Advanced mouse models of brain tumors

Brain tumor developed in mouse models
© Dr. Haikun Liu

A huge amount of data are being collected from patient samples, however, most of these information will be only considered as descriptive results if they are not tested in experimental setting using model system. To provide better mouse models of human brain cancer for this purpose, we are applying several sets of genetic tools including Cre/LoxP, somatic gene transfer and CRISPR/CAS9 to generate mouse models that mimic both the phenotypic and genetic heterogeneity from human patients. The goal is to provide mouse models can be used to study tumor initiation, tumor genetic evolution and preclinical target validation in primary tumor models.

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