Division of Chaperones and Proteases
Prof. Dr. Bernd Bukau
Our research aims at understanding the molecular basis of the intricate functional network of chaperones and proteases that controls protein folding processes in the cytosol. This quality control network is responsible for maintaining protein homeostasis in cells and thereby is directly linked to various diseases and aging. Using bacteria, yeast and mammalian cells as model systems, and a methodological spectrum ranging from genetics, cell biology, biochemistry to biophysics, we are currently focusing on the cell biology and molecular mechanisms of
- folding of newly synthesized proteins,
- quality control and regulation of proteins by the Hsp70 chaperone network,
- AAA-chaperones involved in regulated proteolysis and bacterial pathogenesis, and
- the cellular strategies fighting protein aggregates.