Publications with contributions by the High Throughput Sequencing Unit
Co-authorships of the High Throughput Sequencing Unit group members are indicated in bold.
- Erkek S., Johann P. D., Finetti M. A., Drosos Y., Chou H. C., Zapatka M., Sturm D., Jones D. T. W., Korshunov A., Rhyzova M., Wolf S., Mallm J. P., Beck K., Witt O., Kulozik A. E., Fruhwald M. C., Northcott P. A., Korbel J. O., Lichter P., Eils R., Gajjar A., Roberts C. W. M., Williamson D., Hasselblatt M., Chavez L., Pfister S. M., Kool M., (2019) Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation. Cancer Cell, 35:95-110 e8
link to online source - Chudasama P., Mughal S. S., Sanders M. A., Hubschmann D., Chung I., Deeg K. I., Wong S. H., Rabe S., Hlevnjak M., Zapatka M., Ernst A., Kleinheinz K., Schlesner M., Sieverling L., Klink B., Schrock E., Hoogenboezem R. M., Kasper B., Heilig C. E., Egerer G., Wolf S., von Kalle C., Eils R., Stenzinger A., Weichert W., Glimm H., Groschel S., Kopp H. G., Omlor G., Lehner B., Bauer S., Schimmack S., Ulrich A., Mechtersheimer G., Rippe K., Brors B., Hutter B., Renner M., Hohenberger P., Scholl C., Frohling S., (2018) Integrative genomic and transcriptomic analysis of leiomyosarcoma. Nat Commun, 9:144
link to online source - Dimitrov B., Himmelreich N., Hipgrave Ederveen A. L., Luchtenborg C., Okun J. G., Breuer M., Hutter A. M., Carl M., Guglielmi L., Hellwig A., Thiemann K. C., Jost M., Peters V., Staufner C., Hoffmann G. F., Hackenberg A., Paramasivam N., Wiemann S., Eils R., Schlesner M., Strahl S., Brugger B., Wuhrer M., Christoph Korenke G., Thiel C., (2018) Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. Mol Genet Metab, 123:364-374
link to online source - Grobner S. N., Worst B. C., Weischenfeldt J., Buchhalter I., Kleinheinz K., Rudneva V. A., Johann P. D., Balasubramanian G. P., Segura-Wang M., Brabetz S., Bender S., Hutter B., Sturm D., Pfaff E., Hubschmann D., Zipprich G., Heinold M., Eils J., Lawerenz C., Erkek S., Lambo S., Waszak S., Blattmann C., Borkhardt A., Kuhlen M., Eggert A., Fulda S., Gessler M., Wegert J., Kappler R., Baumhoer D., Burdach S., Kirschner-Schwabe R., Kontny U., Kulozik A. E., Lohmann D., Hettmer S., Eckert C., Bielack S., Nathrath M., Niemeyer C., Richter G. H., Schulte J., Siebert R., Westermann F., Molenaar J. J., Vassal G., Witt H., Icgc PedBrain-Seq Project, Icgc Mmml- Seq Project, Burkhardt B., Kratz C. P., Witt O., van Tilburg C. M., Kramm C. M., Fleischhack G., Dirksen U., Rutkowski S., Fruhwald M., von Hoff K., Wolf S, Klingebiel T., Koscielniak E., Landgraf P., Koster J., Resnick A. C., Zhang J., Liu Y., Zhou X., Waanders A. J., Zwijnenburg D. A., Raman P., Brors B., Weber U. D., Northcott P. A., Pajtler K. W., Kool M., Piro R. M., Korbel J. O., Schlesner M., Eils R., Jones D. T. W., Lichter P., Chavez L., Zapatka M., Pfister S. M., (2018) The landscape of genomic alterations across childhood cancers. Nature, :
link to online source - Gutekunst J., Andriantsoa R., Falckenhayn C., Hanna K., Stein W., Rasamy J., Lyko F., (2018) Clonal genome evolution and rapid invasive spread of the marbled crayfish. Nat Ecol Evol, 2:567-573
link to online source - Mack S. C., Pajtler K. W., Chavez L., Okonechnikov K., Bertrand K. C., Wang X., Erkek S., Federation A., Song A., Lee C., Wang X., McDonald L., Morrow J. J., Saiakhova A., Sin-Chan P., Wu Q., Michaelraj K. A., Miller T. E., Hubert C. G., Ryzhova M., Garzia L., Donovan L., Dombrowski S., Factor D. C., Luu B., Valentim C. L. L., Gimple R. C., Morton A., Kim L., Prager B. C., Lee J. J. Y., Wu X., Zuccaro J., Thompson Y., Holgado B. L., Reimand J., Ke S. Q., Tropper A., Lai S., Vijayarajah S., Doan S., Mahadev V., Minan A. F., Grobner S. N., Lienhard M., Zapatka M., Huang Z., Aldape K. D., Carcaboso A. M., Houghton P. J., Keir S. T., Milde T., Witt H., Li Y., Li C. J., Bian X. W., Jones D. T. W., Scott I., Singh S. K., Huang A., Dirks P. B., Bouffet E., Bradner J. E., Ramaswamy V., Jabado N., Rutka J. T., Northcott P. A., Lupien M., Lichter P., Korshunov A., Scacheri P. C., Pfister S. M., Kool M., Taylor M. D., Rich J. N., (2018) Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. Nature, 553:101-105
link to online source - Mishra R. R., Belder N., Ansari S. A., Kayhan M., Bal H., Raza U., Ersan P. G., Tokat U. M., Eyupoglu E., Saatci O., Jandaghi P., Wiemann S., Uner A., Cekic C., Riazalhosseini Y., Sahin O., (2018) Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer. Clin Cancer Res, 24:1987-2001
link to online source - Paramasivam N., Granzow M., Evers C., Hinderhofer K., Wiemann S., Bartram C.R., Eils R., Schlesner M., (2018) Identification and prioritisation of causal variants in human genetic disorders from exome or whole genome sequencing data. OBM Genetics, 2:1-1
link to online source - Saatci O., Borgoni S., Akbulut O., Durmus S., Raza U., Eyupoglu E., Alkan C., Akyol A., Kutuk O., Wiemann S, Sahin O., (2018) Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer. Oncogene, 37:2251-2269
link to online source - Simm F., Griesbeck A., Choukair D., Weiss B., Paramasivam N., Klammt J., Schlesner M., Wiemann S., Martinez C., Hoffmann G. F., Pfaffle R. W., Bettendorf M., Rappold G. A., (2018) Identification of SLC20A1 and SLC15A4 among other genes as potential risk factors for combined pituitary hormone deficiency. Genet Med, 20:728-736
link to online source - Agaimy A., Bieg M., Michal M., Geddert H., Markl B., Seitz J., Moskalev E. A., Schlesner M., Metzler M., Hartmann A., Wiemann S, Michal M., Mentzel T., Haller F., (2017) Recurrent Somatic PDGFRB Mutations in Sporadic Infantile/Solitary Adult Myofibromas But Not in Angioleiomyomas and Myopericytomas. Am J Surg Pathol, 41:195-203
link to online source - Delacher M., Imbusch C. D., Weichenhan D., Breiling A., Hotz-Wagenblatt A., Trager U., Hofer A. C., Kagebein D., Wang Q., Frauhammer F., Mallm J. P., Bauer K., Herrmann C., Lang P. A., Brors B., Plass C., Feuerer M., (2017) Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues. Nat Immunol, :
link to online source - Evers C., Staufner C., Granzow M., Paramasivam N., Hinderhofer K., Kaufmann L., Fischer C., Thiel C., Opladen T., Kotzaeridou U., Wiemann S., Schlesner M., Eils R., Kolker S., Bartram C. R., Hoffmann G. F., Moog U., (2017) Impact of clinical exomes in neurodevelopmental and neurometabolic disorders. Mol Genet Metab, 121:297-307
link to online source - Heilmann K., Toth R., Bossmann C., Klimo K., Plass C., Gerhauser C., (2017) Genome-wide screen for differentially methylated long noncoding RNAs identifies Esrp2 and lncRNA Esrp2-as regulated by enhancer DNA methylation with prognostic relevance for human breast cancer. Oncogene, 36:6446-6461
link to online source - Horak P., Klink B., Heining C., Groschel S., Hutter B., Frohlich M., Uhrig S., Hubschmann D., Schlesner M., Eils R., Richter D., Pfutze K., Georg C., Meissburger B., Wolf S., Schulz A., Penzel R., Herpel E., Kirchner M., Lier A., Endris V., Singer S., Schirmacher P., Weichert W., Stenzinger A., Schlenk R. F., Schrock E., Brors B., von Kalle C., Glimm H., Frohling S., (2017) Precision oncology based on omics data: The NCT Heidelberg experience. Int J Cancer, 141:877-886
link to online source - Mamlouk S., Childs L. H., Aust D., Heim D., Melching F., Oliveira C., Wolf T., Durek P., Schumacher D., Blaker H., von Winterfeld M., Gastl B., Mohr K., Menne A., Zeugner S., Redmer T., Lenze D., Tierling S., Mobs M., Weichert W., Folprecht G., Blanc E., Beule D., Schafer R., Morkel M., Klauschen F., Leser U., Sers C., (2017) DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer. Nat Commun, 8:14093
link to online source - Northcott P. A., Buchhalter I., Morrissy A. S., Hovestadt V., Weischenfeldt J., Ehrenberger T., Grobner S., Segura-Wang M., Zichner T., Rudneva V. A., Warnatz H. J., Sidiropoulos N., Phillips A. H., Schumacher S., Kleinheinz K., Waszak S. M., Erkek S., Jones D. T. W., Worst B. C., Kool M., Zapatka M., Jager N., Chavez L., Hutter B., Bieg M., Paramasivam N., Heinold M., Gu Z., Ishaque N., Jager-Schmidt C., Imbusch C. D., Jugold A., Hubschmann D., Risch T., Amstislavskiy V., Gonzalez F. G. R., Weber U. D., Wolf S., Robinson G. W., Zhou X., Wu G., Finkelstein D., Liu Y., Cavalli F. M. G., Luu B., Ramaswamy V., Wu X., Koster J., Ryzhova M., Cho Y. J., Pomeroy S. L., Herold-Mende C., Schuhmann M., Ebinger M., Liau L. M., Mora J., McLendon R. E., Jabado N., Kumabe T., Chuah E., Ma Y., Moore R. A., Mungall A. J., Mungall K. L., Thiessen N., Tse K., Wong T., Jones S. J. M., Witt O., Milde T., Von Deimling A., Capper D., Korshunov A., Yaspo M. L., Kriwacki R., Gajjar A., Zhang J., Beroukhim R., Fraenkel E., Korbel J. O., Brors B., Schlesner M., Eils R., Marra M. A., Pfister S. M., Taylor M. D., Lichter P., (2017) The whole-genome landscape of medulloblastoma subtypes. Nature, 547:311-317
link to online source - Pei W., Feyerabend T. B., Rossler J., Wang X., Postrach D., Busch K., Rode I., Klapproth K., Dietlein N., Quedenau C., Chen W., Sauer S., Wolf S., Hofer T., Rodewald H. R., (2017) Polylox barcoding reveals haematopoietic stem cell fates realized in vivo. Nature, 548:456-460
link to online source - Rafiullah R., Long A. B., Ivanova A. A., Ali H., Berkel S., Mustafa G., Paramasivam N., Schlesner M., Wiemann S., Wade R. C., Bolthauser E., Blum M., Kahn R. A., Caspary T., Rappold G. A., (2017) A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity. Eur J Hum Genet, 25:1324-1334
link to online source - Ratnaparkhe M., Hlevnjak M., Kolb T., Jauch A., Maass K. K., Devens F., Rode A., Hovestadt V., Korshunov A., Pastorczak A., Mlynarski W., Sungalee S., Korbel J., Hoell J., Fischer U., Milde T., Kramm C., Nathrath M., Chrzanowska K., Tausch E., Takagi M., Taga T., Constantini S., Loeffen J., Meijerink J., Zielen S., Gohring G., Schlegelberger B., Maass E., Siebert R., Kunz J., Kulozik A. E., Worst B., Jones D. T., Pfister S. M., Zapatka M., Lichter P., Ernst A., (2017) Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis. Leukemia, :
link to online source - Haller F., Knopf J., Ackermann A., Bieg M., Kleinheinz K., Schlesner M., Moskalev E. A., Will R., Satir A. A., Abdelmagid I. E., Giedl J., Carbon R., Rompel O., Hartmann A., Wiemann S., Metzler M., Agaimy A., (2016) Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern. J Pathol, 238:700-10
link to online source - Lin C. Y., Erkek S., Tong Y., Yin L., Federation A. J., Zapatka M., Haldipur P., Kawauchi D., Risch T., Warnatz H. J., Worst B. C., Ju B., Orr B. A., Zeid R., Polaski D. R., Segura-Wang M., Waszak S. M., Jones D. T., Kool M., Hovestadt V., Buchhalter I., Sieber L., Johann P., Chavez L., Groschel S., Ryzhova M., Korshunov A., Chen W., Chizhikov V. V., Millen K. J., Amstislavskiy V., Lehrach H., Yaspo M. L., Eils R., Lichter P., Korbel J. O., Pfister S. M., Bradner J. E., Northcott P. A., (2016) Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature, 530:57-62
link to online source - Oakes C. C., Seifert M., Assenov Y., Gu L., Przekopowitz M., Ruppert A. S., Wang Q., Imbusch C. D., Serva A., Koser S. D., Brocks D., Lipka D. B., Bogatyrova O., Weichenhan D., Brors B., Rassenti L., Kipps T. J., Mertens D., Zapatka M., Lichter P., Dohner H., Kuppers R., Zenz T., Stilgenbauer S., Byrd J. C., Plass C., (2016) DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia. Nat Genet, 48:253-64
link to online source - Rafiullah R., Aslamkhan M., Paramasivam N., Thiel C., Mustafa G., Wiemann S., Schlesner M., Wade R. C., Rappold G. A., Berkel S., (2016) Homozygous missense mutation in the LMAN2L gene segregates with intellectual disability in a large consanguineous Pakistani family. J Med Genet, 53:138-44
link to online source - Salvermoser M., Chotewutmontri S., Braspenning-Wesch I., Hasche D., Rosl F., Vinzon S. E., (2016) Transcriptome analysis of Mastomys natalensis papillomavirus in productive lesions after natural infection. J Gen Virol, :
link to online source - Sturm D., Orr B. A., Toprak U. H., Hovestadt V., Jones D. T. W., Capper D., Sill M., Buchhalter I., Northcott P. A., Leis I., Ryzhova M., Koelsche C., Pfaff E., Allen S. J., Balasubramanian G., Worst B. C., Pajtler K. W., Brabetz S., Johann P. D., Sahm F., Reimand J., Mackay A., Carvalho D. M., Remke M., Phillips J. J., Perry A., Cowdrey C., Drissi R., Fouladi M., Giangaspero F., Lastowska M., Grajkowska W., Scheurlen W., Pietsch T., Hagel C., Gojo J., Lotsch D., Berger W., Slavc I., Haberler C., Jouvet A., Holm S., Hofer S., Prinz M., Keohane C., Fried I., Mawrin C., Scheie D., Mobley B. C., Schniederjan M. J., Santi M., Buccoliero A. M., Dahiya S., Kramm C. M., von Bueren A. O., von Hoff K., Rutkowski S., Herold-Mende C., Fruhwald M. C., Milde T., Hasselblatt M., Wesseling P., Rossler J., Schuller U., Ebinger M., Schittenhelm J., Frank S., Grobholz R., Vajtai I., Hans V., Schneppenheim R., Zitterbart K., Collins V. P., Aronica E., Varlet P., Puget S., Dufour C., Grill J., Figarella-Branger D., Wolter M., Schuhmann M. U., Shalaby T., Grotzer M., van Meter T., Monoranu C. M., Felsberg J., Reifenberger G., Snuderl M., Forrester L. A., Koster J., Versteeg R., Volckmann R., van Sluis P., Wolf S., Mikkelsen T., Gajjar A., Aldape K., Moore A. S., Taylor M. D., Jones C., Jabado N., Karajannis M. A., Eils R., Schlesner M., Lichter P., von Deimling A., Pfister S. M., Ellison D. W., Korshunov A., Kool M., (2016) New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. Cell, 164:1060-1072
link to online source - Worst B. C., van Tilburg C. M., Balasubramanian G. P., Fiesel P., Witt R., Freitag A., Boudalil M., Previti C., Wolf S., Schmidt S., Chotewutmontri S., Bewerunge-Hudler M., Schick M., Schlesner M., Hutter B., Taylor L., Borst T., Sutter C., Bartram C. R., Milde T., Pfaff E., Kulozik A. E., von Stackelberg A., Meisel R., Borkhardt A., Reinhardt D., Klusmann J. H., Fleischhack G., Tippelt S., Dirksen U., Jurgens H., Kramm C. M., von Bueren A. O., Westermann F., Fischer M., Burkhardt B., Wossmann W., Nathrath M., Bielack S. S., Fruhwald M. C., Fulda S., Klingebiel T., Koscielniak E., Schwab M., Tremmel R., Driever P. H., Schulte J. H., Brors B., von Deimling A., Lichter P., Eggert A., Capper D., Pfister S. M., Jones D. T., Witt O., (2016) Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study. Eur J Cancer, 65:91-101
link to online source - Alioto T. S., Buchhalter I., Derdak S., Hutter B., Eldridge M. D., Hovig E., Heisler L. E., Beck T. A., Simpson J. T., Tonon L., Sertier A. S., Patch A. M., Jager N., Ginsbach P., Drews R., Paramasivam N., Kabbe R., Chotewutmontri S., Diessl N., Previti C., Schmidt S., Brors B., Feuerbach L., Heinold M., Grobner S., Korshunov A., Tarpey P. S., Butler A. P., Hinton J., Jones D., Menzies A., Raine K., Shepherd R., Stebbings L., Teague J. W., Ribeca P., Giner F. C., Beltran S., Raineri E., Dabad M., Heath S. C., Gut M., Denroche R. E., Harding N. J., Yamaguchi T. N., Fujimoto A., Nakagawa H., Quesada V., Valdes-Mas R., Nakken S., Vodak D., Bower L., Lynch A. G., Anderson C. L., Waddell N., Pearson J. V., Grimmond S. M., Peto M., Spellman P., He M., Kandoth C., Lee S., Zhang J., Letourneau L., Ma S., Seth S., Torrents D., Xi L., Wheeler D. A., Lopez-Otin C., Campo E., Campbell P. J., Boutros P. C., Puente X. S., Gerhard D. S., Pfister S. M., McPherson J. D., Hudson T. J., Schlesner M., Lichter P., Eils R., Jones D. T., Gut I. G., (2015) A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. Nat Commun, 6:10001
link to online source - Gu L., Frommel S. C., Oakes C. C., Simon R., Grupp K., Gerig C. Y., Bar D., Robinson M. D., Baer C., Weiss M., Gu Z., Schapira M., Kuner R., Sultmann H., Provenzano M., Icgc Project on Early Onset Prostate Cancer, Yaspo M. L., Brors B., Korbel J., Schlomm T., Sauter G., Eils R., Plass C., Santoro R., (2015) BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence. Nat Genet, 47:22-30
link to online source - Haller F., Bieg M., Moskalev E. A., Barthelmess S., Geddert H., Boltze C., Diessl N., Braumandl K., Brors B., Iro H., Hartmann A., Wiemann S., Agaimy A., (2015) Recurrent mutations within the amino-terminal region of beta-catenin are probable key molecular driver events in sinonasal hemangiopericytoma. Am J Pathol, 185:563-71
link to online source - Wegert J., Ishaque N., Vardapour R., Georg C., Gu Z., Bieg M., Ziegler B., Bausenwein S., Nourkami N., Ludwig N., Keller A., Grimm C., Kneitz S., Williams R. D., Chagtai T., Pritchard-Jones K., van Sluis P., Volckmann R., Koster J., Versteeg R., Acha T., O'Sullivan M. J., Bode P. K., Niggli F., Tytgat G. A., van Tinteren H., van den Heuvel-Eibrink M. M., Meese E., Vokuhl C., Leuschner I., Graf N., Eils R., Pfister S. M., Kool M., Gessler M., (2015) Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors. Cancer Cell, 27:298-311
link to online source - Zuckermann M., Hovestadt V., Knobbe-Thomsen C. B., Zapatka M., Northcott P. A., Schramm K., Belic J., Jones D. T., Tschida B., Moriarity B., Largaespada D., Roussel M. F., Korshunov A., Reifenberger G., Pfister S. M., Lichter P., Kawauchi D., Gronych J., (2015) Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling. Nat Commun, 6:7391
link to online source - Haberle V., Li N., Hadzhiev Y., Plessy C., Previti C, Nepal C., Gehrig J., Dong X., Akalin A., Suzuki A. M., van IJcken W. F., Armant O., Ferg M., Strahle U., Carninci P., Muller F., Lenhard B., (2014) Two independent transcription initiation codes overlap on vertebrate core promoters. Nature, 507:381-5
link to online source - Hovestadt V., Jones D. T., Picelli S., Wang W., Kool M., Northcott P. A., Sultan M., Stachurski K., Ryzhova M., Warnatz H. J., Ralser M., Brun S., Bunt J., Jager N., Kleinheinz K., Erkek S., Weber U. D., Bartholomae C. C., von Kalle C., Lawerenz C., Eils J., Koster J., Versteeg R., Milde T., Witt O., Schmidt S., Wolf S., Pietsch T., Rutkowski S., Scheurlen W., Taylor M. D., Brors B., Felsberg J., Reifenberger G., Borkhardt A., Lehrach H., Wechsler-Reya R. J., Eils R., Yaspo M. L., Landgraf P., Korshunov A., Zapatka M., Radlwimmer B., Pfister S. M., Lichter P., (2014) Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature, 510:537-41
link to online source - Kool M., Jones D. T., Jager N., Northcott P. A., Pugh T. J., Hovestadt V., Piro R. M., Esparza L. A., Markant S. L., Remke M., Milde T., Bourdeaut F., Ryzhova M., Sturm D., Pfaff E., Stark S., Hutter S., Seker-Cin H., Johann P., Bender S., Schmidt C., Rausch T., Shih D., Reimand J., Sieber L., Wittmann A., Linke L., Witt H., Weber U. D., Zapatka M., Konig R., Beroukhim R., Bergthold G., van Sluis P., Volckmann R., Koster J., Versteeg R., Schmidt S, Wolf S, Lawerenz C., Bartholomae C. C., von Kalle C., Unterberg A., Herold-Mende C., Hofer S., Kulozik A. E., von Deimling A., Scheurlen W., Felsberg J., Reifenberger G., Hasselblatt M., Crawford J. R., Grant G. A., Jabado N., Perry A., Cowdrey C., Croul S., Zadeh G., Korbel J. O., Doz F., Delattre O., Bader G. D., McCabe M. G., Collins V. P., Kieran M. W., Cho Y. J., Pomeroy S. L., Witt O., Brors B., Taylor M. D., Schuller U., Korshunov A., Eils R., Wechsler-Reya R. J., Lichter P., Pfister S. M., Icgc PedBrain Tumor Project, (2014) Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition. Cancer Cell, 25:393-405
link to online source - Mack S. C., Witt H., Piro R. M., Gu L., Zuyderduyn S., Stutz A. M., Wang X., Gallo M., Garzia L., Zayne K., Zhang X., Ramaswamy V., Jager N., Jones D. T., Sill M., Pugh T. J., Ryzhova M., Wani K. M., Shih D. J., Head R., Remke M., Bailey S. D., Zichner T., Faria C. C., Barszczyk M., Stark S., Seker-Cin H., Hutter S., Johann P., Bender S., Hovestadt V., Tzaridis T., Dubuc A. M., Northcott P. A., Peacock J., Bertrand K. C., Agnihotri S., Cavalli F. M., Clarke I., Nethery-Brokx K., Creasy C. L., Verma S. K., Koster J., Wu X., Yao Y., Milde T., Sin-Chan P., Zuccaro J., Lau L., Pereira S., Castelo-Branco P., Hirst M., Marra M. A., Roberts S. S., Fults D., Massimi L., Cho Y. J., Van Meter T., Grajkowska W., Lach B., Kulozik A. E., von Deimling A., Witt O., Scherer S. W., Fan X., Muraszko K. M., Kool M., Pomeroy S. L., Gupta N., Phillips J., Huang A., Tabori U., Hawkins C., Malkin D., Kongkham P. N., Weiss W. A., Jabado N., Rutka J. T., Bouffet E., Korbel J. O., Lupien M., Aldape K. D., Bader G. D., Eils R., Lichter P., Dirks P. B., Pfister S. M., Korshunov A., Taylor M. D., (2014) Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature, 506:445-50
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26/04/2019