Publications 2012

Abba M., Laufs S., Aghajany M., Korn B., Benner A., Allgayer H.: Look who's talking: deregulated signaling in colorectal cancer. Cancer Genom.Proteom. 9 (1) 15-25, 2012.

Afshar-Oromieh A., Malcher A., Eder M., Eisenhut M., Linart H.G., Hadaschik B.A., Holland-Letz T., Giesel F.L., Kratochwil C., Haufe S., Haberkorn U., Zechmann C.M.: PET imaging with a [(68)Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions. Eur.J.Nucl.Med.Mol.Imag. (epub) 2012.

Ahmadi R., Stockhammer F., Becker N., Hohlen K., Misch M., Christians A., Dictus C., Herold-Mende C., Capper D., Unterberg A., von Deimling A., Wick W., Hartmann C.: No prognostic value of IDH1 mutations in a series of 100 WHO grade II astrocytomas. J.Neurooncol. 109 (1) 15-22, 2012.

Alt C.D., Brocker K.A., Eichbaum M., Sohn C., Kopp-Schneider A., Kauczor H.U., Hallscheidt P.: Accuracy of MRI with an endorectal coil for staging endometrial cancer. Acta Radiol. 53 (5) 580-585, 2012.

Amarteifio E., Wormsbecher S., Krix M., Demirel S., Braun S., Delorme S., Böckler D., Kauczor H.U., Weber M.A.: Dynamic contrast-enhanced ultrasound and transient arterial occlusion for quantification of arterial perfusion reserve in peripheral arterial disease. Eur.J.Radiol. 81 (11) 3332-3338, 2012.

Askoxylakis V., Dinkel J., Eichinger M., Stieltjes B., Sommer G., Strauss L.G., Dimitrakopoulou-Strauss A., Kopp-Schneider A., Haberkorn U., Huber P.E., Bischof M., Debus J., Thieke C.: Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer: the HIL trial. Radiat.Oncol. 7 (1) 157, 2012.

Baer C., Claus R., Frenzel L.P., Zucknick M., Park Y.J., Gu L., Weichenhan D., Fischer M., Pallasch C.P., Herpel E., Rehli M., Byrd J.C., Wendtner C.M., Plass C.: Extensive promoter DNA hypermethylation and hypomethylation is associated with aberrant microRNA expression in chronic lymphocytic leukemia. Cancer Res. 72 (15) 3775-3785, 2012.

Bai A.H., Milde T., Remke M., Rolli C.G., Hielscher T., Cho Y.J., Kool M., Northcott P.A., Jugold M., Bazhin A.V., Eichmüller S.B., Kulozik A.E., Pscherer A., Benner A., Taylor M.D., Pomeroy S.L., Kemkemer R., Witt O., Korshunov A., Lichter P., Pfister S.M.: MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma. Acta Neuropathol. 123 (4) 529-538, 2012.

Bayer H., Essig K., Stanzel S., Frank M., Gildersleeve J.C., Berger M.R., Voss C.: Evaluation of Riproximin binding properties reveals a novel mechanism for cellular targeting. J.Biol.Chem. 287 (43) 35873-35886, 2012.

Bäuerle T., Seyler L., Münter M., Jensen A., Brand K., Fritzsche K.H., Kopp-Schneider A., Schüssler M., Schlemmer H.P., Stieltjes B., Ganten M.: Diffusion-weighted imaging in rectal carcinoma patients without and after chemoradiotherapy: a comparative study with histology. Eur.J.Radiol. (epub) 2012.

Binder H., Benner A., Bullinger L., Schumacher M.: Tailoring sparse multivariable regression techniques for prognostic single-nucleotide polymorphism signatures. Stat.Med. (epub) 2012.

Bondong S., Kiefel H., Hielscher T., Zeimet A.G., Zeilinger R., Pils D., Schuster E., Castillo-Tong D.C., Cadron I., Vergote I., Braicu I., Sehouli J., Mahner S., Fogel M., Altevogt P.: Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-kB activation. Ann.Oncol. 23 (7) 1795-1802, 2012.

Borkosky S.S., Whitley C., Kopp-Schneider A., zur Hausen H., de Villiers E.M.: Epstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis. PLoS_ONE 7 (2) e32160, 2012.

Campa D., Müller P., Edler L., Knöfel L., Barale R., Heussel C.P., Thomas M., Canzian F., Risch A.: A comprehensive study of polymorphisms in ABCB1, ABCC2 and ABCG2 and lung cancer chemotherapy response and prognosis. Int.J.Cancer 131 (12) 2920-2928, 2012.

Christians A., Hartmann C., Benner A., Meyer C., von Deimling A., Weller M., Wick W., Weiler M.: Prognostic value of three different methods of MGMT promoter methylation analysis in a prospective trial on newly diagnosed glioblastoma. PLoS_ONE 7 (3) e33449, 2012.

Claus R., Lucas D.M., Stilgenbauer S., Ruppert A.S., Yu L., Zucknick M., Mertens D., Bühler A., Oakes C.C., Larson R.A., Kay N.E., Jelinek D.F., Klipps T.J., Rassenti L.Z., Gribben J.G., Döhner H., Heerema N.A., Marcucci G., Plass C., Byrd J.C.: Quantitative DNA methylation analysis identifies a single CpG dinucleotide Important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia. J.Clin.Oncol. 30 (20) 2483-2491, 2012.

Claus R., Wilop S., Hielscher T., Sonnet M., Dahl E., Galm O., Jost E., Plass C.: A systematic comparison of quantitative high-resolution DNA methylation analysis and methylation-specific PCR. Epigenetics 7 (7) 772-780, 2012.

Claus R., Hackanson B., Poetsch A.R., Zucknick M., Sonnet M., Blagitko-Dorfs N., Hiller J., Wilop S., Brümmendorf T.H., Galm O., Platzbecker U., Byrd J.C., Döhner K., Döhner H., Lübbert M., Plass C.: Quantitative analyses of DAPK1 methylation in AML and MDS. Int.J.Cancer 131 (2) E138-E142, 2012.

Clothier R., Gomez-Lechon M.J., Kinsner-Ovaskainen A., Kopp-Schneider A., O'Connor J.E., Prieto P., Stanzel S.: Comparative analysis of eight cytotoxicity assays evaluated within the ACuteTox Project. Toxicol.in Vitro (epub) 2012.

Cuk K., Zucknick M., Heil J., Madhavan D., Schott S., Turchinovich A., Arlt D., Rath M., Sohn C., Benner A., Junkermann H., Schneeweiss A., Burwinkel B.: Circulating microRNAs in plasma as early detection markers for breast cancer. Int.J.Cancer (epub) 2012.

Dittmann L.M., Danner A., Gronych J., Wolter M., Stühler K., Grzendowski M., Becker N., Bageritz J., Goidts V., Tödt G., Felsberg J., Sabel M.C., Barbus S., Reifenberger G., Lichter P., Tews B.: Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro. Oncogene 31 (29) 3409-3418, 2012.

Dorne J.L., Doerge D.R., Vandenbroeck M., Fink-Gremmels J., Mennes W., Knutsen H.K., Vernazza F., Castle L., Edler L., Benford D.: Recent advances in the risk assessment of melamine and cyanuric acid in animal feed. Toxicol.Appl.Pharmacol. (epub) 2012.

Dubuc A.M., Remke M., Korshunov A., Northcott P.A., Zhan S.H., Mendez-Lago M., Kool M., Jones D.T., Unterberger A., Morrissy A.S., Shih D., Peacock J., Ramaswamy V., Rolider A., Wang X., Witt H., Hielscher T., Hawkins C., Vibhakar R., Croul S., Rutka J.T., Weiss W.A., Jones S.J., Eberhart C.G., Marra M.A., Pfister S.M., Taylor M.D.: Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma. Acta Neuropathol. (epub) 2012.

Edler L.: as member of the EFSA Panel on Contaminants in the Food Chain (CONTAM): Scientific opinion on the risks for animal and public health related to the presence of phomopsins in feed and food. EFSA J. 10 (2) 2567-(52p.), 2012.

Edler L.: as member of the EFSA Panel on Contaminants in the Food Chain (CONTAM): Scientific opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part II of III . EFSA J. 10 (5) 2703-(150p.), 2012.

Edler L.: as member of the EFSA Panel on Contaminants in the Food Chain (CONTAM): Scientific opinion on mineral oil hydrocarbons in food. EFSA J. 10 (6) 2704-(185p.), 2012.

Edler L.: as member of the EFSA Panel on Contaminants in the Food Chain (CONTAM): Scientific opinion on Ergot alkaloids in food and feed. EFSA J. 10 (7) 2798-(158p.), 2012.

Edler L.: as member of the EFSA Panel on Biological Hazards (BIOHAZ),EFSA Panel on Contaminants in the Food Chain (CONTAM),EFSA Panel on Animal Health and Welfare (AHAW): Scientific opinion on the public health hazards to be covered by inspection of meat (poultry). EFSA J. 10 (6) 2741-(179p.), 2012.

Edler L.: as member of the EFSA Panel on Contaminants in the Food Chain (CONTAM): Scientific opinion on emerging and novel brominated flame retardants (BFRs) in food. EFSA J. 10 (10) 2908-(125p.), 2012.

Edler L.: Obituary for Professor Dr. Dr. h.c. Norbert Victor (1940-2011). Comput.Statist.Data Anal. 56 (5 special issue) 998-1015, 2012.

Edler L.: as member of the EFSA Panel on Biological Hazards (BIOHAZ) and EFSA Panel on Contaminants in the Food Chain (CONTAM): Scientific opinion on the minimum hygiene criteria to be applied to clean seawater and on the public health risks and hygiene criteria for bottled seawater intended for domestic use. EFSA J. 10 (3) 2613-(85p.), 2012.

Edler L.: as member of the EFSA Panel on Contaminants in the Food Chain (CONTAM): Scientific opinion on the risks for public and animal health related to the presence of citrinin in food and feed. EFSA J. 10 (3) 2605-(82p.), 2012.

Edler L.: as member of the EFSA Panel on Contaminants in the Food Chain (CONTAM): Scientific opinion on Brominated Flame Retardants (BFRs) in food: brominated phenols and their derivatives. EFSA J. 10 (4) 2634-(42p.), 2012.

Eichinger M., Optazaite D.E., Kopp-Schneider A., Hintze C., Biederer J., Niemann A., Mall M.A., Wielpütz M.O., Kauczor H.U., Puderbach M.: Morphologic and functional scoring of cystic fibrosis lung disease using MRI. Eur.J.Radiol. 81 (6) 1321-1329, 2012.

Fischer L., Deppert W.R., Pfeifer D., Stanzel S., Weimer M., Hanjalic-Beck A., Stein A., Strasser M., Zahradnik H.P., Schäfer W.R.: Potential hazards to embryo implantation: A human endometrial in vitro model to identify unwanted antigestagenic actions of chemicals. Toxicol.Appl.Pharmacol. 260 (3) 232-240, 2012.

Georges R., Bergmann F., Hamdi H., Zepp M., Eyol E., Hielscher T., Berger M.R., Adwan H.: Sequential biphasic changes in claudin1 and claudin4 expression are correlated to colorectal cancer progression and liver metastasis. J.Cell Mol.Med. 16 (2) 260-272, 2012.

Gerlinger C., Edler L., Friede T., Kieser M., Nakas C.T., Schumacher M., Seldrup J., Victor N.: Considerations on what constitutes a "qualified statistician" in regulatory guidelines. Stat.Med. 31 (11-12) 1303-1305, 2012.

Hillengass J., Ayyaz S., Kilk K., Weber M.A., Hielscher T., Shah R., Hose D., Delorme S., Goldschmidt H., Neben K.: Changes in magnetic resonance imaging before and after autologous stem cell transplantation correlate with response and survival in multiple myeloma. Haematologica 97 (11) 1757-1760, 2012.

Hoffmann S., Hothorn L.A., Edler L., Kleensang A., Suzuki M., Phrakonkham P., Gerhard D.: Two new approaches to improve the analysis of BALB/c 3T3 cell transformation assay data. Mut.Res./Gen.Tox.Environ.Mutagen. 744 (1) 36-41, 2012.

Holland-Letz T., Dette H., Renard D.: Efficient algorithms for optimal designs with correlated observations in pharmacokinetics and dose-finding studies. Biometrics 68 (1) 138-145, 2012.

Holzinger D., Schmitt M., Dyckhoff G., Benner A., Pawlita M., Bosch F.X.: Viral RNA patterns and high viral load reliably define oropharynx carcinomas with active HPV16 involvement. Cancer Res. 72 (19) 4993-5003, 2012.

Kahlert C., Gaitzsch E., Steinert G., Mogler C., Herpel E., Hoffmeister M., Jansen L., Benner A., Brenner H., Chang-Claude J., Rahbari N., Schmidt T., Klupp F., Grabe N., Lahrmann B., Koch M., Halama N., Büchler M., Weitz J.: Expression analysis of aldehyde dehydrogenase 1A1 (ALDH1A1) in colon and rectal cancer in association with prognosis and response to chemotherapy. Ann.Surg.Oncol. 19 4193-4201, 2012.

Kayser S., Zucknick M., Döhner K., Krauter J., Köhne C.H., Horst H.A., Held G., Lilienfeld-Toal M.v., Wilhelm S., Rummel M., Germing U., Götze K., Nachbaur D., Schlegelberger B., Göhring G., Späth D., Morlok C., Teleanu V., Ganser A., Döhner H., Schlenk R.F.: Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies. Blood 119 (2) 551-558, 2012.

Kinsner-Ovaskainen A., Prieto P., Stanzel S., Kopp-Schneider A.: Selection of test methods to be included in a testing strategy to predict acute oral toxicity: An approach based on statistical analysis of data collected in phase 1 of the ACuteTox project. Toxicol.in Vitro (epub) 2012.

Kinsner-Ovaskainen A., Maxwell G., Kreysa J., Barroso J., Adriaens E., Alepee N., Berg N., Bremer S., Coecke S., Comemges J.Z., Corvi S., Casati S., Dal Negro G., Marrec-Fairley M., Griesinger C., Halder M., Heisler E., Hirmann D., Kleensang A., Kopp-Schneider A., Lapenna S., Munn S., Prieto P., Schechtman L., Schultz T., Vidal J.M., Worth A., Zuang V.: Report of the EPAA-ECVAM workshop on the validation of Integrated testing strategies (ITS). Altern.Lab.Anim. 40 (3) 175-181, 2012.

Kloor M., Huth C., Voigt A.Y., Benner A., Schirmacher P., von Knebel-Döberitz M., Bläker H.: Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study. Lancet Oncol. 13 (6) 598-606, 2012.

Kopp-Schneider A., Prieto P., Kinsner-Ovaskainen A., Stanzel S.: Design of a testing strategy using non-animal based test methods: Lessons learnt from the ACuteTox project. Toxicol.in Vitro (epub) 2012.

Korshunov A., Remke M., Kool M., Hielscher T., Northcott P.A., Williamson D., Pfaff E., Witt H., Jones D.T.W., Ryzhova M., Cho Y.J., Wittmann A., Benner A., Weiss W.A., von Deimling A., Scheurlen W., Kulozik A.E., Clifford S.C., Collins V.P., Westermann F., Taylor M.D., Lichter P., Pfister S.M.: Biological and clinical heterogeneity of MYCN-amplified medulloblastoma. Acta Neuropathol. 123 (4) 515-527, 2012.

Krause S., Sterzing F., Neuhof D., Edler L., Debus J., Herfarth K.: Hypofractionated helical intensity-modulated radiotherapy of the prostate bed after prostatectomy with or without the pelvic lymph nodes - the PRIAMOS trial. BMC Cancer 12 504, 2012.

Kunz C., Kieser M.: Blinded versus unblinded covariate selection in confirmatory survival trials. J.Biopharm.Stat. (in press) 2012.

Liedtke S., Schmidt M.E., Vrieling A., Lukanova A., Becker S., Kaaks R., Zaineddin A.K., Buck K., Benner A., Chang-Claude J., Steindorf K.: Postmenopausal sex hormones in relation to body fat distribution. Obesity 20 (5) 1088-1095, 2012.

Longerich T., Müller M.M., Breuhahn K., Schirmacher P., Benner A., Heiss C.: Oncogenetic tree modeling of human hepatocarcinogenesis. Int.J.Cancer 130 (3) 575-583, 2012.

Madhavan D., Zucknick M., Wallwiener M., Cuk K., Modugno C., Scharpff M., Schott S., Heil J., Turchinovich A., Yang R., Benner A., Riethdorf S., Trumpp A., Sohn C., Pantel K., Schneeweiss A., Burwinkel B.: Circulating microRNAs as surrogate markers for circulating tumour cells and prognostic markers in metastatic breast cancer. Clin.Cancer Res. 18 (21) 5972-5982, 2012.

Maier P., Heckmann D., Spier I., Laufs S., Zucknick M., Allgayer H., Frühauf S., Zeller W.J., Wenz F.: F2A sequence linking MGMT(P140K) and MDR1 in a bicistronic lentiviral vector enables efficient chemoprotection of haematopoietic stem cells. Cancer Gene Ther. 19 (11) 802-810, 2012.

Marme F., Hielscher T., Hug S., Bondong S., Zeilinger R., Cacsire Castillo-Tong D., Sehouli J., Braicu I., Vergote I., Cadron I., Mahner S., Ferschke I., Rom J., Sohn C., Schneeweiss A., Altevogt P.: Fibroblast growth factor receptor 4 gene (FGFR4) 388Arg allele predicts prolonged survival and platinum sensitivity in advanced ovarian cancer. Int.J.Cancer 131 (4) E586-E591, 2012.

Marme F., Werft W., Walter A., Keller S., Wang X., Benner A., Burwinkel B., Sinn P., Hug S., Sohn C., Bretz N., Moldenhauer G., Rupp C., Rupp A.K., Biakhov M.Y., Bottini A., Friedrichs K., Khailenko V.A., Manikhas G.M., Ruiz A., Sanchez-Rovira P., Santoro A., Segui M.A., Villena C., Lichter P., Kristiansen G., Altevogt P., Schneeweiss A.: CD24 Ala57Val polymorphism predicts pathologic complete response to sequential anthracycline- and taxane-based neoadjuvant chemotherapy for primary breast cancer. Breast Cancer Res.Treat. 132 (3) 819-831, 2012.

McClanathan F., Hielscher T., Rieger M., Hensel M., Bentz M., Schmidt-Wolf I., Käbisch A., Salwender H., Dürk H., Staiger H., Mandel T., Neben K., Hillengass J., Leo E., Krämer A., Ho A.D., Witzens-Harig M.: Final results of a randomized trial comparing 1, 3, or 6 infusions of Rituximab plus 6 cycles CHOP provide valuable preliminary data towards a more cost-effective and safer treatment of advanced follicular lymphoma. Am.J.Hematol. 87 (10) E68-E71, 2012.

Milde T., Hielscher T., Witt H., Kool M., Mack S.C., Deubzer H.E., Öhme I., Lodrini M., Benner A., Taylor M.D., von Deimling A., Kulozik A.E., Pfister S.M., Witt O., Korshunov A.: Nestin expression Identifies ependymoma patients with poor outcome. Brain Pathol. 22 (6) 848-860, 2012.

Milker-Zabel S., Kopp-Schneider A., Wiesbauer H., Schlegel W., Huber P., Debus J., Zabel-du Bois A.: Proposal for a new prognostic score for linac-based radiosurgery in cerebral arteriovenous malformations. Int.J.Radiat.Oncol.Biol.Phys. 83 (2) 525-532, 2012.

Mittlböck M., Edler L., LeBlanc M., Niland J., Zwindermann K.: Second issue for computational statistics for clinical research. Comput.Statist.Data Anal. 56 (5 special issue) 995-997, 2012.

Neben K., Lokhorst H.M., Jauch A., Bertsch U., Hielscher T., van der Holt B., Salwender H., Blau I.W., Weisel K., Pfreundschuh M., Scheid C., Dührsen U., Lindemann W., Schmidt-Wolf I.G.H., Peter N., Teschendorf C., Martin H., Haenel M., Derigs H.G., Raab M.S., Ho A.D., van de Velde H., Hose D., Sonneveld P., Goldschmidt H.: Administration of bortezomib before and after autologous stem-cell transplantation improves outcome in multiple myeloma patients with deletion 17p. Blood 119 (4) 940-948, 2012.

Popa-Wagner R., Porwal M., Kann M., Reuss M., Weimer M., Florin L., Kleinschmidt J.A.: Impact of VP1-specific protein sequence motifs on adeno-associated virus type 2 intracellular trafficking and nuclear entry. J.Virol. 86 (17) 9163-9174, 2012.

Prieto P., Kinsner-Ovaskainen A., Stanzel S., Albella B., Artursson P., Campillo N., Cecchelli R., Cerrato L., Diaz L., Di Consiglio E., Guerra A., Gombau L., Herrera G., Honegger P., Landry C., O'Connor J.E., Paez J.A., Quintas G., Svensson R., Turco L., Zurich M.G., Zurbano M.J., Kopp-Schneider A.: The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox. Toxicol.in Vitro (epub) , 2012.

Röder F., Timke C., Saleh-Ebrahimi L., Schneider L., Hackert T., Hartwig W., Kopp-Schneider A., Hensley F.W., Büchler M.W., Debus J., Huber P.E., Werner J.: Clinical phase I/II trial to investigate neoadjuvant intensity-modulated short term radiation therapy (5 x 5 gy) and intraoperative radiation therapy (15 gy) in patients with primarily resectable pancreatic cancer - NEOPANC. BMC Cancer 12 (Art.Nr. 112), 2012.

Röder F.F., Schulz-Ertner D., Nikoghosyan A.V., Huber P.E., Edler L., Habl G., Krempien R., Oertel S., Saleh-Ebrahimi L., Hensley F.W., Büchler M.W., Debus J., Koch M., Weitz J., Bischof M.: A Clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcoma. BMC Cancer 12 (1) 287, 2012.

Schrimpf D., Pilz L.: Adaptive randomization procedures for the web-based randomization system RANDI2. Int.J.Clin.Pharm.Therap. 50 (1) 85-86, 2012.

Schwartzentruber J., Korshunov A., Liu X.Y., Jones D.T.W., Pfaff E., Jacob K., Sturm D., Fontebasso A.M., Quang D.A.K., Toenjes M., Hovestadt V., Albrecht S., Nantel A., Konermann C., Jäger N., Rausch T., Ryzhova M., Korbel J., Hielscher T., Hauser P., Garami M., Klekner A., Bognar L., Ebinger M., Schuhmann M.U., Scheurlen W., Pekrun A., Frühwald M., Roggendorf W., Kramm C., Dürken M., Atkinson J., Lepage P., Monpetit A., Zakrzewska M., Zakrzewski K., Liberski P.P., Dong Z., Siegel P., Kulozik A.E., Zapatka M., Guha A., Malkin D., Felsberg J., Reifenberger G., von Deimling A., Ichimura K., Collins V.P., Witt H., Milde T., Witt O., Zhang C., Castelo-Branco P., Lichter P., Faury D., Tabori U., Plass C., Majewski J., Pfister S.M., Jabado N.: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 482 (7384) 226-231, 2012.

Shahmoradgoli M., Riazalhosseini Y., Haag D., Becker N., Hovestadt V., Heck S., Sinn H.P., Schneeweiss A., Mannherz O., Sahin O., Lichter P.: Protein phosphatase 1, regulatory subunit 15B is a survival factor for ER-alpha-positive breast cancer. Int.J.Cancer (epub) 2012.

Strumberg D., Schultheis B., Scheulen M.E., Hilger R.A., Krauss J., Marschner N., Lordick F., Bach F., Reuter D., Edler L., Mross K.: Phase II study of nimotuzumab, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients with locally advanced or metastatic pancreatic cancer. Investigat.New Drugs 30 (3) 1138-1143, 2012.

Sturm D., Witt H., Hovestadt V., Khuong Quang D.A., Jones D., Konermann C., Pfaff E., Tönjes M., Sill M., Bender S., Kool M., Zapatka M., Becker N., Zucknick M., Hielscher T., Liu X.Y., Fontebasso A.M., Ryzhova M., Albrecht S., Jacob K., Wolter M., Ebinger M., Schuhmann M., Van Meter T., Frühwald M., Hauch H., Pekrun A., Radlwimmer B., Niehues T., von Komorowski G., Dürken M., Kulozik A., Madden J., Donson A., Foreman N., Drissi R., Fouladi M., Scheurlen W., von Deimling A., Monoranu C., Roggendorf M., Herold-Mende C., Unterberg A., Kramm C., Felsberg J., Hartmann C., Wiestler B., Wick W., Milde T., Witt O., Lindroth A., Schwartzentruber J., Faury D., Fleming A., Zakrzewska M., Liberski P., Zakrzewski K., Hauser P., Garami M., Klekner A., Bognar L., Morrissy S., Cavalli F., Tayler M., van Sluis P., Koster J., Versteeg R., Volckmann R., Mikkelsen T., Aldape K., Reifenberger G., Collins V., Majewski J., Korshunov A., Lichter P., Plass C., Jabado N., Pfister S.: Hotspot mutations in H3F3A and IDH1 define distincte epigenetic and biological subgroups of glioblastoma. Cancer Cell 22 (4) 425-437, 2012.

Tikidzhieva A., Benner A., Michel S., Formentini A., Link K.H., Dippold W., von Knebel-Döberitz M., Kornmann M., Kloor M.: Microsatellite instability and Beta2-microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial. Br.J.Cancer 106 (6) 1239-1245, 2012.

Uhlmann M.E., Georgieva M., Sill M., Linnemann U., Berger M.R.: Prognostic value of tumor progression-related gene expression in colorectal cancer patients. J.Cancer Res.Clin.Oncol. 138 (10) 1631-1640, 2012.

Vrieling A., Buck K., Heinz J., Obi N., Benner A., Flesch-Janys D., Chang-Claude J.: Pre-diagnostic alcohol consumption and postmenopausal breast cancer survival: a prospective patient cohort study. Breast Cancer Res.Treat. 136 (1) 195-207, 2012.

Ward A., Balwierz A., Zhang J.D., Küblbeck M., Pawitan Y., Hielscher T., Wiemann S., Sahin O.: Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene (epub) 2012.

Weimer M., Jiang X., Ponta O., Stanzel S., Freyberger A., Kopp-Schneider A.: The impact of data transformations on concentration-response modeling. Toxicol.Lett. 213 (2) 292-298, 2012.

Werft W., Benner A., Kopp-Schneider A.: On the identification of predictive biomarkers: detecting treatment-by-gene interaction in high-dimensional data. Comput.Statist.Data Anal. 56 (5) 1275-1286, 2012.

Wunder C., Kopp-Schneider A., Edler L.: An adaptive group sequential phase II design to compare treatments for survival endpoints in rare patient entities. J.Biopharm.Stat. 22 (2) 294-311, 2012.

Zurich M.G., Stanzel S., Kopp-Schneider A., Prieto P., Honegger P.: Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity. Toxicol.in Vitro (epub), 2012.