Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .


These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds

Division of Theoretical Systems Biology

Prof. Dr. Thomas Höfer

Tracking of individual tumor cells in the fluorescence microscope.

The Division of Theoretical Systems Biology pursues multidisciplinary research to understand how biological function emerges from interacting components - molecules within a cell and cells within an organism. Our work is essentially collaborative and characterized by a tight interplay between experimentation, data analysis and mathematical modeling. We dissect the molecular switches that regulate the proliferation and differentiation of T lymphocytes and thus orchestrate adaptive immune responses. The second focus of the division is on growth-factor signaling and cell-cycle control. We study the interplay of these processes in human tumor models to understand how therapy resistance arises from synergistic oncogene action. From both strands of work common principles at the systems level are emerging. Our work aims at identifying the functional behavior of molecular networks in the cell and at quantifying the control exerted by individual components to inform novel therapeutic approaches.

A key challenge of quantitative biology is to understand the interplay between molecular modules - such as those controlling the induction and maintenance of expression of master transcription factors for cell fate - and genome-wide programs that mediate coordinated cell function.


Prof. Dr. Thomas Höfer
Theoretical Systems Biology (B086)
Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 267
69120 Heidelberg
Tel: +49 6221 42-1980

Selected Publications

  • Li C, Cesbron F, Oehler M, Brunner M, Höfer T (2018) Frequency modulation of transcriptional bursting enables sensitive and rapid gene regulation. Cell Systems, 6, 409-423.
  • Ryl T, Kuchen EE, Bell E, Shao C, Floréz A, Moenke G, Gogolin S, Friedrich M, Lamprecht F, Westermann F, Höfer T (2017) Cell-cycle position of single MYC-driven cancer cells dictates their susceptibility to a chemotherapeutic drug. Cell Systems 5, 237-250.
  • Pei W, Feyerabend TB, Rössler J, Wang X, Postrach D, Busch K, Klapproth K, Rode I, Dietlein N, Quedenau C, Chen W, Sauer S, Wolf S, Höfer T, Rodewald HR (2017) Endogenous barcoding reveals hematopoietic stem cell fates realized in vivo. Nature 548, 456-460
  • Busch K, Klapproth K, Barile M, Flossdorf M, Holland-Letz M, Schlenner SM, Reth M, Höfer T, Rodewald HR (2015) Fundamental properties of unperturbed hematopoiesis from stem cells in vivo. Nature 518, 542-546.
to top
powered by webEdition CMS