Publications (selected)

Blasche S, Arens S, Ceol A, Siszler G, Schmidt MA, Häuser R, Schwarz F, Wuchty S, Aloy P, Uetz P, Stradal T, Koegl M.
The EHEC-host interactome reveals novel targets for the translocated intimin receptor.
Sci Rep. 2014 Dec 18
-- A publication based on results from our groups contribution in the FP7 EU project AntiPathoGN --

 

Häuser R1, Ceol A, Rajagopala SV, Mosca R, Siszler G, Wermke N, Sikorski P, Schwarz F, Schick M, Wuchty S, Aloy P, Uetz P.
A Second-generation Protein-Protein Interaction Network of Helicobacter pylori.
Mol Cell Proteomics. 2014 Mar 14
-- A publication based on results from our groups contribution in the FP7 EU project AntiPathoGN --

 

Rajagopala, S. V., Sikorski, P., Kumar, A., Mosca, R., Vlasblom, J., Arnold, R., Franca-Koh, J., Pakala, S. B., Phanse, S., Ceol, A., Häuser, R., Siszler, G., Wuchty, S., Emili, A., Babu, M., Aloy, P., Pieper, R., and Uetz, P. (2014)
The binary protein-protein interaction landscape of Escherichia coli.Nat Biotechnol. 2014 Mar;32(3):285-90
-- A publication with results from our groups contribution in the FP7 EU project AntiPathoGN --

 

Blasche S1, Mörtl M, Steuber H, Siszler G, Nisa S, Schwarz F, Lavrik I, Gronewold TM, Maskos K, Donnenberg MS, Ullmann D, Uetz P, Kögl M.
The E. coli effector protein NleF is a caspase inhibitor.
PLoS One. 2013;8(3):e58937. doi: 10.1371/journal.pone.0058937. Epub 2013 Mar 14.
-- A publication based on results from our groups contribution in the FP7 EU project AntiPathoGN --

 

Häuser, R., Pech, M., Kijek, J., Yamamoto, H., Titz, B., Naeve, F., Tovchigrechko, A., Yamamoto, K., Szaflarski, W., Takeuchi, N., Stellberger, T., Diefenbacher, M. E., Nierhaus, K. H., and Uetz, P
RsfA (YbeB) proteins are conserved ribosomal silencing factors
PLoS Genet 8, (2012)

 

Kerstin Mohr and Manfred Koegl
High-Throughput Yeast Two-Hybrid Screening of Complex cDNA Libraries
Methods Mol Biol. 2012;812:89-102.

Description of the screening system used in our facility

 

Koegl, M., and Uetz, P. (2008)
Improving yeast two hybrid screening systems.
Briefings in Functional Genomics and Proteomics, 6:302-12.(pdf)

An introduction to the yeast two-hybrid method. Discusses the basics of the method, high-throughput projects, considerations for the selection of reliable datasets, and emerging novel methods to study protein-protein interactions.

 

Kremoser, C., Albers, M., Burris, T.P., Deuschle, U. Koegl, M. (2007)
Panning for SNuRMs: Using cofactor profiling for the rational discovery of selective nuclear receptor modulators.
Drug Discov. Today, 12:860-9.

Describes how protein interaction patterns can be used in drug-discovery for nuclear receptor proteins

 

Yan J, Kim YS, Yang XP, Albers M, Koegl M, Jetten AM. (2007)
Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor {alpha}   Nucleic Acids Res. 35:1673-86. (pdf)

 

Albers M., Blume B., Schlueter T., Wright M.B., Kober I., Kremoser C., Deuschle U., Koegl M. (2006)
A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors.
J Biol Chem. 281:4920-4930. (pdf)

 

Uses yeast two-hybrid and other methods to test for protein protein interactions specifically induced by natural LXR-ligands, and drug-like compounds.

Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M. (2005) Automated Yeast Two-hybrid Screening for Nuclear Receptor-interacting Proteins.
Mol. Cell. Proteomics 4:205-213.(pdf)

A large-scale effort to isolate proteins binding to nuclear receptors, or their cofactors, is described. Contains a basic description of the automated method, the rationale behind the selection of high-confidence data sets, as well as a large data set of novel protein-protein interactions.

 

Albert, S., Gaudan, S., Knigge, H., Raetsch, A., Delgado, A., Huhse, B., Albers, M., Rebholz-Schuhmann and Koegl, M. (2003)
Computer-assisted generation of a protein-interaction database for nuclear receptors.
Mol. Endo.17,1555-15567. (pdf)

 

Motz, M. Kober, I., Girardot, C., Loeser, E., Bauer, U., Albers, M., Moeckel, G., Minch, E., Voss, H., Kilger, C. and Koegl, M. (2002).Elucidation of an archaeal replication protein network to generate enhanced PCR enzymes.
J. Biol. Chem. 277, 16179-16188. (pdf)

 

 

 

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last update:
28/02/2019
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