Immunotherapy and Immunoprevention - Molecular Vaccine Design

Mine Özcan, PhD

Postdoctoral Scientist

Scientific CV

Feb - Nov 2018
Postdoctoral scientist, Junior Research Group Immunotherapy and Immunoprevention, DKFZ, Heidelberg

2014-2017
PhD student, Applied Tumor Biology, DKFZ, Heidelberg

2012-2014
MSc Biology, Graduate School of Natural and Applied Sciences, Middle East Technical University, Ankara, Turkey

2008-2012
BSc Biology, Department of Biology, Middle East Technical University, Ankara, Turkey

Research Project

Immunological causes for radiosensitivity of HPV-driven HNSCC

HPV-driven head and neck squamous cell carcinomas (HNSCCs) constitute 80% of oropharyngeal squamous cell carcinomas. They are characterized by a significant survival advantage over HPV-negative HNSCCs. In addition to better overall survival, HPV+ HNSCCs are more sensitive to irradiation than their HPV-negative counterparts. The main goal of this project was to determine if there is a link between the increased radiosensitivity of HPV-driven HNSCC and a possible elevated presentation of HPV-encoded and/or mutation-derived neoepitopes following irradiation as compared to HPV-negative HNSCCs.

Resulting Publications

Enhanced radiation sensitivity of human papillomavirus-driven head and neck cancer: focus on immunological aspects.
Özcan-Wahlbrink M, Schifflers C, Riemer AB.
Frontiers in Immunology 2019, 10:2831

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