Original- und Übersichtsarbeiten im Jahr 2019 und im Druck

Brenner DR, Fehringer G, Zhang ZF, Lee YA, Meyers T, Matsuo K, Ito H, Vineis P, Stucker I, Boffetta P, Brennan P, Christiani DC, Diao N, Hong YC, Landi MT, Morgenstern H, Schwartz AG, Rennert G, Saliba W, McLaughlin JR, Harris CC, Orlow I, Barros Dios JM, Ruano Ravina A, Siemiatycki J, Koushik A, Cote M, Lazarus P, Fernandez-Tardon G, Tardon A, Le Marchand L, Brenner H, Saum KU, Duell EJ, Andrew AS, Consonni D, Olsson A, Hung RJ, Straif K.
Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study.
Cancer Epidemiology 2019; 58:25-32.

Quinzler R, Freitag MH, Wiese B, Beyer M, Brenner H, Dahlhaus A, Döring A, Freund T, Heier M, Knopf H, Luppa M, Prokein J, Riedel-Heller SG, Schäfer I, Scheidt-Nave C, Scherer M, Schöttker B, Szecsenyi J, Thürmann P, van den Bussche H, Gensichen J, Haefeli WE.
A novel superior medication-based chronic disease score predicted all-cause mortality in independent geriatric cohorts.
Journal of Clinical Epidemiology 2019; 105:112-124.

Hohls JK, Wild B, Heider D, Brenner H, Böhlen F, Saum KU, Schöttker B, Matschinger H, Haefeli WE, König HH, Hajek A.
Association of generalized anxiety symptoms and panic with health care costs in older age – Results from the ESTHER cohort study.
Journal of Affective Disorders 2019; 245:978-986.

Gies A, Cuk K, Schrotz-King P, Brenner H.
Combination of different fecal immunochemical tests in colorectal cancer screening: Any gain in diagnostic performance?
Cancers 2019; 11:120.

Gündert M, Edelmann D, Benner A, Jansen L, Jia M, Walter V, Knebel P, Herpel E, Chang-Claude J, Hoffmeister M, Brenner H, Burwinkel B.
Genome-wide DNA methylation analysis reveals a prognostic classifier for non-metastatic colorectal cancer (ProMCol classifier).
Gut 2019; 68:101-110.

Huang L, Jansen L, Balavarca Y, Molina-Montes E, Babaei M, van der Geest L, Lemmens V, Van Eycken L, De Schutter H, Johannesen TB, Fristrup CW, Mortensen MB, Zakelj MP, Zadnik V, Becker N, Hackert T, Mägi M, Cassetti T, Sassatelli R, Grützmann R, Merkel S, Goncalves AF, Bento MJ, Hegyi P, Lakatos G, Szentesi A, Moreau M, van de Velde T, Broeks A, Sant M, Minicozzi P, Mazzaferro V, Real FX, Carrato A, Molero X, Besselink MG, Malats N, Büchler MW, Schrotz-King P, Brenner H.
Resection of pancreatic cancer in Europe and the US: an international large-scale study highlighting large variations.
Gut 2019; 68:130-139.

Doege D, Thong MSY, Koch-Gallenkamp L, Bertram H, Eberle A, Holleczek B, Waldeyer-Sauerland M, Waldmann A, Zeissig SR, Brenner H, Arndt V.
The role of psychosocial resources for long-term breast, colorectal and prostate cancer survivors: Prevalence and associations with health-related quality of life.
Supportive Care in Cancer 2019; 27:275-286.

Hoffmeister M, Holleczek B, Stock C, Zwink N, Stolz T, Stegmaier C, Brenner H.
Utilization and determinants of follow-up colonoscopies within 6 years after screening colonoscopy: prospective cohort study.
International Journal of Cancer 2019; 144:402-410.

Weigl K, Tikk K, Hoffmeister M, De Toni EN, Hampe J, Kolligs F, Klug SJ, Mansmann U, Nasseh D, Radlovic J, Schwab M, Schweigler D, Stephan A, Brenner H.
A web-based survey among adults aged 40-54 years was time-effective and yielded stable response patterns.
Journal of Clinical Epidemiology 2019; 105:10-18.

Campa D, Matarazzi M, Greenhalf W, Bijlsma M, Saum KU,…, Valsuani C, Vashist YK, Brenner H, Canzian F.
Genetic determinants of telomere length and risk of pancreatic cancer: a PANDoRA study.
International Journal of Cancer 2019; 144:1275-1283.

Schöttker B, Hagen L, Zhang Y, Gào X, Holleczek B, Gao X, Brenner H.
Serum 25-hydroxyvitamin D levels as an ageing marker. Strong associations with age and all-cause mortality independent from telomere length, epigenetic age acceleration and 8-isoprostane levels.
Journal of Gerontology: Medical Sciences 2019; 74:121-128.

Mavaddat N, Michailidou K, Dennis J, Lush M, Fachal L,…, Arndt V,…, Brenner H,…, Kraft P, Garcia-Closas M, Simard J, Easton DF.
Polygenic risk scores for prediction of breast cancer and breast cancer subtypes.
The American Journal of Human Genetics 2019; 104:21-34.

Travis RC, Perez-Cornago A, Appleby PN, Albanes D, Joshu CE, Lutsey PL, Mondul AM, Platz EA, Weinstein SJ, Layne TM, Helzlsouer KJ, Visvanathan K, Palli D, Peeters PH, Bueno-de-Mesquita B, Trichopoulou A, Gunter MJ, Tsilidis KK, Sanchez MJ, Olsen A, Brenner H, Schöttker B, Perna L, Holleczek B, Knekt P, Rissanen H, Yeap BB, Flicker L, Almeida OP, Wong YYE, Chan JM, Giovannucci EL, Stampfer MJ, Ursin G, Gislefoss RE, Bjorge T, Meyer HE, Blomhoff R, Tsugane S, Sawada N, English DR, Eyles DW, Heath AK, Williamson EJ, Manjer J, Malm J, Almquist M, Le Marchand L, Haiman CA, Wilkens LR, Schenk JM, Tangen CM, Black A, Cook MB, Huang WY, Ziegler RG, Martin RM, Hamdy FC, Donovan JL, Neal DE, Touvier M, Hercberg S, Galan P, Deschasaux M, Key TJ, Allen NE.
A collaborative analysis of individual participant data from 19 prospective studies assesses circulating vitamin D and prostate cancer risk.
Cancer Research 2019; 79:274-285.

Caputo M, Horn J, Karch A, Akmatov M, Becher H, Braun B, Brenner H, Castell S, Fischer B, Giani G, Günther K, Hoffmann B, Jöckel KH, Keil T, Klüppelholz B, Krist L, Leitzmann MF, Lieb W, Linseisen J, Meisinger C, Moebus S, Obi N, Pischon T, Schipf S, Schmidt B, Sievers C, Steinbrecher A, Völzke H, Mikolajczyk R.
Herpes zoster incidence in Germany – an indirect validation study for self-reported disease data from pretest studies of the population-based German National Cohort.
BMC Infectious Diseases 2019; 19:99.

Möllers T, Perna L, Ihle P, Schubert I, Bauer J, Brenner H.
Factors associated with length of stay in hospital patients with and without dementia.
Journal of Alzheimer’s Disease 2019; 67:1055-1065.

Rahbari NN*, Carr PR*, Jansen L, Chang-Claude J, Weitz J, Hoffmeister M, Brenner H.
Time of metastasis and outcome in colorectal cancer.
Annals of Surgery 2019; 269:494-502.
*contributed equally

Raina P, Gilsing A, Freisling H, van den Heuvel E, Sohel N, Jenab M, Ferrari P, Tjonneland A, Benetou V, Picavet S, Eriksson S, Schöttker B, Brenner H, Saum KU, Perna L, Wilsgaard T, Trichopoulou A, Boffetta P, Griffith L.
The combined effect of cancer and cardio-metabolic conditions on the mortality burden in older adults.
Journals of Gerontology: Medical Sciences 2019; 74:366-372.

Schmit SL, Edlund CK, Schumacher FR, Gong J, Harrison TA,…, Arndt V,…, Brenner H,…, Casey G, Hsu L, Conti DV, Gruber SB.
Novel common genetic susceptibility loci for colorectal cancer.
Journal of the National Cancer Institute 2019; 111:djy099.

Logan C, Weiss J, König W, Stahl B, Carr P, Brenner H, Rothenbacher D, Genuneit J.
Soluble CD14 concentration in human breast milk and its potential role in child atopic dermatitis: Results of the Ulm Birth Cohort Studies.
Clinical & Experimental Allergy 2019; 49:199-206.

Brenner H, Gies A.
Immunologische Stuhlbluttests – welche Verbesserungen gegenüber dem Guajak basierten Test?
Der Gastroenterologe 2019; 14:6-13, sowie Best Practice Onkologie 2019; 5:190-194.

Jiang R, Poschet G, Owen R, Celik M, Jansen L, Hell R, Hoffmeister M, Brenner H, Chang-Claude J.
Serum concentration of genistein, luteolin and colorectal cancer prognosis.
Nutrients 2019; 11:600.

Meyer ML, Lin FC, Jaensch A, Mons U, Hahmann H, Koenig W, Brenner H, Rothenbacher D.
Multi-state models of transitions in depression and anxiety symptom severity and cardiovascular events in patients with coronary heart disease.
PloS ONE 2019; 14:e0213334.

Bläker H, Alwers E, Arnold A, Herpel E, Tagscherer KE, Roth W, Jansen L, Walter V, Kloor M, Chang-Claude J, Brenner H, Hoffmeister M.
The association between mutations in BRAF and colorectal cancer-specific survival depends on microsatellite status and tumor stage.
Clinical Gastroenterology and Hepatology 2019; 17:455-462.

Wild B, Herzog W, Schellberg D, Böhlen F, Brenner H, Saum KU, Maatouk I.
A short intervention targeting psychosomatic care in older adults with complex health care needs – results of a randomized controlled trial.
International Journal of Geriatric Psychiatry 2019; 34:272-279.

Krilaviciute A, Leja M, Kopp-Schneider A, Barash O, Khatib S, Amal H, Broza Y, Polaka I, Parshutin S, Rudule A, Haick H, Brenner H.
Associations of diet and lifestyle factors with common volatile organic compounds in exhaled breath of average-risk individuals.
Journal of Breath Research 2019; 13:026006.

Erben V, Carr PR, Holleczek B, Stegmaier C, Hoffmeister M, Brenner H.
Strong associations of a healthy lifestyle with all stages of colorectal carcinogenesis: results from a large cohort of participants of screening colonoscopy.
International Journal of Cancer 2019; 144:2135-2143.

Jiang X, Finucane H, Schumacher F, Schmit S, Tyrer J,…, Brenner H,…, Hoffmeister M,…, Lane J, Saxena R, Kraft P, Lindstrom S.
Shared heritability and functional enrichment across six solid cancers.
Nature Communications 2019; 10:431.

Gào X, Zhang Y, Burwinkel B, Xuan Y, Holleczek B, Brenner H, Schöttker B.
The associations of DNA methylation alterations in oxidative stress related genes with cancer incidence and mortality outcomes: A population-based cohort study.
Clinical Epigenetics 2019; 11:14.

Kather JN, Krisam J, Charoentong P, Luedde T, Herpel E, Weis CA, Gaiser T, Marx A, Valous NA, Ferber D, Jansen L, Reyes-Aldasoro CC, Zörnig I, Jäger D, Brenner H, Chang-Claude J, Hoffmeister M, Halama N.
Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study.
PLoS Medicine 2019; 16:e1002730.

Brunssen A, Jansen L, Eisemann N, Waldmann A, Weberpals J, Kraywinkel K, Eberle A, Holleczek B, Zeissig SR, Brenner H, Katalinic K, GEKID Cancer Survival Working Group.
A population-based registry study on relative survival from melanoma in Germany stratified by tumor thickness for each histologic subtype.
Journal of the American Academy of Dermatology 2019; 80:938-946.

Amitay E, Gies A, Weigl K, Brenner H.
Fecal immunochemical tests for colorectal cancer screening: Is fecal sampling from multiple sites necessary?
Cancers 2019; 11:400.

Amitay E, Cuk K, Niedermaier T, Weigl K, Brenner H.
Factors associated with false-positive fecal immunochemical tests in a large German colorectal cancer screening study.
International Journal of Cancer 2019; 144:2419-2427.

Böhlen F, Freigofas J, Herzog W, Meid A, Saum KU, Schöttker B, Brenner H, Haefeli W, Wild B.
Evidence for underuse and overuse of antidepressants in older adults: Results of a large population-based study.
International Journal of Geriatric Psychiatry 2019; 34:539-547.

Tian Y, Kharazmi E, Sundquist K, Sundquist J, Brenner H, Fallah M.
Familial colorectal cancer risk in half-siblings and siblings: nationwide cohort study.
BMJ 2019; 364:1803.

Hellmuth C, Kirchberg FF, Brandt S, Moß A, Walter V, Rothenbacher D, Brenner H, Grote V, Gruszfeld D, Socha P, Closa-Monasterolo R, Escribano J, Luque V, Verduci E, Mariani B, Langhendries JP, Poncelet P, Heinrich J, Lehmann I, Standl M, Uhl O, Koletzko B, Thiering E, Wabitsch M.
An individual participant data meta-analysis on metabolomics profiles for obesity and insulin resistance in European children.
Scientific Reports 2019; 9:5053.

Huang L, Balavarca Y, van der Geest L, Lemmens V, Van Eycken L, De Schutter H, Johannesen TB, Zadnik V, Primic-Zakelj M, Mägi M, Grützmann R, Besselink MG, Schrotz-King P, Brenner H, Jansen L.
Development and validation of a prognostic model to predict the prognosis of patients who underwent chemotherapy and resection of pancreatic adenocarcinoma: a large international population-based cohort study.
BMC Medicine 2019; 17:66.

Xuan Y, Bobak M, Anusruti A, Jansen EHJM, Pajak A, Tamosiunas A, Saum KU, Holleczek B, Gao X, Brenner H, Schöttker B.
Association of serum markers of oxidative stress with myocardinal infarction and stroke: Pooled results from four large European cohort studies.
European Journal of Epidemiology 2019; 34:471-481.

Ferreira MA, Al-Ejeh F, Campa D, Gamazon E, Parsons M,…, Arndt V, Brenner H,…, Caldés T, de la Hoya M, BCFR Investigators, GC-HBOC Collaborators.
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer.
Nature Communications 2019; 10:1741.

Gao X, Gào X, Zhang Y, Holleczek B, Schöttker B, Brenner H.
Oxidative stress and epigenetic mortality risk score: associations with all-cause mortality among elderly people.
European Journal of Epidemiology 2019; 34:451-462.

Thomas AM, Manghi P, Asnicar F, Pasolli E, Armanini F,…, Schrotz-King P,…, Brenner H,…, Rescigno M, Waldron L, Naccarati A, Segata N.
Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation.
Nature Medicine 2019; 25:667-678.

Wirbel J, Pyl PT, Kartal E, Zych K, Kashani A,…, Brenner H, Arumugam M, Bork P, Zeller G.
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.
Nature Medicine 2019; 25:679-689.

Chen C, Stock C, Hoffmeister M, Brenner H.
Optimal age for screening colonoscopy: a modeling study.
Gastrointestinal Endoscopy 2019; 89:1017-1025.

Gregson J, Kaptoge S, Bolton T, Pennells L, Willeit P,…, Arndt V,…, Brenner H,…, Thompson SG, Danesh J, Di Angelantonio E, Meade T, for the Emerging Risk Factors Collaboration.
Cardiovascular risk factors associated with venous thromboembolism.
JAMA Cardiology 2019; 4:163-173.

Doege D, Thong MSY, Koch-Gallenkamp L, Bertram H, Eberle A, Holleczek B, Pritzkuleit R, Waldeyer-Sauerland M, Waldmann A, Zeissig SR, Jansen L, Brenner H, Arndt V.
Health-related quality of life in long-term disease-free breast cancer survivors versus female population controls in Germany.
Breast Cancer Research and Treatment 2019; 175:499-510.

Law P, Timofeeva M, Fernandez-Rozadilla C, Broderick P, Studd J,…, Butterbach K, Chang-Claude J, Hoffmeister M, Brenner H,…, Cheadle J, Tomlinson I, Houlston R, Dunlop M.
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Nature Communications 2019; 10:2154.

Di Credico G, Edefonti V, Polesel J, Pauli F, Torelli N,…, Brenner H,…, Boffetta P, Hashibe M, Lee YCA, Dal Maso L.
Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: a bivariate spline model approach.
Oral Oncology 2019; 94:47-57.

Amitay EL, Carr PR, Jansen L, Walter V, Roth W, Herpel E, Kloor M, Bläker H, Chang-Claude J, Brenner H, Hoffmeister M.
Association of aspirin and non-steroidal anti-inflammatory drugs and colorectal cancer risk by molecular subtypes.
Journal of the National Cancer Institute 2019; 111:djy170.

Zaimenko I, Jaeger C, Brenner H, Chang-Claude J, Hoffmeister M, Grötzinger C, Detjen K, Burock S, Schmitt CA, Stein U, Lisec J.
Non-invasive metastasis prognosis from plasma metabolites in stage II colorectal cancer patients: the DACHS study.
International Journal of Cancer 2019; 145:221-231.

Gào X, Wilsgaard T, Jansen EHJM, Holleczek B, Zhang Y, Xuan Y, Anusruti A, Brenner H, Schöttker B.
Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies.
International Journal of Cancer 2019; 145:49-57.

Kar SP, Andrulis IL, Brenner H, Burgess S, Chang-Claude J, Considine D, Dörk T, Evans GR, Gago-Dominguez M, Giles GG, Hartman M, Huo D, Kaaks R, Li J, Lophatananon A, Margolin S, Milne RL, Muir KR, Olsson H, Punie K, Radice P, Simard J, Tamimi RM, Van Nieuwenhuysen E, Wendt C, Zheng W, Pharoah PDP.
The association between weight at birth and breast cancer risk revisited using Mendelian randomisation.
European Journal of Epidemiology 2019; 34:591-600.

Bien S, Su YR, Conti DV, Harrison TA, Qu C,…, Brenner H,…, Hoffmeister M,…, Gruber SB, Hsu L, Zhang W, Peters U.
Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer.
Human Genetics 2019; 138:307-326.

Chen C, Stock C, Jansen L, Chang-Claude J, Hoffmeister M, Brenner H.
Trends in colonoscopy and fecal occult blood test use after the introduction of dual screening offers in Germany: Results from a large population-based study, 2003-2016.
Preventive Medicine 2019; 123:333-340.

Fiorito G, McCrory C, Robinson O, Carmeli C, Rosales CO, Zhang Y,…, Brenner H,…, Elliot P, Stringhini S, Vineis P, Polidoro S, and the Lifepath consortium.
Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.
Aging 2019; 11:2045-2070.

Brenner H, Calderazzo S, Seufferlein T, Ludwig L, Dikopoulos N, Mangold J, Böck W, Stolz T, Eisenbach T, Block T, Kopp-Schneider A, Czock D, Tikk K.
Effect of a single aspirin dose prior to fecal immunochemical testing on test sensitivity for detecting advanced colorectal neoplasms: A randomized clinical trial.
JAMA 2019; 321:1686-1692.

Gào X, Holleczek B, Cuk K, Zhang Y, Anusruti A, Xuan Y, Xu Y, Brenner H, Schöttker B.
Investigation on potential associations of oxidatively generated DNA/RNA damage with lung, colorectal, breast, prostate and total cancer incidence.
Scientific Reports 2019; 9:7109.

NCD Risk Factor Collaboration (NCD-RisC).*
Rising rural body-mass index is the main driver of the global obesity epidemic in adults.
Nature 2019; 569:260-264.
*Collaborators on behalf of the ESTHER study: Brenner H, Saum KU, Schöttker B

Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF,…, Brenner H,…, Schöttker B,…, Scholz M, Teumer A, Köttgen A, Pattaro C.
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
Nature Genetics 2019; 51:957-972.

Holleczek B, Stegmaier C, Radosa JC, Solomayer EF, Brenner H.
Risk of loco-regional recurrence and distant metastases of patients with invasive breast cancer up to ten years after diagnosis – results from a registry-based study from Germany.
BMC Cancer 2019; 19:520.

Thong MSY, Koch-Gallenkamp L, Jansen L, Bertram H, Eberle A, Holleczek B, Waldeyer-Sauerland M, Waldmann A, Zeissig SR, Brenner H, Arndt V.
Age-specific health-related quality of life in long-term and very long-term colorectal cancer survivors versus population controls – A population-based study.
Acta Oncologica 2019; 58:801-810.

Arndt V, Koch-Gallenkamp L, Bertram H, Eberle A, Holleczek B, Pritzkuleit R, Waldeyer-Sauerland M, Waldmann A, Zeissig SR, Doege D, Thong MSY, Brenner H.
Return to work after cancer. A multi-regional population-based study from Germany.
Acta Oncologica 2019; 58:811-818.

Obazee O, Archibugi L, Andriulli A, Soucek P, Malecka-Panas E,…, Brenner H,…, Vodicka P, Tjaden C, Iskierka-Jazdzewska E, Canzian F.
Germline BRCA2 K3326X and CHEK2 I157T mutations increase risk for sporadic pancreatic ductal adenocarcinoma.
International Journal of Cancer 2019; 145:686-693.

Möllers T, Stocker H, Wei W, Perna L, Brenner H.
Length of hospital stay and dementia: a systematic review of observational studies.
International Journal of Geriatric Psychiatry 2019; 34:8-21.

Wild CP, Espina C, Bauld L, Bonanni B, Brenner H, Brown K, Dillner J, Forman D, Kampman E, Nilbert M, Steindorf K, Storm H, Vineis P, Baumann M, Schüz J.
Cancer Prevention Europe.
Molecular Oncology 2019; 13:528-534.

Alwers E, Bläker H, Walter V, Jansen L, Kloor M, Arnold A, Sieber-Frank J, Herpel E, Tagscherer KE, Roth W, Chang-Claude J, Brenner H, Hoffmeister M.
External validation of molecular subtype classifications of colorectal cancer based on microsatellite instability, CIMP, BRAF and KRAS.
BMC Cancer 2019; 19:681.

Raut JR, Guan Z, Schrotz-King P, Brenner H.
Whole-blood DNA methylation markers for risk stratification in colorectal cancer screening: A systematic review.
Cancers 2019; 11:912.

Jansen H, Jaensch A, Schöttker B, Dallmeier D, Schmucker R, Brenner H, Koenig W, Rothenbacher D.
Repeat measurements of high sensitivity troponins for the prediction of recurrent cardiovascular events in patients with established coronary heart disease – an analysis from the KAROLA study.
Journal of the American Heart Association 2019; 8:e011882.

Gies A, Gruner LF, Schrotz-King P, Brenner H.
Effect of imperfect compliance with instructions for fecal sample collection on diagnostic performance of 9 fecal immunochemical tests.
Clinical Gastroenterology and Hepatology 2019; 17:1829-1839.

Broza YY, Khatib S, Gharra A, Krilaviciute A, Amal H, Polaka I, Parshutin S, Kikuste I, Gasenko E, Skapars R, Brenner H, Leja M, Haick H.
Screening for gastric cancer using exhaled breath samples.
British Journal of Surgery 2019; 106:1122-1125.

Khetan P, Boffetta P, Luce D, Stucker I, Curado MP, Menezes A, Wunsch-Filho V, Ahrens W, Lagiou P, Serraino D, Richiardi L, Kjaerheim K, Conway D, Thomson P, Muscat J, Mates D, Ramroth H, Menvielle G, Vaughan TL, Brenner H, Lee YA, La Vecchia C, Hashibe M, Hashim D.
Occupations and the risk of head and neck cancer: A pooled analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium.
Journal of Occupational and Environmental Medicine 2019; 61:397-404.

Kather JN, Pearson AT, Halama N, Jäger D, Krause J, Loosen SH, Marx A, Boor P, Tacke F, Neumann UP, Grabsch HI, Yoshikawa T, Brenner H, Chang-Claude J, Hoffmeister M, Trautwein C, Luedde T.
Deep learning can predict microsatellite instability direct from histology in gastrointestinal cancer.
Nature Medicine 2019; 25:1054-1056.

Pulte D, Weberpals J, Jansen L, Brenner H.
Changes in population-level survival for advanced solid malignancies with new treatment options in the second decade of the 21st century.
Cancer 2019; 125:2656-2665.

Geijsen AJMR, van Roekel EH, van Duijnhoven FJB, Achaintre D, Bachleitner-Hofmann T,…, Brenner H,…, Hoffmeister M,…, Schrotz-King P,…, Ulrich AB, Ulrich CM, Weijenberg MP, Kok DE.
Plasma metabolites associated with colorectal cancer: A discovery-replication strategy.
International Journal of Cancer 2019; 145:1221-1231.

Carr PR, Banbury B, Berndt SI, Campbell PT, Chang-Claude J, Hayes RB, Howard BV, Jansen L, Jacobs E, Lane DS, Nishihara R, Ogino S, Phipps AI, Slattery ML, Stefanick ML, Wallace R, Walter V, White E, Wu K, Peters U, Chan AT, Newcomb PA, Brenner H, Hoffmeister M.
Association between intake of red and processed meat and survival in patients with colorectal cancer in a pooled analysis.
Clinical Gastroenterology and Hepatology 2019; 17:1561-1570.

Campa D, Martino A, Macauda A, Dudzinski M, Suska A,…, Brenner H,…, Zaucha JM, Andersen V, Zawirska D, Canzian F.
Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study.
Leukemia and Lymphoma 2019; 60:1803-1811.

Patel RS, Tragante V, Schmidt AF, McCubrey RO, Holmes MV,…, Breitling LP,…, Mons U,…, Brenner H,…, Wallentin L, Samani NJ, Hingorani AD, Asselbergs FW.
Subsequent event risk in individuals with established coronary heart disease: design and rationale of the GENIUS-CHD consortium.
Circulation: Genomic and Precision Medicine 2019; 12:e002470.

Patel RS, Schmidt AF, Tragante V, McCubrey RO, Holmes MV,…, Breitling L,…, Mons U,…, Brenner H,…, Horne BD, Samani NJ, Hingorani AD, Asselbergs FW.
Association of chromosome 9p21 with subsequent coronary heart disease events: a GENIUS-CHD study of individual participant data.
Circulation: Genomic and Precision Medicine 2019; 12:e002471.

Ran T, Cheng CY, Misselwitz B, Brenner H, Ubels J, Schlander M.
Cost-effectiveness of colorectal cancer screening strategies – A systematic review.
Clinical Gastroenterology and Hepatology 2019; 17:1969-1981.

Logan CA, Siziba LP, König W, Carr P, Brenner H, Rothenbacher D, Genuneit J.
Leptin in human milk and child body mass index: Results of the Ulm Birth Cohort Studies.
Nutrients 2019; 11:1883.

Perna L, Wahl HW, Weberpals J, Jansen L, Mons U, Schöttker B, Brenner H.
Incident depression and mortality among people with different types of dementia: Results from a longitudinal cohort study.
Social Psychiatry and Psychiatric Epidemiology 2019; 54:793-801.

Hung RJ, Spitz MR, Houlston RS, Schwartz AG, Field JK,…, Brenner H,…, Christiani DC, Amos CI, Yang P, Gorlova OY.
Lung cancer risk in never smokers of European descent is associated with genetic variation in the 5P15.33 TERT-CLPTM1L region.
Journal of Thoracic Oncology 2019; 14:1360-1369.

Xuan Y, Gào X, Anusruti A, Holleczek B, Jansen EHJM, Muhlack DC, Brenner H, Schöttker B.
Association of serum markers of oxidative stress with incident major cardiovascular events, cancer incidence and all-cause mortality in type 2 diabetes patients: Pooled results from two cohort studies.
Diabetes Care 2019; 42:1436-1445.

Jia M, Zhang Y, Jansen L, Walter V, Edelmann D, Gündert M, Tagscherer K, Roth W, Bewerunge-Hudler M, Herpel E, Kloor M, Ulrich A, Burwinkel B, Bläker H, Chang-Claude J, Brenner H, Hoffmeister M.
A prognostic CpG score derived from epigenome-wide profiling of tumor tissue was independently associated with colorectal cancer survival.
Clinical Epigenetics 2019; 11:109.

Peng L, Balavarca Y, Weigl K, Hoffmeister M, Brenner H.
Head-to-head comparison of the performance of 17 risk models for predicting presence of advanced neoplasms in colorectal cancer screening.
American Journal of Gastroenterology 2019; 114:1520-1530.

Boakye D, Walter V, Martens U, Chang-Claude J, Hoffmeister M, Jansen L, Brenner H.
Treatment selection bias for chemotherapy persists in colorectal cancer patient cohort studies even in comprehensive propensity score analyses.
Clinical Epidemiology 2019; 11:821-832.

Cardoso R, Niedermaier T, Chen C, Hoffmeister M, Brenner H.
Colonoscopy and sigmoidoscopy use among the average-risk population for colorectal cancer: a systematic review and trend analysis.
Cancer Prevention Research 2019; 12:617-630.

Gào X, Xuan Y, Benner A, Anusruti A, Brenner H, Schöttker B.
Nitric oxide metabolites and lung cancer incidence: A matched case-control study nested in the ESTHER cohort.
Oxidative Medicine and Cellular Longevity 2019; 6470950.

Wang X, Dai JY, Albanes D, Arndt V, Berndt SI,…, Brenner H,…, Hoffmeister M, Wu AH, Gruber SB, Peters U, White E.
Mendelian randomization analysis of C-reactive protein on colorectal cancer risk.
International Journal of Epidemiology 2019; 48:767-780.

Shu X, Wu L, Khankari NK, Shu XO, Wang TJ, Michailidou K, Bolla MK, Wang Q, Dennis J, Milne RL, Schmidt MK, Pharoah PDP, Andrulis IL, Hunter DJ, Simard J, Easton DF, Zheng W, Breast Cancer Association Consortium*.
Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis.
International Journal of Epidemiology 2019; 48:795-806.
*Co-authors on behalf of the ESTHER study: Arndt V, Brenner H

Walter V, Boakye D, Weberpals J, Jansen L, Haefeli WE, Martens UM, Knebel P, Chang-Claude J, Hoffmeister M, Brenner H.
Decreasing use of chemotherapy in older stage III colon cancer patients irrespective of comorbidities.
Journal of the National Comprehensive Cancer Network 2019; 17:1089-1099.

Adam S, Koch-Gallenkamp L, Bertram H, Eberle A, Holleczek B, Pritzkuleit R, Waldeyer-Sauerland M, Waldmann A, Zeissig SR, Rohrmann S, Brenner H, Arndt V.
Health-related quality of life in long-term survivors with localised prostate cancer by therapy – results from a population-based study.
European Journal of Cancer Care 2019; 28:e13076.

The WHO CVD Risk Chart Working Group.*
World Health Organization (WHO) cardiovascular disease risk charts: revised models to estimate risk in 21 global regions.
The Lancet Global Health 2019; 7:e1332-1345.
*Co-authors on behalf of the ESTHER study: Brenner H, Schöttker B

Shepshelovich D, Xu W, Lu L, Fares A, Yang P, Christiani D, Zhang J, Shiraishi K, Ryan BM, Chen C, Schwartz AG, Tardon A, Wu X, Schabath MB, Teare MD, Le Marchand L, Zhang ZF, Field JK, Brenner H, Daio N, Xie J, Kohno T, Harris CC, Wenzlaff AS, Fernandez-Tardon G, Ye Y, Taylor F, Wilkens LR, Davies M, Liu Y, Barnett MJ, Goodman GE, Morgenstern H, Holleczek B, Brown MC, Hung R, Liu G.
Body mass index (BMI), BMI change, and overall survival in patients with SCLC and NSCLC: A pooled analysis of the International Lung Cancer Consortium.
Journal of Thoracic Oncology 2019; 14:1594-1607.

Haffa M, Lin T, Holowatyj AN, Kratz M, Toth R, Benner A, Gigic B, Habermann N, Schrotz-King P, Böhm J, Brenner H, Schneider M, Ulrich A, Herpel E, Schirmacher P, Straub BK, Nattenmüller J, Kauczor HU, Ball CR, Ulrich CM, Glimm H, Scherer D.
Transcriptome profiling of adipose tissue reveals depot-specific metabolic alterations among patients with colorectal cancer.
The Journal of Clinical Endocrinology & Metabolism 2019; 104:5225-5237.

Teumer A, Li Y, Ghasemi S, Prins B, Wuttke M,…, Brenner H,…, Schöttker B,…, Kottgen A, Gerstner L, Chen M, Grundner-Culemann F.  
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.
Nature Communications 2019; 10:4130.

Dörk T, Peterlongo P, Mannermaa A, Bolla MK, Wang Q,…, Brenner H,…, Pharoah PDP, Schindler D, Devilee P, Easton DF.
Two truncating variants in FANCC and breast cancer risk.
Scientific Reports 2019; 9:12524.

Boakye D, Jansen L, Schneider M, Chang-Claude J, Hoffmeister M, Brenner H.
Personalizing the prediction of colorectal cancer prognosis by incorporating comorbidities and functional status into prognostic nomograms.
Cancers 2019; 11:1435.

Bhardwaj M, Gies A, Weigl K, Tikk K, Benner A, Schrotz-King P, Borchers CH, Brenner H.
Evaluation and validation of plasma proteins using two different protein detection methods for early detection of colorectal cancer.
Cancers 2019; 11:1426.

Hu C, Schöttker B, Venisse N, Limousi F, Saulnier PJ, Albouy-Llaty M, Dupuis A, Brenner H, Migeot V, Hadjadj S.
Bisphenol A, chlorinated dervatives of Bisphenol A and occurrence of myocardinal infarction in patients with type 2 diabetes: nested case-control studies in two European cohorts.
Environmental Science & Technology 2019; 53:9876-9883.

Thong MSY, Doege D, Koch-Gallenkamp L, Bertram H, Eberle A, Holleczek B, Waldeyer-Sauerland M, Waldmann A, Zeissig SR, Brenner H, Arndt V.
Age at diagnosis and sex are associated with long-term deficits in disease-specific health-related quality of life of survivors of colon and rectal cancer: a population-based study.
Diseases of the Colon & Rectum 2019; 62:1294-1304.

Brenner H, Gies A, Selby K.
Overestimated sensitivity of fecal immunochemical tests in screening cohorts with registry-based follow-up.
American Journal of Gastroenterology 2019; 114:1795-1801.

Heißer T, Peng L, Weigl K, Hoffmeister M, Brenner H.
Outcomes at follow-up of a negative colonoscopy in average-risk population: a systematic review and meta-analysis.
BMJ 2019; 367:16109.

Selby K, Levine EH, Doan C, Gies A, Brenner H, Quesenberry C, Lee JK, Corley DA.
Effect of sex, age and positivity threshold on fecal immunochemical test accuracy: a systematic review and meta-analysis.
Gastroenterology 2019; 157:1494-1505.

Knüppel S, Clemens M, Conrad J, Gastell S, Michels KB, Leitzmann M, Krist L, Pischon T, Krause G, Ahrens W, Ebert N, Jöckel KH, Kluttig A, Obi N, Kaaks R, Lieb W, Schipf S, Brenner H, Heuer T, Harttig U, Linseisen J, Nöthlings U, Boeing H.
Design and characterization of dietary assessment in the German National Cohort.
European Journal of Clinical Nutrition 2019; 73:1480-1491.

Pardini B, Corrado A, Paolicchi E, Cugliari G, Berndt SI,…, Brenner H,…, Hoffmeister M,…, Gemignani F, Peters U, Naccarati A, Landi S.
DNA repair and cancer in colon and rectum: novel players in genetic susceptibility.
International Journal of Cancer 2019; 146:363-372.

Ooi BNS, Loh H, Ho PJ, Milne R, Giles G, Gao C, Kraft P, John EM, Swerdlow A, Brenner H, Wu AH, Haiman C, Evans DG, Zheng W, Fasching P, Castelao JE, Kwong A, Xia S, Czene K, Hall P, Dunning A, Easton DF, Hartman M, Li J.
The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis.
International Journal of Epidemiology 2019; 48:781-794.

Weigl K, Chang-Claude J, Hsu L, Hoffmeister M, Brenner H.
Establishing a valid approach for estimating familial risk of cancer explained by common genetic variants.
International Journal of Cancer 2019; 146:68-75.

Pennells L, Kaptoge S, Wood A, Sweeting M, Zhao X,…, Brenner H,…, D’Agostino Sr RBD, Thompson SG, Danesh J, Di Angelantonio E, on behalf of the Emerging Risk Factors Collaboration.
Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies.
European Heart Journal 2019; 40:621-631.

Escala-Garcia M, Guo Q, Dörk T, Canisius S, Keeman R,…, Arndt V,…, Brenner H,…, Holleczek B,…, Nevanlinna H, Eccles DM, Pharoah PDP, Schmidt MK.
Genome-wide association study of germline variants and breast cancer-specific mortality.
British Journal of Cancer 2019; 120:647-657.

Inker LA, Grams ME, Levey AS, Coresh J, Cirillo M,…, Kovesdy CP, Woodward M, Levin A, CKD Prognosis Consortium.*
Relationship of estimated GFR and albuminuria to concurrent laboratory abnormalities: an indivicual participant data meta-analysis in a global consortium.
American Journal of Kidney Diseases 2019; 73:206-217.
*Collaborators on behalf of the ESTHER study: Brenner H, Rothenbacher D, Schöttker B, Saum KU

Hohls JK, König HH, Heider D, Brenner H, Böhlen F, Matschinger H, Saum KU, Schöttker B, Haefeli WE, Hajek A, Wild B.
Longitudinal association between panic disorder and health care costs in older adults.
Depress Anxiety 2019; 36:1135-1142.

Huyghe JR, Bien SA, Harrison TA, Kang HM, Chen S,…, Brenner H,…, Hoffmeister M,…, Nickerson DA, Gruber SB, Hsu L, Peters U.
Discovery of common and rare genetic risk variants for colorectal cancer.
Nature Genetics 2019; 51:76-87.

Neumeyer S, Popanda O, Edelmann D, Butterbach K, Toth C, Roth W, Bläker H, Jian R, Herpel E, Jäkel C, Schmezer P, Jansen L, Alwers E, Benner A, Burwinkel B, Hoffmeister M, Brenner H, Chang-Claude J.
Genome-wide DNA methylation differences according to oestrogen receptor beta status in colorectal cancer.
Epigenetics 2019; 14:477-493.

Adams CD, Richmond R, Ferreira DLS, Spiller W, Tan V,…, Brenner H,…, Pandha H, Thibodeau AN, Martin RM, PRACTICAL Consortium.
Circulating metabolic biomarkers of screen-detected prostate cancer in the ProtecT Study.
Cancer Epidemiology & Biomarkers 2019; 28:208-216.

Chang CP, Chang SC, Chuang SC, Berthiller J, Ferro G,…, Brenner H,…, Boffetta P, Zhang ZF, Hashibe M, Lee YA.
Age at start of using tobacco on the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE).
Cancer Epidemiology 2019; 63:101615.

Hoppe LK, Muhlack DC, Koenig W, Brenner H, Schöttker B.
The associations of diuretics and laxatives use with cardiovascular mortality. An individual patient-data meta-analysis of two large cohort studies.
Cardiovascular Drugs and Therapy 2019; 33:567-579.

Figlioli G, Bogliolo M, Catucci I, Caleca L, Lasheras SV,…, Arndt V,…, Brenner H,…, Couch F, Nevanlinna H, Surrallés J, Peterlongo P.
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer.
npj Breast Cancer 2019; 5:38.

Brunner FJ, Waldeyer C, Ojeda F, Salomaa V, Kee F,…, Brenner H,…, Omland T, Kuulasmaa K, Landmesser U, Blankenberg S.
Application of Non-HDL-Cholesterol for population-based cardiovascular risk stratification. Results from the Multinational Cardiovascular Risk Consortium.
Lancet 2019; 394:2173-2183.

Neumeyer S, Popanda O, Butterbach K, Edelmann D, Bläker H, Toth C, Roth W, Herpel E, Jäkel C, Schmezer P, Benner A, Burwinkel B, Hoffmeister M, Brenner H, Chang-Claude J.
DNA methylation profiling to explore colorectal tumor differences according to menopausal hormone therapy use in women.
Epigenomics 2019; 11:1765-1778.

Weigl K, Hsu L, Knebel P, Hoffmeister M, Timofeeva M, Farrington S, Dunlop M, Brenner H.
Head to head comparison of family history of colorectal cancer and a genetic risk score for colorectal cancer risk stratification.
Clinical and Translational Gastroenterology 2019; 10:e00106.

Wang X, O'Connell K, Jeon J, Song M, Hunter D, Hoffmeister M, Lin Y, Berndt S, Brenner H, Chan AT, Chang-Claude J, Gong J, Gunter MJ, Harrison TA, Hayes RB, Joshi A, Newcomb P, Schoen R, Slattery ML, Vargas A, Potter JD, Le Marchand L, Giovannucci E, White E, Hsu L, Peters U, Du M.
Combined effect of modifiable and non-modifiable risk factors for colorectal cancer risk in a pooled analysis of 11 population-based studies.
BMJ Open Gastroenterology 2019; 6:e000339.

Gunter MJ, Alhomoud S, Arnold M, Brenner H, Burn J, Casey G, Chan AT, Cross AJ, Giovannucci E, Hoover R, Houlston R, Jenkins M, Laurent-Puig P, Peters U, Ransohoff D, Riboli E, Sinha R, Stadler ZK, Brennan P, Chanock SJ.
Meeting report from the joint IARC-NCI international cancer seminar series: a
focus on colorectal cancer.
Annals of Oncology 2019; 30:510-519.

Yu H, Guan Z, Cuk K, Zhang Y, Brenner H.
Circulating microRNA biomarkers for lung cancer detection in East Asian populations.
Cancers 2019; 11:415.

Mukama T, Kharazmi E, Xing X, Sundquist K, Sundquist J, Brenner H, Fallah M.
Risk-adapted starting age of screening for relatives of breast cancer patients: Evidence to supplement current screening guidelines.
JAMA Oncology 2019; 6:68-74.

Raut J, Guan Z, Schrotz-King P, Brenner H.
Whole-blood DNA methylation markers for risk stratification in colorectal cancer screening: A systematic review.
Cancers 2019; 11:912.

Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Abate D,..., Brenner H,..., Schöttker B,..., Ziapour A, Zodpey S, Murray CJL.
Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2017: A systematic analysis for the Global Burden of Disease Study.
JAMA Oncology 2019; 5:1749-1769.

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