Axel Benner

Axel Benner

Axel Benner




+49 6221 42 2390


+49 6221 42 2397


TP 4



Research Topics
  • Time to event data analysis
  • Statistics for high-dimensional covariate space
  • Clinical statistics

Education/ Degrees

Diploma in Statistics, University of Dortmund   1978-1986





Previous appointments

Postgraduate Research Assistant, University of Dortmund     1987-1987   

Assistant in Teaching and Research University of Dortmund 1987-1991



Selected peer-reviewed publications (in chronological order)

  1. Döhner H, Stilgenbauer S, Benner A, Leupolt E, Kröber A, Bullinger L, Döhner K, Bentz M, Lichter P.  Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000; 343:1910-1916.
  2. Bender R, Benner A. Calculating ordinal regression models in SAS and S-Plus. Biometr. J. 2000; 42: 677-699.
  3. Sauerbrei W, Meier-Hirmer C, Benner A, Royston P. Multivariable regression model building by using fractional polynomials: description of SAS, STATA and R programs, Comp Stat and Data Analysis, 2006; 50: 3464-3485.
  4. Benner A, Zucknick M, Hielscher T, Ittrich C, Mansmann U. High-dimensional Cox models: the choice of penalty as part of the model building process. Biom J. 2010; 52:50-69.
  5. Hielscher T, Zucknick M, Werft W, Benner A. On the prognostic value of survival models with application to gene expression signatures. Stat Med. 2010; 29:818-829.
  6. Becker N, Toedt G, Lichter P, Benner A. Elastic SCAD as a novel penalization method for SVM classification tasks in high-dimensional data. BMC Bioinformatics 2011; 12:138.
  7. Sill M, Kaiser S, Benner A, Kopp-Schneider A. Robust biclustering by sparse singular value decomposition incorporating stability selection. Bioinformatics 2011; 27: 2089-2097.
  8. Werft W, Benner A, Kopp-Schneider A. On the identification of predictive biomarkers: Detecting treatment-by-gene interaction in high-dimensional data. Comp Stat and Data Analysis 2012; 56: 1275-1286.
  9. Binder H, Benner A, Bullinger L, Schumacher M. Tailoring sparse multivariable regression techniques for prognostic single-nucleotide polymorphism signatures. Stat.Med. 2013; 32:  1778-1791.
  10. Benner A, Mansouri L, Rossi D, Majid A, Willander K, Parker A, Bond G, Pavlova S, Nückel H, Merkel O, Ghia P, Montserrat E, Kaderi MA, Rosenquist R, Gaidano G, Dyer MJ, Söderkvist P, Linderholm M, Oscier D, Tvaruzkova Z, Pospisilova S, Dührsen U, Greil R, Döhner H, Stilgenbauer S, Zenz T (European Research Initiative on CLL).  MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis. Haematologica 2014; 99: 1285-1291.
  11. Saadati M, Benner A. Statistical challenges of high-dimensional methylation data. Stat.Med. 2014; 33(30): 5347-5357.

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