Research Project
Investigation of vaccination platforms for the induction of an efficient anti-HPV16 T cell response at mucosal tumor sites
To investigate new vaccination platforms for their induction of an efficient anti-HPV16 CD8+ T cell response at mucosal tumor sites, the Riemer lab has recently developed orthotopic, HPV-dependent tumor models in MHC-humanized mice that mimic HPV-driven cervical as well as head and neck cancer.
One project explores a Clostridium Assisted Drug Delivery platform (CADD), developed by an industrial collaboration partner, as therapeutic HPV vaccine platform while in another one, recombinant yeast is investigated as option for therapeutic HPV vaccinations.
Using immunopeptidomics, we assess the potential of vaccine candidates to induce a specific immune response based on the epitope presentation on antigen-presenting cells. Promising vaccine candidates are subsequently tested for the induction of systemic as well as mucosal immune responses by means of spectral flow cytometry, and anti-tumor effects will be monitored in our orthotopic tumor models.
Scientific CV
Since Oct 2023
PhD student, Immunotherapy and Immunoprevention, DKFZ, Heidelberg
2020 - 2023
MSc Immunobiology, University of Bonn
2017 - 2020
BSc Molecular Biomedicine, University of Bonn
2016 - 2017
BSc program Molecular Life Sciences, Radboud University Nijmegen, Netherlands