§Sykes S.M., $Kokkaliaris K., §Milsom M.D., Levine R.L. and Majeti R. Clonal evolution of pre-leukemic hematopoietic stem cells in acute myeloid leukemia. §Equal contribution. Exp. Hematology. Epub ahead of print, doi: 10.1016/j.exphem.2015.08.012.

Haas S., Hansson J., Klimmeck D., Löffler D., Velten L., Uckelmann H., Wurzer S., Prendergast A., Schnell A., Hexel K., Santarella-Mellwig R.,Blaszkiewicz S., Kuck A., Geiger H., Milsom M.D., Steinmetz L., Schroeder T., Trumpp A., Krijgsveld J. and Essers M.A.G. (2015). Inflammation-induced emergency megakaryopoiesis driven by hematopoietic stem cell-like megakaryocyte progenitors. Cell Stem Cell, 17(4): pp422-434.

Kaschutnig P., Bogeska R., Walter D., Lier A., Huntscha S. and Milsom M.D. (2015). The Fanconi anemia pathway is required for efficient repair of stress-induced DNA damage in hematopoietic stem cells. Cell Cycle, 14(17): pp2734-2742.

Guda S., Brendel C., Renella R., Du P., Bauer D.E., Canver M.C.,Grenier J.K., Grimson A.W., Kamran S.C., Thornton J., De Boer H., Root D.E., Milsom M.D., Orkin S.H., Gregory R. and Williams D.A. (2015). miRNA-embedded shRNAs for lineage-specific BCL11A knockdown and hemaglobin F induction. Mol. Therapy, 23(9): pp1465-1474.

Walter D., Lier A, Geiselhart A., Thalheimer F.B., Huntscha S., Sobotta M.C., Moehrle B., Brocks D., Bayindir I., Kaschutnig P., Müdder K., Klein C., Jauch A., Schroeder T., Geiger H., Dick T.P., Holland-Letz T., Schmezer P., Lane S.W., Rieger M.A., Essers M.A.G., Williams D.A.W., Trumpp A.and Milsom M.D. (2015). Exit from dormancy provokes DNA damage-induced attrition in haematopoietic stem cells. Nature, 520(7548): pp549-552).


Lipka D.B., Wang Q., Cabezas-Wallscheid N, Klimmeck D, Weichenhan D., Herrmann C, Lier A., Brocks D., Assenov Y., von Paleske L., Renders S., Wünsche P., Zeisberger P., Gu L., Haas S., Essers M.A.G, Brors B, Eils R., §Trumpp A, §Milsom M.D., and §Plass C. (2014). Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulphite sequencing. Cell Cycle, 13(22): pp3476-3487. §Shared senior authorship.

Cabezas-Wallscheid N., Klimmeck D., Hansson J., Lipka D.B., Reyes A., Wang Q., Weichenhan D., Lier A., von Paleske L., Renders S., Wünsche P., Brocks D., Gu L., Herrmann C., Haas S., Essers M., Brors B., Eils R., §Huber W., §Milsom M.D., §Plass C., §Krijgsveld J. and §Trumpp A. (2014). Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome and DNA methylome analysis. Cell Stem Cell, 15(4): pp507-522. §Shared senior authorship.

Placke T., Faber K., Nonami A., Putwain S., Salih H., Heidel F., Krämer A., Root D., Barbie D., Armstrong S., Hahn W., Huntly B., Sykes S., Milsom M.D., Scholl C. and Fröhling S. (2014). Requirement for CDK6 in MLL-rearranged acute myeloid leukemia. Blood, 124 (1): pp13-23

Sonnet M., Claus R., Becker N., Zucknick M., Peterson J., Lipka D.B., Oakes C.C., Andrulis M., Lier A., Milsom M.D., Witte T., Gu L., Kim-Wanner S.-Z., Schirmacher P., Wulfert M., Gattermann N., Lübbert M., Rosenbauer F., Rehli M., Bullinger L., Weichenhan D. and Plass C. (2014). Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia. Genome Medicine, 6 (4): 34


Dorrance A.M., De Vita S., Radu M., Reddy P.N.G., McGuinness M., Harris C.E., Mathieu R., Lane S.W., Kosoff R., Milsom M.D., Chernoff J. and Williams D.A. (2013). The Rac GTPase effector p21 activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood 121 (13): pp2474-82.


Liu J., Hettmer S., Milsom M.D., Bronson R.T., Hofmann I., Hua F., Miller C. and Wagers A.J. (2012). Induction of myeloid sarcoma in mouse skeletal muscle. PLoS ONE, 7(8): e44044.

Geiselhart A., Walter D., Lier A. and Milsom M.D. (2012). Disrupted signalling through the Fanconi anemia pathway leads to dysfunctional hematopoietic stem cell biology: underlying mechanisms and potential therapeutic strategies. Anemia, 2012: 265790.

§Müller L.U.W., §Milsom M.D., Harris C.E., Vyas R., Brumme K.M., Parmar K., Moreau L.A., Schambach A., Park I.H., London W.B., Strait K., D’Andrea A., Daley G.Q. and Williams D.A. (2012). Overcoming reprogramming resistance of Fanconi anemia cells. Blood. 119 (23): pp5449-57. §Equal contribution.

Lane S.W., De Vita S., Kamaran R., Smits P., Warman M., Milsom M.D., Dorrance A.M., Louis L., Bouxsein M. and Williams D.A. (2012). Rac signalling in osteoblastic progenitor cells is required for normal bone development but is dispensable for hematopoietic development. Blood, 119 (3): pp736-44.


Milsom M.D. and Trumpp A. (2011). Bridging the information gap. Nat. Immunol., 12 (5): pp377-9.


Milsom M.D., Lee A.W., Zheng Y. and Cancelas J.A. (2009). Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766. Haematologica, 94 (7): pp1011-15.

Milsom M.D., Schiedlmeier B., Bailey J., Kim M.O., Li D., Jansen M., Ali M.A., Kirby M., Baum C., Fairbairn L.J. and Williams D.A. (2009). Ectopic HOXB4 overcomes the inhibitory effects of tumor necrosis factor-α on Fanconi anemia hematopoietic stem and progenitor cells. Blood, 113 (21): pp5111-20.


Milsom M.D., Jerabek-Willemsen M., Harris C.E., Schambach A., Broun E., Bailey J., Jansen M., Schleimer D., Nattamai K., Wilhelm J., Watson A., Geiger H., Margison G.P., Moritz T., Baum C., Thomale J., and Williams D.A. (2008). Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells. Cancer Res., 68 (15): pp6171-80.

Müller L.U., Milsom M.D., Kim M.O., Schambach A., Schuesler T. and Williams D.A. (2008). Rapid lentiviral transduction preserves engraftment potential of Fanca-/- hematopoietic stem cells. Mol. Therapy, 16 (6): pp1154-60.

Ghiaur G., Ferkowicz M.J., Milsom M.D., Bailey J., Cancelas J.A., Yoder M.C. and Williams D.A. (2008). Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of the fetal liver with hematopoietic progenitor cells. Blood, 111 (7): pp3313-21.



Southgate T.D., Sheard V., Milsom M.D., Ward T.H., Mairs R.J., Boyd M. and Fairbairn L.J. (2006). Radioprotective gene therapy through retroviral expression of manganese superoxide dismutase.  J. Gene Med., 8 (5): pp557-65.

Chinnasamy D, Milsom M.D., Shaffer J, Neuenfeldt J, Shaaban A.F., Margison G.P., Fairbairn L.J. and Chinnasamy N.  (2006).  Multicistronic Lentiviral Vectors Containing the Foot-and-Mouth Disease Virus 2A Cleavage Factor Demonstrate Robust Expression of Encoded Genes at Limiting MOI.  Virol. J., 3: 14

Woolford L.B., Southgate T.D., Margison G.P., Milsom M.D. and Fairbairn L.J.  (2006). The P140K mutant of human O6-methylguanine-DNA-methyltransferase (MGMT)confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O6-(4-bromothenyl)guanine. J. Gene Med., 8 (1): pp29-34.


Milsom M.D., Duxbury R., Gagen D., Humphries R.K., Schmidt M., von Kalle C. and Fairbairn L.J. (2005). Overexpression of HOXB4 Confers a Myelo-Erythroid Differentiation Delay In Vitro. Leukemia, 19 (1): pp148-53.


Milsom M.D., WoolfordL.B., MargisonG.P., HumphriesR.K. and Fairbairn L.J.  (2004). Enhanced In Vivo Selection of Bone Marrow Cells by Retroviral-Mediated Co-expression of Mutant O6-Methylguanine-DNA-Methytransferase and HOXB4.  Mol. Therapy, 10 (5): pp862-73.

Milsom M.D. and Fairbairn L.J. (2004).  Protection and selection for gene therapy in the hematopoietic system.  J. Gene Med., 6 (2): pp133-46.

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