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Identification of methylated genes in preneoplastic mammary lesions as potential biomarkers and chemopreventive targets in invasive breast cancer

Flat epithelial atypia (FEA)
Breast cancer is one of the leading causes of death among women worldwide. Hypermethylation and other epigenetic changes have been shown to occur early in carcinogenesis, and are currently considered as a rare but potentially cancer initiating event.
Therefore, the aim of our project is to clarify the role of DNA methylation events in the initiation of breast cancer and to identify potentially valuable biomarkers for early detection and chemoprevention.

Atypical ductal hyperplasia (ADH)
Our project has the potential to initiate new strategies for early diagnosis of breast cancer and to establish novel targets for chemoprevention.
Funded by FRONTIER Innovation Fund, University of Heidelberg
Links
- Prof. H.P. Sinn, Pathologisches Institut der Universität Heidelberg
- Sinn, J. Mol. Med. 2009, Breast cancer precursors: lessons learned from molecular genetics (PDF | 183,70 KB)
- Faryna et al. FASEB J. 2012, Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis (PDF | 1,32 MB)