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© Photo by Laura Wilson

Throwing a loop to silence gene expression

Cells attach so-called ‘epigenetic’ signals to their genome to select which part of their genetic information is used. Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now systematically investigated the interplay between components of an epigenetic network and developed...

Copyright Wikimedia

TGF-ß prevents self-reactive B cell activation

T follicular helper (TFH) cells contribute to the establishment of humoral immunity by controlling the delivery of helper signals to activated B cells. However, TFH development must be restrained, as aberrant accumulation of these cells is associated with positive selection of self–reactive germinal center B cells and autoimmunity in both humans and mice.

Copyright Christopf Bock Wikimedia commons

How silent genes are activated

DNA methylation is a dynamic and reversible process that governs gene expression during development and disease. Several examples of active DNA demethylation have been documented, involving genome-wide and gene-specific DNA demethylation. How demethylating enzymes are targeted to specific genomic loci remains largely unknown.

last update: 16/09/2014 back to top