Image Processing in Functional Image Series

Dynamic contrast enhanced MRI (DCE MRI)

With dynamic contrast enhanced MRI (DCE MRI) it is possible to visualize physiological processes. The distribution of a contrast agent is analyzed over time by imaging a volume at different points of time. DCE MRI delivers parameters for blood volume and vessel permeability. The calculation of these parameters according to the Brix model [1] and their representation as a parameter map is integrated into VIRTUOS [2].
In current projects the integration of functional parameters into a voxel classification for the automatic segmentation and characterization of tumor tissue is analyzed.


[1] Brix, G., Semmler, W., Port, R., Schad, L.R., Layer, G. und Lorenz, W.J. (1991). Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging. J Comput Assist Tomogr, 15(4):621–628.


[2] Neff, T., Kiessling, F., Brix, G., Baudendistel, K., Zechmann, C., Giesel, F.L. und Bendl, R. (2005). An optimized workflow for the integration of biological information into radiotherapy planning: experiences with T1w DCE-MRI. Phys Med Biol, 50(17):4209– 4223.

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