Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .


These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds

Glucosinolate- and selenium-enriched broccoli as functional food for prostate cancer prevention (BMBF-BroCan)

Prostate cancer is the leading cause of cancer for men in Germany. Epidemiological as well as experimental data suggest a preventive role of broccoli constituents in prostate cancer. Glucosinolates and selenium are suggested as the major anticancer-acting constituents of broccoli. At present, the selenium intake in Germany is at the lower end of the recommended intake; thus, an increased supply of selenium and glucosinolatesy food consumption could substantially contribute to reduce prostate cancer risk.

The aim of the network project is to optimize the content of the two "key components", selenium and glucosinolates, without compromising plant growth and stress tolerance. As a result, functional broccoli products providing elevated quantities of selenium and glucosinolates will become available and will be used to study their chemopreventive activity and their effects on biomarkers of prostate cancer in cell culture and in animal models.

In vivo studies in humans conducted at the Max-Rubner-Institute in Karlsruhe will monitor the bioavailability of key components and investigate short-term health-benefits of such newly developed functional broccoli products. In addition, the potential of glucosinolates and selenium for the prevention of prostate cancer will be investigated in an observational cohort study in Germany (EPIC), applying biomarkers of dietary intake. 

Project partners:

The project benefits from the close interaction between plant scientist, molecular biologists, nutritionists, food chemists, epidemiologists, and partners from industry.

  • DKFZ German Cancer Research CenterDivision of Epigenomics and Cancer Risk Factors, Cancer Chemoprevention Group (Coordinator)Division of Clinical Epidemiology, Unit Nutritional Epidemiology
  • HIP Heidelberg Institute of Plant Sciences Division of Molecular Ecophysiology Division of Molecular Biology
  • MRI Max-Rubner-Institute (Karlsruhe)
    Department of Physiology and Biochemistry of Nutrition
  • DFA Federal Institute of Food Chemistry (Garching)
    Research Group Physiological Effects of Food Ingredients
  • Fa. Unilever Deutschland GmbH / Foods Division (Heilbronn)
  • Fa. Fruchtsaft Bayer (Ditzingen-Heimerdingen)
  • Subcontractor:
    NIG Nahrungsingenieurtechnik GmbH (Magdeburg)


to top
powered by webEdition CMS