Pediatric Targeted Therapy
The improved understanding of underlying mechanisms in tumor development open up new venues for targeted therapies using novel substances. Most tumor cells harbour more than one tumor-propagating change, therefore a strategy employing several targeted therapies seems appropriate as well as very promising
The “Pediatric Targeted Therapy” is a joint venture of several groups in Heidelberg that started with the purpose to identify drugable molecular targets in tumors in single cases. To that aim, we analyze the presence and function of certain structures, that can be blocked in a specific manner in experimental treatment settings. Immunohistochemistry on paraffin-embedded tissue is the method used to study these structures. We currently investigate expression of HDACs, HR23B, p-ERK, p-AKT, p-S6, p-EGFR, PDGFRs, p53, and Integrin avb 5. The list of targets is constantly being extended to novel druggable targets.
If you are interested, please contact Prof. Olaf Witt (o.witt@dkfz.de) or Dr. Till Milde (t.milde@dkfz.de). A request form for the aforementioned analyses can be found here or linked below.
