DKTK Frankfurt: German Cancer Award for Simone Fulda
Joint press release of the German Consortium for Translational Cancer Research and the University Hospital Frankfurt
Professor Simone Fulda, a pediatrician and cancer researcher in the German Consortium for Translational Cancer Research (DKTK) of the University Cancer Center (UCT) of the University Hospital Frankfurt, has been honored with the 2014 Cancer Research Award in the category “Translational Research.”
New vaccine against papillomaviruses protects mice from skin cancer
Scientists have suspected that non-melanoma skin cancer in patients who have received organ transplants can be caused not only by UV radiation, but also by simultaneous infection with specific types of human papillomaviruses (HPV). Scientists from the German Cancer Research Center (DKFZ) and the Charité University Hospital Berlin have now used a vaccine for the first time to protect mice against such skin tumors. The vaccine is even effective in animals with suppressed immune systems and mice that have previously been infected with papillomaviruses.
DNA tags as targets for new therapy against brain cancer
Ependymoma is an aggressive type of brain cancer that primarily affects infants. A comprehensive molecular analysis of these tumors has now been carried out with the major participation of scientists from the German Cancer Research Center (DKFZ) and Heidelberg University Hospital. They discovered that ependymomas with a good prognosis differ significantly from those with a poor prognosis. In aggressively growing tumors, a large number of genes are turned off as a result of methylation, a particular type of chemical change involving DNA. Drugs can remove methyl tags and this slows down the growth of cancer cells. The scientists have published their findings in the latest issue of Nature.
What is the most effective way to prevent smoking in youth?
Young people in Germany between the ages of 12 and 17 smoke considerably less than in 2001: The rate of smokers among youth has dropped from 28 percent in 2001 to 12 percent in 2012. In a recent publication, the German Cancer Research Center (DKFZ) reports that the decline was the result of a number of legal measures that have had a substantial impact on tobacco use among young people.
DKTK Tübingen: Hans-Georg Rammensee receives 2013 German Cancer Aid Award
Joint press release of the German Consortium for Translational Cancer Research and Tübingen University Hospital
German Cancer Aid (Deutsche Krebshilfe) presents its annual award to Professor Hans-Georg Rammensee, a collaborator in the German Consortium for Translational Cancer Research, for research in the area of cancer immunotherapy.
Bayer and German Cancer Research Center (DKFZ) in Strategic Alliance Against Cancer
Bayer HealthCare and the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have agreed on a five-year strategic research alliance against cancer. The two partners have already been collaborating since 2009 with the aim of jointly developing novel therapeutic options for cancer patients. Bayer and the DKFZ will together invest up to 30 million Euros into their collaboration over the next five years to address the high medical need in cancer treatment and diagnosis.
Cancer survival depends on where people live
Based on an analysis of data from one million cancer patients, scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have discovered for the first time that cancer survival depends on the socioeconomic conditions of the place where people live. The DKFZ is making the announcement on the occasion of World Cancer Day on February 4. Patients from economically weak districts have poorer chances of survival, particularly during the first three months after a diagnosis.
Endothelial cells in the driver's seat
Endothelial cells, the inner lining of blood vessels, do not just respond passively to exogenous stimuli. Instead, they themselves control organ function in a very active manner. Scientists from the German Cancer Research Center and Heidelberg University have now discovered a complex growth regulatory mechanism through which endothelial cells control liver regeneration after damage or partial surgical removal.
Colon cancer screening the right way!
Colonoscopy is the safest early-detection method for colorectal (colon) cancer. However, many patients avoid this procedure and prefer to have a test for hidden traces of blood ("occult blood") in the stool instead. However, this test detects only a portion of cases of cancer and occasionally leads to a false alarm. Men should particularly be aware of this, since their risk of developing colorectal cancer is twice as high as that of women. Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now discovered that men whose stool tests are negative have colon cancer or precursor lesions even more frequently than women with positive test results. The scientists therefore recommend that people should not rely on the results of a stool test taken on a single occasion for a proper diagnosis.
RNA switch for safe viral therapy in treating cancer
Using viruses to fight cancer is a novel approach to treatment that is being tested in clinical trials around the globe. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown how the safety of this method can be substantially improved. They have succeeded, for the first time, in using RNA switches (or ‘riboswitches’) to turn off the replication of therapeutic viruses when needed. The method was successful for adenoviruses and the measles virus, both of which are candidates for use in cancer virotherapy. RNA switches may additionally improve the safety of viral therapy in general and thus help achieve a breakthrough in this promising approach to treatment.