Major Cancer Biology Students 2012

> DKFZ Graduation Ceremony on 21. November 2014

© dkfz.de

On Friday, 21. November 2014, the PhD and Master students of the DKFZ, who have successfully completed their studies in course of the year,  will receive their certificates and congratulations during the annual Graduation Ceremony organized by the Helmholtz International Graduate School for Cancer Research.

All Major Cancer Biology students, faculty, friends and family are warmly invited to come to the Grand Lecture Theatre at 4.30 pm to celebrate the new PhDs and Masters and to attend when certificates and scholarships are awarded.

The Ceremony will again be accompanied by the student band "The Wild Types".
Afterwards there is a sekt reception, and starting at 9 pm the legendary PhD party Ph.inishe.D will rock the house.

Welcome to the 23 international students who have joined Major Cancer Biology for the Winter Term 2012/2013:

On 16. October 2012 the new students were welcomed at the DKFZ by Dr. Jörg Hoheisel, Head of the Division of Functional Genome Analysis and Chairman of the Scientific Council of the German Cancer Research Center, and by the Program Coordinator, Prof. Dr. Ilse Hofmann.

download: Program of the 2012 Welcome and Introduction Events

© dkfz.de

Sara AHMED (Egypt)

University Education
10/2012- present: Pursuing M.Sc. in Molecular Biosciences with Major Cancer Biology, Ruprecht-Karls-University of Heidelberg and DKFZ, Germany
08/2007- 08/2012: Bachelor of Science in Pharmacy and Biotechnology, the German University in Cairo.

Highest Degree
Bachelor of Science in Pharmacy and Biotechnology (with Highest Honours)

Title of Bachelor Project
Unveiling the impact of miR 17-5p on hepatocellular carcinoma cellular viability and proliferation

Internships/Work Experience
07/2008: A Lab assistant in Pharmaceutical Analytical Chemistry Department at the German University in Cairo (GUC)
07/2009- 09/2009: Pharmacy trainee
08/2011: Granted a scholarship award from the Eberhard Karls Universität Tübingen funded by the Deutscher Akademischer Austauschdienst to attend a Drug Design intensive practical and theoretical course
10/2011- 1/2012: Worked as a substitute junior teaching assistant of Physical Chemistry Lab for Biotechnology students under the direct supervision of Professor: Ahmed AbdelAziz at the German University in Cairo
2/2012 – 3/2012: Worked as an intern at the Pharmaceutical Technology Department of Bonn University in Professor: Alf Lamprecht’s Research Group. My project’s main concern was regarding both formulation and characterization of micro and nano particles
9/2011 – 9/2012: Junior team member in the Molecular Pathology Research Group (MPRG) at the German University in Cairo with whom I have made my Bachelor Project under the direct supervision of the Post Doctoral Researcher: Hend M. El Tayebi and the Group Leader Associate Professor: Ahmed Ihab Abdelaziz as titled above

Research Interests/Future Plans
During my bachelor studies, not only was I exposed to the knowledge of current chemotherapeutic drugs & targeted therapies in cancer treatment but also to insights into the current areas of biomedical research. Above all, a career in cancer research to me is a pursuit of passion. I'm particularly dazzled by how tiny non-coding RNAs: miRNAs & proteins: chaperones, transcription factors,.. exhibit control over specific target genes thereby altering gene regulation & contributing to the underlying pathogenesis of disease! I strongly believe that upon dedicating effort to further comprehend the roles & possibly individually target those molecular irregularities, therapeutic standards'll greatly be improved. Consequently, not only do I plan to devote a career in exploring further insights into molecular irregularities, their implication in cancers but also optimizing therapies selectively directed to such irregularities/their targets via focusing on gene therapy & translational research. I truly yearn for the day when treatment of cancer patients'll not only be personalized but selective to underlying pathological irregularities & I can’t wait to be a part of that!

Carsten BAHR (Germany)

University Education
10/2012 - present: pursuing M.Sc. in Molecular Biosciences, Ruprecht-Karls-University of Heidelberg and DKFZ
10/2009 - 09/2012: B.Sc. in Biomedical Science, Philipps-University Marburg

Highest Degree
B.Sc. in Biomedical Science

Title of Bachelor Thesis
Analysis of DNA binding sites of the transcription factor Sp3 in vivo

Internships
02/2012 - 07/2012: Institute of Molecular and Tumor Research, Philipps-University Marburg (AG Prof. Suske) – bachelor thesis
09/2011 - 10/2011: Institute for Biomedical Research Georg-Speyer-Haus, Frankfurt (AG PD Dr. Zörnig)
08/2011: Institute of Molecular and Tumor Research, Philipps-University Marburg (AG Prof. Stiewe)
03/2011: Institute of Molecular and Tumor Research, Philipps-University Marburg (AG Prof. Bauer)

Research Interests/Future Plans
My fascination for cancer is based on its several dimensions of complexity. On the molecular level cancer cells exhibit a plethora of aberrations in genes, signaling networks and the metabolism. Due to these abnormalities, the cells are able to change their surrounding microenvironment according to their benefit by promoting angiogenesis and by evading immunological destruction. I am particularly interested in the role of non-coding RNAs in these processes. In addition, I am intrigued by the interplay between cancer stem cells and their surrounding microenvironment. Further understanding of these molecular mechanisms might ultimately lead to the discovery of new therapeutic options and diagnostic markers. During my master studies I hope to deepen my knowledge of these topics and to get in touch with current research projects in these areas. Afterwards, I plan to pursue a PhD in cancer biology.

Contact
c.bahr (at) dkfz.de

Felicitas BOSSLER (Germany)

University Education
10/2012 - present: pursuing M.Sc. in Molecular Biosciences with Major Cancer Biology, Ruprecht-Karls-University of Heidelberg and DKFZ, Germany
10/2009 - 07/2012: B.Sc. in Biomedical Science, Philipps-University Marburg, Germany

Highest Degree
Bachelor of Science in Biomedical Science

Title of Bachelor Thesis
Characterization of PPARβ/δ target genes with functions in invasion and metastasis.

Internships
11/2011 - 12/2011 and 07/2012: Student research assistant at the Institute of Molecular Biology and Tumor Research, Phillips-University Marburg (AG Prof. Müller)
09/2011 - 10/2011: Institute of Molecular Biology and Tumor Research, Phillips-University Marburg (AG Prof. Müller)
08/2011 - 09/2011: Institute of Pathology, Philipps-University Marburg (AG Prof. Moll)

Research Interests/Future Plans
During my bachelor studies I had the opportunity to gain insight into various aspects of cancer biology and developed a deep interest in the complexity of tumor diseases and their underlying molecular mechanisms. I am particularly fascinated by the process of metastasis. As the majority of cancer related deaths is caused by metastases, it is of great importance to further analyze the mechanisms that allow cancer cells to migrate into surrounding tissues and penetrate lymphatic or blood vessels. Within many other fields, I would also like to learn more about translational oncology since the development of new cancer therapies based on the knowledge gained in biomedical research intrigues me. I am looking forward to take part in the progress of current cancer research at the DKFZ and to pursue a PhD after finishing my master studies.

Contact
f.bossler (at) dkfz.de

Kristin DECKER (Germany)

University Education
10/2011- present: pursuing M.Sc. in Molecular Bioscience, Ruprecht-Karls-University of Heidelberg and DKFZ, Germany
10/2008-03/2012: B.Sc. in Biochemistry, University Bayreuth

Highest Degree
B.Sc. in Biochemistry

Title of Bachelor Thesis
Influence of encapsulation of Jurkat cells with N-alginate, calcium, sodium-cellulosesulphate and PMCG on cell growth and cytokine production

Internships
01/2012 - 03/2012: In the Group of Ph. D. Christoph Pröschel, Department of Biomedical genetics, Stem cell research centre, University Rochester, NY
09/2011 - 12/2011: In the group of Prof. Dr. Rajiv Kumar, Department of molecular genetic epidemiology, German Cancer Research Centre (DKFZ), Heidelberg
07/2008 - 09/2008: Department of Chemistry and Biochemistry (Dr. Martha Kandawa-Schulz) University of Namibia, Windhouk, Namibia

Research Interests/Future plans
During my Bachelor studies I got insights into many different research topics. One of those, I was most interested in, was Cancer and cell cycle research. Through different internships and deepening courses I expended my interest and knowledge in that field. I decided to study Cancer biology because this topic offers many opportunities and is closely connected to other fields like Neurobiology or Virology, making it more complex but even more interesting.At the DKFZ I want to get a deep insight and practical knowledge in on top basic as well as applied research. Here to mention especially virus therapy and the use and role of stem cells in cancer. I want to get to know as many different aspects of Cancer research and related topics as possible and want to connect to good and motivated researchers to have a profound base for my later career.

Contact
k.decker (at) dkfz.de

Mostafa ELMAGHRABY (Egypt)

University Education
10/2012 – present: M.Sc. in ´Molecular Biosciences – Major: Cancer Biology´ at Ruprecht-Karls-University and DKFZ, Heidelberg, Germany
10/2008 – 07/2012: B.Sc. in Biotechnology, The German University in Cairo

Highest Degree
B.Sc. in Biotechnology

Title of Bachelor Thesis
Role of microRNA 17-5p in migration and colony formation of hepatocellular carcinoma cell lines

Internships
01/2012 – 06/2012: The German University in Cairo, Molecular Pathology Research Group, Prof. Ahmed I. Abdelaziz; Bachelor thesis
12/2011 – 04/2012: The German University in Cairo, Department of Biochemistry, Prof. Hans-Georg Breitinger; Cysteine mutants in the intracellular loop of the inhibitory glycine receptor
07/2011 – 09/2011: Leibniz-Center for Medicine and Biosciences, Department of Immunology and Cell Biology, Prof. Silvia Bulfone-Paus; Mast cells and Influenza A virus infection

Research Interests/Future Plans
My scientific interests are not set in stone; vast areas of science appeal to me. Therefore, it was logical to choose the Cancer Biology major, as oncogenesis encompasses the fields of signaling, gene regulation, apoptosis, and many more exciting topics. My true joy has always been Immunology, and recently I have been more drawn to the rather uncharted territory of epigenetics and RNA biology regulating our Immune system, and drastically changing the way we perceive gene expression, infection, and most definitely cancer. Above all, I am seriously committed to a career in science for the sake of science, thus, obtaining a PhD is an indispensable aspiration of mine. Hopefully, over the course of my Master studies at the University of Heidelberg and the DKFZ, I will be introduced to new and exciting research topics and techniques that I am very eager to explore.

Müge ERDEM (Turkey)

University Education
10/2012 – present: Master of Science in “Molecular Biosciences with Major Cancer Biology”, Ruprecht-Karls-University Heidelberg and DKFZ, Germany
09/2008 – 06/2012: Bachelor of Science in “Genetics and Bioengineering”, Yeditepe University, Istanbul, Turkey

Highest Degree
Bachelor of Science in Genetics and Bioengineering

Title of Bachelor Thesis
Bone differentiation of human dental germ stem cells onto collagen scaffolds

Internships
06/2011 – 09/2011: Elastin-like polypeptide fusion protein purification by inverse transition cycling, Tumorvirus-specific Vaccination Strategies Group, Division of Tumor Virology, German Cancer Research Center (DKFZ), Heidelberg, Germany (apl. Prof. Dr. Martin Müller)
01/2011 – 02/2011: Special techniques and instrumentation in genetic engineering, Division of Nanobiotechnology, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey (Prof. Dr. Mustafa Culha)
01/2010 – 02/2010: Analysis of genetic background related to formation of kidney stones, Division of Molecular Diagnostics, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey (Assoc. Prof. Dr. Dilek Telci)

Research Interests/Future Plans
During my bachelor studies, I was highly intrigued by stem cells and signal transduction mechanisms leading to carcinogenesis. I am specifically interested in stem cell treatment as a therapeutic strategy against cancer in the context of personalized medicine.For this reason, I would like to gain further insight into stem cell plasticity, development of cancer stem cells, and its prevention. Besides, tumor immunology and metastasis are also so fascinating for me that I would like to gain a deeper knowledge about them during my lab rotations. I am looking forward to be well-prepared with broad knowledge and experience in various fields of cancer biology to develop new therapeutics as well as applications in pharmaceutical industry.

Nese ERDEM (Turkey)

University Education
10/2012 – present: Master of Science in Molecular Biosciences - Major Cancer Biology, University of Heidelberg and DKFZ, Germany
09/2008-06/2012: Bachelor of Science in Biology, Middle East Technical University, Ankara, Turkey

Highest Degree
B.Sc. in Biology

Title of Bachelor Thesis
Regulation of HOXB7 gene by microRNAs in breast cancer cell lines

Internships
06/2011- 09/2011: Mechanisms by which Dnmt3b is guided to its respective target sites, Division of Molecular Biology of the Cell II, Prof. Dr. Ingrid Grummt, DKFZ
08/2010- 09/2010: Department of Medical Biology, Hacettepe University, Ankara
07/2010- 08/2010: Department of Medical Biology and Genetics, Gulhane Military Medical Academy, Ankara

Research Interests/Future Plans
The way of a normal cell turns into a cancer cell and how this cell is able to survive in the body are fascinating concepts for me. My major research interest is gene regulation. Non-coding RNAs like microRNAs are very promising targets for cancer therapy and I want to focus on them sometime during my research. Tumor immunology is another field that I am interested in. I think, for treatment of cancer, understanding the body’s response to cancer cells and the role of immune system in cancer development are the key events. I will try to improve my theoretical knowledge and practical skills on these subjects and I believe, during my master study in DKFZ, I will gain necessary background to continue my science career as a PhD student.

Contact
n.erdem (at) dkfz.de

Isabelle EVERLIEN (Germany)

University Education
10/2012 - present: pursuing M.Sc. in Molecular Biosciences, Ruprecht-Karls-University of Heidelberg and DKFZ
10/2009 - 09/2012: B.Sc. in Biomedical Science, Philipps-University Marburg

Highest Degree
B.Sc. in Biomedical Science

Title of Bachelor Thesis
Functional characterization of the formin hFhod3 and its role in cell-shape-regulation and invasion

Internships
07/2012 – 09/2012: Institute of Pharmacology and Toxicology, Philipps-University Marburg (AG Prof. Grosse)
02/2012 - 07/2012: Institute of Pharmacology and Toxicology, Philipps-University Marburg (AG Prof. Grosse) – bachelor thesis
09/2011 - 10/2011: Max-Planck-Institute for Biophysical Chemistry, Göttingen (AG Dr. Shchrbata)
03/2011 – 04/2011: Institute of Molecular and Tumor Research, Philipps-University Marburg (AG Prof. Müller)

Research Interests/Future Plans
The complex organismic phenotype of the human body is a result of the ability to balance genomic stability and mutations. Therefore cellular functions are orchestrated by complex regulatory circuits regulating multiple lines of defense against malignant alternations that lead to cancer development. Since mutations can affect any of these genes and the fact that human tumor formation is a complex, multistage process which is specific for each tissue, cancer is not one, but many diseases. Therefore I am particularly interested in therapeutic options which are adjusted on the molecular characteristics of tumors to personalize the treatment and reduce aggressive side effects and relapses. Additionally I am intrigued by the process of metastasis and tumor cell invasion which are often associated with a poor outcome for the patients. I am looking forward to take part in the progress of current cancer research in these areas at the DKFZ and to pursue a PhD after finishing my master studies.

Contact
i.everlien (at) dkfz.de

Sabine HARTLIEB (Germany)

University Education
10/2012- present: MSc in 'Molecular Biosciences with Major Cancer Biology', Ruprecht-Karls-University of Heidelberg and DKFZ, Germany
9/2008-6/2012 BSc in 'Biotechnology', University of Applied Sciences Mannheim, Germany

Highest Degree
BSc Biotechnology

Title of Bachelor Thesis
Identification and analysis of molecular biomarkers in elderly patients with malignant gliomas

Internships
11/11-6/12: Clinical Cooperation Unit Neurooncology, DKFZ; Principal Investigator: Prof. Dr. Wolfgang Wick; Project: Bachelor thesis
8/10-3/11: Division of Hematology/Oncology, Department of Pediatrics, Washington University in St. Louis - School of Medicine; Principal Investigator: Joshua B. Rubin, MD, PhD; Project: Sufficiency factors for the formation of pediatric brain tumors

Research Interests/Future Plans
When I first came in contact with cancer research, I was immediately fascinated by the huge diversity of this field and the potential to develop new therapies for patients. My particular interest is neurooncology and pediatric oncology. The topic of my Bachelor thesis was the investigation of molecular and especially epigenetic differences in glioma patients. The main intention of this work was to find a way to classify tumors beyond the usual WHO grading system in order to provide them with a more personalized treatment. For me personally, the approach of a more personalized medicine is one of the most challenging and fascinating topics of current research. I am looking forward to get insight into the various exciting fields of cancer research at the DKFZ and to participate in some of the interesting research projects. After my Master course I plan to get a PhD and pursue a career in cancer research.

Contact
s.hartlieb (at) dkfz.de

Julia HEROLD (Germany

University Education
10/2012 - present: Master of Science in "Molecular Biosciences with Major Cancer Biology" at Ruprecht-Karls-University and DKFZ in Heidelberg, Germany
10/2009 - 09/2012: Bachelor of Science in "Biomedicine" at Julius-Maximillians-University of Würzburg, Germany

Highest Degree
Bachelor of Science in Biomedicine

Title of Bachelor Thesis
Characterization of novel DREAM target genes in mitosis and cytokinesis

Internships
03/2012 – 07/2012 Department of Physiological Chemistry I, Julius-Maximilians-Universtiy of Würzburg AG Gaubatz – Bachelor Thesis

Research Interests/Future Plans
The various molecular mechanisms, which are able to cause tumorigeneses, make cancer biology to a very fascinating subject. During my Bachelor thesis I got an interesting insight into cell cycle, mitosis and cytokinesis. Now I am curious to learn more about further cancer-associated topics, especially gene regulation, metastasis and stem cells. Furthermore I am interested in strategies of cancer therapy, such as immunotherapy or oncolytic viruses. I am looking forward to gain experiences in these and other fields of cancer research.

Federica INTURRISI (Italy)

University Education
10/2012- present: MSc in "Molecular Biosciences with Major Cancer Biology", Ruprecht-Karls-University of Heidelberg and DKFZ, Germany
10/2008-10/2011: BSc in Biological Sciences, University of Catania

Highest Degree
Bachelor in Biogical Sciences

Title of Bachelor Thesis
Folic acid deficiency, SNPs of MTHFR gene and reproductive health: prevention through nutrition

Internships
03/2011-10/2011: Department of Hygiene and Public Health “G.F. Ingrassia”, Prof.Antonella Agodi, University of Catania
03/2010-06/2010: Department of Animal Biology “Marcello La Greca”, Prof. Bianca Maria Lombardo, University of Catania

Research Interests/Future Plans
The decision to continue my studies in this field stems from personal interest and curiosity that I have had all my life. In particular, what really fascinates me is tumor virology and the connection between a specific virus and a particular form of cancer as it was demonstrated, for example, in the case of HPV and cervical cancer. I would be really enthusiastic to pursue my future career in this direction. Moreover, I believe in the cooperation between research and clinical practice and this has enhanced my enthusiasm and interest in prevention, diagnosis and therapies. I am glad I have the chance to prove myself in the scientific world and I am confident that I will contribute with great passion to this enormous and vital field of study.

Kathrin JANSEN (Germany)

University Ecuation
10/2012 - present: Master of Science in "Molecular Biosciences with Major Cancer Biology" at Ruprecht-Karls-University and DKFZ in Heidelberg, Germany
10/2008 - 08/2011: Bachelor of Science in "Biochemistry" at University of Bayreuth, Germany

Highest Degree
Bachelor of Science in Biochemistry

Title of Bachelor Thesis
Affinity purification and characterization of antibodies directed against the Drosophila melanogaster condensin subunit SMC2

Internships
07/2012 – 08/2012 Wellcome Trust Sanger Institute, Division: "Genetics of complex traits in humans", Cambridge (UK)
09/2011 – 02/2012 Fresenius Medical Care, Division: "Biomedical and Pharmaceutical Research", Bad Homburg (Germany)
02/2011 and 06/2011 Student research assistant at University of Bayreuth, Department of Biochemistry, Bayreuth (Germany)

Research Interests/Future Plans
The complexity of (human) genetics and how they work on a molecular level are fascinating to me. I am especially interested in the combination of epigenetic modifications (either on DNA level, chromatin level or histone level) and their influence on the regulation and expression of genes in healthy cells as well as in cancer cells. During lab rotations I would like to gain further insight into the development of cancer stem cells, their epigenetic profiles and possible treatments. Moreover, the regulating mechanisms of the cell cycle offer a lot of interesting questions, that I would like to address in the future. After gaining knowledge in several topics related to cancer research and improving my practical skills, I would like to continue my career in science with a PhD.

Laura LECKER (Germany)

University Education
10/2012 – present: pursuing Master of Science, Molecular Biosciences, Major Cancer Biology, Ruprecht-Karls-University of Heidelberg and DKFZ, Germany
10/2009 – 08/2012: Bachelor of Science, Biotechnology, Major Bioprocess Techniques, Carolo-Wilhelmina Braunschweig University of Technology, Germany

Highest Degree
Bachelor of Science in Biotechnology

Title of Bachelor Thesis
Assessment of bacterial enzymes as potential targets for early stage drug discovery

Internships
04/2012 – 08/2012 Wellcome Trust, Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Scotland (Prof. Bill Hunter)
09/2011 – 10/2011 Lionex GmbH, Diagnostics and Therapeutics, Braunschweig, Germany (Prof. Mahavir Singh)

Research Interests/Future Plans
During my project at the University of Dundee, I attended a lecture of Robert Weinberg on “Cancer stem cells and the Epithelial-Mesenchymal transition”. His lecture deeply impressed me and made me sensitive for the urgency of developing improved strategies for cancer diagnosis and treatment. By being intrinsically motivated to gain fundamental knowledge in molecular cell biology as well as oncology, I decided to focus on cancer research in my master studies. Cancer virology is one of the most exciting fields, as it focuses not only on viruses causing cancer, but also on virotherapy which represents a way of fighting this disease. The DKFZ research program for Infection and Cancer aims e.g. at virus mediated delivery of therapeutic genes and assures me that Heidelberg offers a perfect educational basis and various opportunities to get involved with current research topics. I hope to gain new scientific perspectives in a challenging environment and to make significant contributions to cancer research in the near future.

Marten MEYER (Germany)

University Ecuation
10/2012 - present: Master of Science in ´Molecular Biosciences – Major: Cancer Biology´ at Ruprecht-Karls-University and DKFZ, Heidelberg, Germany
10/2009 - 09/2012: Bachelor of Science in ´Molecular Biomedicine´, Rheinische Friedrich-Wilhelms-University, Bonn, Germany

Highest Degree
B.Sc. in Molecular Biomedicine

Title of Bachelor Thesis
The role of Dickkopf-3 in 3-methylcholanthrene (MCA) induced tumorigenesis

Internships
08/2011 - 09/2011: Laboratory of Experimental Dermatology of Prof. Dr. Thomas Tüting, University Hospital Bonn, Germany Project: Isolation and characterization of Hgf-Cdk4 mutated melanoma derived tumor-associated macrophages (TAMs)
02/2011 - 04/2011: Laboratory of Membrane Biology and Lipid Biochemistry of Prof. Dr. Thomas Lang, Life and Medical Science Institut (LIMES), Bonn, Germany Project: Cloning of a mutated form of the lipid transfer protein StarD1

Research Interests/Future Plans
People dream of curing cancer and I am one of them. New knowledge in cancer research led to different approaches of cancer therapies. But in most cases even the new therapies just slightly increase the lifetime of the patients instead of curing them. Reasons for the therapeutical resistance of the tumor are found in its complex biology and, for instance, in the heterogeneity and plasticity of certain tumor cells. Therefore I am especially interested in taking part in the development of a therapy that combines the advantages of different therapeutic approaches. This new generation of therapies should target different ´hallmarks´ of cancer biology and uses a variation of anti-cancer mechanisms or tools like immunotherapy, small molecules, antibodies or viruses. In order to pursue this interest and find new ones, I like to focus my studies on cancer biology and to lay the best possible foundation for my subsequent PhD-thesis.

Contact
marten.meyer (at) dkfz.de

Soumya MOHAPATRA (India)

University Education
10/2012 - present: Pursuing M.Sc. in Molecular Bioscience Major Cancer Biology, Ruprecht-Karls-University of Heidelberg and DKFZ
07/2008 - 05/2012: 4 years Bachelor of Technology (B.Tech) in Biotechnology, Vellore Institute of Technology (VIT) University, Vellore, India

Highest Degree
Bachelor of Technology (B.Tech)

Title of Diploma Thesis
Study of drug resistance in influenza virus - a computational approach

Internships/Work Experience
05/2011 - 07/2011: Indian Academy of Sciences Summer Research Fellowship at Laboratory of Drosophila Neural Development (Dr. Rohit Joshi), Center For DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India.
09/2009 - 11/2011: Undergraduate Research Assistant, Computational Proteomics Laboratory (Dr. K. Ramanathan), Vellore Institute of Technology (VIT) University, Vellore, India.
01/2012 - 05/2012: Computational Proteomics Laboratory (Dr. V. Shanthi), Vellore Institute of Technology (VIT) University, Vellore, India - Bachelor Thesis.
05/2010 – 06/2010: Summer Research Internship at Institute of Materials and Minerals Technology, Bhubaneswar, Orissa, India.

Research Interests/Future Plans
One area that I am highly interested in is developing therapeutic tools for different types of cancer. The German Cancer Research Center (dkfz.), is carrying out significant research on cancer treatment by investigating the source of cancer i.e genomic instability and DNA repair as well as aspects like signalling pathways, molecular structures and functions, and this aligns well with my interests. I find cancer research particularly attractive because cancer has challenged researchers for decades; the advent of newer technologies like nanotechnology and RNAi could provide viable means of locating and destroying tumors in the body. Another very promising area of research at Heidelberg is the study of stem cells in-relation to cancer. Recent path-breaking papers have talked about the role of potential oncogenes in the life of stem cells. Such revelation on important players could refine our understanding of the concepts of cancer biology. I would like to explore these research areas at University of Heidelberg & DKFZ during my current masters and future PhD studies.

Contact
s.mohapatra (at) dkfz.de

Clarissa NICOLAUS (Germany)

University Education
10/2009 - 9/2012: B.Sc. in Molecular Medicine, University of Tübingen
10/2012 - present: M.Sc. in Molecular Biosciences, Major Cancer Biology, University of Heidelberg

Highest Degree
B.Sc. in Molecular Medicine

Title of Bachelor Thesis
Construction and testing of recombinant bispecific antibodies with CD19 as target specificity

Internships
8/2010 - 9/2010: Effect of the phosphorylation of the transcription factor YB-1 on the survival of melanoma cells, University Dermatological Clinic Tübingen, Section for Dermatological Oncology, Prof. Dr. Schittek
10/2010 - 11/2011: (job as student assistant), Antitumor activity of two different MEK inhibitors in combination with other tyrosine kinase inhibitors in metastatic melanoma cell lines with different mutation signatures, University Dermatological Clinic Tübingen, Section for Dermatological Oncology, Prof. Dr. Meier
12/2011 - 1/2012: Construction of recombinant bispecific antibodies with CD19 as target specificity, Interfaculty Institute for Cell Biology, Department of Immunology, Section of Experimental Antibody Therapy, Prof. Dr. Jung
4/2012 - 8/2012: (job as student assistant), Generation of polyclonal NK-Cells, University Clinic Tübingen, Medical Clinic, Prof. Dr. Salih

Research Interests/Future Plans
Creating new anti-cancer drugs which bind specifically to an altered structure of cancer cells and which are therefore able to inhibit their proliferation or even kill them, seems to me a very promising way to do a step forward in treating cancer. Hence, I found it very interesting to test the effect of different tyrosine kinase inhibitors on melanoma cells and later to first generate and then also test the activity of a bispecific antibody on leukemia cells. As a consequence of that, my main field of interest is translational cancer research.I’m interested in investigating if a drug has an effect on cancer cells or if there is no effect, to find out what the reason for that is. Having the opportunity to test some new drugs i.e. by supervising a clinical trial or by testing it in a pre-clinical manner would be a very interesting task to work on in future.

Omar SALEM (Egypt)

University Education
10/2012 – present: Pursuing MSc. in Molecular Biosciences with Major Cancer Biology, Ruprecht-Karls-University of Heidelberg and DKFZ, Germany
10/2007 – 7/2012: BSc. in Pharmaceutical Sciences and Biotechnology, the German University in Cairo, Egypt

Highest Degree
BSc. in Pharmaceutical Sciences and Biotechnology

Publication
El Hamshary MS, Salem OH, El Nashar RM. Application of Oxybutynin Selective Sensors for Monitoring the Dissolution Profile and Assay of Pharmaceutical Dosage Forms; Anal Sci. 2010;26(4):437-42.

Internships
08/2011 – 09/2011 IFIB, Interfakultäres Institut für Biochemie, Universität Tübingen, professor schluze-osthoff; Expression of pluripotency-inducing transcription factors, Oct4, Sox2, Klf4, cMyc, Glis1, and Nanog in HEK293 and SF9 cell lines.
10/2010 – 07/2011 GUC, the German University in Cairo, Molecular Pathology Research Group, Associate Prof. Ahmed I. Abdelaziz; junior research assistant
07/2008 – 08/2008 GUC, the German University in Cairo, Analytical chemistry department, Associate Prof. Rasha El-Nashar; Application of Oxybutynin Selective Sensors for Monitoring the Dissolution Profile and Assay of Pharmaceutical Dosage Forms.

Research Interests/Future Plans
Just like we, human beings, interact with each other, our tiny microscopic cells do! However, when cellular interactions become impaired, our bodies lose control over cells and this is what typically defines cancer. Searching for the secrets behind these interactions, named signaling pathways, trying to understand the “language” of cells, and going deep through the regulatory mechanisms responsible for controlling the growth, survival and potential spreading of cancer cells clearly highlights my area of interest. More specifically the key-role that non-coding RNAs play; epigenetically altering the behavior of cells and their communication with the surrounding environment strongly captures my focus! I hope that the knowledge I am entitled to gain and all the skills I would be learning throughout my master studies would be a stepping stone that qualifies me to go on with my PhD and my post doctoral studies.

Maximiliane SCHULDNER (Germany)

University Education
10/2012 - present: MSc in 'Molecular Biosciences with Major Cancer Biology', Ruprecht-Karls-University of Heidelberg and DKFZ, Germany
09/2011 - 06/2012: BSc of Honours in 'Molecular Biology' at Dundee University, Scotland
09/2009 - 06/2012: BSc in 'Applied Biology' at Bonn-Rhine-Sieg University of Applied Sciences in Rheinbach, Germany  

Highest Degree
Double degree: BSc in Applied Biology and BSc( Hons) in Molecular Biology 

Title of Bachelor Thesis
Characterisation of antibodies against novel proteins involved in DNA replication in Xenopus laevis egg extracts 

Internships
09/2011 - 03/2012: Wellcome Trust Centre for Gene Regulation and Expression (Cancer Research UK Chromosome Replication Research Group led by Prof. Julian Blow) in Dundee, Scotland  

Research Interests/Future Plans
During my honours project I already got insights into basic cancer research since precise and faithful replication of chromosomal DNA is a prerequisite to prevent genomic instability which might potentially drive tumorigenesis. Also, many antimetabolite cancer drugs target the process of DNA replication rendering the study of how this process is regulated particularly important. I am looking forward to broadening my knowledge about the altered cell cycle regulation during tumorigenesis. However, I am also curious to learn more about other cancer-related topics, especially in the field of cancer stem cells, epigenetics and miRNAs in cancer as well as the development of oncolytic viruses. Certainly, the DKFZ will offer me the opportunity to participate in research projects that will contribute to our understanding of how cancer cells behave and can be selectively targeted with the ultimate goal of progressing towards improved therapies. 

Ann-Kathrin SCHUON (Germany)

University Education
10/2012 - present: pursuing M.Sc. in Molecular Biosciences, Ruprecht-Karls-University of Heidelberg and DKFZ
10/2008 - 09/2011: four-year B.Sc. in Molecular Medicine, University of Tuebingen

Highest Degree
B.Sc. in Molecular Medicine

Title of Bachelor Thesis
Genetic and transcription analysis of the growth of Saccharomyces cerevisiae in maltose

Internships
10/2011-06/2012: Centro de Investigación Biomédica (CIBM), Instituto de Nutrición y Tecnología de los Alimentos, University of Granada; Project: Gut microbial metabolism in humans (Suárez Group)
06/2011-08/2011: European Molecular Biology Laboratory (EMBL), Genome Biology Research Unit; Project: Bachelor thesis (Steinmetz Group)
12/2010-02/2011: European Molecular Biology Laboratory (EMBL), Genome Biology Research Unit; Project: Tiling-Array processing for gene-expression-profiling of S.cerevisiae (Steinmetz Group)

Research Interests/Future Plans
In the course of my undergraduate studies of Molecular Medicine I discovered my interests in Oncology and in Human Genetics and I became particularly fascinated by the idea of Personalized Medicine. It requires a better understanding of the correlation between an organism´s genotype and phenotype. Therefore, I am especially interested in the research area of Tumor Genomics. However, I would like to take the opportunity, given by this master program, to get insights into various areas of cancer research. I am looking forward to gain a broad knowledge in the diverse field of Cancer Biology to be able to deepen my current interests as well as to discover new ones.

Melanie SCHWAB (Germany)

University Education
10/2012-present: pursuing M.Sc. in Molecular Biosciences, Ruprecht-Karls-University of Heidelberg and DKFZ
10/2008-09/2012: four-year B.Sc. in Molecular Medicine, Eberhard-Karls-University of Tübingen

Highest Degree
B.Sc. in Molecular Medicine

Title of Bachelor Thesis
Comparative studies of antagonistic effects of the EGFR-signalling

Internships
09/2011-07/2012: Department of Microbiology, Faculty of Pharmacy, University of Granada, Spain, Project: Quorum Sensing in the Family Halomonadaceae (Inmaculada Llamas Company)
05/2011-07/2011: Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard-Karls-University Tübingen, Project: Bachelor Thesis (AG Prof. Dr. H. Peter Rodemann)
11/2010-01/2011: Interfaculty Institute for Cell Biology, Department of Immunology, Eberhard-Karls-University of Tübingen (AG Prof. Dr. Stefan Stevanović)

Research Interests/Future Plans
During my Bachelor project I got to know how the development of cancer and their changes depend on cell-surface receptors and their ligands, especially if these cells contain resistance to the common therapy. Accordingly, my interests are how patients could be treated using individual medicine depending on the mutated status of the cancer disease. Besides that I am fascinated how cancer cells can colonize a whole body via building metastases and undergo the immune system. Although cancer therapy was successful, metastases are able to repopulate the body. With this Master program I hope to acquire a deeper knowledge of cancer biology, especially in the both topics I mentioned above, so that I am prepared for my future PhD studies.

Contact
melanie.schwab (at) dkfz.de

Sina STÄBLE, née ZIMMERMANN (Germany)

University Education
10/2012 - present:pursuing M.Sc. in Molecular Bioscience, Ruprecht-Karls-University of Heidelberg and DKFZ
10/2007 - 02/2012:Diploma in Biopharmaceutical Technology, Technische Hochschule Mittelhessen - University of Applied Sciences

Highest Degree
Diploma (FH) in Biopharmaceutical Technology

Title of Diploma Thesis
The phosphorylation of HDAC8 and its role in cell cycle regulation in neuroblastoma cells

Internships/Work Experience
04/2011 - 12/2011: German Cancer Research Center Heidelberg, Clinical Cooperation Unit Pediatric Oncology (Prof. Olaf Witt/Dr. Ina Oehme) - Diploma thesis
11/2010 - 04/2011: German Cancer Research Center Heidelberg, Clinical Cooperation Unit Pediatric Oncology (Prof. Olaf Witt/Dr. Ina Oehme) - Identification of kinases influencing the response of neuroblastoma cells to selective HDAC8 inhibitor treatment
02/2010 – 07/2010: Technische Hochschule Mittelhessen - University of Applied Sciences, Laboratory of Analytic Chemistry (Prof. Eduard Alter) - Quality control of aspirin by thermogravimetry and differential scanning calorimetry
08/2008 - 10/2008: Karlsruhe Institute of Technology, Institute of Biological Interfaces (Dr. Kai Hilpert)

Research Interests/Future Plans
Cancer is initiated by an accumulation of alterations in DNA, which lead to dysfunctions in cell growth. However, all these disorders constitute potential targets for anticancer treatment. During my diploma project I had the opportunity to gain insights into the investigation of HDAC-inhibitors, which have the potential to reverse abnormal epigenetic changes associated with several types of cancer. After completing my diploma thesis I felt certain to deepen my knowledge on other treatment strategies against cancer. I am especially interested in oncolytic viruses, gene therapy and small molecules, that interfere with specific molecules involved in cancer relevant signaling pathways like angiogenesis or apoptosis. Due to my background in pharmacy I can well imagine to be active in the field of (pre)clinical trials of anticancer drugs. In this respect, I am intrigued by the investigation of combination therapies aimed at improving antitumoral efficiency and reducing side effects.

Contact
s.staeble (at) dkfz.de

Deepti TALWAR (India)

University Education
10/2012- presently pursuing M.Sc. in Molecular Biosciences, Ruprecht-Karls-University of Heidelberg and DKFZ
07/2008 – 06/2012 – B.Tech (Biotechnology), Gobind Ballabh Pant University of Agriculture & Technology, Pantnagar

Highest Degree
B.Tech in Biotechnology

Title of Bachelor Thesis
Phytosome Preparation from Murraya koenigii leaves

Internships
06/2010 – 07/2010 – Student Research Assisstant in Molecular Biology Lab at Institute of Pathology, ICMR, New Delhi (Dr. Poonam Salotra)
06/2011 – 08/2011 - Summer Research Fellowship awarded by Indian Academy of Sciences, Bangalore on “Cloning of Mycobacterium Tuberculosis pgs gene in pMV261 vector” at School of Biotechnology, Jawaharlal Nehru University, New Delhi. (Dr. Rakesh Bhatnagar)

Research Interests/Future Plans
During my undergraduate studies, I developed an ardent interest in “Cancer Biology”. I wish to know all the intricacies along with cellular signaling pathways and molecular mechanisms taking place in the cancerous cells. Along with this, I am also interested to know about different mechanisms of multi drug resistance in a Cancerous cell and the functioning of MDR pump. The ongoing research in Cancer stem cell and tumor virology are the fields that fascinate me the most. Creating effective and efficient technology to develop and conceptualize Cancer Biology as a valuable elixir to the mankind is the end I have in mind. By this Master’s programme at DKFZ, I am sure of delving deep into my area of interest and will also get a better understanding of the field along with a great practical exposure. This will help me to design my future as a researcher.

Contact
d.talwar (at) dkfz.de

Inna ZAIMENKO (Ukraine)

University Education
10/2012 - present: Master of Science in "Molecular Biosciences with Major Cancer Biology" at Ruprecht-Karls-University and DKFZ in Heidelberg, Germany
09/2008 - 05/2012: Bachelor of Science in "Biology" at Taras Shevchenko Kyiv National University Kyiv, Ukraine

Highest Degree
Bachelor of Science in Biology

Title of Bachelor Thesis
Obtaining of recombinant protein of S6K2 spliced variant C-terminal fragment

Internships
07/11-02/12: Institute of Molecular Biology and Genetics of National Academy of Sciences of Ukraine, Department of Cell Signaling Systems (Prof., Dr. Valeriy Filonenko), Kiev, Ukraine
04/11-05/11: Institute of Technology, University of Tartu (PhD Eva Zusinaite), Tartu, Estonia
06/10, 11/10-03/11: Institute of Molecular Biology and Genetics of National Academy of Sciences of Ukraine, Department of Molecular Genetics (Prof., Dr. Gennadiy Telegeev), Kiev, Ukraine

Research Interests/Future Plans
Signaling cascades are key component in functional cell regulation and in cellular response on variableintra or extra factors. Deep understanding of signaling networks under cancer development and metastasis isinalienable part on the way to overcome this disease.Internship and further carrying-out of Bachelor Thesis at the Department of Cell Signaling Systems have extremely increased my interest to the studying of signaling deregulation under cancer development. I really fascinated by complexity of working cell machinery, diversity and precise control of its regulatory mechanisms. In particular, I am especially interested in mTOR/S6Ks - signaling pathway since those networks, which are involved in tumor progression, are closely connected to it as this pathway is key point in tumor growth. Recent investigations had shown that spliced, noncanonical protein isoforms play not the last role in cancer development, thus I would like to focusmy research during Master and then PhD projects on protein isoforms, which are naturally occurred under physiological conditions, as it is can potentiate discovering of new strategies forcancer treatment.

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