Primary Research Articles (since establishment of the group at the DKFZ in 2012)


Wieland E, Rodriguez-Vita J, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A. (2017) Endothelial Notch1 Activity Facilitates Metastasis. Cancer Cell. Mar 13;31(3):355-367.

Editorial in Cancer Cell.

Editorial in Cancer Discovery.


Spiegler S, Kirchmaier B, Rath M, Korenke GC, Tetzlaff F, van de Vorst M, Neveling K, Acker-Palmer A, Kuss AW, Gilissen C, Fischer A, Schulte-Merker S, Felbor U. (2016) FAM222B is not a likely novel candidate gene for cerebral cavernous malformations. Mol Syndrom Jul;7(3):144-52.


Herberich SE*, Klose R*, Moll I, Yang W-J, Wüstehube-Lausch J, Fischer A (2015) ANKS1B interacts with the cerebral cavernous malformation protein-1 and controls endothelial permeability but not sprouting angiogenesis. PLoS One.10(12):e0145304

Yang W-J*, Hu J*, Uemura A, Tetzlaff F, Augustin HG, Fischer A (2015) Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis. EMBO Mol Med. 7 (10):1267-1284.

Editorial in EMBO Mol Med.

Selected as Cover Image.

Klose R*, Berger C*, Moll I, Adam MG, Schwarz F, Mohr K, Augustin HG, Fischer A (2015) Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis. Cardiovasc Res. 107(1):153-163.

Wöltje K*, Jabs M*, Fischer A (2015) Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS One. 10 (3): e0120547.

Schulz GB, Wieland E, Wüstehube-Lausch J, Boulday G, Moll I, Tournier-Lasserve E, Fischer A (2015) Cerebral cavernous malformation-1 protein controls DLL4-Notch3 signaling between the endothelium and pericytes. Stroke. 46(5):1337-1343.


Adam MGBerger C, Feldner A, Yang W-J, Wüstehube-Lausch J, Herberich SE, Pinder M, Gesierich S, Hammes H-P, Augustin HG, Fischer A (2013) Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res. 113: 1206-1218.

Editorial in Circ Res.

Selected as Cover Image.

Among the 10 most read articles published 2013 in Circ Res.

Schaafhausen MK, Yang WJ, Centanin L, Wittbrodt J, Bosserhoff A, Fischer A, Schartl M, Meierjohann S (2013) Tumor angiogenesis is caused by single melanoma cells in a reactive oxygen species and NF-κB dependent manner. J Cell Sci. 126: 3862-3872.


Liebler SSFeldner A, Adam MG, Korff T, Augustin HG, Fischer A (2012) No evidence for a functional role of bi-directional Notch signaling during angiogenesis. PLoS One. 7 (12): e53074.

Primary Research Articles (before establishment of DKFZ group in 2012)


Wagner TU*, Fischer A*, Thoma EC, Schartl M (2011) Cross Query: a web tool for easy associative querying of transcriptome data. PLoS One 6: e28990.

Thoma EC, Wagner TU, Weber IP, Herpin A, Fischer A, Schartl, M (2011) Ectopic expression of single transcription factors directs differentiation of a medaka spermatogonial cell line. Stem Cells Dev 20: 1425-1438.

Schleider E, Stahl S, Wüstehube J, Walter U, Fischer A, Felbor U (2011) Evidence for anti-angiogenic and pro-survival functions of the cerebral cavernous malformation protein 3. Neurogenetics 12: 83-86.


Wüstehube J, Bartol A, Liebler SS, Brütsch R, Zhu Y, Felbor U, Sure U, Augustin HG, Fischer A (2010) Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A 107: 12640-12645.

Selected as Cover Image.

Brütsch R*, Liebler SS*, Wüstehube J*, Bartol A, Herberich SEAdam MG, Telzerow A, Augustin HG, Fischer A (2010) Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. Circ Res 107: 592-601.


Coulpier F, Le Crom S, Maro GS, Manent J, Giovannini M, Maciorowski Z, Fischer A, Gessler M, Charnay P, Topilko P (2009) Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Glia 57: 1450-1457.


Fischer A, Steidl C, Wagner TU, Lang E, Jakob PM, Friedl P, Knobeloch KP, Gessler M (2007) Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res 100: 856-863.

Diez H, Fischer A, Winkler A, Hu CJ, Hatzopoulos AK, Breier G, Gessler M (2007) Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res 313: 1-9.


Rutenberg JB, Fischer A, Jia H, Gessler M, Zhong TP, Mercola M (2006) Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development 133: 4381-4390.


Fischer A, Klattig J, Kneitz B, Diez H, Maier M, Holtmann B, Englert C, Gessler M (2005) Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol Cell Biol 25: 8960-8970.


Fischer A, Klamt B, Schumacher N, Glaeser C, Hansmann I, Fenge H, Gessler M (2004) Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome. Mamm Genome 15: 711-716.

Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M (2004) The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev 18: 901-911.

Schlaeger TM, Schuh A, Flitter S, Fischer A, Mikkola H, Orkin SH, Vyas P, Porcher C (2004) Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Mol Cell Biol 24: 7491-7502.


Popp H, Kalb R, Fischer A, Lobitz S, Kokemohr I, Hanenberg H, Schindler D (2003) Screening Faconi anemia lymphoid cell lines of non-A, C, D2, E, F, G subtypes for defects in BRCA2/FANCD1. Cytogenet Genome Res 103: 54-57.

Van Wayenbergh R, Taelman V, Pichon B, Fischer A, Kricha S, Gessler M (2003) Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT/Hey1 in Xenopus and mouse. Dev Dyn 228: 716-725.


Gessler M, Knobeloch KP, Helisch A, Amann K, Schumacher N, Rohde E, Fischer A, Leimeister C (2002) Mouse gridlock: no aortic coarctation or deficiency, but fatal cardiac defects in Hey2 -/- mice. Curr Biol 12: 1601-1604.


Leimeister C, Dale K, Fischer A, Klamt B, Hrabe de Angelis M, Radtke F, McGrew MJ, Pourquie O, Gessler M (2000) Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors. Dev Biol 227: 91-103.

group members are underlined

*, equal contribution

Reviews, Books and Book Chapters


Fischer A Physiologie Band 6, Herz und Kreislauf, 7. Auflage, MEDI-LEARN Verlag, Marburg.


Fischer A, Zalvide J, Faurobert E, Albiges-Rizo C, Tournier-Lasserve E (2013) Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis. Trends Mol Med 19 (13): 302-308.


Fischer A, Schremmer C (2011) Physiologie Band 6, Herz und Kreislauf, 3./4. Auflage, MEDI-LEARN Verlag, Marburg.


Fischer A, Augustin H (2009) Eine verhängnisvolle Affäre - Krebszellen gehen mit Blutgefäßen eine unglückselige Liaison ein – eine Beziehung, die sich therapeutisch nutzen lässt. Ruperto Carola, 2/2009, Universität Heidelberg. Universitätsverlag Winter GmbH Heidelberg.


Fischer A, Gessler M (2007) Delta-Notch--and then? Protein interactions and purposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res 35: 4583-4596.

Fischer A, Gessler M (2007) Notch-Regulation der Herzentwicklung. BIOspectrum 13: 352-256.


Fischer A, Gessler M (2003) Hey genes in cardiovascular development. Trends Cardiovasc Med 13: 221-226.


Fischer A, Leimeister C, Winkler C, Schumacher N, Klamt B, Elmasri, H, Steidl, C, Maier M, Kobeloch KP, Amann K, Helisch A, Sendtner M, Gessler M (2002) Hey bHLH factors in cardiovascular development. Cold Spring Harb Symp Quant Biol. 67: 63-70.

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