Research Group Molecular Therapy of Virus-Associated Cancers
Prof. Dr. Felix Hoppe-Seyler
It is the overall aim of our work to get insights into the molecular mechanisms of carcinogenesis with the ultimate goal to use this knowledge for the benefit of cancer patients.
Our work focuses on tumor viruses. By conservative estimations, at least 15-20% of human cancers are known to be linked to viral infections (see: H. zur Hausen. Nobelprize Lecture, Virology 392:1-10; 2009). Viruses thus constitute one of the most important risk factors for cancer development.
In order to transform normal cells into cancer cells, tumor viruses, such as human papillomaviruses (HPV), attack critical regulatory pathways of the cell. The identification and characterization of these pathways is essential for our understanding of viral carcinogenesis and, in addition, should provide us with novel insights into generally relevant mechanisms of human cancer development. Furthermore, the elucidation of the transforming mechanisms is also a pre-requisite for the development of novel therapeutic strategies.
For details see: Research
Honegger, A., Schilling, D., Bastian, S., Sponagel, J., Kuryshev, V., Sültmann, H., Scheffner, M., Hoppe-Seyler, K., Hoppe-Seyler, F. (2015). Dependence of Intracellular and Exosomal microRNAs on Viral E6/E7 Oncogene Expression in HPV-positive Tumor Cells. PLoS Pathogens, 11: e1004712.
Stutz C, Reinz E, Honegger A, Bulkescher J, Schweizer J, Zanier K, Travé G, Lohrey C, Hoppe-Seyler K, Hoppe-Seyler F. (2015). Intracellular Analysis of the Interaction between the Human Papillomavirus Type 16 E6 Oncoprotein and Inhibitory Peptides. PLoS One, 10: e0132339.
Leitz, J., Reuschenbach, M., Lohrey, C., Honegger, A., Accardi, R., Tommasino, M., Llano, M., von Knebel Doeberitz, M., Hoppe-Seyler, K., Hoppe-Seyler, F. (2014). Oncogenic Human Papillomaviruses Activate the Tumor-Associated Lens Epithelial-Derived Growth Factor (LEDGF) Gene. PLoS Pathogens, 10: e1003957.
Zanier, K., Stutz, C., Kintscher, S., Reinz, E., Sehr, P., Bulkescher, J., Hoppe-Seyler, K., Travé, G., Hoppe-Seyler, F. (2014). The E6AP Binding Pocket of the HPV16 E6 Oncoprotein Provides a Docking Site for a Small Inhibitory Peptide Unrelated to E6AP, Indicating Druggability of E6. PLoS ONE 9: e112514.