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Publications of Pediatric Neurooncology

2019

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DNA-methylation profiling is a method of choice for molecular verification of pediatric WNT activated medulloblastomas.
Neuro-Oncology 21(2), 214-221 () [10.1093/neuonc/noy155]  GO BibTeX | EndNote: XML, Text | RIS

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N2M2 (NOA20) phase I/II trial of molecularly matched targeted therapies plus radiotherapy in patients with newly diagnosed non-MGMT hypermethylated glioblastoma.
Neuro-Oncology 21(1), 95-105 () [10.1093/neuonc/noy161]  GO BibTeX | EndNote: XML, Text | RIS

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Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors.
Journal of neuro-oncology 141(1), 43-55 () [10.1007/s11060-018-03018-6]  GO BibTeX | EndNote: XML, Text | RIS

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Global DNA methylation reflects spatial heterogeneity and molecular evolution of lung adenocarcinomas.
International journal of cancer 144(5), 1061 - 1072 () [10.1002/ijc.31939]  GO BibTeX | EndNote: XML, Text | RIS

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Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation.
Cancer cell 35(1), 95 - 110.e8 () [10.1016/j.ccell.2018.11.014]  GO pmc   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma.
Nature Communications 10(1), 332 () [10.1038/s41467-018-08269-5]  GO DBCoverage   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells.l401
PLOS ONE 14(1), e0210665 - () [10.1371/journal.pone.0210665]  GO DBCoverage   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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InTAD: chromosome conformation guided analysis of enhancer target genes.
BMC bioinformatics 20(1), 60 () [10.1186/s12859-019-2655-2]  GO DBCoverage   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre.
Acta Neuropathologica Communications 7(1), 24 () [10.1186/s40478-019-0668-8]  GO DBCoverage   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Integrated molecular characterization of IDH-mutant glioblastomas.
Neuropathology & applied neurobiology 45(2), 108 - 118 () [10.1111/nan.12523]  GO BibTeX | EndNote: XML, Text | RIS

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The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma.
Clinical cancer research 25(6), 1851 - 1866 () [10.1158/1078-0432.CCR-18-1965]  GO BibTeX | EndNote: XML, Text | RIS

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EZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.
Neuro-Oncology 21(7), 878-889 () [10.1093/neuonc/noz058]  GO BibTeX | EndNote: XML, Text | RIS

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Occurrence of high-grade glioma in Noonan syndrome: Report of two cases.
Pediatric blood & cancer 66(5), e27625 () [10.1002/pbc.27625]  GO BibTeX | EndNote: XML, Text | RIS

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TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma.
Acta neuropathologica 137(4), 657 - 673 () [10.1007/s00401-019-01982-5]  GO BibTeX | EndNote: XML, Text | RIS

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Ectopic intracranial retinoblastoma in a 3.5-month-old infant without eye involvement and without evidence of heritability.
Pediatric blood & cancer 66(5), e27599 () [10.1002/pbc.27599]  GO BibTeX | EndNote: XML, Text | RIS

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Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis.
Cancer cell 35(4), 692-704 () [10.1016/j.ccell.2019.02.007]  GO BibTeX | EndNote: XML, Text | RIS

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DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma.
Journal of cancer research and clinical oncology 145(5), 1273-1281 () [10.1007/s00432-019-02895-2]  GO BibTeX | EndNote: XML, Text | RIS

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MYC drives Group 3 medulloblastoma through transformation of Sox2+ astrocyte progenitor cells.
Cancer research 79(8), 1967-1980 () [10.1158/0008-5472.CAN-18-1787]  GO BibTeX | EndNote: XML, Text | RIS

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Newly Diagnosed Metastatic Intracranial Ependymoma in Children: Frequency, Molecular Characteristics, Treatment, and Outcome in the Prospective HIT Series.
The oncologist 24(9), E921-E929 () [10.1634/theoncologist.2018-0489]  GO BibTeX | EndNote: XML, Text | RIS

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Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles.
Acta neuropathologica 137(6), 1003-1015 () [10.1007/s00401-019-01981-6]  GO BibTeX | EndNote: XML, Text | RIS

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Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype.
Clinical Sarcoma Research 9(1), 2 () [10.1186/s13569-019-0113-6]  GO DBCoverage   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging
Brain pathology 29(3), 325 - 335 () [10.1111/bpa.12664]  GO BibTeX | EndNote: XML, Text | RIS

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Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes.
Acta neuropathologica 138(2), 309-326 () [10.1007/s00401-019-02020-0]  GO BibTeX | EndNote: XML, Text | RIS

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Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA.
Acta neuropathologica 137(5), 837 - 846 () [10.1007/s00401-019-01969-2]  GO BibTeX | EndNote: XML, Text | RIS

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Mutational patterns and regulatory networks in epigenetic subgroups of meningioma.
Acta neuropathologica 138(2), 295-308 () [10.1007/s00401-019-02008-w]  GO BibTeX | EndNote: XML, Text | RIS

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RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas.
Acta neuropathologica 138(2), 275-293 () [10.1007/s00401-019-02021-z]  GO BibTeX | EndNote: XML, Text | RIS

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DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development.
Acta Neuropathologica Communications 7(1), 59 () [10.1186/s40478-019-0704-8]  GO DBCoverage   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.
European journal of cancer 114, 27 - 35 () [10.1016/j.ejca.2019.03.019]  GO BibTeX | EndNote: XML, Text | RIS

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DECIPHER pooled shRNA library screen identifies PP2A and FGFR signaling as potential therapeutic targets for DIPGs.
Neuro-Oncology 21(7), 867-877 () [10.1093/neuonc/noz057]  GO BibTeX | EndNote: XML, Text | RIS

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Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
The lancet <London> / Oncology Oncology 20(7), 1011-1022 () [10.1016/S1470-2045(19)30277-3]  GO BibTeX | EndNote: XML, Text | RIS

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TelomereHunter - in silico estimation of telomere content and composition from cancer genomes.
BMC bioinformatics 20(1), 272 () [10.1186/s12859-019-2851-0]  GO DBCoverage BibTeX | EndNote: XML, Text | RIS

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Evaluation of Storage Tubes for Combined Analysis of Circulating Nucleic Acids in Liquid Biopsies.
International journal of molecular sciences 20(3), 704 - () [10.3390/ijms20030704]  GO DBCoverage   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.
Nature Communications 10(1), 2400 () [10.1038/s41467-019-10307-9]  GO DBCoverage BibTeX | EndNote: XML, Text | RIS

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Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Cell stem cell 25(3), 433-446.e7 () [10.1016/j.stem.2019.05.013]  GO BibTeX | EndNote: XML, Text | RIS

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Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma.
BMC cancer 19(1), 571 () [10.1186/s12885-019-5742-x]  GO DBCoverage   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1.
Acta neuropathologica 138(3), 497-504 () [10.1007/s00401-019-02038-4]  GO BibTeX | EndNote: XML, Text | RIS

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Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions.
Acta neuropathologica 138(5), 827-835 () [10.1007/s00401-019-02039-3]  GO BibTeX | EndNote: XML, Text | RIS

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Resolving medulloblastoma cellular architecture by single-cell genomics.
Nature <London> 572(7767), 74 - 79 () [10.1038/s41586-019-1434-6]  GO BibTeX | EndNote: XML, Text | RIS

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Differential response of SHH-expressing adult medulloblastomas to the sonic hedgehog inhibitor vismodegib: whole-genome analysis.
Cancer biology & therapy 20(11), 1398-1402 () [10.1080/15384047.2019.1647057]  GO BibTeX | EndNote: XML, Text | RIS

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RF_Purify: a novel tool for comprehensive analysis of tumor-purity in methylation array data based on random forest regression.
BMC bioinformatics 20(1), 428 () [10.1186/s12859-019-3014-z]  GO DBCoverage   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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MYCN amplification drives an aggressive form of spinal ependymoma.
Acta neuropathologica 138(6), 1075-1089 () [10.1007/s00401-019-02056-2]  GO BibTeX | EndNote: XML, Text | RIS

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DNA methylation signature is prognostic of choroid plexus tumor aggressiveness.
Clinical epigenetics 11(1), 117 () [10.1186/s13148-019-0708-z]  GO DBCoverage   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis.
Nature Communications 10(1), 3914 () [10.1038/s41467-019-11884-5]  GO DBCoverage   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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High impact of miRNA-4521 on FOXM1 expression in medulloblastoma.
Cell death & disease 10(10), 696 () [10.1038/s41419-019-1926-1]  GO DBCoverage BibTeX | EndNote: XML, Text | RIS

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Recurrent non-coding U1-snRNA mutations drive cryptic splicing in Shh medulloblastoma.
Nature <London> 574(7780), 707 - 711 () [10.1038/s41586-019-1650-0]  GO BibTeX | EndNote: XML, Text | RIS

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MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Children's Oncology Group ACNS0332 Trial.
American journal of neuroradiology 40(11), 1796-1803 () [10.3174/ajnr.A6253]  GO BibTeX | EndNote: XML, Text | RIS

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Whole Genome Sequencing of Familial Non-Medullary Thyroid Cancer Identifies Germline Alterations in MAPK/ERK and PI3K/AKT Signaling Pathways.
Biomolecules 9(10), 605 () [10.3390/biom9100605]  GO DBCoverage BibTeX | EndNote: XML, Text | RIS

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Imaging Characteristics of Wingless Pathway Subgroup Medulloblastomas: Results from the German HIT/SIOP-Trial Cohort.
American journal of neuroradiology 40(11), 1811-1817 () [10.3174/ajnr.A6286]  GO BibTeX | EndNote: XML, Text | RIS

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Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.
Cell reports 29(8), 2338-2354.e7 () [10.1016/j.celrep.2019.10.013]  GO DBCoverage BibTeX | EndNote: XML, Text | RIS

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Sox2+ cells in Sonic Hedgehog-subtype medulloblastoma resist p53-mediated cell-cycle arrest response and drive therapy-induced recurrence.
Neuro-Oncology Advances 1(1), vdz027 () [10.1093/noajnl/vdz027]  GO pmc   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Challenges to curing primary brain tumours.
Nature reviews / Clinical oncology Clinical oncology [...] 16(8), 509 - 520 () [10.1038/s41571-019-0177-5]  GO pmc   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'.
Nature reviews / Clinical oncology Clinical oncology [...] 16(8), 522 - 523 () [10.1038/s41571-019-0236-y]  GO BibTeX | EndNote: XML, Text | RIS

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The molecular landscape of ETMR at diagnosis and relapse.
Nature <London> 576(7786), 274-280 () [10.1038/s41586-019-1815-x]  GO BibTeX | EndNote: XML, Text | RIS

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Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia
Clinical epigenetics 11(1), 188 () [10.1186/s13148-019-0775-1]  GO DBCoverage BibTeX | EndNote: XML, Text | RIS

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Establishment of patient-derived orthotopic xenograft model of 1q+ posterior fossa group A ependymoma.
Neuro-Oncology 21(12), 1540 - 1551 () [10.1093/neuonc/noz116]  GO BibTeX | EndNote: XML, Text | RIS

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Translating genomic medicine to the clinic: challenges and opportunities.
Genome medicine 11(1), 9 () [10.1186/s13073-019-0622-1]  GO DBCoverage   Volltext herunterladenFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Excessive Toxicity After Treatment of Congenital Acute Myeloid Leukemia.
Klinische Pädiatrie 231(6), 291-293 () [10.1055/a-0859-7375]  GO BibTeX | EndNote: XML, Text | RIS

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Medulloblastoma.
Nature reviews / Disease Primers Disease Primers [...] 5(1), 11 () [10.1038/s41572-019-0063-6]  GO BibTeX | EndNote: XML, Text | RIS

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Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours.
Nature reviews / Cancer Cancer [...] 19(8), 420 - 438 () [10.1038/s41568-019-0169-x]  GO BibTeX | EndNote: XML, Text | RIS

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[Update on Li-Fraumeni syndrome].
Der Pathologe 40(6), 592-599 () [10.1007/s00292-019-00657-y]  GO BibTeX | EndNote: XML, Text | RIS

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EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.
The lancet <London> / Oncology Oncology 20(12), e715 - e728 () [10.1016/S1470-2045(19)30669-2]  GO BibTeX | EndNote: XML, Text | RIS

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