Selected publications

2020

  • Kleimaier D, Goerke S, Nies C, Zaiss M, Kunz P, Bachert P, Ladd ME, Gottwald E, Schad LR. The cellular heat shock response monitored by chemical exchange saturation transfer MRI. Sci. Rep. 10: 11118 (2020).
  • Loi L, Zimmermann F, Goerke S, Korzowski A, Meissner J-E, Deike-Hofmann K, Stieber A, Bachert P, Ladd ME, Schlemmer H-P, Bickelhaupt S, Schott S, Paech D. Relaxation-compensated CEST (Chemical Exchange Saturation Transfer) Imaging in Breast Cancer Diagnostics at 7T. Eur. J. Radiol. (2020).
  • Korzowski A, Weinfurtner N, Mueller S, Breitling J, Goerke S, Schlemmer HP, Ladd ME, Paech D, Bachert P. Volumetric Mapping of Intra- and Extracellular pH in the Human Brain using 31P MRSI at 7 T. Magn. Reson. Med. 84:1707–1723 (2020).
  • Breitling J, Meissner JE, Zaiss M, Paech D, Ladd ME, Bachert P, Goerke S. Optimized dualCEST-MRI for imaging of endogenous bulk mobile proteins in the human brain. NMR Biomed. (2020);33:e4262.
  • Boyd PS, Breitling J, Zimmermann F, Korzowski A, Zaiss M, Schuenke P, Weinfurtner N, Schlemmer HP, Ladd ME, Bachert P, Paech D, Goerke S. Dynamic glucose-enhanced (DGE) MRI in the human brain at 7 T with reduced motion-induced artifacts based on quantitative R mapping. Magn. Reson. Med. 84:182–191 (2020).
  • Zimmermann F, Korzowski A, Breitling J, Meissner JE, Schuenke P, Loi L, Zaiss M, Bickelhaupt S, Schott S, Schlemmer HP, Paech D, Ladd ME, Bachert P, Goerke S. A novel normalization for APT-CEST MRI to correct for fat-signal-induced artifacts – application to human breast cancer imaging.  Magn. Reson. Med. 83:920–934 (2020).

2019

  • Breitling J, Deshmane A, Goerke S, Korzowski A, Herz K, Ladd ME, Scheffler K, Bachert P, Zaiss M. Adaptive denoising for chemical exchange saturation transfer MR imaging. NMR Biomed. (2019);32:e4133.
  • Zaiss M, Anemone A, Goerke S, Longo DL, Herz K, Pohmann R, Aime S, Rivlin M, Navon G, Golay X, Scheffler K. Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3T, 7T and 9.4 T. NMR Biomed. (2019);32:e4113.
  • Goerke S, Soehngen Y, Deshmane A, Zaiss M, Breitling J, Boyd PS, Herz K, Zimmermann F, Klika KD, Schlemmer H-P, Paech D, Ladd ME, Bachert P. Relaxation‐compensated APT and rNOE CEST‐MRI of human brain tumors at 3 T. Magn. Reson. Med. 82(2): 622-632 (2019).
  • Meissner J-E, Korzowski A, Regnery S, Goerke S, Breitling J, Floca R, Debus J, Schlemmer H-P, Ladd ME, Bachert P, Adeberg S, Paech D. Early response assessment of glioma patients to definitive chemoradiotherapy using Chemical Exchange Saturation Transfer imaging at 7 Tesla. J Magn Reson Imaging 50: 1268-1277 (2019).
  • Paech D, Dreher C, Regnery S, Meissner J-E, Goerke S, Windschuh J, Oberhollenzer J, Schultheiss M, Deike-Hofmann K, Bickelhaupt S, Radbruch A, Zaiss M, Unterberg A, Wick W, Bendszus M, Bachert P, Ladd M, Schlemmer H-P. Relaxation-compensated amide proton transfer (APT) MRI signal intensity is associated with survival and progression in high-grade glioma patients. Eur Radiol (2019) 29: 4957.

2018

  • Regnery S, Adeberg S, Dreher C, Oberhollenzer J, Meissner J-E, Goerke S, Windschuh J, Deike-Hofmann K, Bickelhaupt S, Zaiss M, Radbruch A, Bendszus M, Wick W, Unterberg A, Rieken S, Debus J, Bachert P, Ladd M, Schlemmer H-P, Paech D. Chemical Exchange Saturation Transfer MRI serves as predictor of early progression in glioblastoma patients. Oncotarget. 9(47):28772-28783 (2018).
  • Paech D, Windschuh J, Oberhollenzer J, Dreher C, Sahm F, Meissner J-E, Goerke S, Schuenke P, Zaiss M, Regnery S, Bickelhaupt S, Bäumer P, Bendszus M, Wick W, Unterberg A, Bachert P, Ladd ME, Schlemmer H-P, and Radbruch A. Assessing the predictability of IDH mutation and MGMT methylation status in glioma patients using relaxation-compensated multipool CEST MRI at 7.0 T. Neuro-Oncology (2018): noy073.
  • Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P. Dualfrequency irradiation CEST-MRI of endogenous bulk mobile proteins. NMR Biomed. (2018); e3920.
  • Korzowski A, Bachert P: High-resolution 31P echo-planar spectroscopic imaging in vivo at 7 T. Magn. Reson. Med. 79 (3): 1251–1259 (2018)

2017

  • Paech D, Schuenke P, Koehler C, Windschuh J, Mundiyanapurath S, Bickelhaupt S, Bonekamp D, Bäumer P, Bachert P, Ladd ME, Bendszus M, Wick W, Unterberg A, Schlemmer H–P, Zaiss M, Radbruch A: T1p–weighted dynamic glucose enhanced MRI in the human brain. Radiology 285 (3): 914–922 (2017).
  • Schuenke P, Paech D, Koehler C, Windschuh J, Bachert P, Ladd ME, Schlemmer HP, Radbruch A, Zaiss M: Fast and Quantitative T1p-weighted Dynamic Glucose Enhanced MRI. Sci. Rep. (7): 42093 (2017)
  • Schuenke P, Koehler C, Korzowski A, Windschuh J, Bachert P, Ladd ME, Mundiyanapurath S, Paech D, Bickelhaupt S, Bonekamp D, Schlemmer HP, Radbruch A, Zaiss M: Adiabatically Prepared Spin-Lock Approach for T1p-Based Dynamic Glucose Enhanced MRI at Ultrahigh Fields. Magn. Reson. Med. 78 (1): 215-225 (2017)
  • Schuenke P, Windschuh J, Roeloffs V, Ladd ME, Bachert P, Zaiss M: Simultaneous mapping of water shift and B1 (WASABI) - Application to field-Inhomogeneity correction of CEST MRI data. Magn. Reson. Med. 77 (2): 571-580 (2017)
  • Goerke S, Milde KS, Bukowiecki R, Kunz P, Klika KD, Wiglenda T, Mogk A, Wanker EE, Bukau B, Ladd ME, Bachert P, Zaiss M: Aggregation-induced changes in the chemical exchange saturation transfer (CEST) signals of proteins. NMR Biomed. 30 (1): 1-9 (2017)
  • Zaiss M, Windschuh J, Goerke S, Paech D, Meissner JE, Burth S, Kickingereder P, Wick W, Bendszus M, Schlemmer HP, Ladd ME, Bachert P, Radbruch A: Downfield-NOE-suppressed amide-CEST-MRI at 7 Tesla provides a unique contrast in human glioblastoma. Magn. Reson. Med. 77 (1): 196-208 (2017)

2016

  • Berger MC, Bachert P, Gröbner J, Nagel AM: Multi–contrast T2*–relaxometry upon visual stimulation at 3 T and 7 T. Magn. Reson. Imag. 34: 864–874 (2016).

2015

  • Bodet O, Goerke S, Behl NGR, Roeloffs VB, Zaiss M, Bachert P: Amide proton transfer of carnosine in aqueous solution studied in vitro by WEX and CEST experiments.
    NMR Biomed. 28(9):1097–1103 (2015). doi: 10.1002/nbm.3343.
  • Rerich E, Zaiss M, Korzowski A, Ladd ME, Bachert P: Relaxation-compensated CEST-MRI at 7 T for mapping of creatine content and pH – preliminary application in human muscle tissue in vivo. NMR Biomed. 28 (11): 1402-1412 (2015)
  • Meissner JE, Goerke S, Rerich E, Klika KD, Radbruch A, Ladd ME, Bachert P, Zaiss M: Quantitative pulsed CEST-MRI using Ω-plots. NMR Biomed. 28 (10): 1196–1208 (2015)
  • Zaiss M, Windschuh J, Paech D, Meissner JE, Burth S, Schmitt B, Kickingereder P, Wiestler B, Wick W., Bendszus M,  Schlemmer HP, Ladd ME, Bachert P, Radbruch A: Relaxation-compensated CEST-MRI of the human brain at 7 T: Unbiased insight into NOE and amide signal changes in human glioblastoma. Neuroimage 112: 180–188 (2015)
  • Goerke S, Zaiss M, Kunz P, Klika K, Windschuh J, Mogk A, Bukau B, Ladd M, Bachert P: Signature of protein unfolding in chemical exchange saturation transfer imaging. NMR Biomed. 28 (7): 906–913 (2015)
  • Windschuh J, Zaiss M, Meissner JE, Paech D, Radbruch A., Ladd ME, Bachert P: Correction of B1-inhomogeneities for relaxation-compensated CEST imaging at 7 T. NMR Biomed. 28 (5): 529–537 (2015)
  • Zaiss M, Zu Z, Xu J, Schuenke P, Gochberg DF, Gore JC, Ladd ME, Bachert P: A combined analytical solution for chemical exchange saturation transfer and semi-solid magnetization transfer. NMR Biomed. 28 (2): 217–230 (2015)
  • Paech D, Burth S, Windschuh J, Meissner J–E, Zaiss M, Eidel O, Kickingereder P, Nowosielski M, Wiestler B, Sahm F, Floca RO, Neumann J–O, Wick W, Heiland S, Bendszus M, Schlemmer H–P, Ladd ME, Bachert P, Radbruch A: Nuclear–Overhauser–enhancement imaging of glioblastoma at 7 Tesla: Region–specific correlation with apparent diffusion coefficient and histology. PLoS One 10 (2015). e0121220.

2014

  • Ivchenko O, Whittleston CS, Carr JM, Imhof P, Goerke S, Bachert P, Wales DJ: Proton transfer pathways, energy landscape, and kinetics in creatine–water systems. J. Phys. Chem. B 118: 1969–1975 (2014).
  • Ivchenko O, Bachert P, Imhof P: Umbrella sampling of proton transfer in a creatine–water system. Chem. Phys. Lett. 600: 51–55 (2014).
  • Zaiss M, Xu J, Goerke S, Khan IS, Singer RJ, Gore JC, Gochberg DF, Bachert P: Inverse Z-spectrum analysis for spillover-, MT-, and T1-corrected steady-state pulsed CEST-MRI – application to pH-weighted MRI of acute stroke. NMR Biomed. 27 (3): 240–252 (2014)
  • Goerke S, Zaiss M, Bachert P: Characterization of creatine guanidinium proton exchange by water-exchange (WEX) spectroscopy for absolute-pH CEST imaging in vitro. NMR Biomed. 27 (5): 507–518 (2014)
  • Roeloffs V, Meyer C, Bachert P, Zaiss M: Towards quantification of pulsed spinlock and CEST at clinical MR scanners: An analytical interleaved saturation–relaxation approach. NMR Biomed. 28 (1): 40–53 (2014)
  • Paech D, Zaiss M, Meissner J–E, Windschuh J, Wiestler B, Bachert P, Neumann J–O, Kickingereder P, Schlemmer H–P, Wick W, Nagel AM, Heiland S, Ladd ME, Bendszus M, Radbruch A: Nuclear–Overhauser–enhancement–mediated chemical exchange saturation transfer imaging at 7 Tesla in glioblastoma patients. PLoS One 9(8): 3−10 (2014). doi: 10.1371/journal.pone.0104181.

2013

  • Kuder TA, Bachert P, Windschuh J, Laun FB: Diffusion pore imaging by hyperpolarized xenon–129 nuclear magnetic resonance. Phys. Rev. Lett. 111, 028101 (2013). doi: 10.1103/PhysRevLett.111.028101.
  • Benkhedah N, Bachert P, Semmler W, Nagel AM: Three–dimensional biexponential–weighted 23Na imaging of the human brain with higher SNR and shorter acquisition time. Magn. Reson. Med. 70: 754–765 (2013). doi: 10.1002/mrm.24417.
  • Zaiss M, Bachert P: Exchange–dependent relaxation in the rotating frame for slow and intermediate exchange – modeling off–resonant spin–lock and chemical exchange saturation transfer. NMR Biomed. 26: 507–518 (2013). doi: 10.1002/nbm.2887.
  • Zaiss M, Kunz P, Goerke S, Radbruch A, Bachert P: MR imaging of protein folding in vitro employing nuclear–Overhauser–mediated saturation transfer. NMR Biomed. 26: 1815–1822 (2013). doi: 10.1002/nbm.3021.
  • Zaiss M, Bachert P: Chemical exchange saturation transfer (CEST) and MR Z–spectroscopy in vivo: a review of theoretical approaches and methods (Topical review). Phys. Med. Biol. 58: R221–R269 (2013). doi:10.1088/0031–9155/58/22/R221.

2012

  • Zechmann CM, Menze BH, Kelm BM, Zamecnik P, Ikinger U, Giesel FL, Thieke C, Delorme S, Hamprecht FA, Bachert P: Automated vs. manual pattern recognition of 3D 1H MRSI data of patients with prostate cancer. Academic Radiology 19: 675–684 (2012).
  • Zaiss M, Schnurr M, Bachert P: Analytical solution for the depolarization of hyperpolarized nuclei by chemical exchange saturation transfer between free and encapsulated xenon (HyperCEST). J. Chem. Phys. 136: 144106–1–10 (2012). doi: 10.1063/1.3701178.)

2011

  • Schmitt B, Zaiß M, Zhou J, Bachert P: Optimization of pulse train presaturation for CEST imaging in clinical scanners. Magn. Reson. Med. 65: 1620–1629 (2011). doi: 10.1002/mrm.22750.
  • Zaiß M, Schmitt B, Bachert P: Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian–line–fit analysis of z–spectra. J. Magn. Reson. 211: 149–155 (2011). doi: 10.1016/j.jmr.2011.05.001.

2001 - 2010

  • Wilhelm T, Bachert P: In vivo 31P echo–planar spectroscopic imaging of human calf muscle. J. Magn. Reson. 149: 126–130 (2001).
  • Schlemmer H–P, Bachert P, Herfarth KK, Zuna I, Debus J, van Kaick G: Proton MR spectroscopic evaluation of suspicious brain lesions after stereotactic radiotherapy. AJNR Am. J. Neuroradiol. 22: 1316–1324 (2001).
  • Schlemmer H–P, Bachert P, Henze M, Buslei R, Herfarth KK, Debus J, van Kaick G: Differentiation of radiation necrosis from tumor progression using proton magnetic resonance spectroscopy. Neuroradiology 44: 216–222 (2002).
  • Schröder L, Bachert P: Evidence for a dipolar–coupled AM system in carnosine in human calf muscle from in vivo 1H NMR spectroscopy. J. Magn. Reson. 164: 256–269 (2003).
  • Schulze A, Bachert P, Schlemmer H–P, Harting I, Polster T, Salomons GS, Verhoeven NM, Jakobs C, Fowler B, Hoffmann GF, Mayatepek E: Lack of creatine in muscle and brain in an adult with GAMT deficiency. Ann. Neurol. 53: 248–251 (2003).
  • Schröder L, Schmitz C, Bachert P: Phase modulation in dipolar–coupled A2 spin systems: effect of maximum state mixing in 1H NMR in vivo. J. Magn. Reson. 171: 207–212 (2004).
  • Schröder L, Schmitz C, Bachert P: Molecular dynamics and information on possible sites of interaction of intramyocellular metabolites in vivo from resolved dipolar couplings in localized 1H NMR spectra. J. Magn. Reson. 171: 213–224 (2004).
  • Bachert P, Semmler W, Schlemmer H–P: Magnetresonanzspektroskopie in der klinischen Onkologie.In: "Onkologie — Grundlagen Diagnostik Therapie Entwicklungen" (Zeller WJ, zur Hausen H, Hrsg.), Kap. III–7, p. 1–39, 18. Erg.–Lfg. (12/2004), ecomed Medizin, Heidelberg.
  • Schröder L, Schmitz C, Bachert P: Cumulative „roof effect“ in high–resolution in vivo 31P NMR spectra of human calf muscle and the Clebsch–Gordan coefficients of ATP at 1.5 T. J. Magn. Reson. 174: 68–77 (2005).
  • Port RE, Schuster C, Port CR, Bachert P: Simultaneous sustained release of fludarabine monophosphate and Gd–DTPA from an interstitial liposome depot in rats: potential for indirect monitoring of drug release by magnetic resonance imaging. Cancer Chemother. Pharmacol. 58: 607–617 (2006).
  • Menze BH, Lichy MP, Bachert P, Kelm BM, Schlemmer H–P, Hamprecht FA: Optimal classification of long echo time in vivo magnetic resonance spectra in the detection of recurrent brain tumors. NMR Biomed. 19: 599–609 (2006).
  • Ulrich M, Wokrina T, Ende G, Lang M, Bachert P: 31P–{1H} echo–planar spectroscopic imaging of the human brain in vivo. Magn. Reson. Med. 57: 784–790 (2007).
  • Kirsch S, Bachert P: Diffraction–like phenomena in a periodic magnetization distribution at 1.5 T using the distant dipolar field (DDF). J. Magn. Reson. 185: 183–190 (2007).
  • Schröder L, Schmitz CHJ, Bachert P: Carnosine as molecular probe for sensitive detection of Cu(II) ions using localized 1H NMR spectroscopy. J. Inorg. Biochemistry 102: 174–183 (2008).
  • Kirsch S, Bachert P: Visualization of the distant dipolar field: a numerical study. Concepts Magn. Reson. Part A 34A: 357–364 (2009).
  • Zechmann C, Zamecnik P, Bachert P: Radiologische Diagnostik des Prostatakarzinoms.In: "Onkologie — Grundlagen Diagnostik Therapie Entwicklungen" (Zeller WJ, zur Hausen H, Hrsg.), Kap. V–2.13.1, p. 1–23, 26. Erg.–Lfg. (9/2009), ecomed Medizin, Heidelberg.
  • Matthies C, Nagel AM, Schad LR, Bachert P: Reduction of B0 inhomogeneity effects in triple–quantum–filtered sodium imaging. J. Magn. Reson.  202: 239–244 (2010).

1991 - 1999

  • Port RE, Bachert P, Semmler W: Kinetic modeling of in vivo–nuclear magnetic resonance spectroscopy data: 5–Fluorouracil in liver and liver tumors. Clin. Pharmacol. Ther. 49: 497–505 (1991).
  • Bachert P, Bellemann ME, Layer G, Koch T, Semmler W, Lorenz WJ: In vivo 1H, 31P–{1H} and 13C–{1H} magnetic resonance spectroscopy of malignant histiocytoma and skeletal muscle tissue in man. NMR Biomed. 5: 161–170 (1992).
  • Bachert P, Bellemann ME: Kinetics of the in vivo  31P–1H nuclear Overhauser effect of the human–calf–muscle phosphocreatine resonance. J. Magn. Reson. 100: 146–156 (1992).
  • Ende G, Bachert P: Dynamic 13C–1H nuclear polarization of lipid methylene resonances applied to broadband proton–decoupled in vivo 13C MR spectroscopy of human breast and calf tissue. Magn. Reson. Med. 30: 415–423 (1993).
  • Schlemmer H–P, Bachert P, Semmler W, Hohenberger P, Schlag P, Lorenz WJ, van Kaick G: Drug monitoring of 5–fluorouracil: In vivo 19F NMR study during 5–FU chemotherapy in patients with metastases of colorectal adenocarcinoma. Magn. Reson. Imag. 12: 497–511 (1994).
  • Krems B, Bachert P, Zabel H–J, Lorenz WJ: 19F–{1H} nuclear Overhauser effect and proton decoupling of 5–fluorouracil and a–fluoro–b–alanine. J. Magn. Reson. B 108: 155–164 (1995).
  • Bachert P, Schad LR, Bock M, Knopp MV, Ebert M, Großmann T, Heil W, Hofmann D, Surkau R, Otten EW: Nuclear magnetic resonance imaging of airways in humans with use of hyperpolarized 3He. Magn. Reson. Med. 36: 192–196 (1996).
  • Schulze A, Hess T, Wevers R, Mayatepek E, Bachert P, Marescau B, Knopp MV, De Deyn PP, Bremer HJ, Rating D: Creatine deficiency syndrome caused by guanidinoacetate methyltransferase deficiency: Diagnostic tools for a new inborn error of metabolism. J. Pediatr. 131: 626–631 (1997).
  • Bachert P: Kinetics of heteronuclear cross–relaxation in dipolar coupled–spin systems: Applications to in vivo measurements. Concepts Magn. Reson. 9: 227–245 (1997).
  • Becker M, Port RE, Zabel H–J, Zeller WJ, Bachert P: Monitoring local disposition kinetics of carboplatin in vivo after subcutaneous injection in rats by means of 195Pt NMR. J. Magn. Reson. 133: 115–122 (1998).
  • Bachert P: Pharmacokinetics using fluorine NMR in vivo. Prog. Nuc. Magn. Reson. Spec. 33: 1–56 (1998). doi: 10.1016/S0079–6565(98)00016–8.
  • Schlemmer H–P, Becker M, Bachert P, Dietz A, Rudat V, Vanselow B, Wollensack P, Zuna I, Knopp MV, Weidauer H, Wannenmacher M, van Kaick G: Alterations of intratumoral pharmacokinetics of 5–fluorouracil in head and neck carcinoma during simultaneous radiochemotherapy. Cancer Res. 59: 2363–2369 (1999).

to top
powered by webEdition CMS