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Der digitalisierte Patient

Kennt man die genetischen Ursachen einer Krebserkrankung, ergeben sich dadurch möglicherweise neue Optionen für die Behandlung. Bei der Analyse des Erbgutes kommen modernste Hochdurchsatztechnologien zum Einsatz. Die Medizin ...[more]


GPCF Newsletter Issue November 2018

The Genomics & Proteomics Core Facility at DKFZ  distributes this Newsletters to inform you on latest developments with relevance to your projects! Read more[more]


Mass-Spectrometry based Protein Analysis – new Service implemented

Under the leadership of Dr. Bernd Hessling the newly setup “Mass-Spectrometry Based Protein Analysis Unit” has started its service after installation of the three brand new LC-MS systems.[more]

Genomics and Proteomics Core Facility at the Deutsches Krebsforschungszentrum

The Genomics and Proteomics Core Facility (GPCF) at the Deutsches Krebsforschungszentrum (DKFZ) is a central research infrastructure providing access to sophisticated and expensive key technologies that are of critical relevance in biomedical science and which would otherwise not be accessible to the center’s research groups. Our services are open to external users subject to available capacities.

Dedicated and trained personnel ascertains fast turn-around-times of high-quality data and information. Quality standards have been developed to keep tight quality control during all processes. Know-how of core facility staff is provided by direct consultation prior to and after execution of projects as well as in individual training of personnel from scientific groups. Most technologies are offered as a full service while some high-throughput instruments and bioinformatic analysis tools are available through assisted access.

The GPCF offers state-of-the-art technologies in

  • Genomics
  • Next generation sequencing of genomes, RNA-seq, ChIP-seq, Bisulfite-seq & more
  • Array-based expression profiling of mRNA and miRNA
  • Methylation analysis
  • Genotyping and CNV analysis
  • Proteomics
  • Protein analysis via mass spectrometric peptide fingerprinting, sequencing and quantification
  • NMR Molecular structure analysis and mass spectrometric analysis of posttranslational protein modifications
  • Protein-protein interaction analysis
  • Purification of recombinantly expressed proteins
  • Functional Genomics
  • Stable Isogenic Cell Lines
  • Production of monoclonal antibodies
  • Instruments and Resources
  • Instrumentation
  • Bioinformatic tools
  • Clone resources
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