Clinical investigations


In cooperation with radiation oncologists, our group analyzes clinical data to determine dose response curves and to derive tolerance doses in normal tissues. For ion beams, this allows analyzing the consistency of model-based RBE-predictions with clinical outcome. For photon treatments, it allows comparison of different treatment regimens and quantifying the tolerance of normal tissues.

Selected publications

  • Schlampp I., Karger C.P., Jäkel O., Scholz M., Didinger B., Nikoghosyan A., Hoess A., Krämer M., Edler L., Debus J., Schulz-Ertner D.: Temporal lobe reactions after radiotherapy with carbon ions: incidence and estimation of the relative biological effectiveness (RBE) by the local effect model (LEM). International Journal of Radiation Oncology Biology Physics 80, 815-823, 2011
  • Gillmann C., Jäkel O., Schlampp I., Karger C.P.: Temporal lobe reactions after carbon ion radiation therapy: comparison of relative biological effectiveness-weighted tolerance doses predicted by local effect models I and IV. International Journal of Radiation Oncology Biology Physics 88, 1136-1141, 2014
  • Gillmann C., Lomax A.J., Weber D.C., Jäkel O., Karger C.P.: Dose-response curves for MRI-detected radiation-induced temporal lobe reactions in patients after proton and carbon ion therapy: Does the same RBE-weighted dose lead to the same biological effect? Radiotherapy and Oncology 128, 109–114, 2018
  • Gillmann C., Jäkel O., Karger C.P.: RBE-weighted doses in target volumes of chordoma and chondrosarcoma patients treated with carbon ion radiotherapy: comparison of local effect models I and IV. Radiotherapy and Oncology 141, 234-238, 2019
  • Münter M.W., Karger C.P., Hoffner S.G., Hof H., Thilmann C., Rudat V., Nill S., Wannenmacher M., Debus J.: Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphy. International Journal of Radiation Oncology Biology Physics 58, 175-184, 2004
  • Münter M.W., Hoffner S., Hof H., Herfarth K.K., Haberkorn U., Rudat V., Huber P., Debus J., Karger C.P.: Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: Comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without Amifostine. International Journal of Radiation Oncology Biology Physics 67, 651-659, 2007
  • Kyas I., Hof H., Debus J., Schlegel W., Karger C.P.: Prediction of radiation-induced changes in the lung after stereotactic body radiation therapy of non-small-cell lung cancer. International Journal of Radiation Oncology Biology Physics 67, 768-774, 2007


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