Molecular Therapy of Virus-Associated Cancers

Research Group Molecular Therapy of Virus-Associated Cancers

Prof. Dr. Felix Hoppe-Seyler

Oncogenic types of human papillomaviruses (HPVs) belong to the most important known cancer risk factors. The research group “Molecular Therapy of Virus-Associated Cancers” studies the molecular mechanisms of viral oncogenesis, with a particular emphasis on the interplay between HPVs and the host cell metabolism. We expect that these studies will not only be informative for tumor virology but will also improve our general concepts of human cancer development. Moreover, deciphering the mechanisms of malignant cell transformation is a prerequisite for the development of innovative strategies for targeted cancer therapy.

FUTURE OUTLOOK
Future research will analyze the interplay between the HPV oncogenes and the metabolic state of the host cell, including oxygenation and iron metabolism, and aims to identify metabolic targets for therapeutic intervention.

For details see: Research

Contact

Prof. Dr. Felix Hoppe-Seyler
Molecular Therapy of Virus-Associated Cancers (F065)
Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 280
69120 Heidelberg
Tel: +49 6221 42 4872

Selected Publications

  • Hoppe-Seyler K, Bossler F, Lohrey C, Bulkescher J, Rösl F , Jansen L, Mayer A, Vaupel P, Dürst M, Hoppe-Seyler F. (2017). Induction of Dormancy in Hypoxic Human Papillomavirus-Positive Cancer Cells. Proc. Natl. Acad. Sci. USA, 114: E990-E998
  • Hoppe-Seyler K, Bossler F, Braun JA, Herrmann AL, Hoppe-Seyler F. (2017). The HPV E6/E7 Oncogenes: Key Factors for Viral Carcinogenesis and Therapeutic Targets. Trends in Microbiology, in press. doi: 10.1016/j.tim.2017.07.007
  • Hoppe-Seyler K, Honegger, A., Bossler F, Sponagel J, Bulkescher J, Lohrey C, Hoppe-Seyler F. (2017). Viral E6/E7 Oncogene and Cellular Hexokinase 2 Expression in HPV-Positive Cancer Cell Lines. Oncotarget, in press.
  • Honegger, A., Schilling, D., Bastian, S., Sponagel, J., Kuryshev, V., Sültmann, H., Scheffner, M., Hoppe-Seyler, K., Hoppe-Seyler, F. (2015). Dependence of Intracellular and Exosomal microRNAs on Viral E6/E7 Oncogene Expression in HPV-positive Tumor Cells. PLoS Pathogens, 11: e1004712.
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