Cancer Core Europe: a consortium to address the cancer care – cancer research continuum challenge
Gustave Roussy Cancer Campus Grand Paris (Villejuif – France), Cambridge Cancer Centre (Cambridge, United Kingdom), Karolinska Institutet – KI (Stockholm, Sweden), Netherlands Cancer Institute – NKI (Amsterdam, The Netherlands), Vall d’Hebron Institute of Oncology – VHIO (Barcelona, Spain) and the German Cancer Research Center – DKFZ and its National Center for Tumor Diseases – NCT (Heidelberg, Germany) announce the creation of Cancer Core Europe: a consortium to address the cancer care – cancer research continuum challenge.
Sven Diederichs receives DGVS young investigator award in the field of liver cancer
The German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS), supported by Bayer Health Care, presented its 2014 young investigator award in the field of hepatocellular carcinoma research to Sven Diederichs. Dr. Diederichs, a molecular biologist at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Institute of Pathology of Heidelberg University Hospital, has received the award in recognition of his outstanding scientific achievements in the field of liver cancer research.
Resistance training reduces cancer-related fatigue
A 12-week program of resistance training in conjunction with radiation therapy increases the quality of life of breast cancer patients and reduces symptoms of fatigue, as shown by scientists from the German Cancer Research Center and Heidelberg University Hospital in a trial involving 160 women.
Throwing a loop to silence gene expression
Cells attach so-called ‘epigenetic’ signals to their genome to select which part of their genetic information is used. Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now systematically investigated the interplay between components of an epigenetic network and developed a mathematical model that describes how it operates. The results can be used to predict how cellular gene expression programs respond to drug treatment or other perturbations of the cellular environment.
TGF-ß prevents self-reactive B cell activation
How silent genes are activated
One cancer – many tumors
In studies on prostate cancer, scientists from the German Cancer Research Center (DKFZ) simultaneously investigated the genetic and epigenetic development of the tumors. They used a parallel approach to analyze both the genome and the methylation of the DNA in various tissue samples from a tumor and its metastases. Both processes equally reflect the complex composition of multiple different daughter clones in advanced tumors. As DNA methylation impacts the activity of genes, detecting diverging methylation patterns may help understand the origins of metastases and choose more specific treatment strategies.
Encyclopedia of stem cells – Identification of regulatory networks in hematopoietic stem cells and their immediate progeny
Scientists discover thymus stem cells
Scientists at the German Cancer Research Center (DKFZ) have identified a common progenitor of cortical and medullary thymic epithelial cells
Enough is enough: How tissues regulate their growth
Scientists from the German Cancer Research Center (DKFZ) have discovered a previously unknown mechanism that cells can use to control their growth. This mechanism plays a role in development, and its failure can result in cancer. The DKFZ researchers headed by Aurelio Teleman, jointly with colleagues in the group of Kent Duncan at Hamburg-Eppendorf University Hospital, have now published their results in Nature.