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Original- und Übersichtsarbeiten im Jahr 2022 und im Druck

Bhardwaj, M., Schottker, B., Holleczek, B., Benner, A., Schrotz-King, P., Brenner, H. Potential of Inflammatory Protein Signatures for Enhanced Selection of People for Lung Cancer Screening. CANCERS 2022; 14: 2146.

Lin, H. Y., Tseng, T. S., Wang, X. N., Fang, Z. D., Zea, A. H., Wang, L., . . . , Consortium, P. Intake Patterns of Specific Alcoholic Beverages by Prostate Cancer Status. CANCERS 2022; 14: 1981.

Bhardwaj, M., Schrotz-King, P., Brenner, H. Correlation of Repeat Measurements of 27 Candidate Protein Markers for Colorectal Cancer Screening Taken Three Years and Multiple Freeze-Thaw Cycles Apart. LIFE-BASEL 2022; 12: 359.

Chen, X. C., Hoffmeister, M., Brenner, H. Red and Processed Meat Intake, Polygenic Risk Score, and Colorectal Cancer Risk. NUTRIENTS 2022; 14: 1077.

Fraszczyk, E., Spijkerman, A. M. W., Zhang, Y., Brandmaier, S., Day, F. R., Zhou, L., . . . , Snieder, H. Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts. DIABETOLOGIA 2022; 65: 763-776.

Charvat, H., Freisling, H., Noh, H., Gaudet, M. M., Gunter, M. J., Cross, A. J., . . . , Arnold, M. Excess Body Fatness during Early to Mid-Adulthood and Survival from Colorectal and Breast Cancer: A Pooled Analysis of Five International Cohort Studies. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 2022; 31: 325-333.

Park, H. A., Seibold, P., Edelmann, D., Benner, A., Canzian, F., Alwers, E., . . . , Chang-Claude, J. Validation of Genetic Markers Associated with Survival in Colorectal Cancer Patients Treated with Oxaliplatin-Based Chemotherapy. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 2022; 31: 352-361.

Safizadeh, F., Nguyen, T. N. M., Brenner, H., Schottker, B. Association of renin-angiotensin-aldosterone system inhibition with Covid-19 hospitalization and all-cause mortality in the UK biobank. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 2022; 88: 2830-2842.

Dennis, J., Tyrer, J. P., Walker, L. C., Michailidou, K., Dorling, L., Bolla, M. K., . . . , Investigators, K. C. A. Rare germline copy number variants (CNVs) and breast cancer risk. COMMUNICATIONS BIOLOGY 2022; 5: 65.

Archambault, A. N., Jeon, J., Lin, Y., Thomas, M., Harrison, T. A., Bishop, D. T., . . . , Hayes, R. B. Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 2022; 114: 528-539.

Huang, Y. H., Hua, X. W., Labadie, J. D., Harrison, T. A., Dai, J. Y., Lindstrom, S., . . . , Newcomb, P. A. Genetic variants associated with circulating C-reactive protein levels and colorectal cancer survival: Sex-specific and lifestyle factors specific associations. INTERNATIONAL JOURNAL OF CANCER 2022; 150: 1447-1454.

Ahearn, T. U., Zhang, H. Y., Michailidou, K., Milne, R. L., Bolla, M. K., Dennis, J., . . . , Investigators, K. C. A. Common variants in breast cancer risk loci predispose to distinct tumor subtypes. BREAST CANCER RESEARCH 2022; 24: 2.

Zhao, Z. T., Zhu, A. N., Bhardwaj, M., Schrotz-King, P., Brenner, H. Fecal microRNAs, Fecal microRNA Panels, or Combinations of Fecal microRNAs with Fecal Hemoglobin for Early Detection of Colorectal Cancer and Its Precursors: A Systematic Review. CANCERS 2022; 14: 65.

Kocarnik, J. M., Compton, K., Dean, F. E., Fu, W. J., Gaw, B. L., Harvey, J. D., . . . , Global Burden Dis Canc, C. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019. JAMA ONCOLOGY 2022; 8: 420-444.

Heisser, T., Hoffmeister, M., Brenner, H. Model based evaluation of long-term efficacy of existing and alternative colorectal cancer screening offers: A case study for Germany. INTERNATIONAL JOURNAL OF CANCER 2022; 150: 1471-1480.

Boehlen, F. H., Maatouk, I., Friederich, H. C., Schoettker, B., Brenner, H., Wild, B. Loneliness as a gender-specific predictor of physical and mental health-related quality of life in older adults. QUALITY OF LIFE RESEARCH 2022; 31: 2023-2033.

Schrammen, P. L., Laleh, N. G., Echle, A., Truhn, D., Schulz, V., Brinker, T. J., . . . , Kather, J. N. Weakly supervised annotation-free cancer detection and prediction of genotype in routine histopathology. JOURNAL OF PATHOLOGY 2022; 256: 50-60.

Thong, M. S. Y., Doege, D., Weisser, L., Koch-Gallenkamp, L., Bertram, H., Eberle, A., . . . , Arndt, V. Health and life insurance-related problems in very long-term cancer survivors in Germany: a population-based study. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 2022; 148: 155-162.

Salem, A. A., Trares, K., Kohl, M., Jansen, E., Brenner, H., Schottker, B. Long-term effects of smoking on serum concentrations of oxidative stress biomarkers: Results of a large, population-based cohort study. ENVIRONMENTAL RESEARCH 2022; 204: 111923.

Chen, L. J., Nguyen, T. N. M., Laetsch, D. C., Chang-Claude, J., Hoffmeister, M., Brenner, H., Schottker, B. Association of Comedication Quality With Chemotherapy-Related Adverse Drug Reactions and Survival in Older Colorectal Cancer Patients. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 2022; 77: 1009-1019.

Di Castelnuovo, A., Costanzo, S., Bonaccio, M., McElduff, P., Linneberg, A., Salomaa, V., . . . , Iacoviello, L. Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study. ADDICTION 2022; 117: 312-325.

Hilvo, M., Dhar, I., Laaperi, M., Lysne, V., Sulo, G., Tell, G. S., . . . , Laaksonen, R. Primary cardiovascular risk prediction by LDL-cholesterol in Caucasian middle-aged and older adults: a joint analysis of three cohorts. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY 2022; 29: E128-E137.

Laleh, N. G., Muti, H. S., Loeffler, C. M. L., Echle, A., Saldanha, O. L., Mahmood, F., . . . , Kather, J. N. Benchmarking weakly-supervised deep learning pipelines for whole slide classification in computational pathology. MEDICAL IMAGE ANALYSIS 2022; 79: 102474.

Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., . . . , Program, V. A. M. V. Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. COMMUNICATIONS BIOLOGY 2022; 5: 580.

Georgeson, P., Harrison, T. A., Pope, B. J., Zaidi, S. H., Qu, C. H., Steinfelder, R. S., . . . , Buchanan, D. D. Identifying colorectal cancer caused by biallelic MUTYH pathogenic variants using tumor mutational signatures. NATURE COMMUNICATIONS 2022; 13: 3254.

Huang, L., Jansen, L., Verhoeven, R. H. A., Ruurda, J. P., Van Eycken, L., De Schutter, H., . . . , Brenner, H. Survival trends of patients with non-metastatic gastric adenocarcinoma in the US and European countries: the impact of decreasing resection rates. CANCER COMMUNICATIONS 2022; 42: 648-662.

Mollers, T., Stocker, H., Perna, L., Rujescu, D., Holleczek, B., Schottker, B., Brenner, H. Subjective short-term memory difficulties at ages 50-75 predict dementia risk in a community-based cohort followed over 17 years. AGE AND AGEING 2022; 51: afac113.

Nguyen, T. N. M., Chen, L. J., Trares, K., Stocker, H., Holleczek, B., Beyreuther, K., . . . , Schottker, B. Long-term low-dose acetylsalicylic use shows protective potential for the development of both vascular dementia and Alzheimer's disease in patients with coronary heart disease but not in other individuals from the general population: results from two large cohort studies. ALZHEIMERS RESEARCH & THERAPY 2022; 14: 75.

Nguyen, T. N. M., Sha, S., Chen, L. J., Holleczek, B., Brenner, H., Schottker, B. Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: Results from two large cohorts with new-user design. ALIMENTARY PHARMACOLOGY & THERAPEUTICS 2022; 56: 251-262.

Xie, K., Perna, L., Schottker, B., Kliegel, M., Brenner, H., Mons, U. Type 2 diabetes mellitus and cognitive decline in older adults in Germany - results from a population-based cohort. BMC GERIATRICS 2022; 22: 455.

Niedermaier, T., Gredner, T., Kuznia, S., Schottker, B., Mons, U., Lakerveld, J., . . . , Consortium, P. E. N. Vitamin D food fortification in European countries: the underused potential to prevent cancer deaths. EUROPEAN JOURNAL OF EPIDEMIOLOGY 2022; 37: 309-320.

Wielscher, M., Mandaviya, P. R., Kuehnel, B., Joehanes, R., Mustafa, R., Robinson, O., . . . , Consortium, B. DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. NATURE COMMUNICATIONS 2022; 13: 2408.

Chen, L. J., Nguyen, T. N. M., Chang-Claude, J., Hoffmeister, M., Brenner, H., Schottker, B. Incorporation of functional status, frailty, comorbidities and comedication in prediction models for colorectal cancer survival. INTERNATIONAL JOURNAL OF CANCER 2022; 151: 539-552.

Brenner, H., Li, H. J., Boakye, D., Chen, X. C., Hoffmeister, M. Link Between Obesity and Early-Onset Colorectal Cancers (EOCRC): Importance of Accounting for BMI Trajectories in Early Life. AMERICAN JOURNAL OF GASTROENTEROLOGY 2022; 117: 812-813.

Hawwash, N., Martin, G. P., Sperrin, M., Renehan, A. G. Link Between Obesity and Early-Onset Colorectal Cancers (EOCRC): Importance of Accounting for BMI Trajectories in Early Life. AMERICAN JOURNAL OF GASTROENTEROLOGY 2022; 117: 813-813.

Jordahl, K. M., Shcherbina, A., Kim, A. E., Su, Y. R., Lin, Y., Wang, J., . . . , Peters, U. Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 2022; 31: 1077-1089.

Thong, M. S. Y., Boakye, D., Jansen, L., Martens, U. M., Chang-Claude, J., Hoffmeister, M., . . . , Arndt, V. Comorbidities, Rather Than Older Age, Are Strongly Associated With Higher Utilization of Healthcare in Colorectal Cancer Survivors. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK 2022; 20: 468-+.

Saldanha, O. L., Quirke, P., West, N. P., James, J. A., Loughrey, M. B., Grabsch, H. I., . . . , Kather, J. N. Swarm learning for decentralized artificial intelligence in cancer histopathology. NATURE MEDICINE 2022; 28: 1232-+.

Harlid, S., Van Guelpen, B., Qu, C. H., Gylling, B., Aglago, E. K., Amitay, E. L., . . . , Peters, U. Diabetes mellitus in relation to colorectal tumor molecular subtypes: A pooled analysis of more than 9000 cases. INTERNATIONAL JOURNAL OF CANCER 2022; 151: 348-360.

Brenner, H., Niedermaier, T. POTENTIAL OF VITAMIN D SUPPLEMENTATION OR VITAMIN D FOOD FORTIFICATION FOR PREVENTING CANCER DEATHS IN GERMANYy. ANTICANCER RESEARCH 2022; 42: 2196-2196.

Kuznia, S., Zhu, A., Schottker, B., Brenner, H. EFFICACY OF VITAMIN D3 SUPPLEMENTATION ON CANCER MORTALITY IN THE GENERAL POPULATION AND THE PROGNOSIS OF PATIENTS WITH CANCER: A SYSTEMATIC REVIEW AND INDIVIDUAL PATIENT DATA META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. ANTICANCER RESEARCH 2022; 42: 2202-2203.

Ponce-de-Leon, M., Linseisen, J., Peters, A., Linkohr, B., Heier, M., Grallert, H., . . . , Meisinger, C. Novel associations between inflammation- related proteins and adiposity: A targeted proteomics approach across four population- based studies. TRANSLATIONAL RESEARCH 2022; 242: 93-104.

Rosberg, V., Vishram-Nielsen, J. K. K., Kristensen, A. M. D., Pareek, M., Sehested, T. S. G., Nilsson, P. M., . . . , Olsen, M. H. Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures: The MORGAM prospective cohort project. PREVENTIVE MEDICINE REPORTS 2022; 26: 101700.

Schottker, B., Kuznia, S., Brenner, H. EFFICACY AND SAFETY OF A PERSONALIZED VITAMIN D-3 LOADING DOSE FOLLOWED BY 2,000 IU PER DAY TO RAISE SERUM 25-HYDROXYVITAMIN D IN COLORECTAL CANCER PATIENTS WITH VITAMIN D INSUFFICIENCY. INTERIM ANALYSIS OF A RCT. ANTICANCER RESEARCH 2022; 42: 2209-2210.

Schottker, B., Larsen, E. L., Weimann, A., Henriksen, T., Brenner, H., Poulsen, H. E. Associations of urinary metabolites of oxidized DNA and RNA with the incidence of diabetes mellitus using UPLC-MS/MS and ELISA methods. FREE RADICAL BIOLOGY AND MEDICINE 2022; 183: 51-59.

Sha, S., Nguyen, T. M. N., Kuznia, S., Niedermaier, T., Zhu, A., Brenner, H., Schottker, B. REAL-WORLD EVIDENCE FOR THE EFFECTIVENESS OF VITAMIN D SUPPLEMENTATION IN THE REDUCTION OF TOTAL AND CAUSE-SPECIFIC MORTALITY. RESULTS FROM ALMOST HALF A MILLION PARTICIPANTS OF THE UK BIOBANK COHORT STUDY. ANTICANCER RESEARCH 2022; 42: 2209-2209.

Zhu, A., Kuznia, S., Niedermaier, T., Holleczek, B., Schottker, B., Brenner, H. VITAMIN D-BINDING PROTEIN, TOTAL, "NON-BIOAVAILABLE", BIOAVAILABLE, AND FREE 25-HYDROXYVITAMIN D, AND MORTALITY IN A LARGE POPULATION-BASED COHORT OF OLDER ADULTS. ANTICANCER RESEARCH 2022; 42: 2214-2214.

Zhu, A., Kuznia, S., Niedermaier, T., Holleczek, B., Schottker, B., Brenner, H. DISTRIBUTION AND DETERMINANTS OF VITAMIN D-BINDING PROTEIN, TOTAL, "NON-BIOAVAILABLE" BIOAVAILABLE, AND FREE 25-HYDROXYVITAMIN D CONCENTRATIONS IN A LARGE POPULATIONBASED COHORT OF OLDER ADULTS. ANTICANCER RESEARCH 2022; 42: 2218-2218.

Li, X. W., Chang-Claude, J., Hoffmeister, M., Brenner, H., Jansen, L. Risk of Colorectal Cancer Associated With Lifetime Excess Weight. JAMA ONCOLOGY 2022; 8: 730-737.

Cousin, E., Duncan, B. B., Stein, C., Ong, K. L., Vos, T., Abbafati, C., . . . , Collabor, G. B. D. D. M. Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019. LANCET DIABETES & ENDOCRINOLOGY 2022; 10: 177-192.

Niedermaier, T., Balavarca, Y., Gies, A., Weigl, K., Guo, F., Alwers, E., . . . , Brenner, H. Variation of Positive Predictive Values of Fecal Immunochemical Tests by Polygenic Risk Score in a Large Screening Cohort. CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY 2022; 13: e00458.

Schmid, S., Jiang, M., Brown, M. C., Fares, A., Garcia, M., Soriano, J., . . . , Liu, G. Accounting for EGFR Mutations in Epidemiologic Analyses of Non-Small Cell Lung Cancers: Examples Based on the International Lung Cancer Consortium Data. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 2022; 31: 679-687.

Nichols, E., Steinmetz, J. D., Vollset, S. E., Fukutaki, K., Chalek, J., Abd-Allah, F., . . . , Coll, G. B. D. D. F. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease 2019. LANCET PUBLIC HEALTH 2022; 7: E105-E125.

Gredner, T., Niedermaier, T., Steindorf, K., Brenner, H., Mons, U. Original Research Impact of reducing excess body weight and physical inactivity on cancer incidence in Germany from 2020 to 2050da simulation model. EUROPEAN JOURNAL OF CANCER 2022; 160: 215-226.

Stocker, H., Beyer, L., Perna, L., Rujescu, D., Holleczek, B., Beyreuther, K., . . . , Brenner, H. Association of plasma biomarkers, p-tau181, glial fibrillary acidic protein, and neurofilament light, with intermediate and long-term clinical Alzheimer's disease risk: Results from a prospective cohort followed over 17 years. ALZHEIMERS & DEMENTIA (im Druck).

Huynh-Le, M. P., Karunamuni, R., Fan, C. C., Asona, L., Thompson, W. K., Martinez, M. E., . . . , Consortium, P. Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score. PROSTATE CANCER AND PROSTATIC DISEASES (im Druck).

Scherer-Trame, S., Jansen, L., Koch-Gallenkamp, L., Arndt, V., Chang-Claude, J., Hoffmeister, M., Brenner, H. Quality of life, distress, and posttraumatic growth 5 years after colorectal cancer diagnosis according to history of inpatient rehabilitation. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (im Druck).

Nano, J., Schottker, B., Lin, J. S., Huth, C., Ghanbari, M., Garcia, P. M., . . . , Thorand, B. Novel biomarkers of inflammation, kidney function and chronic kidney disease in the general population. NEPHROLOGY DIALYSIS TRANSPLANTATION (im Druck).

Zhu, A. N., Kuznia, S., Niedermaier, T., Holleczek, B., Schottker, B., Brenner, H. Vitamin D-binding protein, total, "nonbioavailable," bioavailable, and free 25-hydroxyvitamin D, and mortality in a large population-based cohort of older adults. JOURNAL OF INTERNAL MEDICINE (im Druck).

Goyal, N., Hennessy, M., Lehman, E., Lin, W. X., Agudo, A., Ahrens, W., . . . , Muscat, J. E. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium. ORAL DISEASES (im Druck).

Holowatyj, A. N., Ose, J., Gigic, B., Lin, T. D., Ulvik, A., Geijsen, A., . . . , Ulrich, C. M. Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer. AMERICAN JOURNAL OF CLINICAL NUTRITION (im Druck).

Pulte, D., Jansen, L., Brenner, H. Incidence and survival estimates for patients with myelodysplastic syndrome in the early 21st century: no evidence of improvement over time. LEUKEMIA & LYMPHOMA (im Druck).

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