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Publications
2008
Gebhardt C, Riehl A, Durchdewald M, Németh J, Fürstenberger G, Müller-Decker K, Enk A, Arnold B, Bierhaus A, Nawroth PP, Hess J, Angel P. RAGE signaling sustains inflammation and promotes tumor development. J Exp Med. 2008 Feb 18; 205(2):275-285.
2007
Klucky B, Mueller R, Vogt I, Teurich S, Hartenstein B, Breuhahn K, Flechtenmacher C, Angel P, Hess J. Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion. Cancer Res. 2007 Sep 1;67(17):8198-206.
Ott RG, Simma O, Kollmann K, Weisz E, Zebedin EM, Schorpp-Kistner M, Heller G, Zochbauer S, Wagner EF, Freissmuth M, Sexl V. Infarct volume after transient middle cerebral artery occlusion (MCAo) can be reduced by attenuation but not by inactivation of c-Jun action. Brain Res. 2007 Jun 2;1151:12-9. Epub 2007 Mar 13.
2004
Florin L, Hummerich L, Dittrich BT, Kokocinski F, Wrobel G, Gack S, Schorpp-Kistner M, Werner S, Hahn M, Lichter P, Szabowski A, Angel P. Identification of novel AP-1 target genes in fibroblasts regulated during cutaneous wound healing. Oncogene. 2004 Sep 16;23(42):7005-17.
Kenner L, Hoebertz A, Beil T, Keon N, Karreth F, Eferl R, Scheuch H, Szremska A, Amling M, Schorpp-Kistner M, Angel P, Wagner EF. Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J Cell Biol. 2004 Feb 16;164(4):613-23.
2003
Schlingemann J, Hess J, Wrobel G, Breitenbach U, Gebhardt C, Steinlein P, Kramer H, Furstenberger G, Hahn M, Angel P, Lichter P.Profile of gene expression induced by the tumour promotor TPA in murine epithelial cells.
2001
Labrador JP, Azcoitia V, Tuckermann J, Lin C, Olaso E, Manes S, Bruckner K, Goergen JL, Lemke G, Yancopoulos G, Angel P, Martinez C, Klein R. The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep. 2001 May;2(5):446-52.
Maas-Szabowski, N., Szabowski, A., Stark, H. J., Andrecht, S., Kolbus, A., Schorpp-Kistner, M., Angel, P., and Fusenig, N. E. (2001). Organotypic cocultures with genetically modified mouse fibroblasts as a tool to dissect molecular mechanisms regulating keratinocyte growth and differentiation. J Invest Dermatol 116, 816-20.
Passegue, E., Jochum, W., Schorpp-Kistner, M., Mohle-Steinlein, U., and Wagner, E. F. (2001). Chronic Myeloid Leukemia with Increased Granulocyte Progenitors in Mice Lacking JunB Expression in the Myeloid Lineage. Cell 104, 21 32.
Verrecchia, F., Tacheau, C., Schorpp-Kistner, M., Angel, P., and Mauviel, A. (2001). Induction of the AP-1 members c-Jun and JunB by TGF-beta/Smad suppresses early Smad-driven gene activation. Oncogene 20, 2205-11.
2000
Szabowski, A., Maas-Szabowski, N., Andrecht, S., Kolbus, A., Schorpp-Kistner, M., Fusenig, N. E., and Angel, P. (2000). c-Jun and JunB antagonistically control cytokine-regulated mesenchymal- epidermal interaction in skin. Cell 103, 745-55.
Kolbus, A., Herr, I., Schreiber, M., Debatin, K. M., Wagner, E. F., and Angel, P. (2000). c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents. Mol Cell Biol 20, 575-82.
Eichhorst, S. T., Muller, M., Li-Weber, M., Schulze-Bergkamen, H., Angel, P., and Krammer, P. H. (2000). A Novel AP-1 Element in the CD95 Ligand Promoter Is Required for Induction of Apoptosis in Hepatocellular Carcinoma Cells upon Treatment with Anticancer Drugs. Mol Cell Biol 20, 7826-7837.
before 2000
van Dam, H., Huguier, S., Kooistra, K., Baguet, J., Vial, E., van der Eb, A. J., Herrlich, P., Angel, P., and Castellazzi, M. (1998). Autocrine growth and anchorage independence: two complementing Jun- controlled genetic programs of cellular transformation. Genes Dev 12, 1227-39.
Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., and Schutz, G. (1998). DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93, 531-41.
Vallon, R., Muller, R., Moosmayer, D., Gerlach, E., and Angel, P. (1997). The catalytic domain of activated collagenase I (MMP-1) is absolutely required for interaction with its specific inhibitor, tissue inhibitor of metalloproteinases-1 (TIMP-1). Eur J Biochem 244, 81-8.
Zwilling, S., Dieckmann, A., Pfisterer, P., Angel, P., and Wirth, T. (1997). Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. Science 277, 221-5.
Herr, I., Wilhelm, D., Bohler, T., Angel, P., and Debatin, K. M. (1997). Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J 16, 6200-8.
Schorpp, M., Jager, R., Schellander, K., Schenkel, J., Wagner, E. F., Weiher, H., and Angel, P. (1996). The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. Nucleic Acids Res 24, 1787-8.
Schorpp, M., Mattei, M. G., Herr, I., Gack, S., Schaper, J., and Angel, P. (1995). Structural organization and chromosomal localization of the mouse collagenase type I gene. Biochem J 308, 211-7.
van Dam, H., Wilhelm, D., Herr, I., Steffen, A., Herrlich, P., and Angel, P. (1995). ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J 14, 1798-811.
Gack, S., Vallon, R., Schmidt, J., Grigoriadis, A., Tuckermann, J., Schenkel, J., Weiher, H., Wagner, E. F., and Angel, P. (1995). Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. Cell Growth Differ 6, 759-67.
Schreiber, M., Baumann, B., Cotten, M., Angel, P., and Wagner, E. F. (1995). Fos is an essential component of the mammalian UV response. EMBO J 14, 5338-49.
Bannister, A. J., Oehler, T., Wilhelm, D., Angel, P., and Kouzarides, T. (1995). Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11, 2509-14.
Gack, S., Vallon, R., Schaper, J., Ruther, U., and Angel, P. (1994). Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein. J Biol Chem 269, 10363-9.
Oehler, T., Pintzas, A., Stumm, S., Darling, A., Gillespie, D., and Angel, P. (1993). Mutation of a phosphorylation site in the DNA-binding domain is required for redox-independent transactivation of AP1-dependent genes by v-Jun. Oncogene 8, 1141-7.
Hagmeyer, B. M., Konig, H., Herr, I., Offringa, R., Zantema, A., van der Eb, A., Herrlich, P., and Angel, P. (1993). Adenovirus E1A negatively and positively modulates transcription of AP- 1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun. EMBO J 12, 3559-72.
Stein, B., Baldwin, A. S., Jr., Ballard, D. W., Greene, W. C., Angel, P., and Herrlich, P. (1993). Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J 12, 3879-91.
Angel, P., Allegretto, E. A., Okino, S. T., Hattori, K., Boyle, W. J., Hunter, T., and Karin, M. (1988). Oncogene jun encodes a sequence-specific trans-activator similar to AP- 1. Nature 332, 166-71.
Angel, P., Imagawa, M., Chiu, R., Stein, B., Imbra, R. J., Rahmsdorf, H. J., Jonat, C., Herrlich, P., and Karin, M. (1987). Phorbolester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49, 729-39.
