Clinical Epidemiology and Aging Research

CAncEr Survivorship - A multi-Regional (CAESAR) study

To better understand the quality of life and needs of long-term (>5 years post-diagnosis) cancer survivors, the German Cancer Research Center initiated the CAESAR study in cooperation with selected federal cancer registries in Germany.  The study, funded by the German Cancer Aid, aimed to:

1) Better understand long-term effects of cancer and its treatments,

2) Develop approaches to prevent long-term health restrictions, and to

3) Improve the follow-up care and health of long-term cancer survivors.

Study design

The first study round was conducted in 2009/2011 on a population basis in six federal states of Germany (Schleswig-Holstein, North Rhine-Westphalia, Rhineland-Palatinate, Hamburg, Bremen and Saarland). More than 7,000 people, diagnosed with breast, colon or prostate cancer at least 5 years previously, participated in the study. Below are the publications based on this initial study. 

A follow-up study was carried out in 2018/2019. Participants of the initial survey who had given their consent to be contacted again and are alive, were eligible. More than 2,700 participants took part in the follow-up survey. In addition, attending physicians of the participants were also invited to complete a questionnaire to provide in-depth details on treatments and comorbidities. 

Publications

  1. Zeissig SR, Bertram H, Eberle A, et al. Lebensqualität nach Brust-, Darm-, und Prostatakrebs: Start der CAESAR-Studie in Rheinland-Pfalz. Ärzteblatt Rheinland-Pfalz 2010;2010(7):19.
  2. Jansen L, Herrmann A, Stegmaier C, et al. Health-related quality of life during the 10 years after diagnosis of colorectal cancer: a population-based study. J Clin Oncol 2011;29(24):3263-
  3. Koch L, Bertram H, Eberle A, et al. Lebensqualität von Langzeitüberlebenden nach Brust-, Darm- und Prostatakrebs. Forum – Deutsche Krebsgesellschaft. 2013;28(1):43-47.
  4. Koch L, Jansen L, Herrmann A, et al. Quality of life in long-term breast cancer survivors - a 10-year longitudinal population-based study. Acta Oncol 2013;52(6):1119-1128.
  5. Koch L, Bertram H, Eberle A, et al. Fear of recurrence in long-term breast cancer survivors-still an issue. Results on prevalence, determinants, and the association with quality of life and depression from the cancer survivorship--a multi-regional population-based study. Psychooncology 2014;23(5):547-554.
  6. Waldmann A, Bredehoeft M, Koch-Gallenkamp L, et al. Social support is associated with mental health and health-related quality of life in breast cancer survivors: results from the German population-based, multiregional CAESAR-Study. Qual Life Res 2015;24 (S1):88-89.
  7. Zeissig SR, Singer S, Koch L, Blettner M, Arndt V. Inanspruchnahme psychoonkologischer Versorgung im Krankenhaus und in Krebsberatungsstellen durch Brust-, Darm- und Prostatakrebsüberlebende. Psychother Psychosom Med Psychol 2015;65(5):177-182.
  8. Zeissig SR, Singer S, Koch L, et al. Utilisation of psychosocial and informational services in immigrant and non-immigrant German cancer survivors. Psychooncology 2015;24(8):919-925.
  9. Koch-Gallenkamp L, Bertram H, Eberle A, et al. Fear of recurrence in long-term cancer survivors-Do cancer type, sex, time since diagnosis, and social support matter? Health Psychol 2016;35(12):1329-1333.
  10. Arndt V, Koch-Gallenkamp L, Jansen L, et al. Quality of life in long-term and very long-term cancer survivors versus population controls in Germany. Acta Oncol 2017;56(2):190-197.
  11. Koch-Gallenkamp L, Bertram H, Eberle A, et al. Progredienzangst ≥5 Jahre nach Krebsdiagnose. Der Onkologe 2017;23(4):295-299.
  12. Thong MSY, Mols F, Doege D, van de Poll-Franse L, Arndt V. Population-based cancer survivorship research: Experiences from Germany and the Netherlands. J Cancer Policy 2018;15:87-91.
  13. Thong MSY, Wolschon EM, Koch-Gallenkamp L, et al. "Still a Cancer Patient"-Associations of Cancer Identity With Patient-Reported Outcomes and Health Care Use Among Cancer Survivors. JNCI Cancer Spectr 2018;2(2):pky031.
  14. Adam S, Koch-Gallenkamp L, Bertram H, et al. Health-related quality of life in long-term survivors with localised prostate cancer by therapy-Results from a population-based study. Eur J Cancer Care. 2019:e13076.
  15. Arndt V, Koch-Gallenkamp L, Bertram H, et al. Return to work after cancer. A multi-regional population-based study from Germany. Acta Oncol 2019;58(5):811-818.
  16. Doege D, Thong M, Koch-Gallenkamp L, et al. The role of psychosocial resources for long-term breast, colorectal, and prostate cancer survivors: prevalence and associations with health-related quality of life. Support Care Cancer 2019;27(1):275-286.
  17. Doege D, Thong MS, Koch-Gallenkamp L, et al. Health-related quality of life in long-term disease-free breast cancer survivors versus female population controls in Germany. Breast Cancer Res Treat 2019;175(2):499-510.
  18. Thong MSY, Koch-Gallenkamp L, Jansen L, et al. Age-specific health-related quality of life in long-term and very long-term colorectal cancer survivors versus population controls - a population-based study. Acta Oncol 2019;58(5):801-810.
  19. Thong MSY, Doege D, Koch-Gallenkamp L, et al. Age at diagnosis and gender are associated with long-term deficits in disease-specific health-related quality of life of colorectal cancer survivors: A population-based study. Dis Colon Rectum (in print).
  20. Adam S, Doege D, Koch-Gallenkamp L, et al: Age-specific health-related quality of life in disease-free long-term prostate cancer survivors versus male population controls – results from a population-based study. Support Care Cancer (in print).

Project leading

PD Dr. med. Volker Arndt,
Prof. Dr. med. Hermann Brenner
Deutsches Krebsforschungszentrum
Abteilung Klinische Epidemiologie und Alternsforschung
Im Neuenheimer Feld 581
69120 Heidelberg

Contact

CAESAR-Studie
Deutsches Krebsforschungszentrum
Abteilung Klinische Epidemiologie und Alternsforschung
Im Neuenheimer Feld 581
69120 Heidelberg
Tel. 06221-421337

Germany

Linda Weißer (M. Sc.) (currently on maternity leave)
Tel. 06221-421337
Email: https://www.dkfz.de/de/klinepi/mitarbeiter/kontakt/Weisser.php

Dr. Daniela Doege

Tel. 06221-422331

Email: https://www.dkfz.de/de/cancer-survivorship/kontakt/Doege.php

 

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