Clinical Epidemiology and Aging Research

Original and Review Articles in 2020 and in Press

Balavarca Y, Weigl K, Thomsen H, Brenner H.
Performance of individual and joint risk stratification by an environmental risk score and a genetic risk score in a colorectal cancer screening setting.
International Journal of Cancer 2020; 146:627-634.

McNabb S, Harrison TA, Albanes D, Berndt SI, Brenner H,..., Hoffmeister M,..., Wolk A, Woods MO, Phipps AI, Peters U.
Meta-analysis of 16 studies of the association of alcohol with colorectal cancer.
International Journal of Cancer 2020; 146:861-873.

Hilvo M, Meikle PJ, Pedersen ER, Tell GS, Dhar I, Brenner H, Schöttker B, Lääperi M, Kauhanen D, Koistinen KM, Jylhä A, Huynh K, Mellett NA, Tonkin AM, Sullivan DR, Simes J, Nestel P, Koenig W, Rothenbacher D, Nygard O, Laaksonen R.
Development and validation of ceramide and phospholipid based cardiovascular risk estimation score for coronary artery disease patients.
European Heart Journal 2020; 41:371-380.

Gào X, Wilsgaard T, Jansen EHJM, Yang X, Anusruti A, Brenner H, Schöttker B.
Serum total thiol levels and the risk of lung, colorectal, breast and prostate cancer: A prospective case-cohort study.
International Journal of Cancer 2020; 146:1261-1267.

Boakye D, Walter V, Jansen L, Martens U, Chang-Claude J, Hoffmeister M, Brenner H.
Magnitude of the age advancement effect of comorbidites in colorectal cancer prognosis.
Journal of the National Comprehensive Cancer Network 2020; 18:59-68.

Stocker H, Nabers A, Perna L, Möllers T, Rujescu D, Hartmann A, Holleczek B, Schöttker B, Gerwert K, Brenner H.
Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2020; 16:283-291.

Cornish AJ, Law PJ, Timofeeva M, Palin K, Farrington SM, Palles C, Jenkins MA, Casey G, Brenner H, Chang-Claude J, Hoffmeister M, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Dunlop MG, Houlston RS.
Modifiable pathways for colorectal cancer: a Mendelian randomisation analysis.
The Lancet Gastroenterology & Hepatology 2020; 5:55-62.

Niersmann C, Carstensen-Kirberg M, Maalmi H, Holleczek B, Roden M, Brenner H, Herder C, Schöttker B. Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes.
Diabetologia 2020; 63:410-418.

Guan Z, Raut JR, Weigl K, Schöttker B, Holleczek B, Zhang Y, Brenner H.
Individual and joint performance of DNA methylation profiles, genetic risk scores and environmental risk scores for predicting breast cancer risk.
Molecular Oncology 2020; 14:42-53.

Mukama T, Fallah M, Tian Y, Sundquist K, Sundquist J, Brenner H, Kharazmi E.
Risk-tailored starting age of breast cancer screening based on women's reproductive profile: nationwide cohort study.
European Journal of Cancer 2020; 124:207-213.

Niedermaier T, Balavarca Y, Brenner H.
Stage specific sensitivity of fecal immunochemical tests for detecting colorectal cancer: systematic review and meta-analysis.
American Journal of Gastroenterology 2020; 115:56-69.

Möllers T, Perna L, Stocker H, Ihle P, Schubert I, Schöttker B, Frölich L, Bauer J, Brenner H.
Alzheimer's disease medication and outcomes of hospitalization among patients with dementia. Epidemiology and Psychiatric Sciences 2020; 29:e73, 1-9.

Bhardwaj M, Weigl K, Tikk K, Benner A, Schrotz-King P, Brenner H.
Multiplex screening of 275 plasma protein biomarkers for identifying a signature for early detection of colorectal cancer.
Molecular Oncology 2020; 14:8-21.

Gies A, Niedermaier T, Weigl K, Schrotz-King P, Hoffmeister M, Brenner H.
Effect of long-term frozen storage and thawing of stool samples on faecal haemoglobin concentration and diagnostic performance of faecal immunochemical tests.
Clinical Chemistry and Laboratory Medicine 2020; 58:390-398.

Schöttker B, Xuan Y, Gào X, Anusruti A, Brenner H.
Oxidatively damaged DNA/RNA and 8-isoprostane levels are associated with the development of type 2 diabetes mellitus at older age: results from a large cohort study.
Diabetes Care 2020; 43:130-136.

Bielska-Lasota M, Rossi S, Krzyzak M, Haelens A, Domenic A, De Angelis R, Maciejczyk A, Rodriguez-Barranco M, Zadnik V, Minicozzi P, EUROCARE-5 Working Group*.
Reasons for low cervical cancer survival in new accession European Union countries: a EUROCARE-5 study.
Archives of Gynecology and Obstetrics 2020; 301:591-602.
*Collaborator from DKFZ: Brenner H

Fachal L, Aschard H, Beesley J, Barnes DR, Allen J,..., Brenner H,..., Schöttker B,..., Simard J, Easton DF, Kraft P, Dunning AM.
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
Nature Genetics 2020; 52:56-73.

Barahona Ponce C, Scherer D, Boekstegers F, Garate-Calderon V, Jenab M, Aleksandrova K, Katzke V, Weiderpass E, Bonet C, Moradi T, Fischer K, Bossers W, Brenner H, Schöttker B, Holleczek B, Hveem K, Eklund N, Völker U, Waldenberger M, Lorenzo Bermejo J.
Arsenic and gallbladder cancer risk: Mendelian randomization analysis of European prospective data. International Journal of Cancer 2020; 146:2648-2650.

Guo F, Chen C, Schöttker B, Holleczek B, Hoffmeister M, Brenner H.
Changes in colorectal cancer screening use after introduction of alternative screening offer in Germany: Prospective cohort study.
International Journal of Cancer 2020; 146:2423-2432.

Anusruti A, Xuan Y, Gào X, Jansen E, Laetsch DC, Brenner H, Schöttker B.
Factors associated with high oxidative stress in type 2 diabetes patients: a meta-analysis of two cohort studies.
BMJ Open Diabetes Research & Care 2020; 8:e000933.

Anusruti A, Jansen EHJM, Gào X, Xuan Y, Brenner H, Schöttker B.
Longitudinal associations of body mass index, waist circumference and waist to hip ratio with biomarkers of oxidative stress in older adults: Results of a large cohort study.
Obesity Facts 2020; 13:66-76.

Boekstegers F, Marcelain K, Barahona Ponce C, Baez Benavides PF, Müller B, de Toro G, Retamales J, Barajas O, Ahumada M, Morales E, Rojas A, Sanhueza V, Loader D, Rivera MT, Gutiérrez L, Bernal G, Ortega A, Montalvo D, Portino S, Bertrán ME, Gabler F, Spencer L, Olloquequi J, Silos RG, Fischer C, Scherer D, Jenab M, Aleksandrova K, Katzke V, Weiderpass E, Moradi T, Fischer K, Bossers W, Brenner H, Hveem K, Eklund N, Völker U, Waldenberger M, Guajardo MF, Gonzalez-Jose R, Bedoya G, Bortolini MC, Canizales S, Gallo C, Linares AR, Rothhammer F, Bermejo JL.
ABCB1/4 Gallbladder cancer risk variants identified in India also show strong effects in Chileans.
Cancer Epidemiology 2020; 65:101643.

Alwers E, Jansen L, Bläker H, Kloor M, Tagscherer K, Roth W, Boakye D, Herpel E, Grüllich C, Chang-Claude J, Brenner H, Hoffmeister M.
Microsatellite instability and survival after adjuvant chemotherapy among stage II and III colon cancer patients: Results from a population-based study.
Molecular Oncology 2020; 14:363-372.

Carr PR, Amitay E, Jansen L, Alwers E, Roth W, Herpel E, Kloor M, Schneider M, Bläker H, Chang-Claude J, Brenner H, Hoffmeister M.
Association of body mass index and major molecular pathological markers of colorectal cancer among men and women.
American Journal of Clinical Nutrition 2020; 111:562-569.

Beyerle J, Holowatyj AN, Haffa M, Frei E, Gigic B, Schrotz-King P, Böhm J, Habermann N, Stiborova M, Scherer D, Koelsch T, Skender S, Becker N, Herpel E, Schneider M, Ulrich A, Schirmacher P, Chang-Claude J, Brenner H, Hoffmeister M, Haug U, Owen RW, Ulrich CM.
Expression patterns of xenobiotic metabolizing enzymes in tumor and adjacent normal mucosa tissues among patients with colorectal cancer: The ColoCare study.
Cancer Epidemiology, Biomarkers & Prevention 2020; 29:460-469.

Jaeschke L, Steinbrecher A, Boeing H, Gastell S, Ahrens W,..., Brenner H,..., Schipf S, Schmidt B, Zinkhan M, Pischon T.
Factors associated with habitual time spent in different physical activity intensities using multiday accelerometry.
Scientific Reports 2020; 10:774.

Riegger J, Rehm M, Büchele G, Brenner H, Günther KP, Rothenbacher D, Brenner RE.
Serum cartilage oligomeric matrix protein in late-stage osteoarthritis: Association with clinical features, renal function and cardiovascular biomarkers.
Journal of Clinical Medicine 2020; 9:268.

Papadimitriou N, Dimou N, Tsilidis K, Banbury B, Martin R,..., Brenner H,..., Hoffmeister M,..., Wu A, Peters U, Gunter M, Murphy N.
Physical activity and risks of breast and colorectal cancer: a Mendelian randomization analysis.
Nature Communications 2020; 11:597.

Escala-Garcia M, Abraham J, Andrulis IL, Anton-Culver H, Arndt V,..., Brenner H,..., Dörk T, Easton D, Canisius S, Schmidt M.
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
Nature Communications 2020; 11:312.

Bhardwaj M, Weigl K, Tikk K, Holland-Letz T, Schrotz-King P, Borchers CH, Brenner H.
Multiplex quantitation of 270 plasma protein markers to identify a signature for early detection of colorectal cancer.
European Journal of Cancer 2020; 127:30-40.

Boehlen FH, Herzog W, Schellberg D, Maatouk I, Schöttker B, Brenner H, Wild B.
Gender-specific predictors of generalized anxiety disorder symptoms in older adults: results of a large population-based study.
Journal of Affective Disorders 2020; 262:174-181.

Schipf S, Schöne G, Schmidt B, Günther K, Stübs G,..., Brenner H,..., Holleczek B,..., Wirkner K, Völzke H, Pischon T, Ahrens W.
Die Basiserhebung der NAKO Gesundheitsstudie: Teilnahme an den Untersuchungsmodulen, Qualitätssicherung und Nutzung von Sekundärdaten.
Bundesgesundheitsblatt 2020; 63:254-266.

Dragano N, Reuter M, Greiser KH, Becher H, Zeeb H,..., Holleczek B, Brenner H,..., Legath N, Ahrens W, Lampert T, Schmidt B.
Soziodemografische und erwerbsbezogene Merkmale in der NAKO Gesundheitsstudie. Bundesgesungsheitsblatt 2020; 63:267-278.

Leitzmann M, Gastell S, Hillreiner A, Herbolsheimer F, Baumeister SE,..., Brenner H,..., Holleczek B,..., Thierry S, Völzke H, Wirkner K, Steindorf K.
Körperliche Aktivität in der NAKO Gesundheitsstudie: erste Ergebnisse des multimodalen Erhebungskonzepts.
Bundesgesundheitsblatt 2020; 63:301-311.

Karrasch S, Peters A, Meisinger C, Ferland M, Jaeschke L,..., Leitzmann M, Brenner H, Holleczek B, Schulz H.
Lungenfunktion in der NAKO Gesundheitsstudie: Methoden und erste Ergebnisse.
Bundesgesundheitsblatt 2020; 63:322-331.

Wolf K, Kraus U, Dzolan M, Bolte G, Lakes T,..., Brenner H,..., Holleczek B,..., Wirkner K, Zschocke J, Peters A, Schneider A.
Nächtliche Vekehrslärmbelästigung in Deutschland: individuelle und regionale Unterschiede in der NAKO Gesundheitsstudie.
Bundesgesundheitsblatt 2020; 63:332-343.

Wiessner C, Keil T, Krist L, Zeeb H, Dragano N,..., Koch-Gallenkamp L,..., Waniek S, Wigmann C, Willich SN, Becher H.
Personen mit Migrationshintergrund in der NAKO Gesundheitsstudie – soziodemografische Merkmale und Vergleiche mit der autochthonen deutschen Bevölkerung.
Bundesgesundheitsblatt 2020; 63:279-289.

Fischer B, Sedlmeier AM, Hartwig S, Schlett CL, Ahrens W,..., Carr PR,..., Niedermaier T,..., Tiller D, Völzke H, Waniek S, Leitzmann MF.
Anthropometrische Messungen in der NAKO Gesundheitsstudie – mehr als nur Größe und Gewicht. Bundesgesundheitsblatt 2020; 63:290-300.

Kluttig A, Zschocke J, Haerting J, Schmermund A, Gastell S,..., Hoffmeister M,..., Mikolajczyk R, Fischer B, Leitzmann M, Brandes M.
Messung der körperlichen Fitness in der NAKO Gesundheitsstudie – Methoden, Qualitätssicherung und erste deskriptive Ergebnisse.
Bundesgesundheitsblatt 2020; 63:312-321.

Gruner LF, Hoffmeister M, Ludwig L, Brenner H.
Effect of various invitation schemes on use of fecal immunochemical tests (FITs) for colorectal cancer screening: Protocol for a randomized controlled trial.
JMIR Research Protocols 2020; 9:e16413.

Trares K*, Gào X*, Perna L, Rujescu D, Stocker H, Möllers T, Beyreuther K, Brenner H, Schöttker B. Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease and vascular dementia incidence: results from a prospective cohort study.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2020; 16:804-813.
*geteilte Erstautorenschaft

Gigic B, Nattenmüller J, Schneider M, Kulu Y, Syrjala K, Böhm J, Schrotz-King P, Brenner H, Colditz GA, Figueiredo JC, Grady WM, Li CI, Shibata D, Siegel EM, Toriola AT, Kauczor HU, Ulrich A, Ulrich C.
The role of CT-quantified body composition on longitudinal health-related quality of life in colorectal cancer patients: the ColoCare study.
Nutrients 2020; 12:1247.

Mukama T, Kharazmi E, Sundquist K, Sundquist J, Brenner H, Fallah M.
Familial risk of breast cancer by dynamic, accumulative, and static definition of family history.
Cancer 2020; 126:2837-2848.

Amitay E, Carr P, Jansen L, Roth W, Alwers E, Herpel E, Kloor M, Bläker H, Chang-Claude J, Brenner H, Hoffmeister M.
Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways. British Journal of Cancer 2020; 122:1604-1610.

Jansen L, Schröder CC, Emrich K, Holleczek B, Pritzkuleit R, Brenner H.
Disclosing progress in cancer survival with less delay.
International Journal of Cancer 2020; 147:838-846.

Feng H, Gusev A, Pasaniuc B, Wu L, Long J,..., Brenner H,..., Chenevix-Trench G, Zheng W, Kraft P, Jiang X.
Transcriptome-wide association study of breast cancer risk by estrogen-receptor status.
Genetic Epidemiology 2020; 44:442-468.

Liu J, Prager-van der Smissen WJC, Collée M, Bolla MK, Wang Q,..., Arndt V,..., Brenner H,..., Easton DF, Hooning MJ, Martens JWM, Hollestelle A.
Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk.
Scientific Reports 2020; 10:9688.

Yang Y, Wu L, Shu XO, Cai Q, Shu X, Li B, Guo X, Ye F, Michailidou K, Bolla MK, Wang Q, Dennis J, Andrulis IL, Brenner H, Chenevix-Trench G, Campa D, Castelao JE, Gago-Dominguez M, Dörk T, Hollestelle A, Lophatananon A, Muir K, Neuhausen SL, Olsson H, Sandler DP, Simard J, Kraft P, Pharoah PDP, Easton DF, Zheng W, Long J.
Genetically predicted levels of DNA methylation biomarkers and breast cancer risk: data from 228,951 women of European descent.
Journal of the National Cancer Institute 2020; 112:295-304.

NCD Risk Factor Collaboration (NCD-RisC).*
National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: an analysis of trends in Asian and Western countries.
International Journal of Epidemiology 2020; 49:173-192.
*Collaborators on behalf of the ESTHER study: Brenner H, Saum KU, Schöttker B

Holleczek B, SchöttkerB, Brenner H.
Helicobacter pylori infection, chronic atrophic gastritis and risk of stomach and esophagus cancer: results from the prospective population-based ESTHER cohort study.
International Journal of Cancer 2020; 146:2773-2783.

Geijsen AJMR, van Roekel EH, van Duijnhoven FJB, Achaintre D, Bachleitner-Hofmann T,..., Brenner H,..., Hoffmeister M,..., Schrotz-King P,..., Ulrich AB, Ulrich CM, Weijenberg MP, Kok DE.
Plasma metabolites associated with colorectal cancer stage: findings from an international consortium. International Journal of Cancer 2020; 146:3256-3266.

Kapoor PM, Lindström S, Behrens S, Wang X, Michailidou K, Bolla MK, Wang Q, Dennis J, Dunning AM, Pharoah PDP, Schmidt MK, Kraft P, Garcia-Closas M, Easton DF, Milne RL, Chang-Claude J, on behalf of the Breast Cancer Association Consortium.*
Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk in the Breast Cancer Association Consortium.
International Journal of Epidemiology 2020; 49:216-230.
*Co-authors on behalf of ESTHER study: Arndt V, Brenner H, Schöttker B

Adam S, Doege D, Koch-Gallenkamp L, Thong MSY, Bertram H, Eberle A, Holleczek B, Pritzkuleit R, Waldeyer-Sauerland M, Waldmann A, Zeissig SR, Jansen L, Rohrmann S, Brenner H, Arndt V.
Age-specific health-related quality of life in disease-free long-term prostate cancer survivors versus male population controls – results from a population-based study.
Supportive Care in Cancer 2020; 28:2875-2885.

Khankari NK, Banbury BL, Borges MC, Haycock PC, Albanes D, Arndt V,..., Brenner H,..., Hoffmeister M,..., Murff HJ, Gruber SB, Peters U, Zheng W.
Mendelian randomization of circulating polyunsaturated fatty acids and colorectal cancer risk.
Cancer Epidemiology, Biomarkers and Prevention 2020; 29:860-870.

Pulte D, Jansen L, Brenner H.
Changes in long term survival after diagnosis with common hematologic malignancies in the early 21st century.
Blood Cancer Journal 2020; 10:56.

Gruner LF, Hoffmeister M, Ludwig L, Brenner H.
Effect of various invitation schemes on use of fecal immunochemical tests (FITs) for colorectal cancer screening: Protocol for a randomized controlled trial.
JMIR Research Protocols 2020; 9:e16413.

d'Errico M, Alwers E, Zhang Y, Edelmann D, Brenner H, Hoffmeister M.
Identification of prognostic DNA methylation biomarkers in patients with gastrointestinal adenocarcinomas: a systematic review of epigenome-wide studies.
Cancer Treatment Reviews 2020; 82:101933.

Vishram-Nielsen JKK, Laurent S, Nilsson PM, Linneberg A, Sehested TSG, Greve SV, Pareek M, Palmieri
L, Giampaoli S, Donfrancesco C, Kee F, Mancia G, Cesana G, Veronesi G, Kuulasmaa K, Salomaa V, Kontto J, Palosaari T, Sans S, Ferrieres J, Dallongeville J, Söderberg S, Moitry M, Drygas W, Tamosiunas A, Peters A, Brenner H, Njolstad I, Olsen MH, on behalf of the MORGAM project.
Does estimated pulse wave velocity add prognostic information? The MORGAM prospective cohort project.
Hypertension 2020; 75:1420-1428.

Ochoa-Rosales C, Portilla-Fernandez E, Nano J, Wilson R, Lehne B, Mishra PP, Gao X, Ghanbari M, Rueda-Ochoa OL, Juvinao-Quintero D, Loh M, Zhang W, Kooner JS, Grabe HJ, Felix SB, Schöttker B, Zhang Y, Gieger C, Müller-Nurasyid M, Heier M, Peters A, Lehtimäki T, Teumer A, Brenner H, Waldenberger M, Ikram MA, van Meurs JBJ, Franco OH, Voortman T, Chambers J, Stricker BH, Muka T. Epigenetic link between statin therapy and type 2 diabetes.
Diabetes Care 2020; 43:875-884.

Murphy N, Carreras-Torres R, Song M, Chan AT, Martin RM,..., Brenner H,..., Hoffmeister M,..., Wu AH, Zheng W, Peters U, Gunter MJ.
Circulating levels of insulin-like growth factor 1 and insulin-linke growth factor binding protein 3 associate with risk of colorectal cancer based on serologic and Mendelian randomization analyses.
Gastroenterology 2020; 158:1300-1312.

Amitay EL, Carr PR, Jansen L, Alwers E, Roth W, Herpel E, Kloor M, Bläker H, Chang- Claude J, Brenner H, Hoffmeister M.
Postmenopausal hormone replacement therapy and colorectal cancer risk by molecular subtypes and pathways.
International Journal of Cancer 2020; 147:1018-1026.

Archambault AN, Su YR, Jeon J, Thomas M, Lin Y,..., Brenner H,..., Hoffmeister M,..., Corley DA, Hsu L, Peters U, Hayes RB.
Cumulative burden of colorectal cancer-associated genetic variants is more strongly associated with early-onset vs late-onset cancer.
Gastroenterology 2020; 158:1274-1286.

Niedermaier T, Amitay E, Gies A, Weigl K, Hoffmeister M, Brenner H.
Impact of inadequate bowel cleansing on colonoscopic findings in routine screening practice.
Clinical and Translational Gastroenterology 2020; 11:e00169.

Trares K*, Gào X*, Perna L, Rujescu D, Stocker H, Möllers T, Beyreuther K, Brenner H, Schöttker B. Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease and vascular dementia incidence: results from a prospective cohort study.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2020; 16:804-813.
*geteilte Erstautorenschaft

Neumeyer S, Butterbach K, Banbury BL, Berndt SI, Campbell PT, Chlebowski R, Chan AT, Giovannucci EL, Joshi AD, Ogino S, Song M, McCullough M, Manson JE, Sakoda LC, Schoen RE, Slattery ML, White E, Maalmi H, Win AK, Figueiredo JC, Hopper J, Macrae F, Peters U, Brenner H, Hoffmeister M, Newcomb PA, Chang-Claude J.
Genetic predictors of circulating 25-hydroxyvitamin D and prognosis after colorectal cancer.
Cancer Epidemiology, Biomarkers & Prevention 2020; 29:1128-1134.

Möllers T, Perna L, Stocker H, Ihle P, Schubert I, Schöttker B, Frölich L, Brenner H.
New use of psychotropic medication after hospitalization among people with dementia.
International Journal of Geriatric Psychiatry 2020; 35:640-649.

Phipps AI*, Alwers E*, Harrison T*, Banbury B, Brenner H, Campbell PT, Chang-Claude J, Buchanan D, Chan AT, Farris AB, Figueiredo J, Gallinger S, Giles G, Hudson T, Newcomb PA, Slattery ML, Song M, Ogino S, Zaidi SH, Hoffmeister M†, Peters U†.
Association between molecular subtypes of colorectal tumors and patient survival, based on pooled analysis of 7 international studies.
Gastroenterology 2020; 158:2158-2168.
*geteilte Erstautorenschaft
† geteilte Letztautorenschaft

Ji X, Mukherjee S, Landi M, Bossé Y, Joubert P,..., Brenner H, Chanock S, Brennan P, McKay J, Amos C. Protein-altering germline mutations implicate novel genes related to lung cancer development.
Nature Communications 2020; 11:2220.

Eyl RE, Thong MSY, Carr PR, Jansen L, Koch-Gallenkamp L, Hoffmeister M, Chang- Claude J, Brenner H, Arndt V.
Physical activity and long-term fatigue among colorectal cancer survivors – a population- based prospective study.
BMC Cancer 2020; 20:438.

Gigic B, Nattenmüller J, Schneider M, Kulu Y, Syrjala K, Böhm J, Schrotz-King P, Brenner H, Colditz GA, Figueiredo JC, Grady WM, Li CI, Shibata D, Siegel EM, Toriola AT, Kauczor HU, Ulrich A, Ulrich C.
The role of CT-quantified body composition on longitudinal health-related quality of life in colorectal cancer patients: the ColoCare study.
Nutrients 2020; 12:1247.

NCD Risk Factor Collaboration (NCD-RisC).*
Repositioning of the global epicenter of non-optimal cholesterol.
Nature 2020; 582:73-77.
*Collaborators on behalf of the ESTHER study: Brenner H, Saum KU, Schöttker B

Cardoso R, Guo F, Heißer T, Hoffmeister M, Brenner H.
Utilisation of colorectal cancer screening tests in European countries by type of screening offer: Results from the European Health Interview Survey.
Cancers 2020; 12:E1409.

Yu H, Raut JR, Schöttker B, Holleczek B, Zhang Y, Brenner H.
Individual and joint contributions of genetic and methylation risk scores for enhancing lung cancer risk stratification: data from a population-based cohort in Germany.
Clinical Epigenetics 2020; 12:89.

Peng L, Balavarca Y, Niedermaier T, Weigl K, Hoffmeister M, Brenner H.
Risk-adapted cutoffs in colorectal cancer screening by fecal immunochemical tests.
American Journal of Gastroenterology 2020; 115:1110-1116.

Scherer D, Deutelmoser H, Balavarca Y, Toth R, Habermann N, Buck K, Kap EJ, Botma A, Seibold P, Jansen L, Bermejo JL, Weigl K, Benner A, Hoffmeister M, Ulrich A, Brenner H, Burwinkel B, Chang-Claude J, Ulrich CM.
Polymorphisms in the angiogenesis-related genes EFNB2, MMP2 and JAG1 are associated with survival of colorectal cancer patients.
International Journal of Molecular Sciences 2020; 21:5395.

Repky S, Büchele G, Günther KP, Huch K, Brenner H, Stürmer T, Beyersmann J, Brenner RE, Rothenbacher D.
Five years' trajectories of functionality and pain in patients after hip or knee replacement and association with long-term patient survival.
Scientific Reports 2020; 10:14388.

Zhang Y, Bewerbunge-Hudler M, Schick M, Burwinkel B, Herpel E, Hoffmeister M, Brenner H.
Blood-derived DNA methylation predictors of mortality discriminate tumor and healthy tissue in multiple organs.
Molecular Oncology 2020; 14:2111-2123.

Seyed Khoei N, Jenab M, Murphy N, Banbury BL, Carreras-Torres R,..., Brenner H,..., Hoffmeister M,..., Weigl K,..., Peters U, Gunter MJ, Wagner KH, Freisling H.
Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses.
BMC Medicine 2020; 18:229.

Boakye D, Jansen L, Schöttker B, Jansen E, Schneideer M, Halama N, Gào X, Chang-Claude J, Hoffmeister M, Brenner H.
Blood markers of oxidative stress are strongly associated with poorer prognosis in colorectal cancer patients.
International Journal of Cancer 2020; 147:2373-2386.

Kulhánová I, Forman D, Vignat J, Espina C, Brenner H, Storm HH, Bauld L, Soerjomataram I.
Tobacco-related cancers in Europe: The scale of the epidemic in 2018.
European Journal of Cancer 2020; 139:27-36.

Arnold N, Rehm M, Büchele G, Peter RS, Brenner RE, Günther KP, Brenner H, König W, Rothenbacher D.
Growth differentiation factor-15 as a potent predictor of long-term mortality among subjects with Osteoarthritis.
Journal of Clinical Medicine 2020; 9:3107.

Konrad C, Lossnitzer N, Boehlen FH, Haefeli WE, Holleczek B, Brenner H, Schöttker B, Wild B.
Coping resouces of heart failure patients – a comparison with cancer patients and individuals having no chronic condition. Results from the ESTHER study.
Heart & Lung 2020; 49:829-835.

Jansen L*, Merz M*, Engelhardt M, Weisel K, Scheid C, Straka C, Langer C, Salwender H, Einsele H, Kröger N, Beelen D, Dreger P, Goldschmidt H*, Brenner H*, German National Registry for Stem Cell Transplants (DRST).
Autologous stem cell transplantation in multiple myeloma patients: Utilization patterns and hospital effects.
Leukemia and Lymphoma 2020; 61:2365-2374.
*geteilte Erstautorenschaft

Weigl K, Tikk K, Hoffmeister M, Hampe J, Igel S, Kolligs F, Klug SJ, Mansmann U, Müller O, Nagel JM, Pichler M, Schwab M, Schweigler D, Stephan AM, De Toni EN, Brenner H.
Prevalence of a first-degree relative with colorectal cancer and uptake of screening among persons 40 to 54 years old.
Clinical Gastroenterology and Hepatology 2020; 18:2535-2543.

Chen H, Lu M, Liu C, Zou S, Du L, Liao X, Dong D, Wei D, Gao Y, Zhu C, Zhu L, Zheng W, Xiao H, Kong Y, Yin H, Zhou H, Ying R, Wang B, Zhang J, Zhang X, Zhang Q, Zhang X, Zhang Y, Wang H, Guo L, Liu L, Ren J, Shi J, Miao X, Brenner H, Dai M.
Comparative evaluation of participation and diagnostic yield of colonoscopy vs fecal immunochemical test vs risk-adapted screening in colorectal cancer screening: interim analysis of a multicenter randomized controlled trial (TARGET-C).
American Journal of Gastroenterology 2020; 115:1264-1274.

Jansen L, Behrens G, Finke I, Maier W, Gerken M, Pritzkuleit R, Holleczek B, Brenner H.
Area-based socioeconomic inequalities in colorectal cancer survival in Germany: Investigation based on population-based clinical cancer registration.
Frontiers in Oncology 2020; 10:857.

Schrotz-King P, Hoffmeister M, Sauer P, Schaible A, Brenner H.
Protocol oft he DARIO randomized trial: Effects of alternative offers of screening sigmoidoscopy and colonoscopy on utilization and yield of endoscopic screening for colorectal neoplasms.
JMIR Research 2020; 9:e17516.

Jansen L, Holleczek B, Kraywinkel K, Weberpals J, Schröder CC, Eberle A, Emrich K, Kajüter H, Katalinic A, Kieschke J, Nennecke A, Sirri E, Heil J, Schneeweiss A, Brenner H.
Divergent patterns and trends in breast cancer incidence, mortality and survival among older women in Germany and the United States.
Cancers 2020; 12:2460.

Raut J, Guan Z, Schrotz-King P, Brenner H.
Fecal DNA methylation markers for detecting stages of colorectal cancer and its precursors: a systematic review.
Clinical Epigenetics 2020; 12:122.

Huang L, Jansen L, Balavarca Y, Verhoeven RHA, Ruurda JP, Van Eycken L, De Schutter H, Johansson J, Lindblad M, Johannesen TB, Zadnik V, Zagar T, Mägi M, Bastiaannet E, Lagarde SM, van de Velde CJH, Schrotz-King P, Brenner H.
Decreasing resection rates for nonmetastatic gastric cancer in Europe and the United States.
Clinical and Translational Medicine 2020; 10:e203.

Brenner H, Krilaviciute A.
Commonly applied selection criteria for lung cancer screening may have strongly varying diagnostic performance in different countries.
Cancers 2020; 12:3012.

Knoll M, Furkel J, Debus J, Abdollahi A, Karch A, Stock C.
An R package for an integrated evaluation of statistical approaches to cancer incidence projection.
BMC Medical Research Methodology 2020; 20:257.

Scherer D, Deutelmoser H, Balavarca Y, Toth R, Habermann N, Buck K, Kap EJ, Botma A, Seibold P, Jansen L, Lorenzo Bermejo J, Weigl K, Benner A, Hoffmeister M, Ulrich A, Brenner H, Burwinkel B, Chang-Claude J, Ulrich CM.
Polymorphisms in the angiogenesis-related genes EFNB2, MMP2 and JAG1 are associated with survival of colorectal cancer patients.
International Journal of Molecular Sciences 2020; 21:5395.

Guo F, Weigl K, Carr PR, Heißer T, Jansen L, Knebel P, Chang-Claude J, Hoffmeister M, Brenner H.
Use of polygenic risk scores to select screening intervals after negative findings from colonoscopy.
Clinical Gastroenterology and Hepatology 2020; 18:2742-2751.

Gruner LF, Ludwig L, Hoffmeister M, Meny S, Brenner H.
The effects of different invitation schemes on use of fecal immunochemical tests (FITs): Results from a randomized controlled trial.
Effekte verschiedener Einladungsmodelle auf die Inanspruchnahme immunologischer Tests auf Blut im Stuhl: Ergebnisse einer randomisierten kontrollierten Studie.
Deutsches Ärzteblatt 2020; 117:423-430.

Huynh-Le MP, Chieh Fan C, Karunamuni R, Walsh EI, Turner EL,..., Brenner H, Schöttker B, Holleczek B,..., Mills IG, Andreassen OA, Dale AM, Seibert TM.
A genetic risk score to personalize prostate cancer screening, applied to population data.
Cancer Epidemiology, Biomarkers & Prevention 2020; 29:1731-1738.

Echle A, Grabsch HI, Quirke P, van den Brandt PA, West NP, Hutchins GGA, Heij LR, Tan X, Richman SD, Krause J, Alwers E, Jenniskens J, Offermans K, Gray R, Brenner H, Chang-Claude J, Trautwein C, Pearson AT, Boor P, Luedde T, Gaisa NT, Hoffmeister M, Kather JN.
Clinical-grade detection of microsatellite instability in colorectal tumors by deep learning.
Gastroenterology 2020; 159:1406-1416. 

Thomas M, Sakoda LC, Hoffmeister M, Lee JK, van Duijnhoven FJB,..., Arndt V,..., Brenner H, Corley DA, Peters U, Hsu L.
Genome-wide modelling of polygenic risk score in colorectal cancer risk.
The American Journal of Human Genetics 2020; 107:432-444.

Chen C, Stock C, Hoffmeister M, Brenner H.
Self-reported lower gastrointestinal endoscopy use and changes in colorectal cancer mortality rates in European countries.
Clinical and Translational Gastroenterology 2020; 11:e00243.

Perna L, Zhang Y, Matias-Garcia P, Ladwig KH, Wiechmann T, Wild B, Waldenberger M, Schöttker B, Mons U, Ihle A, Kliegel M, Schwettmann L, Peters A, Brenner H.
Subjective mental health, incidence of depressive symptoms in later life, and the role of epigenetics: results from two longitudinal cohort studies.
Translational Psychiatry 2020; 10:323.

NCD Risk Factor Collaboration (NCD-RisC).
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries: Pooled analysis of 2,182 population-based studies with 65 million participants.
Lancet 2020; 396:1511-1524.

Brandao A, Paulo P, Maia S, Pinheiro M, Peixoto A,..., Brenner H,..., Roobol MJ, The Profile Study Steering Committee, The PRACTICAL Consortium, Teixeira MR.
The CHEK2 variant c.349A>G is associated with prostate cancer risk and carriers.
Cancers 2020; 12:3254.

Deutelmoser H, Scherer D, Brenner H, Waldenberger M, Suhre K, Kastenmüller G, Lorenzo Bermejo L.
Robust Huber-Lasso for improved prediction of protein metabolite, and gene expression levels relying on individual genotype data.
Briefings in Bioinformatics 2020; 21:8150.

Huang L, Jansen L, Balavarca Y, van der Geest L, Lemmens V, Groot Koerkamp B, van Santvoort HC, Grützmann R, Besselink MG, Schrotz-King P, Brenner H.
Significance of exmined lymp node number in accurate staging and long-term survival in resected stage I-II pancreatic cancer-more is better? A large international population-based cohort study.
Annals of Surgery (in press).

Laetsch DC, Hoppe LK, Saum KU, Haefeli WE, Brenner H, Schöttker B.
Investigation of a possible association of potentially inappropriate medication for older adults and frailty in a prospective cohort study from Germany.
Age and Ageing (in press).

Niedermaier T, Tikk K, Gies A, Bieck S, Brenner H.
Sensitivity of fecal immunochemical test for colorectal cancer detection differs strongly according to stage and location.
Clinical Gastroenterology and Hepatology (in press).

Campbell PT, Lin Y, Bien SA, Figueiredo JC, Harrison TA, Guinter MJ, Berndt SI, Brenner H, Chan AT, Chang-Claude J, Gallinger SJ, Gapstur SM, Giles GG, Giovannucci E, Gruber SB, Gunter M, Hoffmeister M, Jacobs EJ, Jenkins MA, Le Marchand L, Li L, McLaughlin JR, Murphy N, Milne RL, Newcomb PA, Newton C, Ogino S, Potter JD, Rennert G, Rennert HS, Robinson J, Sakoda LC, Slattery ML, Song Y, White E, Woods MO, Casey G, Hsu L, Peters U.
Association of body mass index with colorectal cancer risk according to genome-wide variants.
Journal of the National Cancer Institute (in press).

Stocker H, Perna L, Weigl K, Möllers T, Schöttker B, Thomsen H, Holleczek B, Rujescu D, Brenner H. Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic riskscore and APOE status in a community-based prospectively followed over 17 years. Molecular Psychiatry (in press).

Kather JN, Heij LR, Grabsch HI, Loeffler C, Echle A, Muti HS, Krause J, Niehues JM, Sommer KAJ, Bankhead P, Kooreman LFS, Schulte JJ, Cipriani NA, Buelow RD, Boor P, Ortiz-Brüchle N, Hanby AM, Speirs V, Kochanny S, Patnaik A, Srisuwananukorn A, Brenner H, Hoffmeister M, van den Brandt PA, Jäger D, Trautwein C, Pearson AT, Luedde T.
Pan-cancer image-based detection of clinically actionable genetic alterations.
Nature Cancer (in press).

Kapoor PM, Mavaddat N, Choudhury PP, Wilcox AN, Lindström S,..., Arndt V,..., Brenner H,..., Holleczek B,..., Schöttker B,..., Easton DF, Milne RL, Garcia-Closas M, Chang-Claude J.
Combined associations of a polygenic risk score and classical risk factors with breast cancer risk.
Journal of the National Cancer Institute (in press).

Chen LJ, Trares K, Laetsch DC, Nguyen Thi Ngoc M, Brenner H, Schöttker B.
Systematic review and meta-analysis on the associations of polypharmacy and potentially inappropriate medication with adverse outcomes in older cancer patients.
Journal of Gerontology: Medical Sciences (in press).

Bravi F, Lee YCA, Hashibe M, Boffetta P, Conway DI, Ferraroni M, La Vecchia C, Edefonti V, on behalf of the INHANCE Consortium investigators.*
Lessons learned from the INHANCE consortium: an overview of recent results on head and neck cancer. Oral Diseases (in press). *Collaborators from DKFZ: Brenner H

Karunamuni R, Huynh-Le MP, Fan C, Eeles R, Easton D,..., Brenner H, Schöttker B, Holleczek B,..., Andreassen O, Dale AM, Seibert T, and the Practical Consortium.
The effect of sample size on polygenic hazard models for prostate cancer.
 European Journal of Human Genetics (in press).

Hoffmeister M, Bläker H, Jansen L, Alwers E, Amitay EL, Carr PR, Kloor M, Herpel E, Roth W, Chang-Claude J, Brenner H.
Colonoscopy and reduction of colorectal cancer risk by molecular tumor subtypes: a population-based case-control study.
American Journal of Gastroenterology (in press).

Xu X, Kharazmi E, Tian Y, Sundquist K, Sundquist J, Brenner H, Fallah M.
Risk of invasive prostate cancer and prostate cancer death in relatives of patients with prostatic borderline or in situ neoplasia: A nationwide cohort study.
Cancer (in press).

Nguyen TNM, Laetsch DC, Chen LJ, Haefeli WE, Meid AD, Brenner H, Schöttker B.
Pain severity and analgesics use in the community-dwelling older population. A drug utilization study from Germany.
European Journal of Clinical Pharmacology (in press).

Ahadova A, Seppälä T, Engel C, Gallon R, Burn J, Holinski-Feder E, Steinke-Lange V, Möslein G, Nielsen M, ten Broeke S, Laghi L, Dominguez-Valentin M, Capella G, Macrae F, Hüneburg R, Nattermann J, Hoffmeister M, Brenner H, Bläker H, von Knebel Doeberitz M, Sampson JR, Vasen H, Mecklin JP, Moller P, Kloor M.
The "unnatural" history of colorectal cancer in Lynch syndrome: lessons from colonoscopy surveillance.
International Journal of Cancer (in press).

Jarvik GP, Wang X, Fontanillas P, Kim E, Chanprasert S,..., Brenner H,..., Hoffmeister M,..., Jenkins MA, Mountain J, Peters U, Crosslin DR.
Hemochromatosis risk genotype is not associated with colorectal cancer or age at its diagnosis.
Human Genetics and Genomics Advances (in press).

Jansen L, Boakye D, Alwers E, Carr PR, Reissfelder C, Schneider M, Martens UM, Chang-Claude J, Hoffmeister M, Brenner H.
Uptake rates of novel therapies and survival among privately compared to publicly insured colorectal cancer patients in Germany.Journal of the National Comprehensive Cancer Network (in press).

Bläker H, Haupt S, Morak M, Holinski-Feder E, Arnold A,..., Alwers E,..., Brenner H,..., von Knebel Doeberitz M, Ahadova A, Hoffmeister M, Kloor M.
Age-dependent performance of BRAF mutations testing in Lynch syndrome diagnostics.
International Journal of Cancer (in press).

Barahona Ponce C, Scherer D, Brinster R, Boekstegers F, Marcelain K,..., Brenner H,..., Gallo C, Ruiz Linares A, Rothhammer F, Lorenzo Bermejo J.
Gallstones, body mass index, C-reactive protein and gallbladder cancer – Mendelian randomization analysis of Chilean and European genotype data.
Hepatology (in press).

Heisser T, Guo F, Niedermaier T, Holleczek B, Hoffmeister M, Brenner H.
Low risk of advanced neoplasms for up to 20 years after negative colonoscopy: potential for personalized follow-up screening intervals.
Gastroenterology (in press).

Perna L, Zhang Y, Wild B, Kliegel M, Ihle A, Schöttker B, Mons U, Brenner H.
Childhood exposure to hunger: Associations with health outcomes in later life and epigenetic markers.
Epigenomics (in press).

Matsushita K, Jassal SK, Sang Y, Ballew SH Grams ME,..., Brenner H,..., Yatsuya H, Zhang L, Schaeffner E, Coresh J.
Incorporating kidney disease measures into cardiovascular risk prediction: development and validation in 9 million adults from 72 datasets.
EClinicalMedicine (in press).

Doege D, Thong M, Koch-Gallenkamp L, Jansen L, Bertram H, Eberle A, Holleczek B, Pritzkuleit R, Waldmann A, Zeissig S, Brenner H, Arndt V.
Age-specific prevalence and determinants of depression in long-term breast cancer survivors compared to female population controls.
Cancer Medicine (in press).

Mukama T, Fallah M, Brenner H, Xu X, Sundquist K, Sundquist J, Kharazmi E.
Risk of invasive breast cancer in relatives of patients with breast carcinoma in situ: a prospective cohort study.
BMC Medicine (in press).

Siziba LP, Lorenz L, Brenner H, Carr P, Stahl B, Mank M, Marosvölgyi T, Decsi T, Rothenbacher D, Genuneit J.
Changes in human milk fatty acid composition and maternal lifestyle-related factors over a decade: a comparison between the two Ulm Birth Cohort studies.
British Journal of Nutrition (in press).

Gorski M, Jung B, Li Y, Matias-Garcia P, Böger C,..., Brenner H,..., Schöttker B,..., Köttgen A, Kronenberg F, Pattaro C, Heid I.
Genome-wide significant variants for rapid kidney function decline from a meta-analysis of up to 35,000 cases and >100,000 controls.
Kidney International (in press).

Huang L, Jansen L, Balavarca Y, Verhoeven RHA, Ruurda JP, van Eycken L, de Schutter H, Johansson J, Lindblad M, Johannesen TB, Zadnik V, Zagar T, Mägi M, Bastiaannet E, Lagarde SM, van de Velde CJH, Schrotz-King P, Brenner H.
Decreasing resection rates for non-metastatic gastric cancer in Europe and the US.
Clinical and Translation Medicine (in press).

Ali Khan U, Fallah M, Sundquist K, Sundquist J, Brenner H, Kharazmi E.
Risk of colorectal cancer in patients with diabetes mellitus: A Swedish nationwide cohort study.
PLOS Medicine (in press).

Möllers T, Schwab M, Gildein L, Hoffmeister M, Albert J, Brenner H, Jäger S.
The second generation of colon capsule endoscopy in the detection of colorectal polyps: A systematic review and meta-analysis of clinical trials.
Endoscopy International Open (in press).

Amitay EL, Carr PR, Gies A, Laetsch DC, Brenner H.
Pro-/symbiotic treatment and postoperative complications in colorectal cancer patients: systematic review and meta-analysis of randomized controlled trials.
Clinical and Translation Gastroenterology (in press).

Bull CJ, Bell JA, Murphy N, Sanderson E, Smith GD,..., Brenner H,..., Hoffmeister M,..., Zheng W, Peters U, Vincent EE, Gunter MJ.
Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study.
BMC Medicine (in press).

 

 

 

 

to top
powered by webEdition CMS