Clinical translation of developed imaging methods


Moreover, our research group is participating in the following consortia projects:

  • MIRACLE, the platform for virtual biopsies; introducing Metabolic MRI-as-a-Service for oncologic care (HORIZON-EIC funded project)
  • HYPERBOLIC – Visualizing Hallmarks of Cancer through Tailored Hyperpolarized Magnetic Resonance Imaging (DKTK funded project)

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