ESTHER

Epidemiologische Studie zu Chancen der Verhütung, Früherkennung und optimierten Therapie chronischer Erkrankungen in der älteren Bevölkerung (ESTHER)

Die Grafik zeigt den Schriftzug "ESTHER" in lila, der über einer schematischen Darstellung einer Region oder eines Gebiets positioniert ist. Der Fokus liegt auf dem Namen, der zentral und deutlich lesbar ist.

ESTHER ist eine epidemiologische Kohortenstudie, die seit mehr als 20 Jahren gemeinsam vom Deutschen Krebsforschungszentrum in Heidelberg (DKFZ) und dem Saarländischen Krebsregister durchgeführt wird. Neben diesem bevölkerungsbezogenen Teil, beinhaltet die Studie noch einen klinischen Teil (ESTHER II), der sich auf neu diagnostizierte Krebserkrankungen im Krankenhaus bzw. in onkologischen Praxen konzentriert.

Ziel der Studie

Das Ziel der ESTHER-Studie ist es, die Prävention, die Früherkennung und die Behandlung chronischer Erkrankungen, wie zum Beispiel Herz-Kreislauf-Erkrankungen oder Krebs, zu verbessern. Aus der statistischen Verteilung der Häufigkeit dieser Erkrankungen lassen sich Rückschlüsse auf mögliche Ursachen und Risikofaktoren ziehen. Dies wird in Zukunft dazu beitragen, solche Erkrankungen früher erkennen oder gar verhindern zu können.

Studienablauf

In den Jahren 2000 bis 2002 wurden 9.940 Frauen und Männer im Alter zwischen 50 und 74 Jahren bei einem Gesundheits-Check-Up durch ihren Hausarzt in die ESTHER-Studie eingeschlossen. Hierbei haben die Teilnehmer erstmalig den Gesundheitsfragebogen der ESTHER-Studie ausgefüllt und Angaben zu ihrem Gesundheitszustand gemacht.

Nach 2, 5, 8, 11, 14, 17,20 und 23 Jahren wurden die Teilnehmer jeweils erneut kontaktiert und gebeten, wiederum einen Gesundheitsfragebogen auszufüllen. Zudem wurden seit der Nachbeobachtung nach 8 Jahren auch die Hausärzte der Studienteilnehmer einbezogen und füllten Gesundheitsfragebögen aus. Bezogen auf die ersten acht Nachbeobachtungszeitpunkte konnten Gesundheitsdaten zu jeweils 9.356, 8.270, 7.011, 5.611, 4.639, 4.165, 3.659 und 2.027 Studienteilnehmern gesammelt werden.

Derzeit findet die Nachbefragung 26 Jahre nach Studienbeginn statt. Die Beteiligung der Studienteilnehmer ist nach wie vor vorbildlich und wir erwarten, dass wir zu ca. 1.500 noch lebenden, inzwischen zwischen 76 und 100 Jahre alten Studienteilnehmern, wieder Gesundheitsdaten erheben können. Insgesamt sollen die ESTHER-Studienteilnehmer über 30 Jahre nachbeobachtet werden.

Bei den Nachbefragungen nach 8, 11 und 14 Jahren wurde den Teilnehmern zusätzlich zum Gesundheitsfragebogen eine 2-3-stündige, umfassende Untersuchung (z.B. Blutdruck-, Puls-, Handgriffkraft und Körpergewichtsmessung) und Befragung durch unsere geschulten ESTHER-Studienärzte im Rahmen eines Hausbesuchs angeboten. Zu den drei Zeitpunkten haben jeweils 3.124, 2.761 und 2.350 Studienteilnehmern an den Hausbesuchen teilgenommen.

Studienleitung

  • Mitarbeiterbild Schöttker

    Prof. Dr. Ben Schöttker

    Studienleiter

    Profil anzeigen
  • Ein Mann steht an einer weißen Wand und lehnt sich leicht darauf. Er trägt einen lila Pullover und schaut in die Kamera. Der Hintergrund zeigt große Fenster und einige Pflanzen, was eine helle, einladende Umgebung schafft.

    Prof. Dr. Hermann Brenner

    Ko-Studienleiter

  • Mitarbeiterbild

    Bernd Holleczek

    Leiter ESTHER-Studienzentrum Saarland

Kontakt

Falls Sie Fragen zum Ablauf der ESTHER-Studie haben, stehen unsere Mitarbeiterinnen im Studiensekretariat in Saarbrücken gerne für Sie bereit.

ESTHER-Studiensekretariat
Neugeländstraße 9
66117 Saarbrücken
Telefon: 0681-501-2387
Telefax: 0681-501-5806
E-Mail: ESTHER-Studie(at)soziales.saarland.de

Häufige Fragen

Frage: Wann werde ich als ESTHER-Teilnehmer erneut kontaktiert?

Antwort: Als Teilnehmer der ESTHER-Studie werden Sie etwa alle 3 Jahre von unserem Studiensekretariat in Saarbrücken erneut angeschrieben und mittels eines Fragebogens um Auskunft zu Ihrem aktuellen Gesundheitszustand gebeten. 
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Frage: Wann bekomme ich Ergebnisse von ESTHER mitgeteilt?

Antwort: Die bei ESTHER erhobenen Daten werden vollständig anonym ausgewertet. Dies gilt auch für die Blut-, Urin- und Stuhlproben. Aus diesem Grund ist eine Zuordnung und Mitteilung von Ergebnissen an einzelne Studienteilnehmer nicht möglich. Die Ergebnisse der ESTHER-Studie werden jedoch in Vorschläge für eine weitere Verbesserung der Verhütung, Früherkennung und Therapie chronischer Erkrankungen münden, die dann künftig allen zu Gute kommen wird.

Zuletzt wurden folgende Zusammenfassungen von relevanten Ergebnissen im Saarländischen Ärzteblatt veröffentlicht und sind als PDF-Download durch Klick auf die folgenden Links abrufbar:

Einzigartige Beiträge zur Präventionsforschung aus dem Saarland: Aktuelles aus der ESTHER-Studie (09/2022)
Die ESTHER-Studie: Aktuelle Erkenntnisse zur Arzneimitteltherapie-Sicherheit im Alter (12/2017)
Die ESTHER-Studie: Stand der 14-Jahres-Nachbefragung und ausgewählte aktuelle Erkenntnisse (12/2014)
Aktuelle Erkenntnisse zu chronischen Erkrankungen im Alter - Die ESTHER-Studie (05/2013)
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Frage: Kann ich noch an der ESTHER-Studie teilnehmen?

Antwort: Nein. Eine Neuaufnahme in die ESTHER-Studie war nur bis zum 31.7.2002 möglich. Sie können jedoch unabhängig von der Teilnahme an ESTHER jederzeit zu den gesetzlichen Vorsorgeuntersuchungen zu Ihrem Arzt gehen.

Publikationen

2026 (Stand 11.09.2026)
1)    Yin Q, Stevenson-Hoare J, Holleczek B, Ben S, Brenner H. Epigenetic aging and cancer incidence in a German cohort of older adults. NPJ Aging. 2026;12(1).
2)    Yin Q, Schottker B, Holleczek B, Fan Z, Stevenson-Hoare J, Brenner H. Tracking DNA methylation-based biological age over 8 years and its association with mortality in community-dwelling older adults. Clin Epigenetics. 2026;18(1).
3)    Vassy JL, Dornisch AM, Karunamuni R, Gatzen M, Kachulis CJ, Lennon NJ, et al. Genomic risk model to implement precision prostate cancer screening in clinical care: the ProGRESS study. Nat Cancer. 2026;7(2):352-67.
4)    Trares K, Duman D, Beyer L, Michaelian JC, Stocker H, Holleczek B, et al. Predictive value of plasma p-tau217 for Alzheimer's dementia compared to other blood-based biomarkers. EMBO Mol Med. 2026;18(8):3374-88.
5)    Stoffel M, Stevenson-Hoare J, Schottker B, Hammer J, Brenner H, Ditzen B. The experience of social loss and epigenome-wide DNA methylation. Soc Sci Med. 2026;388:118718.
6)    Stevenson-Hoare J, Stoffel M, Schottker B, Holleczek B, Zaugg J, Ditzen B, et al. Analysis of blood-based DNA methylation scores reveals associations with shared cohabitation duration in cohabiting pairs. J Gerontol A Biol Sci Med Sci. 2026;81(5).
7)    Peng L, Xie R, Holleczek B, Brenner H, Schottker B. Development of Age- and Sex-Specific Metabolomics-Based Biological Ageing Clocks for 10-Year Mortality Prediction. Adv Sci (Weinh). 2026;13(1):e10189.
8)    Peng L, Hauer K, Holleczek B, Calderazzo S, Brenner H, Schottker B. Comparison of 4 Frailty Measurements in Relation to Ageing, Physical Performance, and All-Cause Mortality. J Am Med Dir Assoc. 2026;27(5):106161.
9)    Neuen BL, Major RW, Grams ME, Sang Y, Coresh J, Ballew SH, et al. Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals. Nat Med. 2026;32(7):2629-38.
10)    Michaelian JC, Trares K, Stevenson-Hoare J, Holleczek B, Schottker B, Brenner H. Frailty, grip strength, blood-based biomarkers of neuropathology, and incident dementia: a 17-year longitudinal population study. J Gerontol A Biol Sci Med Sci. 2026;81(2).
11)    Lam AC, Li Y, Brown MC, Deng Y, Hueniken K, Leighl NB, et al. Evaluating eight smoking metrics for modelling survival in non-small cell lung cancer. Cancer Epidemiol. 2026;102:103052.
12)    de Abreu M, Kowalski LP, Lopez RM, Barul C, Radoi L, Bidoli E, et al. Risk of Head and Neck Cancer in Former Smokers by Subsite: A Multicenter Analysis From the INHANCE Consortium. Int J Cancer. 2026;159(5):1204-17.
13)    Bhardwaj M, Sun YQ, Frick C, Schottker B, Roe OD, Holleczek B, et al. Blood-based DNA methylation marker model for short-term and long-term lung cancer risk prediction. BMC Med. 2026;24(1).
14)    Bhardwaj M, Frick C, Schottker B, Holleczek B, Brenner H. Next-generation proteomics improves lung cancer risk prediction. Mol Oncol. 2026;20(4):995-1007.

2025
15)    Zhao Z, Bhardwaj M, Fan Z, Li X, Schrotz-King P, Brenner H. Smoking-independent DNA methylation markers for lung cancer risk: External validation in a large population-based cohort study. Cancer Sci. 2025;116(3):775-82.
16)    Xie R, Vlaski T, Trares K, Herder C, Holleczek B, Brenner H, et al. Large-Scale Proteomics Improve Risk Prediction for Type 2 Diabetes. Diabetes Care. 2025;48(6):922-6.
17)    Xie R, Sha S, Brenner H, Schottker B. Circulating inflammation-related proteome improves cardiovascular risk prediction. Results from two large European cohort studies. Eur J Epidemiol. 2025;40(10):1191-203.
18)    Xie R, Seum T, Sha S, Trares K, Holleczek B, Brenner H, et al. Improving 10-year cardiovascular risk prediction in patients with type 2 diabetes with metabolomics. Cardiovasc Diabetol. 2025;24(1):18.
19)    Xie R, Herder C, Sha S, Peng L, Brenner H, Schottker B. Novel type 2 diabetes prediction score based on traditional risk factors and circulating metabolites: model derivation and validation in two large cohort studies. EClinicalMedicine. 2025;79:102971.
20)    Xie R, Herder C, Sha S, Brenner H, Carlsson S, Schottker B. Improved sex-specific cardiovascular risk prediction with multi-omics data in people with type 2 diabetes. Cardiovasc Diabetol. 2025;25(1):25.
21)    Stocker H, Gentiluomo M, Trares K, Beyer L, Stevenson-Hoare J, Rujescu D, et al. Mitochondrial DNA abundance in blood is associated with Alzheimer's disease- and dementia-risk. Mol Psychiatry. 2025;30(1):131-9.
22)    Stocker H, Beyer L, Trares K, Stevenson-Hoare J, Rujescu D, Holleczek B, et al. Association of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study. Neurology. 2025;104(9):e213500.
23)    Seum T, Cardoso R, Stevenson-Hoare J, Holleczek B, Schottker B, Hoffmeister M, et al. Exploring metabolomics for colorectal cancer risk prediction: evidence from the UK Biobank and ESTHER cohorts. BMC Med. 2025;23(1):283.
24)    Nguyen T, Koric A, Chang CE, Barul C, Radoi L, Serraino D, et al. Coffee and tea consumption and the risk of head and neck cancer: An updated pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer. 2025;131(2):e35620.
25)    Mok Y, Surapaneni A, Sang Y, Coresh J, Grams ME, Matsushita K, et al. Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis. Br J Cancer. 2025;133(10):1535-43.
26)    Mandic M, Safizadeh F, Schottker B, Holleczek B, Hoffmeister M, Brenner H. Body mass index across adulthood, weight gain and cancer risk: a population-based cohort study. BMC Cancer. 2025;25(1):488.
27)     Ho PJ, Loo CKY, Lim RJY, Goh MH, Abubakar M, Ahearn TU, et al. Threshold-Based Overlap of Breast Cancer High-Risk Classification Using Family History, Polygenic Risk Scores, and Traditional Risk Models in 180,398 Women. Cancers (Basel). 2025;17(21).
28)    Global Cardiovascular Risk C, Magnussen C, Alegre-Diaz J, Al-Nasser LA, Amouyel P, Aviles-Santa L, et al. Global Effect of Cardiovascular Risk Factors on Lifetime Estimates. N Engl J Med. 2025;393(2):125-38.
29)    Giaccherini M, Rende M, Gentiluomo M, Corradi C, Archibugi L, Ermini S, et al. A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma. Mutagenesis. 2025;40(1):61-70.
30)    Galvez-Montosa F, Peduzzi G, Sanchez-Maldonado JM, Ter Horst R, Cabrera-Serrano AJ, Gentiluomo M, et al. Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: A meta-analysis of three large European cohorts and functional characterization. Int J Cancer. 2025;156(2):339-52.
31)    Fan Z, Edelmann D, Zhao Z, Kohler BC, Hoffmeister M, Brenner H. Association of leukocyte composition ratios from blood methylation with cancer mortality outcomes. Commun Med (Lond). 2025;5(1):411.
32)    Estrella MM, Ballew SH, Sang Y, Grams ME, Coresh J, Surapaneni A, et al. Discordance in Creatinine- and Cystatin C-Based eGFR and Clinical Outcomes: A Meta-Analysis. JAMA. 2025;334(21):1915-26.
33)    Disease GBD, Injury, Risk Factor C. Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. Lancet. 2025;406(10513):1873-922.
34)    Cui Z, Xie R, Lu X, Schomburg L, Brenner H, Schottker B. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies. Redox Biol. 2025;85:103755.
35)    Cui Z, Schomburg L, Holleczek B, Hybsier S, Kohrle J, Brenner H, et al. Serum selenoprotein P concentrations and cardiovascular disease: results from a large, prospective cohort study of older German adults. Free Radic Biol Med. 2025;239:270-9.
36)    Collaborators GBDD. Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023. Lancet. 2025;406(10513):1731-810.
37)    Collaborators GBDC. The global, regional, and national burden of cancer, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023. Lancet. 2025;406(10512):1565-86.
38)    Collaborators GBDCoD. Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. Lancet. 2025;406(10513):1811-72.
39)    Blandino A, Scherer D, Boekstegers F, Rounge TB, Langseth H, Roessler S, et al. Small-RNA sequencing reveals potential serum biomarkers for gallbladder cancer: Results from a three-stage collaborative study of large European prospective cohorts. Eur J Cancer. 2025;214:115138.

2024
40)    Zhou B, Rayner AW, Gregg EW, Sheffer KE, Carrillo-Larco RM, Bennett JE, et al. Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants. The Lancet. 2024;404(10467):2077-93.
41)    Zhao Z, Bhardwaj M, Fan Z, Li X, Schrotz-King P, Brenner H. Smoking-independent DNA methylation markers for lung cancer risk: External validation in a large population-based cohort study. Cancer Science. 2024.
42)    Yiangou K, Mavaddat N, Dennis J, Zanti M, Wang Q, Bolla MK, et al. Polygenic score distribution differences across European ancestry populations: implications for breast cancer risk prediction. Breast Cancer Research. 2024;26(1).
43)    Watts EL, Gonzales TI, Strain T, Saint-Maurice PF, Bishop DT, Chanock SJ, et al. Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study. British Journal of Cancer. 2024;130(1):114-24.
44)    Vollset SE, Ababneh HS, Abate YH, Abbafati C, Abbasgholizadeh R, Abbasian M, et al. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021. The Lancet. 2024;403(10440):2204-56.
45)    Ünal P, Lu Y, Bueno-de-Mesquita B, van Eijck CHJ, Talar-Wojnarowska R, Szentesi A, et al. Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk. Human Genomics. 2024;18(1).
46)    Trares K, Wiesenfarth M, Stocker H, Perna L, Petrera A, Hauck SM, et al. Addition of inflammation-related biomarkers to the CAIDE model for risk prediction of all-cause dementia, Alzheimer’s disease and vascular dementia in a prospective study. Immunity and Ageing. 2024;21(1).
47)    Trares K, Stocker H, Stevenson-Hoare J, Perna L, Holleczek B, Beyreuther K, et al. Comparison of subjective cognitive decline and polygenic risk score in the prediction of all-cause dementia, Alzheimer’s disease and vascular dementia. Alzheimer's Research and Therapy. 2024;16(1).
48)    Stevenson-Hoare J, Stocker H, Trares K, Holleczek B, Brenner H. Subjective hearing and memory problems are associated with dementia and cognition in later life. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2024;16(3).
49)    Steinmetz JD, Seeher KM, Schiess N, Nichols E, Cao B, Servili C, et al. Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet Neurology. 2024;23(4):344-81.
50)    Srinivasan S, Kryza T, Bock N, Tse BWC, Sokolowski KA, Janaththani P, et al. A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer. Nature Communications. 2024;15(1).
51)    Sofianopoulou E, Kaptoge SK, Afzal S, Jiang T, Gill D, Gundersen TE, et al. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses. The Lancet Diabetes and Endocrinology. 2024;12(1):e2-e11.
52)    Schumacher AE, Kyu HH, Antony CM, Aravkin AY, Azhar GS, Bisignano C, et al. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021. The Lancet. 2024;403(10440):1989-2056.
53)    Schöttker B, Holleczek B, Hybsier S, Köhrle J, Schomburg L, Brenner H. Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults. European Journal of Epidemiology. 2024;39(2):121-36.
54)    Scholz M, Horn K, Pott J, Wuttke M, Kühnapfel A, Nasr MK, et al. X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements. Nature Communications. 2024;15(1).
55)    Santos JV, Padron-Monedero A, Bikbov B, Grad DA, Plass D, Mechili EA, et al. The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019. BMC Public Health. 2024;24(1).
56)    Reinikainen J, Kuulasmaa K, Oskarsson V, Amouyel P, Biasch K, Brenner H, et al. Regional and temporal differences in the associations between cardiovascular disease and its classic risk factors: an analysis of 49 cohorts from 11 European countries. European Journal of Preventive Cardiology. 2024;31(5):569-77.
57)    Raut JR, Bhardwaj M, Schöttker B, Holleczek B, Schrotz-King P, Brenner H. Cancer-specific risk prediction with a serum microRNA signature. Cancer Science. 2024;115(6):2049-58.
58)    Prendes CF, Rantner B, Hamwi T, Stana J, Feigin VL, Stavroulakis K, et al. Burden of Stroke in Europe: An Analysis of the Global Burden of Disease Study Findings from 2010 to 2019. Stroke. 2024;55(2):432-42.
59)    Phelps NH, Singleton RK, Zhou B, Heap RA, Mishra A, Bennett JE, et al. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. The Lancet. 2024;403(10431):1027-50.
60)    Paul C, Schöttker B, Hartmann M, Friederich HC, Brenner H, Wild B. Gender-specific factors associated with case complexity in middle-aged and older adults—Evidence from a large population-based study. International Journal of Geriatric Psychiatry. 2024;39(6).
61)    Naghavi M, Ong KL, Aali A, Ababneh HS, Abate YH, Abbafati C, et al. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet. 2024;403(10440):2100-32.
62)    Hageman SHJ, Kaptoge S, De Vries TI, Lu W, Kist JM, Van Os HJA, et al. Prediction of individual lifetime cardiovascular risk and potential treatment benefit: Development and recalibration of the LIFE-CVD2 model to four European risk regions. European Journal of Preventive Cardiology. 2024;31(14):1690-9.
63)    Ferrari AJ, Santomauro DF, Aali A, Abate YH, Abbafati C, Abbastabar H, et al. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet. 2024;403(10440):2133-61.
64)    Feigin VL, Abate MD, Abate YH, Abd ElHafeez S, Abd-Allah F, Abdelalim A, et al. Global, regional, and national burden of stroke and its risk factors, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet Neurology. 2024;23(10):973-1003.
65)    Corradi C, Lencioni G, Felici A, Rizzato C, Gentiluomo M, Ermini S, et al. Potential association between PSCA rs2976395 functional variant and pancreatic cancer risk. International Journal of Cancer. 2024;155(8):1432-42.
66)    Comfort H, McHugh TA, Schumacher AE, Harris A, May EA, Paulson KR, et al. Global, regional, and national stillbirths at 20 weeks' gestation or longer in 204 countries and territories, 1990–2021: findings from the Global Burden of Disease Study 2021. The Lancet. 2024;404(10466):1955-88.
67)    Bryazka D, Reitsma MB, Abate YH, Abd Al Magied AHA, Abdelkader A, Abdollahi A, et al. Forecasting the effects of smoking prevalence scenarios on years of life lost and life expectancy from 2022 to 2050: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet Public Health. 2024;9(10):e729-e44.
68)    Brauer M, Roth GA, Aravkin AY, Zheng P, Abate KH, Abate YH, et al. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet. 2024;403(10440):2162-203.

2023
69)    Zhou B, Sheffer KE, Bennett JE, Gregg EW, Danaei G, Singleton RK, et al. Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c. Nature Medicine. 2023;29(11):2885-901.
70)    Zanti M, O'Mahony DG, Parsons MT, Li H, Dennis J, Aittomäkkiki K, et al. A likelihood ratio approach for utilizing case-control data in the clinical classification of rare sequence variants: Application to BRCA1 and BRCA2. Human Mutation. 2023;2023.
71)    Wichert K, Hoppe R, Ickstadt K, Behrens T, Winter S, Herold R, et al. Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer. European Journal of Epidemiology. 2023;38(10):1053-68.
72)    Wang A, Shen J, Rodriguez AA, Saunders EJ, Chen F, Janivara R, et al. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nature Genetics. 2023;55(12):2065-74.
73)    Stocker H, Trares K, Beyer L, Perna L, Rujescu D, Holleczek B, et al. Alzheimer’s polygenic risk scores, APOE, Alzheimer’s disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years. Alzheimer's Research and Therapy. 2023;15(1).
74)    Stocker H, Beyer L, Trares K, Perna L, Rujescu D, Holleczek B, et al. Association of Kidney Function With Development of Alzheimer Disease and Other Dementias and Dementia-Related Blood Biomarkers. JAMA network open. 2023;6(1):e2252387.
75)    Stocker H, Beyer L, Perna L, Rujescu D, Holleczek B, Beyreuther K, et al. Association of plasma biomarkers, p-tau181, glial fibrillary acidic protein, and neurofilament light, with intermediate and long-term clinical Alzheimer's disease risk: Results from a prospective cohort followed over 17 years. Alzheimer's and Dementia. 2023;19(1):25-35.
76)    Perna L, Stocker H, Burow L, Beyer L, Trares K, Kurz C, et al. Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study. Alzheimer's Research and Therapy. 2023;15(1).
77)    Perna L, Mons U, Stocker H, Beyer L, Beyreuther K, Trares K, et al. High cholesterol levels change the association of biomarkers of neurodegenerative diseases with dementia risk: Findings from a population-based cohort. Alzheimer's and Dementia. 2023;19(7):2913-22.
78)    Pennells L, Kaptoge S, Østergaard HB, Read SH, Carinci F, Franch-Nadal J, et al. SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe. European Heart Journal. 2023;44(28):2544-56.
79)    Ong KL, Stafford LK, McLaughlin SA, Boyko EJ, Vollset SE, Smith AE, et al. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet. 2023;402(10397):203-34.
80)    Mueller SH, Lai AG, Valkovskaya M, Michailidou K, Bolla MK, Wang Q, et al. Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry. Genome Medicine. 2023;15(1).
81)    Middha P, Wang X, Behrens S, Bolla MK, Wang Q, Dennis J, et al. A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. Breast Cancer Research. 2023;25(1).
82)    Matsushita K, Kaptoge S, Hageman SHJ, Sang Y, Ballew SH, Grams ME, et al. Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP. European Journal of Preventive Cardiology. 2023;30(1):8-16.
83)    Magnussen C, Ojeda FM, Leong DP, Alegre-Diaz J, Amouyel P, Aviles-Santa L, et al. Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. New England Journal of Medicine. 2023;389(14):1273-85.
84)    Lopes Cardozo JMN, Andrulis IL, Bojesen SE, Dörk T, Eccles DM, Fasching PA, et al. Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival. Journal of Clinical Oncology. 2023;41(10):1849-63.
85)    Kaptoge S, Seshasai SRK, Sun L, Walker M, Bolton T, Spackman S, et al. Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation. The Lancet Diabetes and Endocrinology. 2023;11(10):731-42.
86)    Hess T, Maj C, Gehlen J, Borisov O, Haas SL, Gockel I, et al. Dissecting the genetic heterogeneity of gastric cancer. eBioMedicine. 2023;92.
87)    Haller PM, Goßling A, Magnussen C, Brenner H, Schöttker B, Iacoviello L, et al. Biomarker-based prediction of fatal and non-fatal cardiovascular outcomes in individuals with diabetes mellitus. European Journal of Preventive Cardiology. 2023;30(12):1218-26.
88)    Gwenzi T, Schrotz-King P, Schöttker B, Hoffmeister M, Brenner H. Vitamin D Status, Cdx2 Genotype, and Colorectal Cancer Survival: Population-Based Patient Cohort. Nutrients. 2023;15(12).
89)    Goyal N, Hennessy M, Lehman E, Lin W, Agudo A, Ahrens W, et al. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium. Oral Diseases. 2023;29(4):1565-78.
90)    Giaccherini M, Gori L, Gentiluomo M, Farinella R, Cervena K, Skieceviciene J, et al. A scan of all coding region variants of the human genome, identifies 13q12.2-rs9579139 and 15q24.1-rs2277598 as novel risk loci for pancreatic ductal adenocarcinoma. Carcinogenesis. 2023;44(8-9):642-9.
91)    Giaccherini M, Farinella R, Gentiluomo M, Mohelnikova-Duchonova B, Kauffmann EF, Palmeri M, et al. Association between a polymorphic variant in the CDKN2B-AS1/ANRIL gene and pancreatic cancer risk. International Journal of Cancer. 2023;153(2):373-9.
92)    García-Pardo M, Chang A, Schmid S, Dong M, Brown MC, Christiani D, et al. Respiratory and Cardiometabolic Comorbidities and Stages I to III NSCLC Survival: A Pooled Analysis From the International Lung Cancer Consortium. Journal of Thoracic Oncology. 2023;18(3):313-23.
93)    Di Castelnuovo A, Bonaccio M, Costanzo S, McElduff P, Linneberg A, Salomaa V, et al. Drinking alcohol in moderation is associated with lower rate of all-cause mortality in individuals with higher rather than lower educational level: findings from the MORGAM project. European Journal of Epidemiology. 2023;38(8):869-81.
94)    Corradi C, Lencioni G, Gentiluomo M, Felici A, Latiano A, Kiudelis G, et al. Polymorphic variants involved in methylation regulation: A strategy to discover risk loci for pancreatic ductal adenocarcinoma. Journal of Medical Genetics. 2023;60(10):980-6.
95)    Campa D, Gentiluomo M, Stein A, Aoki MN, Oliverius M, Vodičková L, et al. The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer. Critical Reviews in Oncology/Hematology. 2023;186.
96)    Boehlen FH, Heider D, Schellberg D, Hohls JK, Schöttker B, Brenner H, et al. Gender-specific association of loneliness and health care use in community-dwelling older adults. BMC Geriatrics. 2023;23(1).
97)    Bhardwaj M, Schöttker B, Holleczek B, Brenner H. Enhanced selection of people for lung cancer screening using AHRR (cg05575921) or F2RL3 (cg03636183) methylation as biological markers of smoking exposure. Cancer Communications. 2023;43(8):956-9.
98)    Beyer L, Stocker H, Rujescu D, Holleczek B, Stockmann J, Nabers A, et al. Amyloid-beta misfolding and GFAP predict risk of clinical Alzheimer's disease diagnosis within 17 years. Alzheimer's and Dementia. 2023;19(3):1020-8.

2022
99)    Zhu A, Kuznia S, Niedermaier T, Holleczek B, Schöttker B, Brenner H: Consistent Inverse Associations of Total, “Bioavailable”, Free, and “Non-Bioavailable” Vitamin D with Incidence of Diabetes among Older Adults with Lower Baseline HbA1c (≤6%) Levels. Nutrients 2022, 14(16).
100)    Zhu A, Kuznia S, Niedermaier T, Holleczek B, Schöttker B, Brenner H: Vitamin D–binding protein, total, “nonbioavailable,” bioavailable, and free 25-hydroxyvitamin D, and mortality in a large population-based cohort of older adults. Journal of Internal Medicine 2022, 292(3):463-476.
101)    Xie K, Perna L, Schöttker B, Kliegel M, Brenner H, Mons U: Type 2 diabetes mellitus and cognitive decline in older adults in Germany – results from a population-based cohort. BMC Geriatrics 2022, 22(1).
102)    Winkler TW, Rasheed H, Teumer A, Gorski M, Rowan BX, Stanzick KJ, Thomas LF, Tin A, Hoppmann A, Chu AY et al: Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Communications Biology 2022, 5(1).
103)    Wielscher M, Mandaviya PR, Kuehnel B, Joehanes R, Mustafa R, Robinson O, Zhang Y, Bodinier B, Walton E, Mishra PP et al: DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. Nature Communications 2022, 13(1).
104)    Trares K, Bhardwaj M, Perna L, Stocker H, Petrera A, Hauck SM, Beyreuther K, Brenner H, Schöttker B: Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study. Alzheimer's Research and Therapy 2022, 14(1).
105)    Schöttker B, Larsen EL, Weimann A, Henriksen T, Brenner H, Poulsen HE: Associations of urinary metabolites of oxidized DNA and RNA with the incidence of diabetes mellitus using UPLC-MS/MS and ELISA methods. Free Radical Biology and Medicine 2022, 183:51-59.
106)    Schmid S, Jiang M, Brown MC, Fares A, Garcia M, Soriano J, Dong M, Thomas S, Kohno T, Leal LF et al: Accounting for EGFR Mutations in Epidemiologic Analyses of Non-Small Cell Lung Cancers: Examples Based on the International Lung Cancer Consortium Data. Cancer Epidemiol Biomarkers Prev 2022, 31(3):679-687.
107)    Salem AA, Trares K, Kohl M, Jansen E, Brenner H, Schöttker B: Long-term effects of smoking on serum concentrations of oxidative stress biomarkers: Results of a large, population-based cohort study. Environmental Research 2022, 204.
108)    Rosberg V, Vishram-Nielsen JK, Kristensen AMD, Pareek M, Sehested TSG, Nilsson PM, Linneberg A, Palmieri L, Giampaoli S, Donfrancesco C et al: Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures: The MORGAM prospective cohort project. Preventive Medicine Reports 2022, 26.
109)    Ponce-de-Leon M, Linseisen J, Peters A, Linkohr B, Heier M, Grallert H, Schöttker B, Trares K, Bhardwaj M, Gào X et al: Novel associations between inflammation-related proteins and adiposity: A targeted proteomics approach across four population-based studies. Translational Research 2022, 242:93-104.
110)    Perna L, Trares K, Perneczky R, Tato M, Stocker H, Möllers T, Holleczek B, Schöttker B, Brenner H: Risk of Late-Onset Depression and Cognitive Decline: Results From Inflammatory Proteome Analyses in a Prospective Population-Based Cohort Study. American Journal of Geriatric Psychiatry 2022, 30(6):689-700.
111)    Peduzzi G, Archibugi L, Katzke V, Gentiluomo M, Capurso G, Milanetto AC, Gazouli M, Goetz M, Brenner H, Vermeulen RCH et al: Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women. Scientific Reports 2022, 12(1).
112)    Nguyen TNM, Sha S, Chen LJ, Holleczek B, Brenner H, Schöttker B: Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: results from two large cohorts with new-user design. Alimentary Pharmacology and Therapeutics 2022, 56(2):251-262.
113)    Nguyen TNM, Chen LJ, Trares K, Stocker H, Holleczek B, Beyreuther K, Brenner H, Schöttker B: Long-term low-dose acetylsalicylic use shows protective potential for the development of both vascular dementia and Alzheimer’s disease in patients with coronary heart disease but not in other individuals from the general population: results from two large cohort studies. Alzheimer's Research and Therapy 2022, 14(1).
114)    Nano J, Schöttker B, Lin JS, Huth C, Ghanbari M, Garcia PM, Maalmi H, Karrasch S, Koenig W, Rothenbacher D et al: Novel biomarkers of inflammation, kidney function and chronic kidney disease in the general population. Nephrology Dialysis Transplantation 2022, 37(10):1916-1926.
115)    Möllers T, Stocker H, Perna L, Rujescu D, Holleczek B, Schöttker B, Brenner H: Subjective short-Term memory difficulties at ages 50-75 predict dementia risk in a community-based cohort followed over 17 years. Age and Ageing 2022, 51(6).
116)    Lin HY, Tseng TS, Wang X, Fang Z, Zea AH, Wang L, Pow-Sang J, Tangen CM, Goodman PJ, Wolk A et al: Intake Patterns of Specific Alcoholic Beverages by Prostate Cancer Status. Cancers (Basel) 2022, 14(8).
117)    Li X, Schöttker B, Holleczek B, Brenner H: Associations of DNA methylation algorithms of aging and cancer risk: Results from a prospective cohort study. eBioMedicine 2022, 81.
118)    Li X, Schöttker B, Holleczek B, Brenner H: Association of longitudinal repeated measurements of frailty index with mortality: Cohort study among community-dwelling older adults: Longitudinal repeated measurements of frailty and mortality. eClinicalMedicine 2022, 53.
119)    Li X, Delerue T, Schöttker B, Holleczek B, Grill E, Peters A, Waldenberger M, Thorand B, Brenner H: Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults. Nature Communications 2022, 13(1).
120)    Lam SY, Mommersteeg MC, Yu B, Broer L, Spaander MCW, Frost F, Weiss S, Völzke H, Lerch MM, Schöttker B et al: Toll-Like Receptor 1 Locus Re-examined in a Genome-Wide Association Study Update on Anti–Helicobacter pylori IgG Titers. Gastroenterology 2022, 162(6):1705-1715.
121)    Huynh-Le MP, Karunamuni R, Fan CC, Asona L, Thompson WK, Martinez ME, Eeles RA, Kote-Jarai Z, Muir KR, Lophatananon A et al: Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score. Prostate cancer and prostatic diseases 2022, 25(4):755-761.
122)    Hilvo M, Dhar I, Lääperi M, Lysne V, Sulo G, Tell GS, Jousilahti P, Nygård OK, Brenner H, Schöttker B et al: Primary cardiovascular risk prediction by LDL-cholesterol in Caucasian middle-aged and older adults: a joint analysis of three cohorts. European Journal of Preventive Cardiology 2022, 29(3):E128-E137.
123)    Gorski M, Rasheed H, Teumer A, Thomas LF, Graham SE, Sveinbjornsson G, Winkler TW, Günther F, Stark KJ, Chai JF et al: Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies. Kidney International 2022, 102(3):624-639.
124)    Gentiluomo M, Giaccherini M, Gào X, Guo F, Stocker H, Schöttker B, Brenner H, Canzian F, Campa D: Genome-wide association study of mitochondrial copy number. Human Molecular Genetics 2022, 31(8):1346-1355.
125)    Gaziano L, Sun L, Arnold M, Bell S, Cho K, Kaptoge SK, Song RJ, Burgess S, Posner DC, Mosconi K et al: Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses. Circulation 2022, 146(20):1507-1517.
126)    Gao X, Huang N, Jiang M, Holleczek B, Schöttker B, Huang T, Brenner H: Mortality and morbidity risk prediction for older former smokers based on a score of smoking history: Evidence from UK Biobank and ESTHER cohorts. Age and Ageing 2022, 51(7).
127)    Fraszczyk E, Spijkerman AMW, Zhang Y, Brandmaier S, Day FR, Zhou L, Wackers P, Dollé MET, Bloks VW, Gào X et al: Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts. Diabetologia 2022, 65(5):763-776.
128)    Fiorito G, Pedron S, Ochoa-Rosales C, McCrory C, Polidoro S, Zhang Y, Dugu PA, Ratliff S, Zhao WN, McKay GJ et al: The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis. Journals of Gerontology - Series A Biological Sciences and Medical Sciences 2022, 77(9):1750-1759.
129)    Di Castelnuovo A, Costanzo S, Bonaccio M, McElduff P, Linneberg A, Salomaa V, Männistö S, Moitry M, Ferrières J, Dallongeville J et al: Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study. Addiction 2022, 117(2):312-325.
130)    Byun J, Han Y, Li Y, Xia J, Long E, Choi J, Xiao X, Zhu M, Zhou W, Sun R et al: Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. Nature Genetics 2022, 54(8):1167-1177.
131)    Boehlen FH, Maatouk I, Friederich HC, Schoettker B, Brenner H, Wild B: Loneliness as a gender-specific predictor of physical and mental health-related quality of life in older adults. Quality of Life Research 2022, 31(7):2023-2033.
132)    Bhardwaj M, Schöttker B, Holleczek B, Brenner H: Comparison of discrimination performance of 11 lung cancer risk models for predicting lung cancer in a prospective cohort of screening-age adults from Germany followed over 17 years. Lung Cancer 2022, 174:83-90.
133)    Bhardwaj M, Schöttker B, Holleczek B, Benner A, Schrotz-King P, Brenner H: Potential of Inflammatory Protein Signatures for Enhanced Selection of People for Lung Cancer Screening. Cancers (Basel) 2022, 14(9).

2021
134)    Schlosser, P., Tin, A., Matias-Garcia, P. R., Thio, C. H. L., Joehanes, R., Liu, H. B., . . . , Genetics, D. N. A. M. C. Meta-analyses identify DNA methylation associated with kidney function and damage. NATURE COMMUNICATIONS 2021; 12: 
135)    Tin, A., Schlosser, P., Matias-Garcia, P. R., Thio, C. H. L., Joehanes, R., Liu, H. B., . . . , Genetics, D. N. A. M. C. Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus. NATURE COMMUNICATIONS 2021; 12: 
136)    Lu, Y., Gentiluomo, M., Macauda, A., Gioffreda, D., Gazouli, M., Petrone, M. C., . . . , Canzian, F. Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk. FRONTIERS IN ONCOLOGY 2021; 11: 
137)    Peduzzi, G., Gentiluomo, M., Tavano, F., Arcidiacono, P. G., Ermini, S., Vodicka, P., . . . , Campa, D. Genetic Polymorphisms Involved in Mitochondrial Metabolism and Pancreatic Cancer Risk. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 2021; 30: 2342-2345.
138)    Schöttker, B., Salem, A. A., Schwenk, M., Gao, X., Jansen, E., Brenner, H. Relationship of Physical Activity at Older Age with Biomarkers of Oxidative Stress: A Large, Population-based Cohort Study. MEDICINE & SCIENCE IN SPORTS & EXERCISE 2021; 53: 2528-2535.
139)    Li, X. W., Zhang, Y., Gao, X., Holleczek, B., Schöttker, B., Brenner, H. Comparative validation of three DNA methylation algorithms of ageing and a frailty index in relation to mortality: results from the ESTHER cohort study. EBIOMEDICINE 2021; 74: 
140)    Sofianopoulou, E., Kaptoge, S. K., Afzal, S., Jiang, T., Gill, D., Gundersen, T. E., . . . , Emerging Risk Factors, C. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses. LANCET DIABETES & ENDOCRINOLOGY 2021; 9: 837-846.
141)    Sinning, C., Makarova, N., Völzke, H., Schnabel, R. B., Ojeda, F., Dorr, M., . . . , Thorand, B. Association of glycated hemoglobin A(1c) levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium. CARDIOVASCULAR DIABETOLOGY 2021; 20: 
142)    Zhu, A. N., Kuznia, S., Niedermaier, T., Holleczek, B., Schoettker, B., Brenner, H. Distribution and Determinants of Vitamin D-Binding Protein, Total, "Non-Bioavailable", Bioavailable, and Free 25-Hydroxyvitamin D Concentrations among Older Adults. NUTRIENTS 2021; 13: 
143)    Sinning, C., Makarova, N., Schnabel, R., Ojeda, F., Felix, S. B., Koenig, W., . . . , BiomarCaRe. Association of glycated haemoglobin A1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE consortium. EUROPEAN HEART JOURNAL 2021; 42: 2624-2624.
144)    Stocker, H., Perna, L., Weigl, K., Mollers, T., Schottker, B., Thomsen, H., . . . , Brenner, H. Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years (October, 10.1038/s41380-021-01311-x, 2021). MOLECULAR PSYCHIATRY 2021; 26: 5823-5823.
145)    Zhou, B., Carrillo-Larco, R. M., Danaei, G., Riley, L. M., Paciorek, C. J., Stevens, G. A., . . . , Collaboration, N. C. D. R. F. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. LANCET 2021; 398: 957-980.
146)    Möllers, T., Stocker, H., Perna, L., Nabers, A., Rujescu, D., Hartmann, A. M., . . . , Brenner, H. A beta misfolding in blood plasma is inversely associated with body mass index even in middle adulthood. ALZHEIMERS RESEARCH & THERAPY 2021; 13: 
147)    Raut, J. R., Schöttker, B., Holleczek, B., Guo, F., Bhardwaj, M., Miah, K., . . . , Brenner, H. A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction. NATURE COMMUNICATIONS 2021; 12: 
148)    Park, H. A., Neumeyer, S., Michailidou, K., Bolla, M. K., Wang, Q., Dennis, J., . . . , Investigators, K. C. Mendelian randomisation study of smoking exposure in relation to breast cancer risk. BRITISH JOURNAL OF CANCER 2021; 125: 1135-1145.
149)    Jaensch, A., Schöttker, B., Schmucker, R., Koenig, W., Brenner, H., Rothenbacher, D. Prevalence and Prognostic Value of Psychological Stress Events in Patients with First Myocardial Infarction-Long-Term Follow-Up Study. JOURNAL OF CLINICAL MEDICINE 2021; 10: 
150)    Hageman, S., Pennells, L., Ojeda, F., Kaptoge, S., Kuulasmaa, K., de Vries, T., . . . , Collaboration, E. S. C. C. R. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. EUROPEAN HEART JOURNAL 2021; 42: 2439-2454.
151)    Matias-Garcia, P. R., Ward-Caviness, C. K., Raffield, L. M., Gao, X., Zhang, Y., Wilson, R., . . . , Waldenberger, M. DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function. CLINICAL EPIGENETICS 2021; 13: 
152)    Karabegovic, I., Portilla-Fernandez, E., Li, Y., Ma, J. T., Maas, S. C. E., Sun, D. K., . . . , Ghanbari, M. Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption. NATURE COMMUNICATIONS 2021; 12: 
153)    Butt, J., Murugan, R., Hippchen, T., Olberg, S., van Straaten, M., Wardemann, H., . . . , Waterboer, T. From Multiplex Serology to Serolomics-A Novel Approach to the Antibody Response against the SARS-CoV-2 Proteome. VIRUSES-BASEL 2021; 13: 
154)    Dimou, N., Yarmolinsky, J., Bouras, E., Tsilidis, K. K., Martin, R. M., Lewis, S. J., . . . , Murphy, N. Causal Effects of Lifetime Smoking on Breast and Colorectal Cancer Risk: Mendelian Randomization Study. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 2021; 30: 953-964.
155)    Guo, F., Chen, C., Holleczek, B., Schottker, B., Hoffmeister, M., Brenner, H. Strong Reduction of Colorectal Cancer Incidence and Mortality After Screening Colonoscopy: Prospective Cohort Study From Germany. AMERICAN JOURNAL OF GASTROENTEROLOGY 2021; 116: 967-975.
156)    Stocker, H., Nabers, A., Perna, L., Mollers, T., Rujescu, D., Hartmann, A. M., . . . , Brenner, H. Genetic predisposition, A beta misfolding in blood plasma, and Alzheimer's disease. TRANSLATIONAL PSYCHIATRY 2021; 11: 
157)    Lin, H. Y., Huang, P. Y., Cheng, C. H., Tung, H. Y., Fang, Z. D., Berglund, A. E., . . . , Consortium, P. KLK3 SNP-SNP interactions for prediction of prostate cancer aggressiveness. SCIENTIFIC REPORTS 2021; 11: 
158)    Vishram-Nielsen, J. K. K., Kristensen, A. M. D., Pareek, M., Laurent, S., Nilsson, P. M., Linneberg, A., . . . , Project, M. Predictive Importance of Blood Pressure Characteristics With Increasing Age in Healthy Men and Women The MORGAM Project. HYPERTENSION 2021; 77: 1076-1085.
159)    Amadou, A., Freisling, H., Jenab, M., Tsilidis, K. K., Trichopoulou, A., Boffetta, P., . . . , Romieu, I. Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium. BRITISH JOURNAL OF CANCER 2021; 124: 1882-1890.
160)    Nguyen, T. N. M., Laetsch, D. C., Chen, L. J., Holleczek, B., Meid, A. D., Brenner, H., Schöttker, B. Comparison of Five Lists to Identify Potentially Inappropriate Use of Non-Steroidal Anti-Inflammatory Drugs in Older Adults. PAIN MEDICINE 2021; 22: 1962-1969.
161)    Gorski, M., Jung, B., Li, Y., Matias-Garcia, P. R., Wuttke, M., Coassin, S., . . . , Regeneron Genetics, C. Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline. KIDNEY INTERNATIONAL 2021; 99: 926-939.
162)    Iurilli, M. L. C., Zhou, B., Bennett, J. E., Carrillo-Larco, R. M., Sophiea, M. K., Rodriguez-Martinez, A., . . . , NCD, N. C. D. R. F. C. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC). ELIFE 2021; 10: 
163)    Huynh-Le, M. P., Fan, C. C., Karunamuni, R., Thompson, W. K., Martinez, M. E., Eeles, R. A., . . . , Consortium, P. Polygenic hazard score is associated with prostate cancer in multi-ethnic populations. NATURE COMMUNICATIONS 2021; 12: 
164)    Coignard, J., Lush, M., Beesley, J., O'Mara, T. A., Dennis, J., Tyrer, J. P., . . . , Investigators, A. A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers. NATURE COMMUNICATIONS 2021; 12: 
165)    Corradi, C., Gentiluomo, M., Gajdan, L., Cavestro, G. M., Kreivenaite, E., Di Franco, G., . . . , Campa, D. Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility. INTERNATIONAL JOURNAL OF CANCER 2021; 148: 2779-2788.
166)    Bhardwaj, M., Terzer, T., Schrotz-King, P., Brenner, H. Comparison of Proteomic Technologies for Blood-Based Detection of Colorectal Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021; 22: 
167)    Jiang, M., Fares, A. F., Shepshelovich, D., Yang, P., Christiani, D., Zhang, J., . . . , Liu, G. The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients. LUNG CANCER 2021; 152: 58-65.
168)    Lin, H. Y., Wang, X. N., Tseng, T. S., Kao, Y. H., Fang, Z. D., Molina, P. E., . . . , Consortium, P. Alcohol Intake and Alcohol-SNP Interactions Associated with Prostate Cancer Aggressiveness. JOURNAL OF CLINICAL MEDICINE 2021; 10: 
169)    Johnson, N., Maguire, S., Morra, A., Kapoor, P. M., Tomczyk, K., Jones, M. E., . . . , kConFab, I. CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers. BRITISH JOURNAL OF CANCER 2021; 124: 842-854.
170)    Karunamuni, R. A., Huynh-Le, M. P., Fan, C. C., Thompson, W., Eeles, R. A., Kote-Jarai, Z., . . . , Consortium, P. Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer. PROSTATE CANCER AND PROSTATIC DISEASES 2021; 24: 532-541.
171)    Stocker, H., Perna, L., Weigl, K., Mollers, T., Schottker, B., Thomsen, H., . . . , Brenner, H. Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. MOLECULAR PSYCHIATRY 2021; 26: 5812-5822.

2020
172)    Brandao A, Paulo P, Maia S, Pinheiro M, Peixoto A,…, Brenner H,…, Roobol MJ, The Profile Study Steering Committee, The PRACTICAL Consortium, Teixeira MR. The CHEK2 variant c. 349A>G is associated with prostate cancer risk and carriers. Cancers 2020; 12:3254. 
173)    Perna L, Zhang Y, Wild B, Kliegel M, Ihle A, Schöttker B, Mons U, Brenner H. Childhood exposure to hunger: associations with health outcomes in later life and epigenetic markers. Epigenomics. 2020; 12(21):1861-1870.
174)    NCD Risk Factor Collaboration (NCD-RisC). Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries: Pooled analysis of 2,182 population-based studies with 65 million participants. Lancet 2020; 396:1511-1524. 
175)    Perna L, Zhang Y, Matias-Garcia P, Ladwig KH, Wiechmann T, Wild B, Waldenberger M, Schöttker B, Mons U, Ihle A, Kliegel M, Schwettmann L, Peters A, Brenner H. Subjective mental health, incidence of depressive symptoms in later life, and the role of epigenetics: results from two longitudinal cohort studies. Translational Psychiatry 2020; 10:323. 
176)    Huynh-Le MP, Chieh Fan C, Karunamuni R, Walsh EI, Turner EL,…, Brenner H,    Schöttker B, Holleczek B,…, Mills IG, Andreassen OA, Dale AM, Seibert TM. A genetic risk score to personalize prostate cancer screening, applied to population data. Cancer Epidemiology, Biomarkers & Prevention 2020; 29:1731-1738. 
177)    Konrad C, Lossnitzer N, Boehlen FH, Haefeli WE, Holleczek B, Brenner H, Schöttker B, Wild B. Coping resouces of heart failure patients – a comparison with cancer patients and individuals having no chronic condition. Results from the ESTHER study. Heart & Lung 2020; 49:829-835. 
178)    Brenner H, Holleczek B, Schöttker B. Vitamin D insufficiency and deficiency and mortality from respiratory diseases in a cohort  of older adults: potential for limiting the death toll during and beyond the COVID-19 pandemic? Nutrients 2020; 12:E2488. 
179)    Ma J, Rebholz CM, Braun KVE, Reynolds LM, Aslibekyan S,…, Zhang Y, Schöttker B, Brenner H,…, Hu FB, Fornage M, Voortman T, Levy D. Whole blood DNA methylation signatures of diet are associated with cardiovascular disease risk factors and all-cause mortality. Circulation: Genomic and Precision Medicine 2020; 13:e002766. 
180)    Campa D, Gentiluomo M, Obazee O, Ballerini A, Vodickova L,…, Brenner H,…,  Schöttker B,…, Kaaks R, Neoptolemos J, Lucchesi M, Canzian F. Genome-wide association study identifies an early onset pancreatic cancer risk locus. International Journal of Cancer 2020; 147:2065-2074. 
181)    Yu H, Raut JR, Schöttker B, Holleczek B, Zhang Y, Brenner H. Individual and joint contributions of genetic and methylation risk scores for enhancing lung cancer risk stratification: data from a population-based cohort in Germany. Clinical Epigenetics 2020; 12:89. 
182)    NCD Risk Factor Collaboration (NCD-RisC)*. Repositioning of the global epicenter of non-optimal cholesterol. Nature 2020; 582:73-77. *Collaborators on behalf of the ESTHER study: Brenner H, Saum KU, Schöttker B
183)    Möllers T, Perna L, Stocker H, Ihle P, Schubert I, Schöttker B, Frölich L, Brenner H. New use of psychotropic medication after hospitalization among people with dementia. International Journal of Geriatric Psychiatry 2020; 35:640-649. 
184)    Ochoa-Rosales C, ... , Muka T. Epigenetic link between statin therapy and type 2 diabetes. Diabetes Care 2020; 43:875-884. 
185)    Vishram-Nielsen JKK, ... , on behalf of the MORGAM project. Does estimated pulse wave velocity add prognostic information? The MORGAM prospective cohort project. Hypertension 2020; 75:1420-1428. 
186)    Kapoor PM, Lindström S, Behrens S, , on behalf of the Breast Cancer Association Consortium. Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk in the Breast Cancer Association Consortium. International Journal of Epidemiology 2020; 49:216-230. 
187)    Holleczek B, Schöttker B, Brenner H. Helicobacter pylori infection, chronic atrophic gastritis and risk of stomach and esophagus  cancer: results from the prospective population-based ESTHER cohort study. International Journal of Cancer 2020; 146:2773-2783. 
188)    NCD Risk Factor Collaboration (NCD-RisC). *National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: an analysis of trends in Asian and Western countries. International Journal of Epidemiology 2020; 49:173-192. *Collaborators on behalf of the ESTHER study: Brenner H, Saum KU, Schöttker B
189)    Yang Y, Wu L, ... , Long J. Genetically predicted levels of DNA methylation biomarkers and breast cancer risk: data from 228,951 women of European descent. Journal of the National Cancer Institute 2020; 112:295-304. 
190)    Trares K, Gào X, Perna L, Rujescu D, Stocker H, Möllers T, Beyreuther K, Brenner H, Schöttker B. Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer’s disease and vascular dementia incidence: results from a prospective cohort study. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association 2020; 16:804-813. 
191)    Boehlen FH, Herzog W, Schellberg D, Maatouk I, Schöttker B, Brenner H, Wild B. Gender-specific predictors of generalized anxiety disorder symptoms in older adults:  results of a large population-based study. Journal of Affective Disorders 2020; 262:174-181. 
192)    Anusruti A, Jansen EHJM, Gào X, Xuan Y, Brenner H, Schöttker B. Longitudinal associations of body mass index, waist circumference and waist to hip ratio with biomarkers of oxidative stress in older adults: Results of a large cohort study. Obesity Facts 2020; 13:66-76. 
193)    Anusruti A, Xuan Y, Gào X, Jansen E, Laetsch DC, Brenner H, Schöttker B. Factors associated with high oxidative stress in type 2 diabetes patients: a meta-analysis of two cohort studies. BMJ Open Diabetes Research & Care 2020; 8:e000933. 
194)    Guo F, Chen C, Schöttker B, Holleczek B, Hoffmeister M, Brenner H. Changes in colorectal cancer screening use after introduction of alternative screening offer in Germany: Prospective cohort study. International Journal of Cancer 2020; 146:2423-2432. 
195)    Barahona Ponce C, Scherer D, Boekstegers F, ... , Brenner H,  Schöttker B, Holleczek B, et al. Arsenic and gallbladder cancer risk: Mendelian randomization analysis of European prospective data. International Journal of Cancer 2020; 146:2648-2650. 
196)    Fachal L, Aschard H, Beesley J, Barnes DR, Allen J,…, Brenner H,…, Schöttker B,…, Simard J, Easton DF, Kraft P, Dunning AM. Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Nature Genetics 2020; 52:56-73. 
197)    Schöttker B, Xuan Y, Gào X, Anusruti A, Brenner H. Oxidatively damaged DNA/RNA and 8-isoprostane levels are associated with the development of type 2 diabetes mellitus at older age: results from a large cohort study. Diabetes Care 2020; 43:130-136. 
198)    Möllers T, Perna L, Stocker H, Ihle P, Schubert I, Schöttker B, Frölich L, Bauer J, Brenner H. Alzheimer’s disease medication and outcomes of hospitalization among patients with dementia. Epidemiology and Psychiatric Sciences 2020; 29:e73, 1-9. 
199)    Guan Z, Raut JR, Weigl K, Schöttker B, Holleczek B, Zhang Y, Brenner H. Individual and joint performance of DNA methylation profiles, genetic risk scores and environmental risk scores for predicting breast cancer risk. Molecular Oncology 2020; 14:42-53. 
200)    Niersmann C, Carstensen-Kirberg M, Maalmi H, Holleczek B, Roden M, Brenner H, Herder C, Schöttker B. Higher circulating omentin is associated with increased risk of primary cardiovascularevents in individuals with diabetes. Diabetologia 2020; 63:410-418. 
201)    Stocker H, Nabers A, Perna L, Möllers T, Rujescu D, Hartmann A, Holleczek B, Schöttker B, Gerwert K, Brenner H. Prediction of Alzheimer’s disease diagnosis within 14 years through Aβ misfolding inblood plasma compared to APOE4 status, and other risk factors. Alzheimer’s & Dementia: 2020; 16:283-291. 
202)    Gào X, Wilsgaard T, Jansen EHJM, Yang X, Anusruti A, Brenner H, Schöttker B. Serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: A  prospective case-cohort study. International Journal of Cancer 2020; 146:1261-1267. 
203)    Hilvo M, Meikle PJ, Pedersen ER, Tell GS, Dhar I, Brenner H, Schöttker B, et al. Development and validation of ceramide and phospholipid based cardiovascular risk estimation score for coronary artery disease patients. European Heart Journal 2020; 41:371-380.

2019
204)    Brenner DR, ... , Straif K. Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study. Cancer Epidemiology 2019; 58:25-32. 
205)    Quinzler R, Freitag MH, Wiese B, Beyer M, Brenner H, Dahlhaus A, Döring A, Freund T, Heier M, Knopf H, Luppa M, Prokein J, Riedel-Heller SG, Schäfer I, Scheidt-Nave C, Scherer M, Schöttker B, Szecsenyi J, Thürmann P, van den Bussche H, Gensichen J, Haefeli WE. A novel superior medication-based chronic disease score predicted all-cause mortality in independent geriatric cohorts. Journal of Clinical Epidemiology 2019; 105:112-124. 
206)    Hohls JK, Wild B, Heider D, Brenner H, Böhlen F, Saum KU, Schöttker B, Matschinger H, Haefeli WE, König HH, Hajek A. Association of generalized anxiety symptoms and panic with health care costs in older age – Results from the ESTHER cohort study. Journal of Affective Disorders 2019; 245:978-986. 
207)    Campa D, Matarazzi M, Greenhalf W, Bijlsma M, Saum KU,…, Valsuani C, Vashist YK, Brenner H, Canzian F. Genetic determinants of telomere length and risk of pancreatic cancer: a PANDoRA study. International Journal of Cancer 2019; 144:1275-1283. 
208)    Schöttker B, Hagen L, Zhang Y, Gào X, Holleczek B, Gao X, Brenner H. Serum 25-hydroxyvitamin D levels as an ageing marker. Strong associations with age and all-cause mortality independent from telomere length, epigenetic age acceleration and 8-isoprostane levels. Journal of Gerontology: Medical Sciences 2019; 74:121-128. 
209)    Mavaddat N, Michailidou K, Dennis J, Lush M, Fachal L,…, Arndt V,…, Brenner H,…, Kraft P, Garcia-Closas M, Simard J, Easton DF. Polygenic risk scores for prediction of breast cancer and breast cancer subtypes. The American Journal of Human Genetics 2019; 104:21-34. 
210)    Travis RC, . . , Allen NE. A collaborative analysis of individual participant data from 19 prospective studies assesses circulating vitamin D and prostate cancer risk. Cancer Research 2019; 79:274-285. 
211)    Raina P, Gilsing A, Freisling H, van den Heuvel E, Sohel N, Jenab M, Ferrari P, Tjonneland A, Benetou V, Picavet S, Eriksson S, Schöttker B, Brenner H, Saum KU, Perna L, Wilsgaard T, Trichopoulou A, Boffetta P, Griffith L. The combined effect of cancer and cardio-metabolic conditions on the mortality burden in older adults. Journals of Gerontology: Medical Sciences 2019; 74:366-372. 
212)    Wild B, Herzog W, Schellberg D, Böhlen F, Brenner H, Saum KU, Maatouk I. A short intervention targeting psychosomatic care in older adults with complex health care needs – results of a randomized controlled trial. International Journal of Geriatric Psychiatry 2019; 34:272-279. 
213)    Gào X, Zhang Y, Burwinkel B, Xuan Y, Holleczek B, Brenner H, Schöttker B. The associations of DNA methylation alterations in oxidative stress related genes with cancer incidence and mortality outcomes: A population-based cohort study. Clinical Epigenetics 2019; 11:14. 
214)    Böhlen F, Freigofas J, Herzog W, Meid A, Saum KU, Schöttker B, Brenner H, Haefeli W, Wild B. Evidence for underuse and overuse of antidepressants in older adults: Results of a large population-based study. International Journal of Geriatric Psychiatry 2019; 34:539-547. 
215)    Xuan Y, Bobak M, Anusruti A, Jansen EHJM, Pajak A, Tamosiunas A, Saum KU, Holleczek B, Gao X, Brenner H, Schöttker B. Association of serum markers of oxidative stress with myocardinal infarction and stroke: Pooled results from four large European cohort studies. European Journal of Epidemiology 2019; 34:471-481. 
216)    Ferreira MA, Al-Ejeh F, Campa D, Gamazon E, Parsons M,…, Arndt V, Brenner H,…, Caldés T, de la Hoya M, BCFR Investigators, GC-HBOC Collaborators. Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer. Nature Communications 2019; 10:1741. 
217)    Gao X, Gào X, Zhang Y, Holleczek B, Schöttker B, Brenner H. Oxidative stress and epigenetic mortality risk score: associations with all-cause mortality among elderly people. European Journal of Epidemiology 2019; 34:451-462. 
218)    Gregson J, Kaptoge S, Bolton T, Pennells L, Willeit P,…, Arndt V,…, Brenner H,…, Thompson SG, Danesh J, Di Angelantonio E, Meade T, for the Emerging Risk Factors Collaboration. Cardiovascular risk factors associated with venous thromboembolism. JAMA Cardiology 2019; 4:163-173. 
219)    Di Credico G, Edefonti V, Polesel J, Pauli F, Torelli N,…, Brenner H,…, Boffetta P, Hashibe M, Lee YCA, Dal Maso L. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: a bivariate spline model approach. Oral Oncology 2019; 94:47-57. 
220)    Gào X, Wilsgaard T, Jansen EHJM, Holleczek B, Zhang Y, Xuan Y, Anusruti A, Brenner H, Schöttker B. Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies. International Journal of Cancer 2019; 145:49-57. 
221)    Kar SP, Andrulis IL, Brenner H, Burgess S, Chang-Claude J, Considine D, Dörk T, Evans GR, Gago-Dominguez M, Giles GG, Hartman M, Huo D, Kaaks R, Li J, Lophatananon A, Margolin S, Milne RL, Muir KR, Olsson H, Punie K, Radice P, Simard J, Tamimi RM, Van Nieuwenhuysen E, Wendt C, Zheng W, Pharoah PDP. The association between weight at birth and breast cancer risk revisited using Mendelian randomisation. European Journal of Epidemiology 2019; 34:591-600. 
222)    Fiorito G, McCrory C, Robinson O, Carmeli C, Rosales CO, Zhang Y,…, Brenner H,…, Elliot P, Stringhini S, Vineis P, Polidoro S, and the Lifepath consortium. Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis. Aging 2019; 11:2045-2070. 
223)    Gào X, Holleczek B, Cuk K, Zhang Y, Anusruti A, Xuan Y, Xu Y, Brenner H, Schöttker B. Investigation on potential associations of oxidatively generated DNA/RNA damage with lung, colorectal, breast, prostate and total cancer incidence. Scientific Reports 2019; 9:7109. 
224)    NCD Risk Factor Collaboration (NCD-RisC). *Rising rural body-mass index is the main driver of the global obesity epidemic in adults. Nature 2019; 569:260-264. *Collaborators on behalf of the ESTHER study: Brenner H, Saum KU, Schöttker B
225)    Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF,…, Brenner H,…, Schöttker B,…, Scholz M, Teumer A, Köttgen A, Pattaro C. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics 2019; 51:957-972. 
226)    Obazee O, Archibugi L, Andriulli A, Soucek P, Malecka-Panas E,…, Brenner H,…, Vodicka P, Tjaden C, Iskierka-Jazdzewska E, Canzian F. Germline BRCA2 K3326X and CHEK2 I157T mutations increase risk for sporadic pancreatic ductal adenocarcinoma. International Journal of Cancer 2019; 145:686-693. 
227)    Khetan P, . , Hashim D. Occupations and the risk of head and neck cancer: A pooled analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Journal of Occupational and Environmental Medicine 2019; 61:397-404. 
228)    Campa D, Martino A, Macauda A, Dudzinski M, Suska A,…, Brenner H,…, Zaucha JM, Andersen V, Zawirska D, Canzian F. Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study. Leukemia and Lymphoma 2019; 60:1803-1811. 
229)    Perna L, Wahl HW, Weberpals J, Jansen L, Mons U, Schöttker B, Brenner H. Incident depression and mortality among people with different types of dementia: Results from a longitudinal cohort study. Social Psychiatry and Psychiatric Epidemiology 2019; 54:793-801. 
230)    Hung RJ, Spitz MR, Houlston RS, Schwartz AG, Field JK,…, Brenner H,…, Christiani DC, Amos CI, Yang P, Gorlova OY. Lung cancer risk in never smokers of European descent is associated with genetic variation in the 5P15. 33 TERT-CLPTM1L region. Journal of Thoracic Oncology 2019; 14:1360-1369. 
231)    Xuan Y, Gào X, Anusruti A, Holleczek B, Jansen EHJM, Muhlack DC, Brenner H, Schöttker B. Association of serum markers of oxidative stress with incident major cardiovascular events, cancer incidence and all-cause mortality in type 2 diabetes patients: Pooled results from two cohort studies. Diabetes Care 2019; 42:1436-1445. 
232)    Gào X, Xuan Y, Benner A, Anusruti A, Brenner H, Schöttker B. Nitric oxide metabolites and lung cancer incidence: A matched case-control study nested in the ESTHER cohort. Oxidative Medicine and Cellular Longevity 2019; 6470950. 
233)    Shu X, Wu L, Khankari NK, Shu XO, Wang TJ, Michailidou K, Bolla MK, Wang Q, Dennis J, Milne RL, Schmidt MK, Pharoah PDP, Andrulis IL, Hunter DJ, Simard J, Easton DF, Zheng W, Breast Cancer Association Consortium*. Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis. International Journal of Epidemiology 2019; 48:795-806. *Co-authors on behalf of the ESTHER study: Arndt V, Brenner H
234)    The WHO CVD Risk Chart Working Group. *World Health Organization (WHO) cardiovascular disease risk charts: revised models to estimate risk in 21 global regions. The Lancet Global Health 2019; 7:e1332-1345. *Co-authors on behalf of the ESTHER study: Brenner H, Schöttker B. 
235)    Shepshelovich D, . , Liu G. Body mass index (BMI), BMI change, and overall survival in patients with SCLC and NSCLC: A pooled analysis of the International Lung Cancer Consortium. Journal of Thoracic Oncology 2019; 14:1594-1607. 
236)    Teumer A, Li Y, Ghasemi S, Prins B, Wuttke M,…, Brenner H,…, Schöttker B,…, Kottgen A, Gerstner L, Chen M, Grundner-Culemann F. Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. Nature Communications 2019; 10:4130. 
237)    Dörk T, Peterlongo P, Mannermaa A, Bolla MK, Wang Q,…, Brenner H,…, Pharoah PDP, Schindler D, Devilee P, Easton DF. Two truncating variants in FANCC and breast cancer risk. Scientific Reports 2019; 9:12524. 
238)    Hu C, Schöttker B, Venisse N, Limousi F, Saulnier PJ, Albouy-Llaty M, Dupuis A, Brenner H, Migeot V, Hadjadj S. Bisphenol A, chlorinated dervatives of Bisphenol A and occurrence of myocardinal infarction in patients with type 2 diabetes: nested case-control studies in two European cohorts. Environmental Science & Technology 2019; 53:9876-9883. 
239)    Ooi BNS, Loh H, Ho PJ, Milne R, Giles G, Gao C, Kraft P, John EM, Swerdlow A, Brenner H, Wu AH, Haiman C, Evans DG, Zheng W, Fasching P, Castelao JE, Kwong A, Xia S, Czene K, Hall P, Dunning A, Easton DF, Hartman M, Li J. The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis. International Journal of Epidemiology 2019; 48:781-794. 
240)    Pennells L, Kaptoge S, Wood A, Sweeting M, Zhao X,…, Brenner H,…, D’Agostino Sr RBD, Thompson SG, Danesh J, Di Angelantonio E, on behalf of the Emerging Risk Factors Collaboration. Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies. European Heart Journal 2019; 40:621-631. 
241)    Escala-Garcia M, Guo Q, Dörk T, Canisius S, Keeman R,…, Arndt V,…, Brenner H,…, Holleczek B,…, Nevanlinna H, Eccles DM, Pharoah PDP, Schmidt MK. Genome-wide association study of germline variants and breast cancer-specific mortality. British Journal of Cancer 2019; 120:647-657. 
242)    Inker LA, Grams ME, Levey AS, Coresh J, Cirillo M,…, Kovesdy CP, Woodward M, Levin A, CKD Prognosis Consortium. * Relationship of estimated GFR and albuminuria to concurrent laboratory abnormalities: an indivicual participant data meta-analysis in a global consortium. American Journal of Kidney Diseases 2019; 73:206-217. *Collaborators on behalf of the ESTHER study: Brenner H, Rothenbacher D, Schöttker B, Saum KU
243)    Hohls JK, König HH, Heider D, Brenner H, Böhlen F, Matschinger H, Saum KU, Schöttker B, Haefeli WE, Hajek A, Wild B. Longitudinal association between panic disorder and health care costs in older adults. Depress Anxiety 2019; 36:1135-1142. 
244)    Adams CD, Richmond R, Ferreira DLS, Spiller W, Tan V,…, Brenner H,…, Pandha H, Thibodeau AN, Martin RM, PRACTICAL Consortium. Circulating metabolic biomarkers of screen-detected prostate cancer in the ProtecT Study. Cancer Epidemiology & Biomarkers 2019; 28:208-216. 
245)    Chang CP, Chang SC, Chuang SC, Berthiller J, Ferro G,…, Brenner H,…, Boffetta P, Zhang ZF, Hashibe M, Lee YA. Age at start of using tobacco on the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE). Cancer Epidemiology 2019; 63:101615. 
246)    Hoppe LK, Muhlack DC, Koenig W, Brenner H, Schöttker B. The associations of diuretics and laxatives use with cardiovascular mortality. An individual patient-data meta-analysis of two large cohort studies. Cardiovascular Drugs and Therapy 2019; 33:567-579. 
247)    Figlioli G, Bogliolo M, Catucci I, Caleca L, Lasheras SV,…, Arndt V,…, Brenner H,…, Couch F, Nevanlinna H, Surrallés J, Peterlongo P. The FANCM:p. Arg658* truncating variant is associated with risk of triple-negative breast cancer. npj Breast Cancer 2019; 5:38. 
248)    Brunner FJ, Waldeyer C, Ojeda F, Salomaa V, Kee F,…, Brenner H,…, Omland T, Kuulasmaa K, Landmesser U, Blankenberg S. Application of Non-HDL-Cholesterol for population-based cardiovascular risk stratification. Results from the Multinational Cardiovascular Risk Consortium. Lancet 2019; 394:2173-2183.

2018
249)    Campa D, Pastore M, Capurso G, Hackert T, Di Leo M,…, Brenner H,…, Oliverius M, Pezzilli R, Landi S, Canzian F. Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation. International Journal of Cancer 2018; 142:290-296. 
250)    Seibert TM, Fan CC, Wang Y, Zuber V, Karunamuni R,…, Brenner H,…, Andreassen OA, Dale AM, The PRACTICAL Consortium. Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large-scale cohorts. BMJ 2018; 360:j5757. 
251)    Klein AP, Wolpin BM, Risch HA, Stolzenberg-Solomon RZ, Mocci E,…, Brenner H,…, Chanock S, Obazee O, Petersen GM, Amundadottir TL. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Nature Communications 2018; 9:556. 
252)    Ordóñez-Mena JM, ... , Brenner H, on behalf of the Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES). Impact of prediagnostic smoking and smoking cessation on colorectal cancer prognosis: a meta-analysis of individual patient data from cohorts within the CHANCES consortium. Annals of Oncology 2018; 29:472-483. 
253)    Hajek A, Bock JO, Saum KU, Matschinger H, Brenner H, Holleczek B, Haefeli WE, Heider D, König HH. Frailty and health care costs – longitudinal results of a prospective cohort study. Age and Ageing 2018; 47:233-241. 
254)    Wood AM, ... , for the Emerging Risk Factors Collaboration/EPIC-CVD/UK Biobank Alcohol Study Group. Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599912 current drinkers in 83 prospective studies. Lancet 2018; 391:1513-1523. 
255)    Vijayakrishnan J, ... , The PRACTICAL consortium*, et al. Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. Nature Communications 2018; 9:1340. *Collaborator from DKFZ: Brenner H, 
256)    Zhang Y, Saum KU, Schöttker B, Holleczek B, Brenner H. Methylomic survival predictors, frailty, and mortality. Aging 2018; 10:339-357. 
257)    Colombo M, Lòpez-Perolio I, Meeks HD, Caleca L, Parsons M,…, Arndt V,…, Brenner H,…, Spurdle AB, Goldgar DE, de la Hoya M, Radice P. The BRCA2 c. 68-7T>A variant is not pathogenic: a model for clinical calibration of spliceogenicity. Human Mutation 2018; 39:729-741. 
258)    Horne HN, Oh H, Sherman ME, Palakal M, Hewitt SM,…, Brenner H,…, Van Leeuwen FF, Van’t Veer LJ, Garcia-Closas M, Figueroa JD. E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium. Scientific Reports 2018; 8:6574. 
259)    Nabers A, Perna L, Lange J, Mons U, Schartner J, Güldenhaupt J, Saum KU, Janelidze S, Holleczek B, Rujescu D, Hansson O, Gerwert K, Brenner H. Amyloid blood biomarker detects alzheimer’s disease. EMBO Molecular Medicine 2018; 10:e8763. 
260)    Painter J, O’Mara T, Morris A, Cheng T, Gorman M,…, Brenner H,…, Tomlinson I, Easton D, Thompson D, Spurdle A. Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses. Cancer Medicine 2018; 7:1978-1987. 
261)    Rudolph A, Song M, Brook MN, Milne RL, Mavaddat N,…, Brenner H, Arndt V,…, Easton DF, Chatterjee N, Chang-Claude J, Garcia-Closas M. Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium. International Journal of Epidemiology 2018; 47:526-536. 
262)    Gao X, Zhang Y, Schöttker B, Brenner H. Vitamin D status and epigenetic-based mortality risk score: strong independent and joint prediction of all-cause mortality in a population-based cohort study. Clinical Epigenetics 2018; 10:84. 
263)    Dadaev T, Saunders E, Newcombe P, Anokian E, Leongamornlert D,…, Brenner H,…, Haiman C, Eeles R, Conti D, Kote-Jarai Z. Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. Nature Communications 2018; 9:2256. 
264)    Gào X, Brenner H, Holleczek B, Cuk K, Zhang Y, Anusruti A, Xuan Y, Xu Y, Schöttker B. Urinary 8-isoprostane levels and occurrence of lung, colorectal, prostate, breast and overall cancer: Results from a large, population-based cohort study with 14 years of follow-up. Free Radical Biology & Medicine 2018; 123:20-26. 
265)    Abubakar M, ... , Brenner H, et al. Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation. International Journal of Cancer 2018; 143:746-757. 
266)    Hajek A, Bock JO, Saum KU, Schöttker B, Brenner H, Heider D, König HH. Unterschiede in der Morbidität nach Krankenversichertenstatus im Alter. Das Gesundheitswesen 2018; 80:551-556. 
267)    O’Mara TA, Glubb DM, Amant F, Annibali D, Ashton K,…, Brenner H,…, Tomlinson I, Easton DF, Spurdle AB, Thompson DJ. Identification of nine new susceptibility loci for endometrial cancer. Nature Communications 2018; 9:3166. 
268)    Shi J, Wu L, Zheng W, Wen W, Wang S, Shu X, Long J, Shen CY, Wu PE, Saloustros E, Chang-Claude J, Brenner H, Shu XO, Cai Q. Genetic evidence for the association between schizophrenia and breast cancer. Journal of Psychiatry and Brain Science 2018; 3:7. 
269)    Went M, Sud A, Försti A, Halvarsson BM, Weinhold N,…, the PRACTICAL consortium*,…, Morgan GJ, Hemminki K, Nilsson B, Houlston RS. Identification of multiple risk loci and regulatory mechnisms influencing susceptibility to multiple myeloma. Nature Communications 2018; 9:3707. *Collaborator from DKFZ: Brenner H
270)    Schumacher FR, Al Olama AA, Berndt SI, Benlloch S, Ahmed M,…, Brenner H,…, Henderson BE, Kote-Jarai Z, Haiman CA, Eeles RA. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Nature Genetics 2018; 50:928-936. 
271)    Wu L, Shi W, Long J, Guo X, Michailidou K,... , Arndt V,…, Brenner H,…, Kraft P, Easton DF, Chenevix-Trench G, Zheng W. A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. Nature Genetics 2018; 50:968-978. 
272)    Heinrichs SKM,…, Brenner H, et al. Evidence for PTGER4, PSCA and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level. Cancer Medicine 2018; 7:5057-5065. 
273)    Gao X, Zhang Y, Mons U, Brenner H. Leukocyte telomere length and epigenetic-based mortality risk score: associations with all-cause mortality among older adults. Epigenetics 2018; 13:846-857. 
274)    Matejcic M, Saunders E, Dadaev T, Brook M, Wang K,…, Brenner H,…, Eeles R, Kote-Jarai Z, Conti D, Haiman C. Germline variation at 8q24 and prostate cancer risk in men of European ancestry. Nature Communications 2018; 9:4616. 
275)    NCD Risk Factor Collaboration (NCD-RisC)*. Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88. 6 million participants. International Journal of Epidemiology 2018; 47:872-883i. *Collaborators on behalf of the ESTHER study: Brenner H, Saum KU, Schöttker B
276)    Muhlack DC, Hoppe LK, Stock C, Haefeli WE, Brenner H, Schöttker B. The associations of geriatric syndromes and other patient characteristics with the current and future use of potentially inappropriate medications in a large cohort study. European Journal of Clinical Pharmacology 2018; 74:1633-1644. 
277)    Xuan Y, Gào X, Holleczek B, Brenner H, Schöttker B. Prediction of myocardial infarction, stroke and cardiovascular mortality with urinary biomarkers of oxidative stress: Results from a large cohort study. International Journal of Cardiology 2018; 273:223-229. 
278)    Lin HY, ... , the PRACTICAL consortium, Park JY. AA9int: SNP interaction pattern search using non-hierarchical additive model set. Bioinformatics 2018; 34:4141-4150. 
279)    Parmar P, Lowry E, Cugliari G, Sudermann M, Wilson R,…, Zhang Y,…, Schöttker B,…, Brenner H, Verweij N, Li S, Chambers JC, Järvelin MR, Sebert S, for the GLOBAL Meth QTL consortium. Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults. EBioMedicine 2018; 38:206-216.

2017 
280)    Taylor AE, Martin RM, Geybels MS, Stanford JL, Shui I, ... , Brenner H, ... . Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis. International Journal of Cancer 2017; 140:322-328. 
281)    Brunner C, Davies NM, Martin RM, Eeles R, Easton DF,…, Brenner H,…, Teixeira MR, Pandha H, the PRACTICAL Consortium, Zuccolo L. Alcohol consumption and prostate cancer incidence and progression: a Mendelian randomization study. Int J Cancer 2017; 140:75-85. 
282)    Jankovic N, Geelen A, Winkels RM, Mwungura B, Fedirko V, ... ,  Brenner H, ... . Adherence to the WCRF/AICR dietary recommendations for cancer prevention and risk of cancer in elderly from Europe and the United States: A Meta-Analysis within the CHANCES project. Cancer Epidemiology, Biomarkers and Prevention 2017; 26:136-144. 
283)    Skender S, Böhm J, Schrotz-King P, Chang-Claude J, Siegel EM, Steindorf K, Owen RW, Ose J, Hoffmeister M, Brenner H, Ulrich CM. Plasma 25-hydroxyvitamin D3 levels in colorectal cancer patients and associations with physical activity. Nutrition and Cancer 2017; 69:229-237. 
284)    Zhang Y, Hapala J, Brenner H, Wagner W. Individual CpG sites that are associated with age and life expectancy become hypomethylated upon aging. Clinical Epigenetics 2017; 9:9. 
285)    Katsoulis M, Benetou V, Karapetyan T, Feskanich D, Grodstein F, Kymmer U, Eriksson S, Wilsgaard T, Jorgensen L, Ahmed L, Schöttker B, Brenner H, Bellavia A, Wolk A, Kubinova R, Stegeman B, Bobak M, Boffetta P, Trichopoulou A. Excess mortality after hip fractures in elderly from Europe and United States: the CHANCES project. Journal of Internal Medicine 2017; 281:300-310. 
286)    Muhlack DC, Hoppe LK, Weberpals J, Brenner H, Schöttker B. Association of potentially inappropriate medication at older age with cardiovascular events and overall mortality: a systematic review and meta-analysis of cohort studies. Journal of the American Medical Directors Association 2017; 18:211-220. 
287)    Saum KU, Schöttker B, Meid A, Holleczek B, Haefeli W, Hauer K, Brenner H. Is polypharmacy associated with frailty in older people? Results from the ESTHER Cohort Study. Journal of the American Geriatrics Society 2017; 65:e27-e32. 
288)    Gao X, Zhang Y, Saum KU, Schöttker B, Breitling LP, Brenner H. Tobacco smoking and smoking-related DNA methylation are associated with the development of frailty among older adults. Epigenetics 2017; 12:149-156. 
289)    Fehringer G, Brenner DR, Zhang ZF, Lee YCA, Matsuo K,…, Brenner H,…, Consonni D, Olsson A, Straif K, Hung RJ. Alcohol and lung cancer risk among never smokers: a pooled analysis from the International Lung Cancer Consortium and the SYNERGY study. International Journal of Cancer 2017; 140:1976-1984. 
290)    Walter V, Jansen L, Knebel P, Chang-Claude J, Hoffmeister M, Brenner H. Physical activity and survival of colorectal cancer patients: population-based study from Germany. International Journal of Cancer 2017; 140:1985-1997. 
291)    Hajek A, Bock J-O, Brenner H, Saum K-U, Matschinger H, Haefeli WE, Quinzler R, Heider D, König H-H. Welche Faktoren beeinflussen die privaten Zuzahlungen zu Gesundheitsleistungen im Alter? Ergebnisse einer Längsschnittstudie. Das Gesundheitswesen 2017; 79:e18-e25. 
292)    Berendsen A, Kang J, van de Rest O, Jankovic N, ... , Brenner H, ... . Association of adherence to a healthy diet with cognitive decline in European and American older adults: a meta-analysis within the CHANCES consortium. Dementia and Geriatric Cognitive Disorders 2017; 43:215-227. 
293)    Zhang Y, Wilson R, Heiss J, Breitling LP, Saum KU, Schöttker B, Holleczek B, Waldenberger M, Peters A, Brenner H. DNA methylation signatures in peripheral blood strongly predict all-cause mortality. Nature Communications 2017; 8:14617. 
294)    Zuber V, Bettella F, Witoelar A, PRACTICAL Consortium*, CRUK GWAS, BCAC Consortium, TRICL Consortium, Andreassen OA, Mills IG, Urbanucci A. Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer. BMC Genomics 2017; 18:270. *Collaborator from DKFZ: Brenner H
295)    Steele CJ, Schöttker B, Marshall AH, Kouvonen A, O’Doherty MG, Mons U, Saum KU, Boffetta P, Trichopoulou A, Brenner H*, Kee F*. Education achievement and type 2 diabetes – What mediates the relationship in older adults? Data from the ESTHER study: a population-based cohort study. BMJ Open 2017; 0:e013569. *shared last authorship
296)    Mayer T, Meid AD, Saum KU, Brenner H, Schöttker B, Seidling HM, Haefeli WE. Comparison of nine instruments to calculate anticholinergic load in a large cohort of older outpatients: association with cognitive and functional decline, falls, and use of laxatives. American Journal of Geriatric Psychiatry 2017; 25:531-540. 
297)    NCD Risk Factor Collaboration (NCD-RisC)*. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1,479 population-based measurement studies with 19. 1 million participants. The Lancet 2017; 389:37-*Collaborators on behalf of the ESTHER study: Brenner H, Saum KU. 
298)    Ordóñez-Mena JM, Maalmi H, Schöttker B, Saum KU, Holleczek B, Wang TJ, Burwinkel B, Brenner H. Genetic variants in the vitamin D pathway, 25(OH)D levels, and mortality in a large population-based cohort study. Journal of Clinical Endocrinology & Metabolism 2017; 102:470-477. 
299)    Sluik D, Jankovic N, Hughes M, O’Doherty MG, Schöttker B,…, Brenner H,…,. Alcoholic beverage preference and diabetes incidence across Europe: the Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES) project. European Journal of Clinical Nutrition 2017; 71:659-668. 
300)    Lin HY, Chen DT, Huang PY, Liu YH, Ochoa A,…, Brenner H,…, Pandha H, Lu YJ, the PRACTICAL consortium, Park JY. SNP interaction pattern identifier (SIPI): An intensive search for SNP-SNP interaction patterns. Bioinformatics 2017; 33:822-833. 
301)    Freisling H, Arnold M, Soerjomataram I, O’Doherty M, Ordóñez-Mena J, ... , Brenner H, ... . Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe. British Journal of Cancer 2017; 116:1486-1497. 
302)    Ben Khedher S, Neri M, Papadopoulos A, Christiani DC, Diao N, ... , Brenner H, Saum KU, ... . Menstrual and reproductive factors and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium (ILCCO). International Journal of Cancer 2017; 141:309-323. 
303)    Muranen TA, Greco D, Blomqvist C, Aittomäki K, Khan S,…, Brenner H, Arndt V,…, Dennis J, Easton DF, Schmidt MK, Nevanlinna H. Genetic modifiers of CHEK2*1100delC associated breast cancer risk. Genetics in Medicine 2017; 19:599-603. 
304)    Shimelis H, Mesman RLS, Von Nicolai C, Ehlen A, Guidugli L,…, Arndt V,…, Brenner H,…, Goldgar DE, Carreira A, Vreeswijk MPG, Couch FJ. BRCA2 hypomorphic missense variants confer moderate risks of breast cancer. Cancer Research 2017; 77:2789-2799. 
305)    Schöttker B, Saum KU, Muhlack DC, Hoppe LK, Holleczek B, Brenner H. Polypharmacy and mortality: new insights from a large cohort of older adults by detection of effect modification by multi-morbidity and comprehensive correction of confounding by indication. European Journal of Clinical Pharmacology 2017; 73:1041-1048. 
306)    Brenner H, Jansen L, Saum KU, Holleczek B, Schöttker B. Vitamin D supplementation trials aimed at reducing mortality have much higher power when focusing on people with low serum 25-hydroxyvitamin D concentrations. Journal of Nutrition 2017; 147:1325-1333. 
307)    Gao X, Gào X, Zhang Y, Breitling LP, Schöttker B, Brenner H. Associations of self-reported smoking, cotinine levels and epigenetic smoking indicators with oxidative stress among older adults: a population-based study. European Journal of Epidemiology 2017; 32:443-456. 
308)    Thomas B, Matsushita K, Abate KH, Al-Aly Z, Ärnlöv J,…, Brenner H,…, Schöttker B,…, Vos T, Global Burden of Disease 2013 GFR Collaborators, CKD Prognosis Consortium, Global Burden of Disease Genitourinary Expert Group. Global cardiovascular and renal outcomes of reduced GFR. Journal of the American Society of Nephrology 2017; 28:2167-2179. 
309)    Ordóñez-Mena JM, Schöttker B, Saum KU, Holleczek B, Burwinkel B, Wang TJ, Brenner H. No association of vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults. Cancer Epidemiology, Biomarkers & Prevention 2017; 26:1459-1461. 
310)    Gao X, Thomsen H, Zhang Y, Breitling LP, Brenner H. The impact of methylation quantitative trait loci (mQTLs) on active smoking-related DNA methylation changes. Clinical Epigenetics 2017; 9:87. 
311)    Bamia C, Orfanos P, Juerges H, Schöttker B, Brenner H... . Self-rated health and all-cause and cause-specific mortality of older adults. Individual data meta-analysis of prospective cohort studies participating in the CHANCES Consortium. Maturitas 2017; 103:37-44. 
312)    Lophatananon A, Stewart-Brown S, Kote-Jarai Z, Al Olama AA, Benlloch Garcia S, ... , Brenner H, ... . , Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium. British Journal of Cancer 2017; 117:734-743. 
313)    Matsushita K, Ballew SH, Coresh J, Arima H, Ärnlöv J, ... . Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data. Lancet Diabetes & Endocrinology 2017; 5:718-728. Collaborators from the ESTHER study: Brenner H, Schöttker B, Rothenbacher D, Saum KU
314)    Meistere I, Werner S, Zayakin P, Siliņa K, Rulle U, Pismennaja A, Šantare D, Kikuste I, Isajevs S, Leja M, Kupčinskas L, Kupčinskas J, Jonaitis L, Wu CY, Brenner H, Linē A, Kalniņa Z. The prevalence of cancer-associated autoantibodies in patients with gastric cancer and progressive grades of premalignant lesions. Cancer Epidemiology, Biomarkers & Prevention 2017; 26:1564-1574. 
315)    Gu F, Zhang H, Hyland PL, Berndt S, Gapstur SM, ... , Brenner H, ... . Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia. International Journal of Cancer 2017; 141:1794-1802. 
316)    Barrdahl M, Rudolph A, Hopper JL, Southey MC, Broeks A,…, Brenner H, Arndt V,…, Garcia-Closas M, Easton DF, Milne RL, Chang-Claude J. Gene-environment interactions involving functional variants: results from the Breast Cancer Association Consortium. International Journal of Cancer 2017; 141:1830-1840. 
317)    Gao X, Zhang Y, Brenner H. Associations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic ageing in older adults. British Journal of Cancer 2017; 117:1211-1214. 
318)    Boehlen FH, Herzog W, Schellberg D, Maatouk I, Saum KU, Brenner H, Wild B. Self-perceived coping resources of middle-aged and older adults – results of a large population-based study. Aging and Mental Health 2017; 21:1303-1309. 
319)    Maddock J, Zhou A, Cavadino A, Kuzma E, Bao Y,…, Brenner H, Kumari M, Power C, Llewellyn DJ, Hyppönen E. Vitamin D and cognitive function: A mendelian randomisation study. Scientific Reports 2017; 7:13230. 
320)    Mons U, Müezzinler A, Schöttker B, Dieffenbach AK, Butterbach K, Schick M, Peasey A, De Vivo I, Trichopoulou A, Boffetta P, Brenner H. Leukocyte telomere length and all-cause, cardiovascular disease, and cancer mortality: Results from individual participant-data meta-analysis of two large prospective cohort studies. American Journal of Epidemiology 2017; 185:1317-1326. 
321)    Dimitrakopoulou VI, ... , and TRICL-ILCCO. Circulating vitamin D concentration and risk of seven cancers: Mendelian randomization study. The BMJ 2017; 359:j4761. 
322)    Michailidou K, Lindström S, Dennis J, Beesley J, Hui S,…, Arndt V,…, Brenner H,…, Chenevix-Trench G, Simard J, Kraft P, Easton DF. Association analysis identifies 65 new breast cancer risk loci. Nature 2017; 551:92-94. 
323)    Brouckaert O, Rudolph A, Laenen A, Keeman R, Bolla MK,…, Arndt V,…, Brenner H,…, Garcia-Closas M, Chang-Claude J, Lambrechts D, Neven P. Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study. Breast Cancer Research 2017; 19:119. 
324)    Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S,…, Arndt V,…, Brenner H,…, Chenevix-Trench G, Garcia-Closas M, Schmidt MK, Antoniou AC, Simard J. Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Nature Genetics 2017; 49: 1767-1778
325)    Bock JO, Hajek A, Brenner H, Saum KU, Matschinger H, Haefeli WE, Schöttker B, Quinzler R, Heider D, König HH. A longitudinal investigation of willingness to pay for health insurance in Germany. Health Services Research 2017; 52:1099-1117. 
326)    Papadimitriou N, Tsilidis KK, Orfanos P, Benetou V, Ntzani EE, ... , Brenner H, Schöttker B, Saum KU, Holleczek B, ... . Burden of hip fracture using disability-adjusted life-years: a pooled analysis of prospective cohorts in the CHANCES consortium. Lancet Public Health 2017; 2:e239-246. 
327)    NCD Risk Factor Collaboration (NCD-RisC). *Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128. 9 million children, adolescents, and adults. The Lancet 2017; 390:2627-2642. *Collaborators on behalf of the ESTHER study: Brenner H, Saum KU

2016
328)    Bock JO, König HH, Brenner H, Haefeli WE, Quinzler R, Matschinger H, Saum KU, Schöttker B, Heider D. Associations of frailty with health care costs - results of the ESTHER cohort study. BMC Health Serv Res. 2016 Apr 14;16(1):128. 
329)    Bock JO, Heider D, Matschinger H, Brenner H, Saum KU, Haefeli WE, Konig HH. Willingness to pay for health insurance among the elderly population in Germany. Eur J Health Econ. 2016 Mar;17(2):149-58. 
330)    Boehlen FH, Herzog W, Maatouk I, Saum KU, Brenner H, Wild B. [Treatment preferences of elderly patients with mental disorders]. Z Gerontol Geriatr. 2016 Feb;49(2):120-5. doi:10. 1007/s00391-015-0908-x. 
331)    Bonilla C, Lewis SJ, Martin RM, […], Brenner H et al. Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort. BMC Med. 2016 Apr 4;14:66. 
332)    Bonilla C, Lewis SJ, Rowlands MA, […], Brenner H et al. Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels. Int J Cancer. 2016 Oct 1;139(7):1520-33. 
333)    Breitling LP, Saum KU, Perna L, Schöttker B, Holleczek B, Brenner H. Frailty is associated with the epigenetic clock but not with telomere length in a German cohort. Clin Epigenetics. 2016;8:21. 
334)    Breitling LP, Saum KU, Schöttker B, Holleczek B, Herth FJ, Brenner H. Pneumonia in the Noninstitutionalized Older Population. Dtsch Arztebl Int. 2016 Sep 16;113(37):607-14. 
335)    Brück K, Stel VS, Gambaro G, […], Brenner H et al. European CKD Burden Consortium. CKD Prevalence Varies across the European General Population. J Am Soc Nephrol. 2016 Jul;27(7):2135-47. 
336)    Bull CJ, Bonilla C, Holly JM, […], Brenner H et al. Blood lipids and prostate cancer: a Mendelian randomization analysis. Cancer Med. 2016 Jun;5(6):1125-36. 
337)    Chen LS, Baker T, Hung RJ, Horton A, […], Brenner H et al. Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis. EBioMedicine. 2016 Sep;11:219-26. 
338)    Chen XZ, Schöttker B, Castro FA, Chen H, Zhang Y, Holleczek B, Brenner H. Association of helicobacter pylori infection and chronic atrophic gastritis with risk of colonic, pancreatic and gastric cancer: A ten-year follow-up of the ESTHER cohort study. Oncotarget. 2016 Mar 29;7(13):17182-93. 
339)    Fehringer G, Kraft P, Pharoah PD, […], Brenner H et al. Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. Cancer Res. 2016 Sep 1;76(17):5103-14. 
340)    Florath I, Butterbach K, Heiss J, Bewerunge-Hudler M, Zhang Y, Schöttker B, Brenner H. Type 2 diabetes and leucocyte DNA methylation: an epigenome-wide association study in over 1,500 older adults. Diabetologia. 2016 Jan;59(1):130-8. 
341)    Fuchs J, Scheidt-Nave C, Gaertner B, Dapp U, von Renteln-Kruse W, Saum KU, Thorand B, Strobl R, Grill E. [Frailty in Germany: status and perspectives : Results from a workshop of the German Society for Epidemiology]. Z Gerontol Geriatr. 2016 Dec;49(8):734-42. doi:10. 1007/s00391-015-0999-4. 
342)    Gao X, Mons U, Zhang Y, Breitling LP, Brenner H. DNA methylation changes in response to active smoking exposure are associated with leukocyte telomere length among older adults. Eur J Epidemiol. 2016 Dec;31(12):1231-41. 
343)    Gao X, Zhang Y, Breitling LP, Brenner H. Tobacco smoking and methylation of genes related to lung cancer development. Oncotarget. 2016 Sep 13;7(37):59017-28. 
344)    Gao X, Zhang Y, Breitling LP, Brenner H. Relationship of tobacco smoking and smoking-related DNA methylation with epigenetic age acceleration. Oncotarget. 2016 Jul 26;7(30):46878-89. 
345)    Gusev A, Shi H, Kichaev G, Pomerantz M, […], Brenner H et al. The PRACTICAL Consortium. Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation. Nat Commun. 2016 Apr 7;7:10979. 
346)    Hajek A, Bock JO, Saum KU, Schöttker B, Brenner H, Heider D, Konig HH. [Morbidity Differences by Health Insurance Status in Old Age]. Gesundheitswesen. 2016 Jun 28. 
347)    Kar SP, Beesley J, Amin Al Olama A, [... ], Brenner H et al. The PRACTICAL Consortium. Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. Cancer Discov. 2016 Sep;6(9):1052-67. 
348)    Khankari NK, Murff HJ, Zeng C, […], Brenner H et al. The PRACTICAL Consortium. Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium. Br J Cancer. 2016 Aug 23;115(5):624-31. 
349)    Lechner S, Herzog W, Boehlen F, Maatouk I, Saum KU, Brenner H, Wild B. Control preferences in treatment decisions among older adults - Results of a large population-based study. J Psychosom Res. 2016 Jul;86:28-33. 
350)    Maatouk I, Herzog W, Bohlen F, Quinzler R, Lowe B, Saum KU, Brenner H, Wild B. Association of hypertension with depression and generalized anxiety symptoms in a large population-based sample of older adults. J Hypertens. 2016 Sep;34(9):1711-20. 
351)    Meid AD, Quinzler R, Groll A, Wild B, Saum KU, Schöttker B, Heider D, Konig HH, Brenner H, Haefeli WE. Longitudinal evaluation of medication underuse in older outpatients and its association with quality of life. Eur J Clin Pharmacol. 2016 Jul;72(7):877-85. 
352)    Muezzinler A, Mons U, Dieffenbach AK, Butterbach K, Saum KU, Schick M, Stammer H, Boukamp P, Holleczek B, Stegmaier C, Brenner H. Body mass index and leukocyte telomere length dynamics among older adults: Results from the ESTHER cohort. Exp Gerontol. 2016 Feb;74:1-8. doi:10. 1016/j. exger. 2015. 11. 019. 
353)    NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4. 4 million participants. Lancet. 2016 Apr 9;387(10027):1513-30. 
354)    NCD Risk Factor Collaboration (NCD-RisC). Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19. 2 million participants. Lancet. 2016 Apr 2;387(10026):1377-96. 
355)    NCD Risk Factor Collaboration (NCD-RisC). A century of trends in adult human height. Elife. 2016 Jul 26;5. 
356)    O'Doherty MG, Cairns K, O'Neill V, Lamrock F, Jorgensen T, Brenner H, Schöttker B, Wilsgaard T, Siganos G, Kuulasmaa K, Boffetta P, Trichopoulou A, Kee F. Effect of major lifestyle risk factors, independent and jointly, on life expectancy with and without cardiovascular disease: results from the Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES). Eur J Epidemiol. 2016 May;31(5):455-68. 
357)    Ordóñez-Mena JM, Schöttker B, Mons U, […], Brenner H; Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES). Quantification of the smoking-associated cancer risk with rate advancement periods: meta-analysis of individual participant data from cohorts of the CHANCES consortium. BMC Med. 2016 Apr 5;14(1):62. 
358)    Ordonez-Mena JM, Schöttker B, Fedirko V, Jenab M, Olsen A, Halkjaer J, Kampman E, de Groot L, Jansen E, Bueno-de-Mesquita HB, Peeters PH, Siganos G, Wilsgaard T, Perna L, Holleczek B, Pettersson-Kymmer U, Orfanos P, Trichopoulou A, Boffetta P, Brenner H. Pre-diagnostic vitamin D concentrations and cancer risks in older individuals: an analysis of cohorts participating in the CHANCES consortium. Eur J Epidemiol. 2016 Mar;31(3):311-23. 
359)    Perna L, Mons U, Rujescu D, Kliegel M, Brenner H. Apolipoprotein E e4 and Cognitive Function: A Modifiable Association Results from Two Independent Cohort Studies. Dement Geriatr Cogn Disord. 2016;41(1-2):35-45. 
360)    Perna L, Zhang Y, Mons U, Holleczek B, Saum KU, Brenner H. Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort. Clin Epigenetics. 2016;8:64. 
361)    Schmidt MK, Hogervorst F, van Hien R, […], Brenner H et al. Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers. J Clin Oncol. 2016 Aug 10;34(23):2750-60. 
362)    Schöttker B, Rathmann W, Herder C, Thorand B, Wilsgaard T, Njolstad I, Siganos G, Mathiesen EB, Saum KU, Peasey A, Feskens E, Boffetta P, Trichopoulou A, Kuulasmaa K, Kee F, Brenner H. HbA1c levels in non-diabetic older adults - No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confounders in a meta-analysis of individual participant data from six cohort studies. BMC Med. 2016 Feb 11;14:26. 
363)    Schöttker B, Saum KU, Jansen EH, Holleczek B, Brenner H. Associations of metabolic, inflammatory and oxidative stress markers with total morbidity and multi-morbidity in a large cohort of older German adults. Age Ageing. 2016 Jan;45(1):127-35. 
364)    Shi J, Park JH, Duan J, Berndt ST, […], Brenner H et al. Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data. PLoS Genet. 2016 Dec;12(12):e1006493. 
365)    Walter V, Jansen L, Hoffmeister M, Ulrich A, Roth W, Blaker H, Chang-Claude J, Brenner H. Prognostic relevance of prediagnostic weight loss and overweight at diagnosis in patients with colorectal cancer. Am J Clin Nutr. 2016 Oct;104(4):1110-20. 
366)    Walter V, Jansen L, Ulrich A, Roth W, Blaker H, Chang-Claude J, Hoffmeister M, Brenner H. Alcohol consumption and survival of colorectal cancer patients: a population-based study from Germany. Am J Clin Nutr. 2016 Jun;103(6):1497-506. 
367)    Zhang Y, Florath I, Saum KU, Brenner H. Self-reported smoking, serum cotinine, and blood DNA methylation. Environ Res. 2016 Apr;146:395-403.

2015
368)    Amin Al Olama A, Benlloch S, Antoniou AC, […], Brenner H et al. Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci. Cancer Epidemiol Biomarkers Prev. 2015 Jul;24(7):1121-9. 
369)    Amin Al Olama A, Dadaev T, Hazelett DJ, […], Brenner H et al. Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans. Hum Mol Genet. 2015 Oct 1;24(19):5589-602. 
370)    Benetou V, Orfanos P, Feskanich D, Michaelsson K, Pettersson-Kymmer U, Ahmed LA, Peasey A, Wolk A, Brenner H, Bobak M, Wilsgaard T, Schöttker B, Saum KU, Bellavia A, Grodstein F, Klinaki E, Valanou E, Papatesta EM, Boffetta P, Trichopoulou A. Education, marital status, and risk of hip fractures in older men and women: the CHANCES project. Osteoporos Int. 2015 Jun;26(6):1733-46. 
371)    Boehlen F, Herzog W, Quinzler R, Haefeli WE, Maatouk I, Niehoff D, Saum KU, Brenner H, Wild B. Loneliness in the elderly is associated with the use of psychotropic drugs. Int J Geriatr Psychiatry. 2015 Sep;30(9):957-64. 
372)    Bozorgmehr K, Maier W, Brenner H, Saum KU, Stock C, Miksch A, Holleczek B, Szecsenyi J, Razum O. Social disparities in Disease Management Programmes for coronary heart disease in Germany: a cross-classified multilevel analysis. J Epidemiol Community Health. 2015 Nov;69(11):1091-101. 
373)    Bozorgmehr K, San Sebastian M, Brenner H, Razum O, Maier W, Saum KU, Holleczek B, Miksch A, Szecsenyi J. Analysing horizontal equity in enrolment in Disease Management Programmes for coronary heart disease in Germany 2008-2010. Int J Equity Health. 2015 Mar 10;14:28. 
374)    Cheng TH, Thompson D, Painter J, […], Brenner H et al. Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Sci Rep. 2015 Dec 1;5:17369. 
375)    Davies NM, Gaunt TR, Lewis SJ, […], Brenner H et al. The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium. Cancer Causes Control. 2015 Nov;26(11):1603-16. 
376)    Day FR, Ruth KS, Thompson DJ, […], Brenner H et al. The BCAC Breast Cancer Association Consortium. Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet. 2015 Nov;47(11):1294-303. 
377)    Emrich IE, Pickering JW, Schöttker B, Lennartz CS, Rogacev KS, Brenner H, Rothenbacher D, Holleczek B, Saum KU, Fliser D, Heine GH. Comparison of the performance of 2 GFR estimating equations using creatinine and cystatin C to predict adverse outcomes in elderly individuals. Am J Kidney Dis. 2015 Apr;65(4):636-8. 
378)    Freigofas J, Seidling HM, Quinzler R, Schöttker B, Saum KU, Brenner H, Haefeli WE. Characteristics of medication schedules used by elderly ambulatory patients. Eur J Clin Pharmacol. 2015 Sep;71(9):1109-20. 
379)    Laitinen VH, Rantapero T, Fischer D, Vuorinen EM, Tammela TL, Wahlfors T, Schleutker J. The PRACTICAL Consortium. Fine-mapping the 2q37 and 17q11. 2-q22 loci for novel genes and sequence variants associated with a genetic predisposition to prostate cancer. Int J Cancer. 2015 May 15;136(10):2316-27. 
380)    Meid AD, Quinzler R, Freigofas J, Saum KU, Schöttker B, Holleczek B, Heider D, Konig HH, Brenner H, Haefeli WE. Medication Underuse in Aging Outpatients with Cardiovascular Disease: Prevalence, Determinants, and Outcomes in a Prospective Cohort Study. PLoS One. 2015;10(8):e0136339. 
381)    Muezzinler A, Mons U, Dieffenbach AK, Butterbach K, Saum KU, Schick M, Stammer H, Boukamp P, Holleczek B, Stegmaier C, Brenner H. Smoking habits and leukocyte telomere length dynamics among older adults: Results from the ESTHER cohort. Exp Gerontol. 2015 Oct;70:18-25. 
382)    Muezzinler A, ... , Brenner H. Smoking and All-cause Mortality in Older Adults: Results From the CHANCES Consortium. Am J Prev Med. 2015 Nov;49(5):e53-e63. 
383)    Painter JN, O'Mara TA, Batra J, […], Brenner H et al. Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. Hum Mol Genet. 2015 Mar 1;24(5):1478-92. 
384)    Perna L, Wahl HW, Mons U, Saum KU, Holleczek B, Brenner H. Cognitive impairment, all-cause and cause-specific mortality among non-demented older adults. Age Ageing. 2015 May;44(3):445-51. 
385)    Saum KU, Dieffenbach AK, Jansen EH, Schöttker B, Holleczek B, Hauer K, Brenner H. Association between Oxidative Stress and Frailty in an Elderly German Population: Results from the ESTHER Cohort Study. Gerontology. 2015;61(5):407-15. 
386)    Schöttker B, Brenner H. Vitamin D as a Resilience Factor, Helpful for Survival of Potentially Fatal Conditions: A Hypothesis Emerging from Recent Findings of the ESTHER Cohort Study and the CHANCES Consortium. Nutrients. 2015 May 6;7(5):3264-78. 
387)    Schöttker B, Brenner H, Jansen EH, Gardiner J, Peasey A, Kubinova R, Pajak A, Topor-Madry R, Tamosiunas A, Saum KU, Holleczek B, Pikhart H, Bobak M. Evidence for the free radical/oxidative stress theory of ageing from the CHANCES consortium: a meta-analysis of individual participant data. BMC Med. 2015 Dec 15;13:300. 
388)    Schöttker B, Saum KU, Jansen EH, Boffetta P, Trichopoulou A, Holleczek B, Dieffenbach AK, Brenner H. Oxidative stress markers and all-cause mortality at older age: a population-based cohort study. J Gerontol A Biol Sci Med Sci. 2015 Apr;70(4):518-24. 
389)    Schöttker B, Zhang Y, Heiss JA, Butterbach K, Jansen EH, Bewerunge-Hudler M, Saum KU, Holleczek B, Brenner H. Discovery of a novel epigenetic cancer marker related to the oxidative status of human blood. Genes Chromosomes Cancer. 2015 Sep;54(9):583-94. 
390)    Stegeman S, Amankwah E, Klein K, […], Brenner H et al. A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer. Cancer Discov. 2015 Apr;5(4):368-79. 
391)    Szulkin R, Karlsson R, Whitington T, […], Brenner H et al. Genome-wide association study of prostate cancer-specific survival. Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1796-800. 
392)    Szulkin R, Whitington T, Eklund M, […], Brenner H et al. Prediction of individual genetic risk to prostate cancer using a polygenic score. Prostate. 2015 Sep;75(13):1467-74. 
393)    Vart P, Bakker SJ, Schöttker B, de Zeeuw D, Rothenbacher D, Brenner H, Heerspink HJ, Saum KU, Reijneveld SA, Bültmann U, Koenig W, Gansevoort RT. Relevance of correction for drift and day-to-day variation in cystatin C measurement: a post-hoc analysis of the PREVEND cohort, with independent replication in the ESTHER cohort. Clin Chem Lab Med. 2015 Aug;53(9):1381-90. 
394)    Walter V, Jansen L, Hoffmeister M, Ulrich A, Chang-Claude J, Brenner H. Smoking and survival of colorectal cancer patients: population-based study from Germany. Int J Cancer. 2015 Sep 15;137(6):1433-45. doi:10. 1002/ijc. 29511. 
395)    Winn DM, Lee YC, Hashibe M, Boffetta P. The INHANCE consortium: toward a better understanding of the causes and mechanisms of head and neck cancer. Oral Dis. 2015 Sep;21(6):685-93. 
396)    Zhang Y, Schöttker B, Ordonez-Mena J, Holleczek B, Yang R, Burwinkel B, Butterbach K, Brenner H. F2RL3 methylation, lung cancer incidence and mortality. Int J Cancer. 2015 Oct 1;137(7):1739-48.

2014
397)    Agarwal D, Pineda S, Michailidou K, [... ], Brenner H, Dieffenbach AK, Arndt V, Stegmaier C et al. FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium. Br J Cancer. 2014 Feb 18; 110(4): 1088–1100. Published online 2014 Feb 18. 
398)    Al Olama AA, Kote-Jarai Z, Berndt SI, […], Brenner H et al. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nat Genet. 2014 Oct;46(10):1103-9. 
399)    Bock JO, Matschinger H, Brenner H, Wild B, Haefeli WE, Quinzler R, Saum KU, Heider D, König HH. Inequalities in out-of-pocket payments for health care services among elderly Germans--results of a population-based cross-sectional study. Int J Equity Health. 2014 Jan 8;13(1):3. 
400)    The Emerging Risk Factors Collaboration*. Glycated hemoglobin measurement and prediction of cardiovascular disease. JAMA. 2014 Mar 26;311(12):1225-33. doi: 10. 1001/jama. 2014. 1873. Authors on behalf of the ESTHER study: Brenner H. 
401)    Florath I, Butterbach K, Muller H, Bewerunge-Hudler M, Brenner H. Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites. Hum Mol Genet. 2014 Mar 1;23(5):1186-201. 
402)    Hazelett DJ, Rhie SK, Gaddis M, Yan C, Lakeland DL, Coetzee SG, Henderson BE, Noushmehr H, Cozen W, Kote-Jarai Z, Eeles RA, Easton DF, Haiman CA, Lu W, Farnham PJ, Coetzee GA. The PRACTICAL Consortium. Comprehensive functional annotation of 77 prostate cancer risk loci. PLoS Genet. 2014 Jan;10(1):e1004102. 
403)    Heider D, Matschinger H, Müller H, Saum KU, Quinzler R, Haefeli WE, Wild B, Lehnert T, Brenner H, König HH. Health care costs in the elderly in Germany: an analysis applying Andersen's behavioral model of health care utilization. BMC Health Serv Res. 2014 Feb 14;14:71. 
404)    Jansen L, Hoffmeister M, Arndt V, Chang-Claude J, Brenner H. Stage-specific associations between beta blocker use and prognosis after colorectal cancer. Cancer. 2014 Apr 15;120(8):1178-86. 
405)    Koch L, Bertram H, Eberle A, Holleczek B, Schmid-Hopfner S, Waldmann A, Zeissig SR, Brenner H, Arndt V. Fear of recurrence in long-term breast cancer survivors-still an issue. Results on prevalence, determinants, and the association with quality of life and depression from the cancer survivorship--a multi-regional population-based study. Psychooncology. 2014 May;23(5):547-54. 
406)    Leoncini E, Ricciardi W, Cadoni G, […], Brenner H et al. Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium. Eur J Epidemiol. 2014 Jan;29(1):35-48. 
407)    Milne RL, Herranz J, Michailidou K, […], Brenner H et al. A large-scale assessment of two-way SNP interactions in breast cancer suceptibility using 46. 450 cases and 42. 461 controls from the Breast Cancer Association Consortium. Hum Mol Genet. 2014 Apr 1;23(7):1934-46. 
408)    O'Doherty MG, ... , Brenner H, Schöttker B, ... , Kee F. Repeated measures of body mass index and C-reactive protein in relation to all-cause mortality and cardiovascular disease: results from the consortium on health and ageing network of cohorts in Europe and the United States (CHANCES). Eur J Epidemiol. 2014 Dec;29(12):887-97. doi:10. 1007/s10654-014-9954-8. 
409)    Pennells L, Kaptoge S, White IR, Thompson SG, Wood AM; Emerging Risk Factors Collaboration. Assessing risk prediction models using individual participant data from multiple studies. Am J Epidemiol. 2014 Mar 1;179(5):621-32. 
410)    Perna L, Mons U, Kliegel M, Brenner H. Serum 25-hydroxyvitamin D and cognitive decline: a longitudinal study among non-demented older adults. Dement Geriatr Cogn Disord. 2014;38(3-4):254-63. 
411)    Saum KU, Dieffenbach AK, Müezzinler A, Müller H, Holleczek B, Stegmaier C, Butterbach K, Schick M, Canzian F, Stammer H, Boukamp P, Hauer K, Brenner H. Frailty and telomere length: Cross-sectional analysis in 3537 older adults from the ESTHER cohort. Exp Gerontol. 2014 Aug 21;58C:250-255. . 
412)    Saum KU, Dieffenbach AK, Muller H, Holleczek B, Hauer K, Brenner H. Frailty prevalence and 10-year survival in community-dwelling older adults: results from the ESTHER cohort study. Eur J Epidemiol. 2014 Mar;29(3):171-9. 
413)    Saunders EJ, Dadaev T, Leongamornlert DA, […], Brenner H et al. Fine-mapping the HOXB region detects common variants tagging a rare coding allele: evidence for synthetic association in prostate cancer. PLoS Genet. 2014 Feb;10(2):e1004129. 
414)    Schoeps A, Rudolph A, Seibold P, […], Brenner H et al. Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions. Genetic Epidemiology 2014; 38: 84-93. 
415)    Schöttker B, Saum KU, Perna L, Ordonez-Mena JM, Holleczek B, Brenner H. Is vitamin D deficiency a cause of increased morbidity and mortality at older age or simply an indicator of poor health? Eur J Epidemiol. 2014 Mar;29(3):199-210. 
416)    Wen CP, . . , and the Chronic Kidney Disease Prognosis Consortium. Relative risks of chronic kidney disease for mortality and end-stage renal disease across races are similar. Kidney Int. 2014 Feb 12. doi: 10. 1038/ki. 2013. 553. 
417)    Wild B, Eckl A, Herzog W, Niehoff D, Lechner S, Maatouk I, Schellberg D, Brenner H, Muller H, Lowe B. Assessing generalized anxiety disorder in elderly people using the GAD-7 and GAD-2 scales: results of a validation study. Am J Geriatr Psychiatry. 2014 Oct;22(10):1029-38. 
418)    Wild B, Heider D, Maatouk I, Slaets J, Konig HH, Niehoff D, Saum KU, Brenner H, Sollner W, Herzog W. Significance and costs of complex biopsychosocial health care needs in elderly people: results of a population-based study. Psychosom Med. 2014 Sep;76(7):497-502. 
419)    Zhang Y, Yang R, Burwinkel B, Breitling LP, Brenner H. F2RL3 methylation as a biomarker of current and lifetime smoking exposures. Environmental Health Perspectives 2014; 122: 131-137.

2013
420)    Perna L, Schöttker B, Holleczek B, Brenner H. Serum 25-hydroxyvitamin D and incidence of fatal and non-fatal cardiovascular events: a prospective study with repeated measurements. Journal of Clinical Endocrinology & Metabolism 2013; 98: 4908-4915. 
421)    Perna L, Hoffmeister M, Schöttker B, Arndt V, Haug U, Holleczek B, Burwinkel B, Ordonez-Mena JM, Brenner H. Vitamin D receptor polymorphism and colorectal cancer-specific and all-cause mortality. Cancer Epidemiology 2013; 37: 905-907. 
422)    Silbernagel G, Schöttker B, Appelbaum S, Scharnagl H, Kleber ME, Grammer TB, Ritsch A, Mons U, Holleczek B, Goliasch G, Niessner A, Boehm BO, Schnabel RB, Brenner H, Blankenberg S, Landmesser U, März W. High-density lipoprotein cholesterol, coronary artery disease and cardiovascular mortality. European Heart Journal 2013; 34: 3563-71. 
423)    Breitling LP, Olsen H, Müller H, Schöttker B, Kliegel M, Brenner H. Self- or physician-reported diabetes, glycemia markers, and cognitive functioning in older adults in Germany. American Journal of Geriatric Psychiatry 2013; S1064-7481(13)00282-0. 
424)    Wild B, Eckl A, Herzog W, Niehoff D, Lechner S, Maatouk I, Schellberg D, Brenner H, Müller H, Löwe B. Assessing generalized anxiety disorder in elderly people by use of the GAD-7 and GAD-2 scales - results of a validation study. American Journal of Geriatric Psychiatry 2013; S1064-7481(13)00116-4. 
425)    Matsushita K, Ballew SH, Astor BC, de Jong PE, Gansevoort RT, Hemmelgarn BR, Levey AS, Levin A, Wen C-P, Woodward M, Coresh J, and for the CKD Prognosis Consortium*. Cohort profile: the chronic kidney disease prognosis consortium. International Journal of Epidemiology 2013; 42: 1660-1668. *Authors on behalf of the ESTHER study: Rothenbacher D, Brenner H, Müller H, Schöttker B. 
426)    Yin L, Ordonez-Mena JM, Chen T, Schöttker B, Arndt V, Brenner H. Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: a systematic review and meta-analysis. Preventive Medicine 2013; 57: 753-764. 
427)    Schöttker B, Brenner H, Koenig W, Müller H, Rothenbacher D. Prognostic association of HbA1c and fasting plasma glucose with reduced kidney function in subjects with and without diabetes mellitus. Results from a population-based cohort study from Germany. Preventive Medicine 2013; 57: 596-600. 
428)    Singh GM, ... , Emerging risk Factor Collaboration (ERFC)*, Prospective Studies Collaboration (PSC). The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: A pooled analysis. PloS One 2013; 8:e65174. *Authors on behalf of the ESTHER study: Brenner H, Schöttker B, Müller H, Rothenbacher D. 
429)    Mons U, Schöttker B, Müller H, Kliegel M, Brenner H. History of lifetime smoking, smoking cessation and cognitive function in the elderly population. European Journal of Epidemiology 2013; 28:823-831. 
430)    Pesatori AC, Carugno M, Consonni D, Hung RJ, Papadoupolos A, Landi M, Brenner H, Müller H, Harris C, Duell E, Andrew A, McLaughlin J, Schwartz AG, Wenzlaff A, Stucker I. Hormone use and risk for lung cancer: a pooled analysis from the International Lung Cancer Consortium (ILCCO). British Journal of Cancer 2013; 109:1954-1964. 
431)    Yu OH, Foulkes WD, Dastani Z, Martin RM, Eeles R, PRACTICAL Consortium*, CRUK GWAS Investigators, Richards JB. An assessment of the shared allelic architecture between type II diabetes and prostate cancer. Cancer Epidemiology, Biomarkers & Prevention 2013; 22:1473-1475. *Author on behalf of the ESTHER study: Brenner H. 
432)    Gellert C, Schöttker B, Müller H, Holleczek B, Brenner H. Impact of smoking and quitting on cardiovascular outcomes and risk advancement periods among older adults. European Journal of Epidemiology 2013; 28:648-658. 
433)    Shlipak MG, Matsushita K, Ärnlöv J, Inker LA, Katz R, Polkinghorne K, Rothenbacher D, Sarnak MJ, Astor BC, Coresh J, Levey AS, Gansevoort RT, for the CKD Prognosis Consortium. *
434)    Cystatin C versus creatinine for determining risk based on kidney function. New England Journal of Medicine 2013; 369:932-943. *Authors on behalf of the ESTHER study: Rothenbacher D, Brenner H, Schöttker B, Koenig W. 
435)    Kote-Jarai Z, ... ; PRACTICAL Consortium, Easton DF, Eeles RA. Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. Human Molecular Genetics 2013; 22: 2520-2528. 
436)    Ordóñez-Mena JM, Schöttker B, Haug U, Müller H, Köhrle J, Schomburg L, Holleczek B, Brenner H. Serum 25-hydroxyvitamin D and cancer risk in older adults. Results from a large German prospective cohort study. Cancer Epidemiology, Biomarkers & Prevention 2013; 22: 905-916. 
437)    Zhang Y, Weck MN, Schöttker B, Rothenbacher D, Brenner H. Gastric parietal cell antibodies, Helicobacter pylori infection, and chronic atrophic gastritis: Evidence from a large population-based study in Germany. Cancer Epidemiology, Biomarkers & Prevention 2013; 22: 821-826. 
438)    Shen H, ... ; PRACTICAL Consortium, ... , Pearce CL. Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nature Communications 2013; 4:1628. Doi: 10. 1038/ncomms2629. * Author on behalf of the ESTHER study: Brenner H. 
439)    Eeles RA, ... ; PRACTICAL Consortium, Kote-Jarai Z, Easton DF. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nature Genetics 2013; 45: 385-391. 
440)    Bojesen SE, ... , Dunning AM. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nature Genetics 2013; 45: 371-384. 
441)    Michailidou K, ... , Easton DF. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nature Genetics 2013; 45: 353-361. 
442)    French JD, ... F, Dunning AM. Functional variants at the 11q13 risk locus for breast cancer regulate Cyclin D1 expression through long-range enhancers. American Journal of Human Genetics 2013; 92: 489-503. 
443)    Nickels S, ... , Chang-Claude J. Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors. PLoS Genetics 2013; 9: e1003284. 
444)    Schöttker B, Herder C, Rothenbacher D, Perna L, Müller H, Brenner H. Serum 25-hydroxyvitamin D levels and incident diabetes mellitus type 2. A competing risk analysis in a large population-based cohort of older adults. European Journal of Epidemiology 2013; 28: 267-275. 
445)    Schöttker B, Haug U, Schomburg L, Köhrle J, Perna L, Müller H, Holleczek B, Brenner H. Strong associations of 25-hydroxyvitamin D levels with all-cause, cardiovascular, cancer and respiratory disease mortality in a large cohort study. The American Journal of Clinical Nutrition 2013; 97: 782-793. 
446)    Perna L, Butterbach K, Haug U, Schöttker B, Müller H, Arndt V, Holleczek B, Burwinkel B, Brenner H. Vitamin D receptor genotype rs731236 (Taq1) and breast cancer prognosis. Cancer Epidemiology, Biomarkers & Prevention 2013; 22: 437-442. 
447)    Nitsch D, Grams M, Sang Y, Black C, Cirillo M, Djurdjev O, Iseki K, Jassal SK, Kimm H, Kronenberg F, Øien CM, Levey AS, Levin A, Woodward M, Hemmelgarn BR, for the CKD Prognosis Consortium. Do the associations of eGFR and albuminuria with mortality and renal failure differ by gender? A meta-analysis from a global consortium. British Medical Journal 2013; 346:f324. 
448)    Amin Al Olama A, . . , Eeles RA. A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Human Molecular Genetics 2013; 22: 408-415. 
449)    Schöttker B, Herder C, Rothenbacher D, Roden M, Kolb H, Müller H, Brenner H. Proinflammatory cytokines, adiponectin and increased risk of primary cardiovascular events in patients with diabetes and renal dysfunction: results from the ESTHER study. Diabetes Care 2013; 36: 1703-1711. 
450)    Garcia-Closas M, ... , Kraft P. Genome-wide association studies identify four ER-negative specific breast cancer risk loci. Nature Genetics 2013; 45: 392-398. 
451)    Schöttker B, Müller H, Rothenbacher D, Brenner H. Fasting plasma glucose and HbA1c in cardiovascular risk prediction: a sex-specific comparison in individuals without diabetes mellitus. Diabetologia 2013; 56: 92-100. 
452)    Gellert C, Schöttker B, Holleczek B, Stegmaier C, Müller H, Brenner H. Using rate advancement periods for communicating the benefits of quitting to older smokers. Tobacco Control 2013; 22: 227-230. 
453)    Perna L, Felix J, Breitling LP, Haug U, Raum E, Burwinkel B, Schöttker B, Brenner H. Genetic variations in the vitamin D binding protein and season specific serum levels of 25-hydroxyvitamin D among older adults. Epidemiology 2013; 24: 104-109.

2012
454)    Breitling LP, Perna L, Müller H, Raum E, Kliegel M, Brenner H. Vitamin D and cognitive functioning in the elderly population in Germany. Experimental Gerontology 2012; 47: 122-127. 
455)    Chuang SC, Jenab M, Heck JE, Bosetti C, Talamini R, Matsuo K, Castellsague X, Franceschi S, Herrero R, Winn DM, Vecchia CL, Morgenstern H, Zhang ZF, Levi F, Maso LD, Kelsey K, McClean MD, Vaughan T, Lazarus P, 
456)    Muscat J, ... , Hashibe M. Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium. Cancer Causes and Control 2012; 23: 69-88. 
457)    Schöttker B, Adamu MA, Weck MN, Müller H, Brenner H. Helicobacter pylori infection, chronic atrophic gastritis and major cardiovascular events: a population-based cohort study. Atherosclerosis 2012; 220: 569-574. 
458)    Maatouk I, Wild B, Wesche D, Herzog W, Raum E, Müller H, Rothenbacher D, Stegmaier C, Schellberg D, Brenner H. Temporal predictors of health-related quality of life in elderly people with diabetes: results of a German cohort study. PLoS One 2012; 7: e31088. 
459)    Stott-Miller M, ... , Schwartz SM. History of diabetes and risk of head and neck cancer:a pooled analysis from the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Cancer Epidemiology Biomarkers & Prevention 2012; 21: 294-304. 
460)    Frank B, Weck MN, Müller H, Klopp N, Illig T, Raum E, Brenner H. Polymorphisms in MUC1, MUC2, MUC5B and MUC6 genes are not associated with the risk of chronic atrophic gastritis. European Journal of Cancer 2012; 48: 114-120. 
461)    Ghoussaini M, Fletcher O, ... , Easton DF. Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nature Genetics 2012; 44: 312-318. 
462)    Schöttker B, Herder C, Müller H, Brenner H, Rothenbacher D. RE: Original Article - Clinical utility of creatinine and cystatin C based definition of renal function for risk prediction of primary cardiovascular events in patients with diabetes. Diabetes Care 2012; 35: 879-886. 
463)    Wild B, Herzog W, Schellberg D, Lechner S, Niehoff D, Brenner H, Rothenbacher D, Stegmaier C, Raum E. Association between the prevalence of depression and age in a large representative German sample of people aged 53 to 80. International Journal of Geriatric Psychiatry 2012; 27: 375-381. 
464)    Wild B, Herzog W, Lechner S, Niehoff D, Brenner H, Müller H, Rothenbacher D, Stegmaier C, Raum E. Gender Specific Temporal and Cross-Sectional Associations between BMI-class and Symptoms of Depression in the Elderly. Journal of Psychosomatic Research 2012; 72: 376-382. 
465)    Stevens KN... , Couch FJ. 19p13. 1 is a triple negative-specific breast cancer susceptibility locus. Cancer Research 2012; 72: 1795-1803. 
466)    Schöttker B, Adamu M, Weck MN, Brenner H. Helicobacter pylori infection is strongly associated with gastric and duodenal ulcers in a large prospective study. Clinical Gastroenterology and Hepatology 2012; 10: 487-493. 
467)    Matsushita K, ... , for the Chronic Kidney Disease Prognosis Consortium. Comparison of risk prediction using the CKD-EPI equation and the MDRD Study equation for estimated glomerular filtration rate. JAMA 2012; 307: 1941-1951. 
468)    Lambrechts D, ... , Brauch H. 11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer. Human Mutation 2012; 33: 1123-1132. 
469)    Krämer HU, Müller H, Stegmaier C, Rothenbacher D, Raum E, Brenner H. Type 2 diabetes mellitus and gender-specific risk for colorectal neoplasia. European Journal of Epidemiology 2012; 27: 341-347. 
470)    Coté ML, ... , Hung RJ. Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium. European Journal of Cancer 2012; 48: 1957-1968. 
471)    Maatouk I, Wild B, Herzog W, Wesche D, Schellberg D, Schöttker B, Müller H, Rothenbacher D, Stegmaier C, Brenner H. Longitudinal predictors of health-related quality of life in middle-aged and older adults with hypertension: results of a population based study. Journal of Hypertension 2012; 30: 1364-1372. 
472)    The Emerging Risk Factors Collaboration. * C-reactive protein, fibrinogen, and cardiovascular disease prediction. New England Journal of Medicine 2012; 367: 1310-1320. * Participating investigators on behalf of the ESTHER Study: Brenner H (member of writing committee), Schöttker B, Müller H, Rothenbacher D). 
473)    Perna L, Haug U, Schöttker B, Müller H, Raum E, Jansen EHJM, Brenner H. Public health implications of standardized 25-hydroxyvitamin D levels: a decrease in the prevalence of vitamin D deficiency among older women in Germany. Preventive Medicine 2012; 55: 228-232. 
474)    The Emerging Risk Factors Collaboration. *  Adult height and the risk of cause-specific death and vascular morbidity in 1 million adults. International Journal of Epidemiology 2012; 41: 1419-1433. *Participating Investigators on behalf of the ESTHER Study: Brenner H, Schöttker B, Müller H, Rothenbacher D. 
475)    Warren H, ... , Dos Santos Silva I. 9q31. 2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium. Cancer Epidemiology, Biomarkers & Prevention 2012; 21: 1783-1791. 
476)    Schöttker B, Jansen EHJM, Haug U, Schomberg L, Köhrle J, Brenner H. Standardization of misleading immunoassay based 25-hydroxyvitamin D levels with liquid chromatography tandem-mass spectrometry in a large cohort study. PLoS One 2012; 7: e48774. 
477)    Saum K-U, Müller H, Stegmaier C, Hauer K, Raum E, Brenner H. Development and evaluation of a modification of the Fried frailty criteria using population-independent cutpoints. Journal of the American Geriatrics Society 2012; 60: 2110-2115. 
478)    Fox CS, ... , on behalf of the CKD Prognosis Consortium. Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis. Lancet 2012; 380: 1662-1673. 
479)    Mahmoodi BK, ... , for the Chronic Kidney Disease Prognosis Consortium. Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension: a meta-analysis. Lancet 2012; 380; 1649-1661. 
480)    Breitling LP, Müller H, Stegmaier C, Kliegel M, Brenner H. Association of prion protein with cognitive functioning in humans. Experimental Gerontology 2012; 47: 919-924. 
481)    Hallan SI, ... , for the Chronic Kidney Disease Prognosis Consortium. * Age and association of kidney measures with mortality and end-stage renal disease. JAMA 2012; 308: 2349-2360.

2011
482)    Adamu MA, Weck MN, Rothenbacher D, Brenner H. Incidence and risk factors for the development of chronic atrophic gastritis: five year follow-up of a population based cohort study. International Journal of Cancer 2011; 128: 1652-1658. 
483)    Wild B, Lechner S, Herzog W, Maatouk I, Raum E, Müller H, Brenner H, Slaets J, Huyse F, Söllner W. Reliable integrative assessment of health care needs in elderly persons - the INTERMED for the Elderly (IM-E). Journal of Psychosomatic Research 2011; 70: 169-178. 
484)    Yang R, Dick M, Marme F, Schneeweiss A, Langheinz A, Hemminki K, Sutter C, Bugert P, Wappenschmidt B, Varon R, Schott S, Weber BHF, Niederacher D, Arnold N, Meindl A, Bartram CR, Schmutzler RK, Müller H, Arndt V, Brenner H, Sohn C, Burwinkel B. Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk. Breast Cancer Research and Treatment 2011; 127: 549-554. 
485)    The Emerging Risk Factors Collaboration. *Diabetes mellitus, fasting glucose, and risk of cause-specific mortality. New England Journal of Medicine 2011; 364: 829-841. * Authors on behalf of the ESTHER study: Brenner H, Raum E, Müller H, Rothenbacher D. 
486)    Breitling LP, Yang R, Korn B, Burwinkel B, Brenner H. Tobacco smoking-related differential DNA methylation: 27k discovery and replication. American Journal of Human Genetics 2011; 88: 450-457. 
487)    Herder C, Schoettker B, Rothenbacher D, Roden M, Kolb H, Müller H, Brenner H. Interleukin-6 in the prediction of primary cardiovascular events in diabetes patients: results from the ESTHER study. Atherosclerosis 2011; 216: 244-247. 
488)    Kote-Jarai Z, . . , Eeles RA. Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nature Genetics 2011; 43: 785-791. doi: 10. 1038/ng. 882. 
489)    Breitling LP, Müller H, Illig T, Rujescu D, Winterer G, Dahmen N, Nitz B, Raum E, Rothenbacher D, Brenner H. Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers. Pharmacogenomics 2011; 12: 1099-1106. 
490)    Nicolotti N, ... , Boccia S. Recreational physical activity and risk of head and neck cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. European Journal of Epidemiology 2011; 26: 619-628. 
491)    Milne RL, ... , Easton DF. Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer. Cancer Epidemiology, Biomarkers & Prevention 2011; 20: 2222-2231. 
492)    Frank B, Müller H, Weck MN, Klopp N, Illig T, Raum E, Brenner H. DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study. BMC Cancer 2011; 11: 440. 
493)    Figueroa JD, ... , Spurdle AB. Associations of common variants at 1p11. 2 and 14q24. 1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium. Human Molecular Genetics 2011; 20: 4693-4706. 
494)    Schöttker B, Raum E, Rothenbacher D, Müller H, Brenner H. Prognostic value of haemoglobin A1c and fasting plasma glucose for incident diabetes and implications for screening. European Journal of Epidemiology 2011; 26: 779-787.

2010
495)    The Emerging Risk Factors Collaboration. *C-reactive protein concentration and the risk of coronary heart disease, stroke and mortality. Lancet 2010; 375: 132-140. * Authors on behalf of the ESTHER study: Brenner H, Raum E, Müller H, Rothenbacher D. 
496)    Gao L, Weck MN, Stegmaier C, Rothenbacher D, Brenner H. Alcohol consumption, serum gamma-glutamyltransferase and Helicobacter pylori infection in a population-based study among 9733 older adults. Annals of Epidemiology 2010; 20: 122-128. 
497)    Gao L, Weck MN, Raum E, Stegmaier C, Rothenbacher D, Brenner H. Sibship size, Helicobacter pylori infection and chronic atrophic gastritis: a population-based study among 9444 older adults from Germany. International Journal of Epidemiology 2010; 39: 129-134. 
498)    Mobascher A, Rujescu D, Mittelstraß K, Giegling I, Lamina C, Nitz B, Brenner H, Fehr C, Breitling LP, Gallinat J, Rothenbacher D, Raum E, Müller H, Ruppert A, Hartmann AM, Möller HJ, Gal A, Gieger C, Wichmann HE, Illig T, Dahmen N, Winterer G. Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction. American Journal of Medical Genetics Part B - Neuropsychiatric Genetics 2010; 153B: 684-690. 
499)    Breitling LP, Müller H, Raum E, Rothenbacher D, Brenner H. Low-to-moderate alcohol consumption and smoking cessation rates: retrospective analysis of 4576 elderly ever-smokers. Drug Alcohol Depend 2010; 108: 122-129. 
500)    Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration. *Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet 2010; 375: 1634-1639. * Authors on behalf of the ESTHER study: Brenner H, Raum E, Müller H, Rothenbacher D. 
501)    Chronic Kidney Disease Prognosis Consortium. *Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet 2010; 375: 2073-2081. * Authors on behalf of the ESTHER study: Rothenbacher D, Brenner H, Raum E, Koenig W. 
502)    Zhang Q-L, Brenner H, Koenig W, Rothenbacher D. Prognostic value of chronic kidney disease in patients with coronary heart disease: role of estimating equations. Atherosclerosis 2010; 211: 342-347. 
503)    The Emerging Risk Factors Collaboration. *Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 2010; 375: 2215-2222. * Authors on behalf of the ESTHER study: Brenner H, Raum E, Müller H, Rothenbacher D. 
504)    Truong T, ... , Spitz M. Replication of lung cancer susceptibility loci at chromosome 15q25, 5p15, and 6p21: A pooled analysis from the International Lung Cancer Consortium. Journal of the National Cancer Institute 2010; 102: 959-971. 
505)    Gao L, Weck MN, Rothenbacher D, Brenner H. Body mass index, chronic atrophic gastritis and heartburn: a population-based study among 8936 older adults from Germany. Alimentary Pharmacology & Therapeutics 2010; 32: 296-302. 
506)    Gao L, Weck MN, Nieters A, Brenner H. Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacter pylori infection and chronic atrophic gastritis among older adults from Germany. Molecular Carcinogenesis 2010; 49: 869-873. 
507)    Breitling LP, Wolf M, Müller H, Raum E, Kliegel M, Brenner H. Large-scale application of a telephone-based test of cognitive functioning in older adults. Dementia and Geriatric Cognitive Disorders 2010; 30: 309-316. 
508)    Thompson S, Kaptoge S, White I, Wood A, Perry P, Danesh J and The Emerging Risk Factors Collaboration. *Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies. International Journal of Epidemiology 2010; 39: 1345-1359. * Authors on behalf of the ESTHER study: Brenner H, Raum E, Müller H, Rothenbacher D. 
509)    Winterer G, ... , Rujescu D. Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 2010; 153B: 1448-1458.

2009
510)    Zhang Q-L, Koenig W, Raum E, Stegmaier C, Brenner H, Rothenbacher D. Epidemiology of chronic kidney disease: results from a population of older adults in Germany. Preventive Medicine 2009; 48: 122-127. 
511)    Breitling LP, Raum E, Müller H, Rothenbacher D, Brenner H. Synergism between smoking and alcohol consumption with respect to serum gamma-glutamyltransferase. Hepatology 2009; 49: 802-808. 
512)    Gao L, Weck MN, Michel A, Pawlita M, Brenner H. Association between chronic atrophic gastritis and serum antibodies to 15 Helicobacter pylori proteins measured by multiple serology. Cancer Research 2009; 69: 2973-2980. 
513)    Breitling LP, Dahmen N, Mittelstraß K, Illig T, Rujescu D, Raum E, Winterer G, Brenner H. Smoking cessation and variations in nicotinic acetylcholine receptor subunits a-5, a-3 and b-4 genes. Biological Psychiatry 2009; 65: 691-695. 
514)    Müller H, Raum E, Rothenbacher D, Stegmaier C, Brenner H. Association of diabetes and body mass index with levels of prostate-specific antigen: Implications for correction of prostate-specific antigen cut-off values?Cancer Epidemiology, Biomarkers & Prevention 2009; 18: 1350-1356. 
515)    Weck MN, Gao L, Brenner H. Helicobacter pylori infection and chronic atrophic gastritis: associations according to severity of disease. Epidemiology 2009; 20: 569-574. 
516)    Widschwendter M, Lichtenberg-Frate H, Hasenbrink G, Schwarzer S, Dawnay A, Lam A, Menon U, Apostolidou S, Raum E, Stegmaier C, Jacobs IJ, Brenner H. Serum oestrogen receptor alpha- and beta-bioactivity are independently associated with breast cancer - a proof of principle study. British Journal of Cancer 2009; 101: 160-165. 
517)    The Emerging Risk Factors Collaboration. * Lipoprotein(a) concentration and the risk of coronary heart disease, stroke and nonvascular mortality. Individual data analysis of 126,634 participants from 36 prospective studies. JAMA 2009; 302: 412-423. * Authors on behalf of the ESTHER study: Brenner H, Raum E, Müller H, Rothenbacher D. 
518)    Gao L, Michel A, Weck MN, Arndt V, Pawlita M, Brenner H. Helicobacter pylori infection and gastric cancer risk: evaluation of 15 Helicobacter pylori proteins determined by novel multiplex serology. Cancer Research 2009; 69: 6164-6160. 
519)    Breitling LP, Dahmen N, Illig T, Rujescu D, Nitz B, Raum E, Winterer G, Rothenbacher D, Brenner H. Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events. Pharmacogenetics & Genomics 2009; 19: 657-659. 
520)    Breitling LP, Dahmen N, Mittelstraß K, Rujescu D, Gallinat J, Fehr C, Giegling I, Lamina C, Illig T, Müller H, Raum E, Rothenbacher D, Wichmann HE, Brenner H, Winterer G. Association of nicotinic acetylcholine receptor subunit alpha-4 polymorphisms with nicotine dependence in 5500 Germans. The Pharmacogenomics Journal 2009; 9: 219-224. 
521)    Gao L, Weck MN, Nieters A, Brenner H. Association between chronic atrophic gastritis and serum antibodies to 15 Helicobacter pylori proteins measured by multiple serology. European Journal of Cancer; 69: 2973-2980. 
522)    Gao L, Weck MN, Stegmaier C, Rothenbacher D, Brenner H. Alcohol consumption and chronic atrophic gastritis: population-based study among 9444 older adults from Germany. International Journal of Cancer 2009; 125:2918-2922. 
523)    The Emerging Risk Factors Collaboration. * Major lipids, apolipoproteins and risk of vascular disease. 
524)    JAMA 2009; 302: 1993-2000. * Authors on behalf of the ESTHER study: Brenner H, Raum E, Müller H, Rothenbacher D.

2008
525)    Raum E, Lietzau S, Stegmaier C, Brenner H. , Rothenbacher D. For the majority of patients with diabetes blood pressure and lipid management is not in line with recommendations. Results from a large population-based cohort in Germany. Pharmacoepidemiology and Drug Safety 2008; 17: 485-494. 
526)    Widschwendter M, Apostolidou S, Raum E, Rothenbacher D, Fiegl H, Menon U, Stegmaier C, Jacobs IJ, Brenner H. Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study. PloS ONE 2008; 3: e2656. 
527)    Müller H, Haug U, Rothenbacher D, Stegmaier C, Brenner H. Evaluation of serum and urine MRP-14 as marker for early detection of prostate cancer. Journal of Urology 2008; 180: 1309-1313.

2007
528)    Haug U, Hillebrand T, Bendzko P, Löw M, Rothenbacher D, Stegmaier C, Brenner H. Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras-mutations in stool DNA: High prevalence in a large sample of older adults. Clinical Chemistry 2007; 53: 787-790. 
529)    Wolkewitz M, Rothenbacher D, Löw M, Stegmaier C, Ziegler H, Radulescu M, Brenner H, Diepgen TL. Lifetime prevalence of self-reported atopic diseases in a population-based sample of elderly: results of the ESTHER-study. British Journal of Dermatology 2007; 156: 693-697. 
530)    Haug U, Rothenbacher D, Wente MN, Seiler CM, Stegmaier C, Brenner H. Tumor M2-PK as a stool marker for colorectal cancer: comparative analysis in a large sample of unselected older adults versus colorectal cancer patients. British Journal of Cancer 2007; 96: 1329-1334. 
531)    Raum E, Rothenbacher D, Ziegler H, Brenner H. Heavy physical activity – risk or protective factor for cardiovascular disease? A life course perspective. Annals of Epidemiology 2007; 17: 417-424. 
532)    Weck MN, Stegmaier C, Rothenbacher D, Brenner H. Epidemiology of chronic atrophic gastritis: population based study among 9,444 older adults from Germany. Alimentary Pharmacology & Therapeutics 2007; 26: 879-887. 
533)    Brenner H, Rothenbacher D, Weck MN. Epidemiologic findings on serologically defined chronic atrophic gastritis strongly depend on the choice of the cutoff-value. International Journal of Cancer 2007; 121: 2782-2786. 
534)    Raum E, Rothenbacher D, Löw M, Stegmaier C, Ziegler H, Brenner H. Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: a life course approach. European Journal of Cardiovascular Prevention and Rehabilitation 2007; 14: 809-814.

2006
535)    Twardella D, Loew M, Rothenbacher D, Stegmaier C, Ziegler H, Brenner H. The diagnosis of a smoking-related disease is a prominent trigger for smoking cessation in a retrospective cohort study. Journal of Clinical Epidemiology 2006; 59: 82-89. 
536)    Twardella D, Loew M, Rothenbacher D, Stegmaier C, Ziegler H, Brenner H. The impact of body weight on smoking cessation in German adults. Preventive Medicine 2006; 42: 109-113. 
537)    Wang H, Rothenbacher D, Löw M, Stegmaier C, Brenner H, Diepgen TL. Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung und colorectum. International Journal of Cancer 2006; 119: 695-701.

2004
538)    Löw M, Stegmaier C, Ziegler H, Rothenbacher D, Brenner H. Epidemiologische Studie zu Chancen der Verhütung, Früherkennung und optimierten Therapie chronischer Erkrankungen in der älteren Bevölkerung (ESTHER-Studie). Deutsche Medizinische Wochenschrift 2004; 129: 2643-2647. 
539)    Bergk V, Gasse C, Rothenbacher D, Loew M, Brenner H, Haefeli WE. Drug interactions in primary care: impact of a new algorithm on risk determination. Clinical Pharmacology and Therapeutics 2004; 76: 85-96. 
 

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