Brain tumor stem cells and brain tumor heterogeneity

Brain tumor stem cells and brain tumor heterogeneity

Brain tumor stem cells marked by GFP
© Dr. Haikun Liu

We generated a set of mouse models to investigate the role of BTSCs and brain tumor heterogeneity in vivo. We could show that Tlx-expressing BTSCs are essential for tumor maintenance, and we further demonstrated the potential of these cells using single cell lineage tracing in vivo. This further consolidated the CSC hypothesis. We also performed several screens to discover novel targets in BTSCs. By applying our single cell technology, we are also trying to map the brain tumors on single cell level. These include visualizing single cell behavior both during tumor progression and therapy. We believe these results will lead more precise treatment of brain tumors in the future. We are actively collaborating with pharmaceutical companies to translate our basic finding into drug discovery projects.

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