Publications

2016                                                                                                                    
Rowald K, Mantovan M, Passos, J, Buccitelli C, Mardin BR, Korbel JO, Jechlinger M, Sotillo R.(2016)
Negative selection and chromosome instability induced by Mad2 overexpression delay breast cancer but facilitate oncogene-independent outgrowth. Cell Rep.15(12): 2679-91.

2014
Rowald K, Sotillo R. (2014)
Is aneuploidy deciding your fate? Cell Cycle 13(9):1370.

2011
Schvartzman JM, Duijf PH, Sotillo R, Coker C, Benezra R. (2011)
Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.Cancer Cell 19(6):701-714.

2010
Sotillo R, Schvartzman JM, Socci ND, Benezra R. (2010)
Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature 464(7287):436-440.

Schvartzman JM, Sotillo R, Benezra R. (2010)
Mitotic chromosomal instability and cancer: mouse modelling of the human disease.
Nat. Rev. Cancer 10(2):102-115.

2009
Sotillo R, Schvartzman JM, Benezra R. (2009)
Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity. Cancer Cell 16(6):451-452.

2008
Diaz-Rodríguez E, Sotillo R, Schvartzman JM, Benezra R. (2008)
Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo. Proc. Natl. Acad. Sci. U.S.A. 105(43):16719-16724.

2007
Niault T, Hached K, Sotillo R, Sorger PK, Maro B, Benezra R, Wassmann K. (2007)
Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I. PLoS ONE 2(11):e1165.

Sotillo R, Hernando E, Díaz-Rodríguez E, Teruya-Feldstein J, Cordón-Cardo C, Lowe SW, Benezra R. (2007)
Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 11(1):9-23.

2005
Sotillo R, Renner O, Dubus P, Ruiz-Cabello J, Martín-Caballero J, Barbacid M, Carnero A, Malumbres M. (2005)
Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity. Cancer Res. 65(9):3846-3852.

Barbacid M, Ortega S, Sotillo R, Odajima J, Martín A, Santamaría D, Dubus P, Malumbres M. (2005)
Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.
Cold Spring Harb. Symp. Quant. Biol. 70:233-240.

2004
Malumbres M, Sotillo R, Santamaría D, Galán J, Cerezo A, Ortega S, Dubus P, Barbacid M. (2004)
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.
Cell 118(4):493-504.

2003
Ortega S, Prieto I, Odajima J, Martín A, Dubus P, Sotillo R, Barbero JL, Malumbres M, Barbacid M. (2003)
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat. Genet. 35(1):25-31.

Martín J, Hunt SL, Dubus P, Sotillo R, Néhmé-Pélluard F, Magnuson MA, Parlow AF, Malumbres M, Ortega S, Barbacid M. (2003)
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene 22(34):5261-5269.

Malumbres M, Hunt SL, Sotillo R, Martín J, Odajima J, Martín A, Dubus P, Ortega S, Barbacid M. (2003).Driving the cell cycle to cancer. Adv. Exp. Med. Biol. 532:1-11.

2001
Sotillo R, Dubus P, Martín J, de la Cueva E, Ortega S, Malumbres M, Barbacid M. (2001).
Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. EMBO J. 20(23):6637-6647.

Sotillo R, García JF, Ortega S, Martin J, Dubus P, Barbacid M, Malumbres M. (2001)
Invasive melanoma in Cdk4-targeted mice. Proc. Natl. Acad. Sci. U.S.A. 98(23):13312-13317.

2000
Latres E, Malumbres M, Sotillo R, Martín J, Ortega S, Martín-Caballero J, Flores JM, Cordón-Cardo C, Barbacid M. (2000)
Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO J. 19(13):3496-3506.

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