Prof. Dr. Annette Kopp-Schneider

Prof. Dr. Annette Kopp-Schneider

Prof. Dr. Annette Kopp-Schneider


Head of Division


+49 6221 42 2391


+49 6221 42 2397


TP 4




  • Diploma in Mathematics, RWTH Aachen, Germany, 1984
  • Dr. rer. nat., Mathematics, RWTH Aachen, Germany, 1987
  • Habilitation, Medical Biometry, University Heidelberg, 1997

Areas of Work

  • Biologically based mechanistic modelling of cell systems
  • Dose response modelling
  • Quantitative cancer risk assessment
  • Methods for agreement
  • Integrative analysis of omics data

Selected Publications

  1. Holland-Letz T., Kopp-Schneider A. (2015) Optimal experimental designs for dose-response studies with continuous endpoints. Archives of Toxicology 89(11) 2059-2068. DOI: 10.1007/s00204-014-1335-2
  2. Jiang X., Kopp-Schneider A. (2015) Statistical strategies for averaging EC50 from multiple dose-response experiments.Archives of Toxicology 89(11), 2119-2127. DOI: 10.1007/s00204-014-1350-3
  3. Jiang X., Kopp-Schneider A. (2014) Summarizing EC50 estimates from multiple dose-response experiments: a comparison of a meta-analysis strategy to a mixed-effects model approach. Biometrical Journal 56(3), 493-512. DOI: 10.1002/bimj.201300123
  4. Renner M., Zurich M.-G., Kopp-Schneider A. (2013) Stochastic time-concentration activity models for cytotoxicity in 3D brain cell cultures. Theoretical Biology and Medical Modelling 10, 19. DOI: 10.1186/1742-4682-10-19
  5. Kopp-Schneider A., Prieto P., Kinsner-Ovaskainen A., Stanzel S. (2013) Design of a testing strategy using non-animal based test methods: lessons learnt from the ACuteTox project. Toxicology in Vitro 27(4), 1395–1401. DOI: 0.1016/j.tiv.2012.08.016
  6. Weimer M., Jiang X., Ponta O., Stanzel S., Freyberger A., Kopp-Schneider A. (2012) The impact of data transformations on concentration-response modeling. Toxicology Letters 213(2), 292–298. DOI: 1016/j.toxlet.2012.07.012
  7. Groos J., Bannasch P., Schwarz M., Kopp-Schneider A. (2007) Comparison of mode of action of four hepatocarcinogens: A model based approach. Toxicological Sciences 99(2), 446-454. DOI: 10.1093/toxsci/kfm183  

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