Molecular Therapy of Virus-Associated Cancers

Research Group Molecular Therapy of Virus-Associated Cancers

Prof. Dr. Felix Hoppe-Seyler

Oncogenic types of human papillomaviruses (HPVs) belong to the most important known cancer risk factors. The research group “Molecular Therapy of Virus-Associated Cancers” studies the molecular mechanisms of viral oncogenesis, with a particular emphasis on the interplay between HPVs and the host cell metabolism. We expect that these studies will not only be informative for tumor virology but will also improve our general concepts of human cancer development. Moreover, deciphering the mechanisms of malignant cell transformation is a prerequisite for the development of innovative strategies for targeted cancer therapy.

Future research will analyze the interplay between the HPV oncogenes and the metabolic state of the host cell, including oxygenation and iron metabolism, and aims to identify metabolic targets for therapeutic intervention.

For details see: Research


Prof. Dr. Felix Hoppe-Seyler
Molecular Therapy of Virus-Associated Cancers (F065)
Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 280
69120 Heidelberg
Tel: +49 6221 42 4872

Selected Publications

  • Honegger, A., Schilling, D., Bastian, S., Sponagel, J., Kuryshev, V., Sültmann, H., Scheffner, M., Hoppe-Seyler, K., Hoppe-Seyler, F. (2015). Dependence of Intracellular and Exosomal microRNAs on Viral E6/E7 Oncogene Expression in HPV-positive Tumor Cells. PLoS Pathogens, 11: e1004712.
  • Stutz C, Reinz E, Honegger A, Bulkescher J, Schweizer J, Zanier K, Travé G, Lohrey C, Hoppe-Seyler K, Hoppe-Seyler F. (2015). Intracellular Analysis of the Interaction between the Human Papillomavirus Type 16 E6 Oncoprotein and Inhibitory Peptides. PLoS One, 10: e0132339.
  • Leitz, J., Reuschenbach, M., Lohrey, C., Honegger, A., Accardi, R., Tommasino, M., Llano, M., von Knebel Doeberitz, M., Hoppe-Seyler, K., Hoppe-Seyler, F. (2014). Oncogenic Human Papillomaviruses Activate the Tumor-Associated Lens Epithelial-Derived Growth Factor (LEDGF) Gene. PLoS Pathogens, 10: e1003957.
  • Zanier, K., Stutz, C., Kintscher, S., Reinz, E., Sehr, P., Bulkescher, J., Hoppe-Seyler, K., Travé, G., Hoppe-Seyler, F. (2014). The E6AP Binding Pocket of the HPV16 E6 Oncoprotein Provides a Docking Site for a Small Inhibitory Peptide Unrelated to E6AP, Indicating Druggability of E6. PLoS ONE 9: e112514.
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