Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.
Statistics

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external video platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name Youtube
Purpose External media

Division of Epigenetics

Prof. Dr. Frank Lyko

Microscopic image of cancer stem cells expressing EGFP under the control of the OCT4-promoter.
© dkfz.de

Epigenetic mechanisms regulate the interpretation of genetic information and adapt gene expression patterns to changing developmental or environmental contexts. Several epigenetic mechanisms have been identified so far, with DNA cytosine methylation representing the best-studied and possibly most relevant epigenetic mark. Interestingly, cytosine methylation is also present in RNA, suggesting conserved epigenetic functions of DNA and RNA methylation. Our research focuses on understanding the biological function of cytosine methylation as a versatile epigenetic mark. Importantly, altered DNA methylation patterns represent one of the earliest and most consistent hallmarks of human cancers. We are using molecular approaches in combination with genome-wide epigenetic profiling technologies to analyze epigenetic alterations in premalignant lesions and during tumor formation. We have also developed a detailed mechanistic understanding of RNA methylation as a novel epigenetic mark. Finally, we are establishing the marbled crayfish as a unique animal model for clonal genome evolution and epigenetic variation.

FUTURE OUTLOOK
The division will continue its focus on the mechanisms that drive epigenetic alterations during tumorigenesis. We will also continue to explore the role of RNA methylation in the re-coding of the cancer transcriptome and further investigate adaptive functions of DNA methylation in marbled crayfish.

Contact

Prof. Dr. Frank Lyko
Epigenetics (A130)
Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 280
69120 Heidelberg
Tel: +49 6221 42 3800

Selected Publications

  • Lyko, F. (2018). The DNA methyltransferase family: a versatile toolkit for epigenetic regulation. Nat. Rev. Genet. 19: 81-92.
  • Rodriguez-Paredes, M., Bormann, F., Raddatz, G., Gutekunst, J., Lucena-Porcel, C., Köhler, F., Wurzer, E., Schmidt, K., Gallinat, S., Wenck, H., Röwert-Huber, J., Denisova, E., Feuerbach, L., Park, J., Brors, B., Herpel, E., Nindl, I., Hofmann, T.G., Winnefeld, M., and Lyko, F. (2018). Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin. Nat. Commun. 9: 577.
  • Legrand, C., Tuorto, F., Hartmann, M., Liebers, R., Jacob, D., Helm, M., and Lyko, F. (2017). Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs. Genome Res. 27: 1589-1596.
  • Gutekunst, J., Andriantsoa, R., Falckenhayn, C., Hanna, K., Stein, W., Rasamy, J., and Lyko, F. (2018). Clonal genome evolution and rapid invasive spread of the marbled crayfish. Nat. Ecol. Evol. 2: 567-573.
to top
powered by webEdition CMS