Tumor Models

PD. Dr. Karin Müller-Decker

In vivo tumor models are indispensable tools in cancer research

In vivo tumor models are indispensable tools in cancer research
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Malignant tumors are complex tissues which arise from normal cells in a protracted multi-step process. Driving forces of tumor development are the progressive accumulation of genetic and epigenetic DNA alterations. As a consequence, such changes disturb cellular signaling pathways and regulatory circuits in affected cells conferring growth advantages, landscaping the micro-environment of the tumor cells, and supporting escape from immunosurveillance. Concomitantly, new blood vessels are formed, inflammatory cells are recruited, and fibroblasts are activated in the surrounding tumor stroma. The complex interactions between tumor cells and vessel, immune, or stroma cells are not yet traceable in an authentic manner in cell cultures in vitro. Therefore, in vivo mouse models of cancer including genetically engineered mouse lines and hetero-grafted mice are indispensable tools for the exploration of the molecular and cellular fundamentals of tumor growth as well as translational applications in cancer research.

The Core Facility Tumor Models offers expertise, specific technical equipment, and resources to efficiently and successfully organize the design, realization, and data interpretation of animal experiments in approved in vivo cancer-related models, thereby using state-of-the-art-protocols that comply with legal requirements.

Our current offer of service comprises:
1. Inflammation tests
2. Multi-stage carcinogenesis tests in mouse skin
3. Heterograft tumor models
4. COX-2 tumor models
5. MITO database for models in Translational Oncology

The tasks will be met either in a full or in an assisted service. This implies a training of participating experimenter, particularly in the application of carcinogens and irritating agents. The range of tumor models will be adjusted to changing scientific needs.

Contact

PD Dr. rer. nat. K. Müller-Decker

Tumor Models

German Cancer Research Center Heidelberg

Im Neuenheimer Feld 280
69120 Heidelberg
Germany

Tel: +49-6221- 424 531
Fax: +49-6221-424 406

E-mail: k.mueller-decker@dkfz.de

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