Clinical Cooperation Unit Dermato-Oncology

Prof. Dr. Jochen Utikal

Primary malignant melanoma
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The Clinical Cooperation Unit “Dermato-Oncology” is engaged in the prevention, diagnosis, and therapy of skin tumors. Research results obtained are transferred directly into clinical practice. The main focus is malignant melanoma, a tumor that originates from the pigment cells of the skin. The Clinical Cooperation Unit “Dermato-Oncology” conducts several translational research projects including different Phase I - IV clinical trials with innovative melanoma therapies. (LINK: clinical trials)

Basic researchers at the department work on similarities of tumor cells such as melanoma cells and embryonic stem cells, on immunosuppressive mechanisms in tumors, on chronic inflammation and its impact on tumor development and progression and on novel biomarkers for malignant melanoma.

The Clinical Cooperation Unit Dermato-Oncology is part of the Research Program Translational Cancer Research and is associated with the Program Tumor Immunology.

Contact

Prof. Dr. Jochen Utikal
Dermato-Oncology (G300)
Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 280
69120 Heidelberg
Tel: +49 621 383 4461

Selected Publications

  • Bernhardt M, et al. (2012). Mediators of induced pluripotency and their role in cancer cells - current scientific knowledge and future perspectives. Biotechnol J. 2012; 7:810-21.
  • Flaherty KT, et al. (2012). Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma. N Engl J Med. 2012 Jun 4.
  • Meyer C, et al. (2011). Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model. Proc Natl Acad Sci U S A. 2011; 108:17111-6.
  • Utikal, J. et al. (2009). Immortalization eliminates a roadblock during the reprogramming of somatic cells into iPS cells. Nature., 460, 1145-8.
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