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Research

Publications 2020

Edelmann, D. (First author) ; Richards, D. ; Vogel, D.
The distance standard deviation
The annals of statistics 48(6), 3395 - 3416 (2020) [10.1214/19-AOS1935]2020 BibTeX | EndNote: XML, Text | RIS

Jahn, N. ; Terzer, T. ; Sträng, E. ; Dolnik, A. ; Cocciardi, S. ; Panina, E. ; Corbacioglu, A. ; Herzig, J. ; Weber, D. ; Schrade, A. ; Götze, K. ; Schröder, T. ; Lübbert, M. ; Wellnitz, D. ; Koller, E. ; Schlenk, R. F. ; Gaidzik, V. I. ; Paschka, P. ; Rücker, F. G. ; Heuser, M. ; Thol, F. ; Ganser, A. ; Benner, A. ; Döhner, H. ; Bullinger, L. ; Döhner, K.
Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implication.
Blood advances 4(24), 6342 - 6352 (2020) [10.1182/bloodadvances.2020002673]2020 BibTeX | EndNote: XML, Text | RIS

Hüser, L. (First author) ; Kokkaleniou, M.-M. ; Granados, K. ; Dworacek, J. ; Federico, A. ; Vierthaler, M. ; Novak, D. ; Arkhypov, I. ; Hielscher, T. ; Umansky, V. ; Altevogt, P. ; Utikal, J. (Last author)
HER3-Receptor-Mediated STAT3 Activation Plays a Central Role in Adaptive Resistance toward Vemurafenib in Melanoma
Cancers 12(12), 3761 (2020) [10.3390/cancers12123761]2020 DBCoverage BibTeX | EndNote: XML, Text | RIS

Granados, K. (First author) ; Hüser, L. ; Federico, A. ; Sachindra, S. ; Wolff, G. ; Hielscher, T. ; Novak, D. ; Madrigal-Gamboa, V. ; Sun, Q. ; Vierthaler, M. ; Larribère, L. ; Umansky, V. ; Utikal, J. (Last author)
T-type calcium channel inhibition restores sensitivity to MAPK inhibitors in de-differentiated and adaptive melanoma cells.
British journal of cancer 122(7), 1023 - 1036 (2020) [10.1038/s41416-020-0751-8]2020 pmc Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

Deutelmoser, H. (First author) ; Lorenzo Bermejo, J. ; Benner, A. ; Weigl, K. ; Park, H. A. ; Haffa, M. ; Herpel, E. ; Schneider, M. ; Ulrich, C. M. ; Hoffmeister, M. ; Chang-Claude, J. ; Brenner, H. ; Scherer, D. (Last author)
Genotype-Based Gene Expression in Colon Tissue-Prediction Accuracy and Relationship with the Prognosis of Colorectal Cancer Patients.
International journal of molecular sciences 21(21), 8150 (2020) [10.3390/ijms21218150]2020 DBCoverage BibTeX | EndNote: XML, Text | RIS

Holland-Letz, T. (First author) ; Kopp-Schneider, A. (Last author)
The design heatmap: A simple visualization of D -optimality design problems.
Biometrical journal 62(8), 2013-2031 (2020) [10.1002/bimj.202000087]2020 BibTeX | EndNote: XML, Text | RIS

Neumeyer, S. (First author) ; Hua, X. ; Seibold, P. ; Jansen, L. ; Benner, A. ; Burwinkel, B. ; Halama, N. ; Berndt, S. I. ; Phipps, A. I. ; Sakoda, L. C. ; Schoen, R. E. ; Slattery, M. L. ; Chan, A. T. ; Gala, M. ; Joshi, A. D. ; Ogino, S. ; Song, M. ; Herpel, E. ; Bläker, H. ; Kloor, M. ; Scherer, D. ; Ulrich, A. ; Ulrich, C. M. ; Win, A. K. ; Figueiredo, J. C. ; Hopper, J. L. ; Macrae, F. ; Milne, R. L. ; Giles, G. G. ; Buchanan, D. D. ; Peters, U. ; Hoffmeister, M. ; Brenner, H. ; Newcomb, P. A. ; Chang-Claude, J. (Last author)
Genetic variants in the regulatory T cell related pathway and colorectal cancer prognosis
Cancer epidemiology, biomarkers & prevention 29(12), 2719-2728 (2020) [10.1158/1055-9965.EPI-20-0714]2020 BibTeX | EndNote: XML, Text | RIS

Schelb, P. (First author) ; Kohl, S. ; Radtke, J. P. ; Wiesenfarth, M. ; Kickingereder, P. ; Bickelhaupt, S. ; Kuder, T. A. ; Stenzinger, A. ; Hohenfellner, M. ; Schlemmer, H. -. ; Maier-Hein, K. H. ; Bonekamp, D. (Last author)
Closing the Gap between Prostate Cancer and Deep Learning Detection Tools Response
Radiology 295(3), E9 - + (2020)2020 BibTeX | EndNote: XML, Text | RIS

Maier-Hein, L. (First author) ; Reinke, A. ; Kozubek, M. ; Martel, A. L. ; Arbel, T. ; Eisenmann, M. ; Hanbury, A. ; Jannin, P. ; Müller, H. ; Onogur, S. ; Saez-Rodriguez, J. ; van Ginneken, B. ; Kopp-Schneider, A. ; Landman, B. A.
BIAS: Transparent reporting of biomedical image analysis challenges.
Medical image analysis 66, 101796 (2020) [10.1016/j.media.2020.101796]2020 BibTeX | EndNote: XML, Text | RIS

Sachpekidis, C. ; Schepers, R. ; Marti, M. ; Kopp-Schneider, A. ; Alberts, I. ; Keramida, G. ; Afshar-Oromieh, A. ; Rominger, A.
99mTc-MAG3 Diuretic Renography: Intra- and Inter-Observer Repeatability in the Assessment of Renal Function.
Diagnostics 10(9), 709 (2020) [10.3390/diagnostics10090709]2020 DBCoverage BibTeX | EndNote: XML, Text | RIS

Ballhausen, A. (First author) ; Przybilla, M. J. (First author) ; Jendrusch, M. (First author) ; Haupt, S. ; Pfaffendorf, E. ; Seidler, F. ; Witt, J. ; Hernandez Sanchez, A. ; Urban, K. ; Draxlbauer, M. ; Krausert, S. ; Ahadova, A. ; Kalteis, M. S. ; Pfuderer, P. ; Heid, D. ; Stichel, D. ; Gebert, J. ; Bonsack, M. ; Schott, S. ; Bläker, H. ; Seppälä, T. ; Mecklin, J.-P. ; Ten Broeke, S. ; Nielsen, M. ; Heuveline, V. ; Krzykalla, J. ; Benner, A. ; Riemer, A. ; von Knebel Doeberitz, M. ; Kloor, M. (Last author)
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution.
Nature Communications 11(1), 4740 (2020) [10.1038/s41467-020-18514-5]2020 DBCoverage BibTeX | EndNote: XML, Text | RIS

Wennmann, M. (First author) ; Hielscher, T. ; Kintzelé, L. ; Menze, B. H. ; Langs, G. ; Merz, M. ; Sauer, S. ; Kauczor, H.-U. ; Schlemmer, H.-P. ; Delorme, S. ; Goldschmidt, H. ; Weinhold, N. ; Hillengass, J. ; Weber, M.-A.
Spatial Distribution of Focal Lesions in Whole-Body MRI and Influence of MRI Protocol on Staging in Patients with Smoldering Multiple Myeloma According to the New SLiM-CRAB-Criteria.
Cancers 12(9), 2537 (2020) [10.3390/cancers12092537]2020 DBCoverage BibTeX | EndNote: XML, Text | RIS

Holland-Letz, T. (First author) ; Kopp-Schneider, A. (Last author)
Drawing statistical conclusions from experiments with multiple quantitative measurements per subject.
Radiotherapy and oncology 152, 30-33 (2020) [10.1016/j.radonc.2020.08.009]2020 BibTeX | EndNote: XML, Text | RIS

Sadik, A. (First author) ; Somarribas Patterson, L. F. ; Öztürk, S. ; Mohapatra, S. R. ; Panitz, V. ; Secker, P. F. ; Pfänder, P. ; Loth, S. ; Salem, H. ; Prentzell, M. T. ; Berdel, B. ; Iskar, M. ; Faessler, E. ; Reuter, F. ; Kirst, I. ; Kalter, V. ; Foerster, K. I. ; Jäger, E. ; Guevara, C. R. ; Sobeh, M. ; Hielscher, T. ; Poschet, G. ; Reinhardt, A. ; Hassel, J. C. ; Zapatka, M. ; Hahn, U. ; von Deimling, A. ; Hopf, C. ; Schlichting, R. ; Escher, B. I. ; Burhenne, J. ; Haefeli, W. E. ; Ishaque, N. ; Böhme, A. ; Schäuble, S. ; Thedieck, K. ; Trump, S. ; Seiffert, M. ; Opitz, C. (Last author)
IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.
Cell 182(5), 1252-1270.e34 (2020) [10.1016/j.cell.2020.07.038]2020 BibTeX | EndNote: XML, Text | RIS

Kapp-Schwoerer, S. ; Weber, D. ; Corbacioglu, A. ; Gaidzik, V. I. ; Paschka, P. ; Krönke, J. ; Theis, F. ; Rücker, F. G. ; Teleanu, M.-V. ; Panina, E. ; Jahn, N. ; Herzig, J. K. ; Kubanek, L. ; Schrade, A. ; Gohring, G. ; Fiedler, W. ; Kindler, T. ; Schroeder, T. ; Mayer, K. ; Lübbert, M. ; Wattad, M. ; Götze, K. ; Horst, H. A. ; Koller, E. ; Wulf, G. G. ; Schleicher, J. ; Bentz, M. ; Krauter, J. ; Bullinger, L. ; Krzykalla, J. ; Benner, A. ; Schlenk, R. F. ; Thol, F. ; Heuser, M. ; Ganser, A. ; Döhner, H. ; Döhner, K.
Impact of gemtuzumab ozogamicin on MRD and relapse risk in NPM1 mutated AML patients: results from the AMLSG 09-09 Trial.
Blood 136(26), 3041-3050 (2020) [10.1182/blood.2020005998]2020 BibTeX | EndNote: XML, Text | RIS

Edelmann, D. (First author) ; Ohneberg, K. ; Becker, N. ; Benner, A. (Last author) ; Schumacher, M.
Which patients to sample in clinical cohort studies when the number of events is high and measurement of additional markers is constrained by limited resources.
Cancer medicine 9(20), 7398-7406 (2020) [10.1002/cam4.3381]2020 DBCoverage BibTeX | EndNote: XML, Text | RIS

Calderazzo, S. (Last author)
Introduction to statistical decision theory
Biometrical journal 62(7), 1826-1826 (2020) [10.1002/bimj.202000229]2020 BibTeX | EndNote: XML, Text | RIS

Schöttker, B. (First author) ; Kuznia, S. ; Laetsch, D. C. ; Czock, D. ; Kopp-Schneider, A. ; Caspari, R. ; Brenner, H. (Last author)
Protocol of the VICTORIA study: personalized vitamin D supplementation for reducing or preventing fatigue and enhancing quality of life of patients with colorectal tumor - randomized intervention trial.
BMC cancer 20(1), 739 (2020) [10.1186/s12885-020-07219-z]2020 DBCoverage Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

Scherer, D. (First author) ; Deutelmoser, H. ; Balavarca, Y. ; Toth, R. ; Habermann, N. ; Buck, K. ; Kap, E. J. ; Botma, A. ; Seibold, P. ; Jansen, L. ; Lorenzo Bermejo, J. ; Weigl, K. ; Benner, A. ; Hoffmeister, M. ; Ulrich, A. ; Brenner, H. ; Burwinkel, B. ; Chang-Claude, J. ; Ulrich, C. M.
Polymorphisms in the Angiogenesis-Related Genes EFNB2, MMP2 and JAG1 Are Associated with Survival of Colorectal Cancer Patients.
International journal of molecular sciences 21(15), 5395 (2020) [10.3390/ijms21155395]2020 DBCoverage BibTeX | EndNote: XML, Text | RIS

Prutsch, N. ; Gurnhofer, E. ; Suske, T. ; Liang, H. C. ; Schlederer, M. ; Roos, S. ; Wu, L. C. ; Simonitsch-Klupp, I. ; Alvarez-Hernandez, A. ; Kornauth, C. ; Leone, D. A. ; Svinka, J. ; Eferl, R. ; Limberger, T. ; Aufinger, A. ; Shirsath, N. ; Wolf, P. ; Hielscher, T. ; Sternberg, C. ; Aberger, F. ; Schmoellerl, J. ; Stoiber, D. ; Strobl, B. ; Jäger, U. ; Staber, P. B. ; Grebien, F. ; Moriggl, R. ; Müller, M. ; Inghirami, G. G. ; Sanda, T. ; Look, A. T. ; Turner, S. D. ; Kenner, L. ; Merkel, O.
Correction: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.
Leukemia 24(11), 3105 (2020) [10.1038/s41375-020-0968-9]2020 BibTeX | EndNote: XML, Text | RIS

Jutzi, T. (First author) ; Krieghoff-Henning, E. I. ; Holland-Letz, T. ; Utikal, J. S. ; Hauschild, A. ; Schadendorf, D. ; Sondermann, W. ; Fröhling, S. ; Hekler, A. ; Schmitt, M. ; Maron, R. C. ; Brinker, T. (Last author)
Artificial Intelligence in Skin Cancer Diagnostics: The Patients' Perspective
Frontiers in medicine 7, 233 (2020) [10.3389/fmed.2020.00233]2020 DBCoverage BibTeX | EndNote: XML, Text | RIS

Sievers, P. (First author) ; Hielscher, T. ; Schrimpf, D. ; Stichel, D. ; Reuss, D. E. ; Berghoff, A. S. ; Neidert, M. C. ; Wirsching, H.-G. ; Mawrin, C. ; Ketter, R. ; Paulus, W. ; Reifenberger, G. ; Lamszus, K. ; Westphal, M. ; Etminan, N. ; Ratliff, M. ; Herold-Mende, C. ; Pfister, S. M. ; Jones, D. T. W. ; Weller, M. ; Harter, P. N. ; Wick, W. ; Preusser, M. ; von Deimling, A. ; Sahm, F. (Last author)
CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas.
Acta neuropathologica 140(3), 409-413 (2020) [10.1007/s00401-020-02188-w]2020 BibTeX | EndNote: XML, Text | RIS

Usta, D. (First author) ; Sigaud, R. ; Buhl, J. L. ; Selt, F. ; Marquardt, V. ; Pauck, D. ; Jansen, J. ; Pusch, S. ; Ecker, J. ; Hielscher, T. ; Vollmer, J. ; Sommerkamp, A. C. ; Rubner, T. ; Hargrave, D. ; van Tilburg, C. M. ; Pfister, S. M. ; Jones, D. T. W. ; Remke, M. ; Brummer, T. ; Witt, O. ; Milde, T. (Last author)
A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells.
Molecular cancer therapeutics 19(8), 1736-1750 (2020) [10.1158/1535-7163.MCT-19-1021]2020 BibTeX | EndNote: XML, Text | RIS

Edelmann, D. (First author) ; Saadati, M. ; Putter, H. ; Goeman, J.
A global test for competing risks survival analysis.
Statistical methods in medical research 29(12), 3666-3683 (2020) [10.1177/0962280220938402]2020 BibTeX | EndNote: XML, Text | RIS

Sachpekidis, C. (First author) ; Kopp-Schneider, A. ; Merz, M. ; Jauch, A. ; Raab, M.-S. ; Goldschmidt, H. ; Dimitrakopoulou-Strauss, A. (Last author)
Can 18F-NaF PET/CT before Autologous Stem Cell Transplantation Predict Survival in Multiple Myeloma?
Cancers 12(5), 1335 (2020) [10.3390/cancers12051335]2020 DBCoverage Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

van Tilburg, C. M. (First author) ; Witt, R. ; Heiss, M. ; Pajtler, K. W. ; Plass, C. ; Poschke, I. ; Platten, M. ; Harting, I. ; Sedlaczek, O. ; Freitag, A. ; Meyrath, D. ; Taylor, L. ; Balasubramanian, G. P. ; Jäger, N. ; Pfaff, E. ; Jones, B. C. ; Milde, T. ; Pfister, S. M. ; Jones, D. T. W. ; Kopp-Schneider, A. ; Witt, O. (Last author)
INFORM2 NivEnt: The first trial of the INFORM2 biomarker driven phase I/II trial series: the combination of nivolumab and entinostat in children and adolescents with refractory high-risk malignancies
BMC cancer 20(1), 523 (2020) [10.1186/s12885-020-07008-8]2020 DBCoverage BibTeX | EndNote: XML, Text | RIS

Schlenk, R. F. ; Paschka, P. ; Krzykalla, J. ; Weber, D. ; Kapp-Schwoerer, S. ; Gaidzik, V. I. ; Leis, C. ; Fiedler, W. ; Kindler, T. ; Schroeder, T. ; Mayer, K. ; Lübbert, M. ; Wattad, M. ; Götze, K. ; Horst, H. A. ; Koller, E. ; Wulf, G. ; Schleicher, J. ; Bentz, M. ; Greil, R. ; Hertenstein, B. ; Krauter, J. ; Martens, U. ; Nachbaur, D. ; Abu Samra, M. ; Girschikofsky, M. ; Basara, N. ; Benner, A. ; Thol, F. ; Heuser, M. ; Ganser, A. ; Döhner, K. ; Döhner, H.
Gemtuzumab Ozogamicin in NPM1-Mutated Acute Myeloid Leukemia: Early Results From the Prospective Randomized AMLSG 09-09 Phase III Study.
Journal of clinical oncology 38(6), 623 - 632 (2020) [10.1200/JCO.19.01406]2020 pmc Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

Kim-Wanner, S.-Z. (First author) ; Assenov, Y. ; Nair, M. B. ; Weichenhan, D. ; Benner, A. ; Becker, N. ; Landwehr, K. ; Kuner, R. ; Sültmann, H. ; Esteller, M. ; Koch, I. ; Lindner, M. ; Meister, M. ; Thomas, M. ; Bieg, M. ; Klingmueller, U. ; Schlesner, M. ; Warth, A. ; Brors, B. ; Seifried, E. ; Bonig, H. ; Plass, C. ; Risch, A. ; Muley, T.
Genome-wide DNA methylation profiling in early stage I lung adenocarcinoma reveals predictive aberrant methylation in the promoter region of the long non-coding RNA PLUT - an exploratory study.
Journal of thoracic oncology 15(8), 1338-1350 (2020) [10.1016/j.jtho.2020.03.023]2020 BibTeX | EndNote: XML, Text | RIS

Blocka, J. ; Hielscher, T. ; Goldschmidt, H. ; Department of Hematology and Oncology, N. C. f. T. D. ; Hillengass, J.
Response improvement rather than response status after 1st ASCT is a significant prognostic factor for survival benefit from tandem compared to single ASCT in multiple myeloma patients.
Biology of blood and marrow transplantation 26(7), 1280-1287 (2020) [10.1016/j.bbmt.2020.03.006]2020 BibTeX | EndNote: XML, Text | RIS

Wierzbinska, J. A. (First author) ; Toth, R. ; Ishaque, N. ; Rippe, K. ; Mallm, J.-P. ; Klett, L. C. ; Mertens, D. ; Zenz, T. ; Hielscher, T. ; Seifert, M. ; Küppers, R. ; Assenov, Y. ; Lutsik, P. ; Stilgenbauer, S. ; Roessner, P. M. ; Seiffert, M. ; Byrd, J. ; Oakes, C. C. ; Plass, C. (Last author) ; Lipka, D. (Last author)
Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL.
Genome medicine 12(1), 29 (2020) [10.1186/s13073-020-00724-7]2020 DBCoverage BibTeX | EndNote: XML, Text | RIS

Carr, P. (First author) ; Weigl, K. ; Edelmann, D. ; Jansen, L. ; Chang-Claude, J. ; Brenner, H. ; Hoffmeister, M. (Last author)
Estimation of Absolute Risk of Colorectal Cancer Based on Healthy Lifestyle, Genetic Risk, and Colonoscopy Status in a Population-based Study.
Gastroenterology 159(1), 129-138.e9 (2020) [10.1053/j.gastro.2020.03.016]2020 BibTeX | EndNote: XML, Text | RIS

Knauf, W. ; Dingeldein, G. ; Schlag, R. ; Welslau, M. ; Moehler, T. ; Terzer, T. ; Walter, S. ; Goldschmidt, H. ; Raab, M.-S. ; group, B. t.
First-line therapy with Bendamustine/Prednisone/Bortezomib (BPV) - A GMMG trial for non-transplant eligible symptomatic multiple myeloma patients.
European journal of haematology 105(2), 116-125 (2020) [10.1111/ejh.13409]2020 BibTeX | EndNote: XML, Text | RIS

Sommerburg, O. ; Wielpütz, M. O. ; Trame, J.-P. ; Wuennemann, F. ; Optazaite, E. ; Stahl, M. ; Puderbach, M. U. ; Kopp-Schneider, A. ; Fritzsching, E. ; Kauczor, H.-U. ; Baumann, I. ; Mall, M. A. ; Eichinger, M.
MRI Detects Chronic Rhinosinusitis in Infants and Preschool Children with Cystic Fibrosis.
Annals of the American Thoracic Society 17(6), 714-723 (2020) [10.1513/AnnalsATS.201910-777OC]2020 BibTeX | EndNote: XML, Text | RIS

Möhrmann, L. (First author) ; Zowada, M. K. (First author) ; Strakerjahn, H. ; Siegl, C. ; Kopp-Schneider, A. ; Krunic, D. ; Strunk, D. ; Schneider, M. ; Kriegsmann, M. ; Kriegsmann, K. ; Herbst, F. ; Ball, C. R. ; Glimm, H. ; Dieter, S. (Last author)
A Perivascular Niche in the Bone Marrow Hosts Quiescent and Proliferating Tumorigenic Colorectal Cancer Cells.
International journal of cancer 147(2), 519-531 (2020) [10.1002/ijc.32933]2020 BibTeX | EndNote: XML, Text | RIS

Goldschmidt, H. ; Mai, E. K. ; Dürig, J. ; Scheid, C. ; Weisel, K. C. ; Kunz, C. ; Bertsch, U. ; Hielscher, T. ; Merz, M. ; Munder, M. ; Lindemann, H.-W. ; Hügle-Dörr, B. ; Tichy, D. ; Giesen, N. ; Hose, D. ; Seckinger, A. ; Huhn, S. ; Luntz, S. ; Jauch, A. ; Elmaagacli, A. ; Rabold, B. ; Fuhrmann, S. ; Brossart, P. ; Goerner, M. ; Bernhard, H. ; Hoffmann, M. ; Hillengass, J. ; Raab, M. S. ; Blau, I. W. ; Hänel, M. ; Salwender, H. J. ; Group, G. M. M. (Collaboration Author)
Response-adapted lenalidomide maintenance in newly diagnosed myeloma: results from the phase III GMMG-MM5 trial.
Leukemia 34(7), 1853-1865 (2020) [10.1038/s41375-020-0724-1]2020 BibTeX | EndNote: XML, Text | RIS

Berberich, A. ; Schneider, C. ; Herweh, C. ; Hielscher, T. ; Reiff, T. ; Bendszus, M. ; Gumbinger, C. ; Ringleb, P.
Risk factors associated with progressive lacunar strokes and benefit from dual anti-platelet therapy.
European journal of neurology 27(5), 817-824 (2020) [10.1111/ene.14159]2020 BibTeX | EndNote: XML, Text | RIS

Bochtler, T. (First author) ; Reiling, A. ; Endris, V. ; Hielscher, T. ; Volckmar, A.-L. ; Neumann, O. ; Kirchner, M. ; Budczies, J. ; Heukamp, L. C. ; Leichsenring, J. ; Allgäuer, M. ; Kazdal, D. ; Löffler, H. ; Weichert, W. ; Schirmacher, P. ; Stenzinger, A. ; Krämer, A. (Last author)
Integrated clinico-molecular characterization identifies RAS activation and CDKN2A deletion as independent adverse prognostic factors in cancer of unknown primary.
International journal of cancer 146(11), 3053-3064 (2020) [10.1002/ijc.32882]2020 BibTeX | EndNote: XML, Text | RIS

Maros, M. E. ; Capper, D. ; Jones, D. T. W. ; Hovestadt, V. ; von Deimling, A. ; Pfister, S. M. ; Benner, A. ; Zucknick, M. ; Sill, M. (Last author)
Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data.
Nature protocols 15(2), 479-512 (2020) [10.1038/s41596-019-0251-6]2020 BibTeX | EndNote: XML, Text | RIS

Giesen, N. (First author) ; Schwarzbich, M.-A. ; Dischinger, K. ; Becker, N. ; Hummel, M. ; Benner, A. ; Radujkovic, A. ; Müller-Tidow, C. ; Dreger, P. ; Luft, T.
CXCL9 predicts Severity at Onset of Chronic Graft-Versus-Host Disease.
Transplantation 104(11), 2354-2359 (2020) [10.1097/TP.0000000000003108]2020 BibTeX | EndNote: XML, Text | RIS

Döhner, K. ; Thiede, C. ; Jahn, N. ; Panina, E. ; Gambietz, A. ; Larson, R. A. ; Prior, T. W. ; Marcucci, G. ; Jones, D. ; Krauter, J. ; Heuser, M. ; Voso, M. T. ; Ottone, T. ; Nomdedeu, J. F. ; Mandrekar, S. J. ; Klisovic, R. ; Wei, A. H. ; Sierra, J. ; Sanz, M. A. ; Brandwein, J. ; de Witte, T. M. ; Jansen, J. H. ; Niederwieser, D. ; Appelbaum, F. ; Medeiros, B. C. ; Tallman, M. S. ; Schlenk, R. F. ; Ganser, A. ; Serve, H. ; Ehninger, G. ; Amadori, S. ; Gathmann, I. ; Benner, A. ; Pallaud, C. ; Stone, R. M. ; Döhner, H. ; Bloomfield, C. D.
Impact of NPM1/FLT3-ITD genotypes defined by the2017 European LeukemiaNet in patients with acute myeloid leukemia.
Blood 135(5), 371-380 (2020) [10.1182/blood.2019002697]2020 BibTeX | EndNote: XML, Text | RIS

Krzykalla, J. (First author) ; Benner, A. ; Kopp-Schneider, A. (Last author)
Exploratory identification of predictive biomarkers in randomized trials with normal endpoints.
Statistics in medicine 39(7), 923-939 (2020) [10.1002/sim.8452]2020 BibTeX | EndNote: XML, Text | RIS

Stanifer, M. (First author) ; Mukenhirn, M. ; Muenchau, S. ; Pervolaraki, K. ; Kanaya, T. ; Albrecht, D. ; Odendall, C. ; Hielscher, T. ; Haucke, V. ; Kagan, J. C. ; Bartfeld, S. ; Ohno, H. ; Boulant, S. (Last author)
Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells.
Nature microbiology 5(1), 181-191 (2020) [10.1038/s41564-019-0594-3]2020 BibTeX | EndNote: XML, Text | RIS

Holland-Letz, T. (First author) ; Leibner, A. ; Kopp-Schneider, A. (Last author)
Modeling dose-response functions for combination treatments with log-logistic or Weibull functions.
Archives of toxicology 94(1), 197-204 (2020) [10.1007/s00204-019-02631-2]2020 BibTeX | EndNote: XML, Text | RIS

d'Errico, M. (First author) ; Alwers, E. ; Zhang, Y. ; Edelmann, D. ; Brenner, H. ; Hoffmeister, M. (Last author)
Identification of prognostic DNA methylation biomarkers in patients with gastrointestinal adenocarcinomas: A systematic review of epigenome-wide studies.
Cancer treatment reviews 82, 101933 (2020) [10.1016/j.ctrv.2019.101933]2020 BibTeX | EndNote: XML, Text | RIS

Berberich, A. (First author) ; Schmitt, L.-M. ; Pusch, S. ; Hielscher, T. ; Rübmann, P. ; Hucke, N. ; Latzer, P. ; Heßling, B. ; Lemke, D. ; Kessler, T. ; Platten, M. ; Wick, W. (Last author)
cMyc and ERK activity are associated with resistance to ALK inhibitory treatment in glioblastoma.
Journal of neuro-oncology 146(1), 9-23 (2020) [10.1007/s11060-019-03348-z]2020 BibTeX | EndNote: XML, Text | RIS

Püllen, L. ; Radtke, J. P. ; Wiesenfarth, M. ; Roobol, M. J. ; Verbeek, J. F. M. ; Wetter, A. ; Guberina, N. ; Pandey, A. ; Hüttenbrink, C. ; Tschirdewahn, S. ; Pahernik, S. ; Hadaschik, B. A. ; Distler, F. A.
External validation of novel MRI-based models for prostate cancer prediction.
BJU international 125(3), 407-416 (2019) [10.1111/bju.14958]2019 BibTeX | EndNote: XML, Text | RIS

De Bin, R. ; Boulesteix, A.-L. ; Benner, A. ; Becker, N. ; Sauerbrei, W.
Combining clinical and molecular data in regression prediction models: insights from a simulation study.
Briefings in bioinformatics 21(6), 1904-1919 (2020) [10.1093/bib/bbz136]2020 BibTeX | EndNote: XML, Text | RIS

Merz, M. ; Hielscher, T. ; Schult, D. ; Mai, E. K. ; Raab, M. S. ; Hillengass, J. ; Seckinger, A. ; Hose, D. ; Granzow, M. ; Jauch, A. ; Goldschmidt, H.
Cytogenetic subclone formation and evolution in progressive smoldering multiple myeloma.
Leukemia 34(4), 1192-1196 (2020) [10.1038/s41375-019-0634-2]2020 BibTeX | EndNote: XML, Text | RIS

Haupt, F. ; Dijkstra, L. ; Alberts, I. ; Sachpekidis, C. ; Fech, V. ; Boxler, S. ; Gross, T. ; Holland-Letz, T. ; Zacho, H. D. ; Haberkorn, U. ; Rahbar, K. ; Rominger, A. ; Afshar-Oromieh, A.
68Ga-PSMA-11 PET/CT in patients with recurrent prostate cancer-a modified protocol compared with the common protocol.
European journal of nuclear medicine and molecular imaging 47(3), 624-631 (2020) [10.1007/s00259-019-04548-5]2020 BibTeX | EndNote: XML, Text | RIS

Bhardwaj, M. (First author) ; Weigl, K. ; Tikk, K. ; Benner, A. ; Schrotz-King, P. ; Brenner, H. (Last author)
Multiplex screening of 275 plasma protein biomarkers to identify a signature for early detection of colorectal cancer.
Molecular oncology 14(1), 8-21 (2020) [10.1002/1878-0261.12591]2020 DBCoverage BibTeX | EndNote: XML, Text | RIS

Rathke, H. ; Holland-Letz, T. ; Mier, W. ; Flechsig, P. ; Mavriopoulou, E. ; Röhrich, M. ; Kopka, K. ; Hohenfellner, M. ; Giesel, F. L. ; Haberkorn, U. A. ; Kratochwil, C.
Response prediction of 177Lu-PSMA-617 RLT using PSA, Chromogranin A, and LDH.
Journal of nuclear medicine 61(5), 689-695 (2020) [10.2967/jnumed.119.231431]2020 BibTeX | EndNote: XML, Text | RIS

Luft, T. ; Benner, A. ; Terzer, T. ; Jodele, S. ; Dandoy, C. E. ; Storb, R. ; Kordelas, L. ; Beelen, D. ; Gooley, T. ; Sandmaier, B. M. ; Sorror, M. ; Zeisbrich, M. ; Radujkovic, A. ; Dreger, P. ; Penack, O.
EASIX and mortality after allogeneic stem cell transplantation.
Bone marrow transplantation 55(3), 553-561 (2019) [10.1038/s41409-019-0703-1]2019 BibTeX | EndNote: XML, Text | RIS

Edelmann, D. (First author) ; Habermehl, C. ; Schlenk, R. F. ; Benner, A. (Last author)
Adjusting Simon's optimal two-stage design for heterogeneous populations based on stratification or using historical controls.
Biometrical journal 62(2), 311-329 (2020) [10.1002/bimj.201800390]2020 BibTeX | EndNote: XML, Text | RIS

Wiesenfarth, M. (First author) ; Calderazzo, S. (Last author)
Quantification of prior impact in terms of effective current sample size
Biometrics 76(1), 326-336 (2020) [10.1111/biom.13124]2020 BibTeX | EndNote: XML, Text | RIS

Edelmann, D. (First author) ; Hummel, M. ; Hielscher, T. ; Saadati, M. ; Benner, A. (Last author)
Marginal variable screening for survival endpoints.
Biometrical journal 62(3), 610-626 (2020) [10.1002/bimj.201800269]2020 BibTeX | EndNote: XML, Text | RIS

Blocka, J. ; Hielscher, T. ; Mueller-Tidow, C. ; Goldschmidt, H. ; Hillengass, J.
Salvage therapy versus upfront autologous stem cell transplantation in multiple myeloma patients with progressive disease after first-line induction therapy.
Leukemia and lymphoma 61(1), 27-36 (2020) [10.1080/10428194.2019.1646905]2020 BibTeX | EndNote: XML, Text | RIS

Radujkovic, A. ; Kordelas, L. ; Krzykalla, J. ; Benner, A. ; Schult, D. ; Majer-Lauterbach, J. ; Beelen, D. W. ; Müller-Tidow, C. ; Kasperk, C. ; Dreger, P. ; Luft, T.
Pre-transplant testosterone and outcome of men after allogeneic stem cell transplantation.
Haematologica 105(5), 1454-1464 (2020) [10.3324/haematol.2019.220293]2020 DBCoverage BibTeX | EndNote: XML, Text | RIS

Koerber, S. A. ; Stach, G. ; Kratochwil, C. ; Haefner, M. F. ; Rathke, H. ; Herfarth, K. ; Kopka, K. ; Holland-Letz, T. ; Choyke, P. L. ; Will, L. ; Haberkorn, U. ; Debus, J. ; Giesel, F. (Last author)
Lymph node involvement in treatment-naïve prostate cancer patients - correlation of PSMA-PET/CT imaging and Roach formula in 280 men in the Radiotherapeutic management.
Journal of nuclear medicine 61(1), 46-50 (2020) [10.2967/jnumed.119.227637]2020 BibTeX | EndNote: XML, Text | RIS

Kopp-Schneider, A. (First author) ; Calderazzo, S. ; Wiesenfarth, M. (Last author)
Power gains by using external information in clinical trials are typically not possible when requiring strict type I error control.
Biometrical journal 62(2), 361-374 (2020) [10.1002/bimj.201800395]2020 BibTeX | EndNote: XML, Text | RIS

Krieg, P. (First author) ; Dick, A. ; Latzko, S. ; Rosenberger, S. ; Meyer, J. ; Crumrine, D. ; Hielscher, T. ; Elias, P. M. ; Rauh, M. ; Schneider, H.
Conditional Alox12b knockout: degradation of the corneocyte lipid envelope in a mouse model of autosomal recessive congenital ichthyoses.
The journal of investigative dermatology 140(1), 249-253.e6 (2020) [10.1016/j.jid.2019.06.134]2020 BibTeX | EndNote: XML, Text | RIS

Nyarangi-Dix, J. ; Wiesenfarth, M. ; Bonekamp, D. ; Hitthaler, B. ; Schütz, V. ; Dieffenbacher, S. ; Mueller-Wolf, M. ; Roth, W. ; Stenzinger, A. ; Duensing, S. ; Roethke, M. ; Teber, D. ; Schlemmer, H.-P. ; Hohenfellner, M. ; Radtke, J. P. (Last author)
Combined Clinical Parameters and Multiparametric Magnetic Resonance Imaging for the Prediction of Extraprostatic Disease-A Risk Model for Patient-tailored Risk Stratification When Planning Radical Prostatectomy.
European urology focus 6(6), 1205-1212 (2020) [10.1016/j.euf.2018.11.004]2020 BibTeX | EndNote: XML, Text | RIS

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