How fasting helps fight fatty liver disease
Jointly with colleagues from Helmholtz Zentrum München, scientists at the German Cancer Research Center in Heidelberg have new information on what happens at the molecular level when we go hungry. In cooperation with the German Center for Diabetes Research they were able to show that upon deprivation of food a certain protein is produced that adjusts the metabolism in the liver.
Founding of an International Cancer Genome Consortium for medicine: Scientists combine data from cancer genome with information on disease progression
During the American Association for Cancer Research annual meeting, members of the International Cancer Genome Consortium (ICGC) announced their entering of a new phase: The ICGCmed now combine data from cancer genome with information on disease progression. The objective of this initiative is to make optimal use of the consolidated information for prevention, early detection, diagnostics, prognosis and tailor-made cancer therapies.
Endogenous oxidants: New methods for monitoring processes in the organism
Diet, physical activity, infection, cancer, and possibly aging are all factors that can have an impact on the oxidation state of cells and tissues. Scientists from the German Cancer Research Center (DKFZ) have now developed two novel biological measuring systems that facilitate better analysis of disease-relevant changes in the oxidation state of cells. One of the methods can be used, for the first time, to observe variations and changes in cellular oxidation states in tissue sections. The other is a newly developed biosensor that is a sensitive enough to facilitate real-time measurements of subtle oxidative changes in metabolism.
DKFZ trainee wins Helmholtz Apprentice Award with a stem cell culture
A great success for one of DKFZ's young staff members: 22-year old Franziska Pilz came second in the Helmholtz Apprentice Award. The jury commended her for her “significant contribution to the further development of stem cell research and for her independent, proactive and responsible work”. Franziska Pilz who is currently training to be a biology laboratory assistant, worked on a project on the stem cell niche. She accepted her award on April 7.
Richtzenhain Award 2016: Call for Proposals
The Management Board of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) announces the Walther and Christine Richtzenhain Foundation Award 2016 for a scientific paper in translational cancer research. The prize is endowed with a sum of € 10.000.
A reason to celebrate: 40 years of German-Israeli collaboration in cancer research
At a festive symposium in Tel Aviv, scientists and politicians came together to celebrate the 40th anniversary of the science cooperation agreement between the German Cancer Research Center (DKFZ) and the Israeli Research Ministry.
Maternal smoking during pregnancy leaves its lasting mark on the child’s genetic make-up
If mothers smoke during pregnancy, they influence the epigenetic programming of their unborn child’s genetic make-up in the long term. This may give rise to an increased risk of the development of disease risks later in the child’s life. Researchers at the Helmholtz Centre for Environmental Research (UFZ) in Leipzig, the German Cancer Research Center (DKFZ) in Heidelberg and the Heidelberg University discovered that these changes are not limited to individual regions of DNA. In fact, the researchers stated in the “Molecular Systems Biology” journal that they particularly accumulate in enhancers of gene expression.
Joint press release by the German Cancer Research Center and Heidelberg University
Worldwide trend towards obesity continues
Only four decades ago, there were twice as many underweight people than obese people in the world. However, this situation has changed dramatically over this relatively short period. Today, there are considerably more people who are obese than people who are underweight. This holds true worldwide, with the exception of Southeast Asia and some parts of Africa. These are findings obtained by an international research consortium using data from over 19 million people. The investigators have now reported their results in an article published in the journal “The Lancet”.
Mother’s gut microbiota strengthens newborn's immunity
Already during pregnancy, microbes in the mother’s gut shape the baby's immune system. This effect is brought about by microbial molecules that are transmitted to the baby across the placenta or via antibodies in the mother's milk. Scientists from Bern University Hospital, the University of Bern, the German Cancer Research Center (DKFZ) and ETH Zurich have now reported this finding in an article published in Science.
Altered DNA methylation as a warning sign of radiation-induced fibrosis
Radiation-induced fibrosis is a common late effect of radiation therapy. In a study on breast cancer, scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and Mannheim University Hospital have now identified an epigenetic pattern that indicates an increased risk of fibrosis. In the future, this epigenetic characteristic might be used before starting radiation therapy as a biomarker indicating whether a patient is highly susceptible to fibrosis. Its effect is that skin cells increase the production of an enzyme that induces the development of fibrosis. Specific agents might interrupt this process.