Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .


These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds

Fluorescence-Guided Robotic Surgery


Recent breakthrough developments in the field of targeted radiotracers are now enabling the detection of prostatic tissue in lymph nodes using PET-CT or PET-MRI imaging. These radiotracers target the prostate-specific membrane antigen (PSMA), a membrane-bound receptor which is highly upregulated in all stages of prostate cancer. To date, however, it is still challenging to remove these lesions as diagnostic knowledge cannot be used for a precise therapy in a straight forward manner. Instead, diagnostic images must be mentally fused with the partially visible anatomy. This approach is associated with a high level of uncertainty and requires a lot of experience, especially in the presence of organ deformation. The aim of this multidisciplinary research project is to investigate the feasibility of computer-assisted fluorescence-guided surgery using prostate-specific membrane antigen (PSMA)-targeted imaging probes. The main scientific contributions so far are related to intra-operative data fusion using fluorescent structures [4-7] as well as the development of a fluorescent PSMA-based dye [2,3].

Key collaborators

  • PD Dr. Dogu Teber and Dr. Tobi Simpfendörfer
    University of Heidelberg, Department of Urology

  • Prof. Dr. Klaus Kopka
    German Cancer Research Center (DKFZ), Division of Radiopharmaceutical Chemistry

  • Dr. Jonathan Sorger
    Intuitive Surgical, Inc.

  • Dr. Hannes Kenngott
    University of Heidelberg, Division of Minimally-invasive Surgery of the Department of General Surgery

  • Dr. Arianeb Mehrabi, 
    University of Heidelberg, Division of Visceral Surgery of the Department of General Surgery


Partial funding from Intuitive Surgical, Inc., in the form of equipment and hardware support.


  1. Majlesara A, Golriz M, Hafezi M, Saffari A, Stenau E, Maier-Hein L, Müller-Stich BP, Mehrabi A. Indocyanine green fluorescence imaging in hepatobiliary surgery. Photodiagnosis and Photodynamic Therapy. 2017;17:208-15.
  2. Baranski A-C, Schäfer M, Bauder-Wüst U, Roscher M, Schmidt J, Stenau E, Simpfendörfer T, Teber D, Maier-Hein L, Hadaschik B, Haberkorn U, Eder M, Kopka K. PSMA-11 Derived Dual-labeled PSMA-Inhibitors for Preoperative PET Imaging and Precise Fluorescence-Guided Surgery of Prostate Cancer. Journal of Nuclear Medicine. 2017 Nov 30;jnumed.117.201293
  3. Baranski A-C, Schaefer M, Bauder-Wuest U, Roscher M, Schmidt J, Stenau E, Simpfendoerfer T, Maier-Hein L, Hadaschik B, Haberkorn U, Eder M, Kopka K. Preclinical evaluation of dual-labeled PSMA-inhibitors for the diagnosis and therapy of prostate cancer. Journal of Nuclear Medicine. 2017;58(supplement 1):531-531.
  4. Stenau E, Simpfendörfer T, Azizian M, Liu W, Anderson KK, Bergman D, Mohareri O, Sorger JM, Teber D and Maier-Hein L. In vivo robustness analyses of intraoperative registration with fluorescent markers. In: International Society for Computer Aided Surgery. 2017.
  5. Wild E, Teber D, Schmid D, Simpfendörfer T, Müller M, Baranski A-C, Kenngott H, Kopka K, Maier-Hein L. Robust augmented reality guidance with fluorescent markers in laparoscopic surgery. International Journal of Computer Assisted Radiology and Surgery. 2016;11(6):899-907.
  6. Wild E, Teber D, Schmid D, Simpfendörfer T, Müller M, Kenngott, H. und Maier-Hein L. Robuste intraoperative Registrierung mit fluoreszierenden Markern für die computergestützte Laparoskopie. In: Bildverarbeitung für die Medizin (BVM). 2016.
  7. Maier-Hein L, Wild E and Teber D. System for fluorescence aided surgery. EP 15 193 169.8. 


  • ISCAS Koh Young Young Investigator Best Paper Award (2017)
    International Congress and Exhibition on Computer Assisted Radiology and Surgery (CARS)
    E. Stenau et al., for the paper "In vivo robustness analyses of intraoperative registration with fluorecent markers."

  • 2017 Henry N. Wagner, Jr, MD, Image of the Year Award
    A.C. Baranski, ..., E. Stenau et al. for the abstract image used in "Preclinical evaluation of dual-labeled PSMA-inhibitors for the diagnosis and therapy of prostata cancer."
  • Philips / IPCAI Audience Best Paper Award (2016)
    E. Wild et al., for the paper, "Robust Augmented Reality Guidance with Fluorescent Markers in Laparoscopic Surgery."

  • PhD Poster Presentation Award (2016)
    DKFZ Heidelberg
    E. Wild, "Robust augmented reality guidance with fluorescent markers in laparoscopic surgery."

to top
powered by webEdition CMS