Research in the Division Molecular Genome Analysis

The major focus of research carried out in the division is on deciphering molecular mechanisms leading to cancer. To this end we utilize functional genomic, quantitative proteomic and other approaches to measure phenotypes and molecular processes.

In Functional Profiling we implement and apply large scale genomics and functional genomics tools and resources for gene gain- and loss-of-function screening.

In Quantitative Proteomics technologies are developed and applied to determine changes in the abundance and activation states of key proteins in cancer signaling pathways.

We combine functional genomics and quantitative proteomics approaches in several projects to determine Mechanisms of Cancer Cell Signaling that are causative of the development and progression of tumor diseases.

The genetics of Autism Spectrum disorders is investigated as a prototype for polygenetic disorders, where we identify and functionally characterize candidate genes and proteins.

The division had worked for a long time on the human chromosomal region Xq28 to develop and test technologies for the systematic genomic and functional analysis of the human genome. The mapping and transcript identification methods contributed essentially to the identification of a number of disease genes and to the sequencing of the genome.

Alumni

Prof. Dr. Petra Kioschis, Dr. Nina Heiss, Dr. Bernhard Korn, Dr. Heike Köpf, Dr. Renate Siebenhaar, Dr. Eric Steck, Dr. Rainer Himmele, Dr. Rüdiger Salowsky, Dr. Judith Boer, Dr. Kim Beyer, Dr. Ute Rogner, Dr. Sdenek Sedlaczek, Dr. Inge Krebs, Dr. Dorothea Zink, Dr. Frank Bergmann, Dr. Claudia Büche, Dr. Alexander Dietrich, Dr. Stefanie Rauskolb, Renate Gaul, Dr. Antonella Manca, Dr. Weilong Gong, Dr. Stefan Haas, Dr. Klaus Wilke, Dr. Johannes Coy, Gregor Haberhauer, Dr. Klaus Wilgenbus, Prof. Dr. Jan Mollenhauer, Dr. Stephan Herbertz, Dr. Dorit Arlt, Dr. Özgür Sahin, Dr. Ruth Wellenreuther, Dr. Peter Seranski, Dr. Celine Hoff, Dr. Uli Tschulena, Petra Wilgenbus, Alexandra Ochs, Gaby Bergmann, Dr. Birgit Guilleaume, Markus Stauch, Kerstin Hettler, Regina Zahn, Dr. Patricia McCabe, Dr. Andrea Wilson, Dr. Silke Argo, Dr. Lee Bergman, Dr. Hanna Müller, Dr. Ben Waldau, Dr. Mamatha Sauermann, Dr. Meher Majety, Dr. Florian Hahne, Dr. Andreja Vasiljev, Dr. Alexander Mehrle, Dr. Friederike Wilmer, Yvonne Meyer, Michaela Klein, Dr. Detlev Bannasch, Dr. Rainer Wittig, Dr. Anja Kolb-Kokocinski, Dr. Petra Moosmayer, Dr. Regina Albert, Dr. Markus Seiler, Esther Backes, Dr. Stephanie Bechtel, Ute Ernst, Nina Claudino, Anja Irsigler, Angelika Duda, Christian Schmidt, Dr. David Zhang, Anja Schwäger, Sandra Blaszkiewicz, Dirk Ledwinka, Heiko Rosenfelder, Sarah Jurmeister, Marek Baumann, Aysenur Torun, Jörg Kunert, Klaus Steiner, Sara Burmester, Özlem Sener Sahin, Dr. Fritz Klimek, Jennifer Metzger, Dr. Frauke Henjes, Dr. Vladimir Kuryshev, Simone Schleeger, Stephan Gade, Dr. Maria Fälth, Prof. Dr. Holger Sültmann, Dr. Ruprecht Kuner, Dr. Julia Starmann, Lukasz Kacprzyk, Mark Laible, Sabrina Balaguer-Puig, Dr. Rainer Will, Dr. Marc Johannes, Dr. Jan Christoph Brase, Dr. Stephanie Wittig-Blaich, Dr. Melanie Bewerunge-Hudler, Dr. Sabine Gronert-Sum, Dr. Olga Strobel-Freidekind, Karl-Heinz Nolte, Claudia Schuster, Rita Schatten, Thorsten Kühlwein, Dr. Nicole Chui Pressinotti, Dr. Caroline End, Prof. Dr. Tim Beißbarth, Dr. Alberto Calabró, Dr. Mark Fellmann, Dr. Christian Löbke, Dr. Markus Ruschhaupt, Dr. Van Duc Luu, Dr. Michael Stojanov, Andreas Buneß, Prof. Dr. Holger Fröhlich, Prof. Dr. Achim Tresch, Dr. Jörg Schneider, Dr. Katharina Finis, Dr. Wolfgang Huber, Dr. Markus Vogt, PD Dr. Florian Haller, PD Dr. Frank Breitling, Dr. Volker Stadler, Dr. Mario Beyer, Dr. Simon Fernandez, Corina Ackermann, Anastasia Bachmann, Hanna Bausbacher, Dr. Christian Bender, Christina Berg, Judith Becker, Dr. Andreas Chiocchetti, Anke Colberg, Elke Bohn, Melanie Bonaus, Dr. Daniel Bongartz, Christina Bootz, Elke Braunwell, Christina Brechtel, Bastian Buchholz, Dr. Coral Del Val, Tanja Detzel, Uwe Fasching, Dr. Bärbel Felder, Kerstin Feßler, Ute Flörchinger, Dr. Frank Götschel, Carmen Götz, Nicole Grattolf, Dr. Stefanie Greschner, Bärbel Groß, Claudia Grosser, Myriam Grüner, Dr. Caroline Günther†, Gregor Haberhauer, Dagmar Hack, Christine Happes, Dr. Claudia Heine, Patrick Herde, Daniela Holzwarth, Stefan Hrubyj, Dr. Azeemudeen Hussain, Helen Hülsmann, Dr. Anika Jöcker, Rolf Kabbe, Asma Kaleem, Denise Keitel, Alexander Kerner, Yvonne Keßler, Dörthe Kieslich de Hol, Michaela Klein, Dr. Thorsten Kohl, Dr. David Konecki, Birgit Kornacker, Carina Konrad, Dr. Gregor Kraffert, Tatjana Weschenfelder, Stefanie Krauth, Amelie Lier, Diana Lutz, Dr. Stefan Lyer, Dr. Heiko Mannsperger, Eva Mendel, Yvonne Meyer, Carola Mietag, Esther Münch, Veronika Neubrand, Richard Nickodemus, Silvia Noack-Häfner, Seema Noor, Henrik Ochmann, Dr. Geeta Pakalapati, Elke Pick, Dr. Sophie Pollet, Kinga Przibilla, Claire Psyllaki, Nicole Pustelnik, Dr. Ercole Rao, Martin Reimann, Dr. Marcus Renner, Volker Rössler, Melanie Roth, Gabi Rottsahl, Dr. Patricia Ruiz, Inaam Shatila, Nikul Soni, Anja Spieler, Stefanie Süß, Marcello Schifani, Simone Schleger, Corinna Schmitt, Liane Schmitt, Dr. Ingo Schupp, Cordula Stahl, Saskia Stegmüller, Andrea Takacz, Dr. Ramesh Ummanni, Dr. Nils Wedemeyer, Michael Weidlich, Dr. Friedrich Weindler, Konstantin Werthmann, Maike Wosch, Kai Wunderlich, Dr. Laura Diedrichs, Dr. Floris Bikker, Dr. Kristina Reitz, Vivian Szabo, Katharina Genreith, Patrick Neubert, Melanie Melchers, Ena Kolundzic, Nina Stojceva, Holger Armbruster, Sophie Hetterich, Angela Riedel, Benjamin Neunstöcklin, Gerrit Erdmann, Tetyana Ruda, Jochen Thomas, Natascha Boldt, Tanja Schepua, Jalil Khan, Daniel Schütz, Martin Feil, Georg Geiger, Jörg Uhlmann, Dr. Thomas Felgenhauer, Lars Ebert, Astrid Gödde, Oliver Heil, Sabine Henze, Gabi Hoock, Mona Kessler, Prof. Dr. Christian Maercker, Effi Rees, Dr. Heidrun Ridinger†, Christiane Rutenberg, Matthias Schick, Dr. Anke Schroth, Markus Schuster, Silke Wolterink, Jens Mattern, Steve Wagner, Dr. Stefan Uhlmann, Dr. Ioanna Keklikoglou, Dr. Aoife Ward, Dr. Kirti Shukla, Dr. Johanna Sonntag, Moritz Küblbeck,

Prof. Dr. Annemarie Poustka†

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