Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .


These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds

Identification and evaluation of novel potential cancer chemopreventive agents

Scheme of multistage carcinogenesis (left) and mechanisms of cancer chemoprevention (right)

Carcinogenesis can be regarded as an accumulation of genetic or biochemical cell damage, which offers a variety of targets for chemopreventive agents to prevent or inhibit the slow progression from early genetic lesions to tumor development.

Well established molecular mechanisms of chemoprevention include modulation of drug metabolism, anti-oxidant, radical-scavenging, anti-inflammatory, anti-tumor promoting and anti-proliferative activities as well as induction of terminal cell differentiation and apoptosis.

Knowledge of molecular mechanisms is of importance for safe application of known, but also for further development of novel potential cancer preventive agents.

Consequently, we have set up a battery of cell- and enzyme-based in vitro marker systems relevant for inhibition of carcinogenesis in vivo. These test systems offer fast (within days), sensitive and inexpensive identification and evaluation of lead compounds for the development of effective chemopreventive agents and the elucidation of their modes of action [Gerhauser et al., 2003]. Mechanisms are targeted at all stages of carcinogenesis and include modulation of xenobiotic metabolism, determination of radical-scavenging and anti-oxidant effects, inhibition of tumor promotion through anti-inflammatory and anti-hormonal mechanisms, inhibition of cell proliferation by induction of cell cycle arrest and apoptosis, and anti-angiogenic effects.

to top
powered by webEdition CMS