Mine Özcan, PhD

Postdoctoral Scientist

Scientific CV

Feb - Nov 2018
Postdoctoral scientist, Junior Research Group Immunotherapy and Immunoprevention, DKFZ, Heidelberg

PhD student, Applied Tumor Biology, DKFZ, Heidelberg

MSc Biology, Graduate School of Natural and Applied Sciences, Middle East Technical University, Ankara, Turkey

BSc Biology, Department of Biology, Middle East Technical University, Ankara, Turkey

Research Project

Immunological causes for radiosensitivity of HPV-driven HNSCC

HPV-driven head and neck squamous cell carcinomas (HNSCCs) constitute 80% of oropharyngeal squamous cell carcinomas. They are characterized by a significant survival advantage over HPV-negative HNSCCs. In addition to better overall survival, HPV+ HNSCCs are more sensitive to irradiation than their HPV-negative counterparts. The main goal of this project was to determine if there is a link between the increased radiosensitivity of HPV-driven HNSCC and a possible elevated presentation of HPV-encoded and/or mutation-derived neoepitopes following irradiation as compared to HPV-negative HNSCCs.

Resulting Publications

Enhanced radiation sensitivity of human papillomavirus-driven head and neck cancer: focus on immunological aspects.
Özcan-Wahlbrink M, Schifflers C, Riemer AB.
Frontiers in Immunology 2019, 10: 2831

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