Publications with contributions of the GPCF
Co-authorships of GPCF staff are indicated in bold.
- Christians A., Poisel E., Hartmann C., von Deimling A., Pusch S., (2019) Characterization of the epithelial membrane protein 3 interaction network reveals a potential functional link to mitogenic signal transduction regulation. Int J Cancer, 145:461-473
link to online source - Erkek S., Johann P. D., Finetti M. A., Drosos Y., Chou H. C., Zapatka M., Sturm D., Jones D. T. W., Korshunov A., Rhyzova M., Wolf S., Mallm J. P., Beck K., Witt O., Kulozik A. E., Fruhwald M. C., Northcott P. A., Korbel J. O., Lichter P., Eils R., Gajjar A., Roberts C. W. M., Williamson D., Hasselblatt M., Chavez L., Pfister S. M., Kool M., (2019) Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation. Cancer Cell, 35:95-110 e8
link to online source - Haller F., Bieg M., Will R., Korner C., Weichenhan D., Bott A., Ishaque N., Lutsik P., Moskalev E. A., Mueller S. K., Bahr M., Woerner A., Kaiser B., Scherl C., Haderlein M., Kleinheinz K., Fietkau R., Iro H., Eils R., Hartmann A., Plass C., Wiemann S, Agaimy A., (2019) Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands. Nat Commun, 10:368
link to online source - Barenz F., Kschonsak Y. T., Meyer A., Jafarpour A., Lorenz H., Hoffmann I, (2018) Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry. Mol Biol Cell, :mbcE18020115
link to online source - Bunse L., Pusch S., Bunse T., Sahm F., Sanghvi K., Friedrich M., Alansary D., Sonner J. K., Green E., Deumelandt K., Kilian M., Neftel C., Uhlig S., Kessler T., von Landenberg A., Berghoff A. S., Marsh K., Steadman M., Zhu D., Nicolay B., Wiestler B., Breckwoldt M. O., Al-Ali R., Karcher-Bausch S., Bozza M., Oezen I., Kramer M., Meyer J., Habel A., Eisel J., Poschet G., Weller M., Preusser M., Nadji-Ohl M., Thon N., Burger M. C., Harter P. N., Ratliff M., Harbottle R., Benner A., Schrimpf D., Okun J., Herold-Mende C., Turcan S., Kaulfuss S., Hess-Stumpp H., Bieback K., Cahill D. P., Plate K. H., Hanggi D., Dorsch M., Suva M. L., Niemeyer B. A., von Deimling A., Wick W., Platten M., (2018) Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. Nat Med, 24:1192-1203
link to online source - Bure I., Geer S., Knopf J., Roas M., Henze S., Strobel P., Agaimy A., Wiemann S., Hoheisel J. D., Hartmann A., Haller F., Moskalev E. A., (2018) Long noncoding RNA HOTAIR is upregulated in an aggressive subgroup of gastrointestinal stromal tumors (GIST) and mediates the establishment of gene-specific DNA methylation patterns. Genes Chromosomes Cancer, 57:584-597
link to online source - Capper D., Jones D. T. W., Sill M., Hovestadt V., Schrimpf D., Sturm D., Koelsche C., Sahm F., Chavez L., Reuss D. E., Kratz A., Wefers A. K., Huang K., Pajtler K. W., Schweizer L., Stichel D., Olar A., Engel N. W., Lindenberg K., Harter P. N., Braczynski A. K., Plate K. H., Dohmen H., Garvalov B. K., Coras R., Holsken A., Hewer E., Bewerunge-Hudler M., Schick M., Fischer R., Beschorner R., Schittenhelm J., Staszewski O., Wani K., Varlet P., Pages M., Temming P., Lohmann D., Selt F., Witt H., Milde T., Witt O., Aronica E., Giangaspero F., Rushing E., Scheurlen W., Geisenberger C., Rodriguez F. J., Becker A., Preusser M., Haberler C., Bjerkvig R., Cryan J., Farrell M., Deckert M., Hench J., Frank S., Serrano J., Kannan K., Tsirigos A., Bruck W., Hofer S., Brehmer S., Seiz-Rosenhagen M., Hanggi D., Hans V., Rozsnoki S., Hansford J. R., Kohlhof P., Kristensen B. W., Lechner M., Lopes B., Mawrin C., Ketter R., Kulozik A., Khatib Z., Heppner F., Koch A., Jouvet A., Keohane C., Muhleisen H., Mueller W., Pohl U., Prinz M., Benner A., Zapatka M., Gottardo N. G., Driever P. H., Kramm C. M., Muller H. L., Rutkowski S., von Hoff K., Fruhwald M. C., Gnekow A., Fleischhack G., Tippelt S., Calaminus G., Monoranu C. M., Perry A., Jones C., Jacques T. S., Radlwimmer B., Gessi M., Pietsch T., Schramm J., Schackert G., Westphal M., Reifenberger G., Wesseling P., Weller M., Collins V. P., Blumcke I., Bendszus M., Debus J., Huang A., Jabado N., Northcott P. A., Paulus W., Gajjar A., Robinson G. W., Taylor M. D., Jaunmuktane Z., Ryzhova M., Platten M., Unterberg A., Wick W., Karajannis M. A., Mittelbronn M., Acker T., Hartmann C., Aldape K., Schuller U., Buslei R., Lichter P., Kool M., Herold-Mende C., Ellison D. W., Hasselblatt M., Snuderl M., Brandner S., Korshunov A., von Deimling A., Pfister S. M., (2018) DNA methylation-based classification of central nervous system tumours. Nature, 555:469-474
link to online source - Capper D., Stichel D., Sahm F., Jones D. T. W., Schrimpf D., Sill M., Schmid S., Hovestadt V., Reuss D. E., Koelsche C., Reinhardt A., Wefers A. K., Huang K., Sievers P., Ebrahimi A., Scholer A., Teichmann D., Koch A., Hanggi D., Unterberg A., Platten M., Wick W., Witt O., Milde T., Korshunov A., Pfister S. M., von Deimling A., (2018) Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience. Acta Neuropathol, 136:181-210
link to online source - Chudasama P., Mughal S. S., Sanders M. A., Hubschmann D., Chung I., Deeg K. I., Wong S. H., Rabe S., Hlevnjak M., Zapatka M., Ernst A., Kleinheinz K., Schlesner M., Sieverling L., Klink B., Schrock E., Hoogenboezem R. M., Kasper B., Heilig C. E., Egerer G., Wolf S., von Kalle C., Eils R., Stenzinger A., Weichert W., Glimm H., Groschel S., Kopp H. G., Omlor G., Lehner B., Bauer S., Schimmack S., Ulrich A., Mechtersheimer G., Rippe K., Brors B., Hutter B., Renner M., Hohenberger P., Scholl C., Frohling S., (2018) Integrative genomic and transcriptomic analysis of leiomyosarcoma. Nat Commun, 9:144
link to online source - Dimitrov B., Himmelreich N., Hipgrave Ederveen A. L., Luchtenborg C., Okun J. G., Breuer M., Hutter A. M., Carl M., Guglielmi L., Hellwig A., Thiemann K. C., Jost M., Peters V., Staufner C., Hoffmann G. F., Hackenberg A., Paramasivam N., Wiemann S., Eils R., Schlesner M., Strahl S., Brugger B., Wuhrer M., Christoph Korenke G., Thiel C., (2018) Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. Mol Genet Metab, 123:364-374
link to online source - Forget A., Martignetti L., Puget S., Calzone L., Brabetz S., Picard D., Montagud A., Liva S., Sta A., Dingli F., Arras G., Rivera J., Loew D., Besnard A., Lacombe J., Pages M., Varlet P., Dufour C., Yu H., Mercier A. L., Indersie E., Chivet A., Leboucher S., Sieber L., Beccaria K., Gombert M., Meyer F. D., Qin N., Bartl J., Chavez L., Okonechnikov K., Sharma T., Thatikonda V., Bourdeaut F., Pouponnot C., Ramaswamy V., Korshunov A., Borkhardt A., Reifenberger G., Poullet P., Taylor M. D., Kool M., Pfister S. M., Kawauchi D., Barillot E., Remke M., Ayrault O., (2018) Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling. Cancer Cell, 34:379-395 e7
link to online source - Grasse S., Lienhard M., Frese S., Kerick M., Steinbach A., Grimm C., Hussong M., Rolff J., Becker M., Dreher F., Schirmer U., Boerno S., Ramisch A., Leschber G., Timmermann B., Grohe C., Luders H., Vingron M., Fichtner I., Klein S., Odenthal M., Buttner R., Lehrach H., Sultmann H., Herwig R., Schweiger M. R., (2018) Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance. Genome Med, 10:55
link to online source - Grobner S. N., Worst B. C., Weischenfeldt J., Buchhalter I., Kleinheinz K., Rudneva V. A., Johann P. D., Balasubramanian G. P., Segura-Wang M., Brabetz S., Bender S., Hutter B., Sturm D., Pfaff E., Hubschmann D., Zipprich G., Heinold M., Eils J., Lawerenz C., Erkek S., Lambo S., Waszak S., Blattmann C., Borkhardt A., Kuhlen M., Eggert A., Fulda S., Gessler M., Wegert J., Kappler R., Baumhoer D., Burdach S., Kirschner-Schwabe R., Kontny U., Kulozik A. E., Lohmann D., Hettmer S., Eckert C., Bielack S., Nathrath M., Niemeyer C., Richter G. H., Schulte J., Siebert R., Westermann F., Molenaar J. J., Vassal G., Witt H., Icgc PedBrain-Seq Project, Icgc Mmml- Seq Project, Burkhardt B., Kratz C. P., Witt O., van Tilburg C. M., Kramm C. M., Fleischhack G., Dirksen U., Rutkowski S., Fruhwald M., von Hoff K., Wolf S, Klingebiel T., Koscielniak E., Landgraf P., Koster J., Resnick A. C., Zhang J., Liu Y., Zhou X., Waanders A. J., Zwijnenburg D. A., Raman P., Brors B., Weber U. D., Northcott P. A., Pajtler K. W., Kool M., Piro R. M., Korbel J. O., Schlesner M., Eils R., Jones D. T. W., Lichter P., Chavez L., Zapatka M., Pfister S. M., (2018) The landscape of genomic alterations across childhood cancers. Nature, :
link to online source - Gutekunst J., Andriantsoa R., Falckenhayn C., Hanna K., Stein W., Rasamy J., Lyko F., (2018) Clonal genome evolution and rapid invasive spread of the marbled crayfish. Nat Ecol Evol, 2:567-573
link to online source - Insua-Rodriguez J., Pein M., Hongu T., Meier J., Descot A., Lowy C. M., De Braekeleer E., Sinn H. P., Spaich S., Sutterlin M., Schneeweiss A., Oskarsson T., (2018) Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis. EMBO Mol Med, :
link to online source - Junge K. M., Leppert B., Jahreis S., Wissenbach D. K., Feltens R., Grutzmann K., Thurmann L., Bauer T., Ishaque N., Schick M., Bewerunge-Hudler M., Roder S., Bauer M., Schulz A., Borte M., Landgraf K., Korner A., Kiess W., von Bergen M., Stangl G. I., Trump S., Eils R., Polte T., Lehmann I., (2018) MEST mediates the impact of prenatal bisphenol A exposure on long-term body weight development. Clin Epigenetics, 10:58
link to online source - Kessler T., Sahm F., Sadik A., Stichel D., Hertenstein A., Reifenberger G., Zacher A., Sabel M., Tabatabai G., Steinbach J., Sure U., Krex D., Grosu A. L., Bewerunge-Hudler M., Jones D., Pfister S. M., Weller M., Opitz C., Bendszus M., von Deimling A., Platten M., Wick W., (2018) Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation. Neuro Oncol, 20:367-379
link to online source - Klett H., Balavarca Y., Toth R., Gigic B., Habermann N., Scherer D., Schrotz-King P., Ulrich A., Schirmacher P., Herpel E., Brenner H., Ulrich C. M., Michels K. B., Busch H., Boerries M., (2018) Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles. Epigenetics, 13:386-397
link to online source - Klett H., Fuellgraf H., Levit-Zerdoun E., Hussung S., Kowar S., Kusters S., Bronsert P., Werner M., Wittel U., Fritsch R., Busch H., Boerries M., (2018) Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma. Front Genet, 9:108
link to online source - Koelsche C., Hartmann W., Schrimpf D., Stichel D., Jabar S., Ranft A., Reuss D. E., Sahm F., Jones D. T. W., Bewerunge-Hudler M., Trautmann M., Klingebiel T., Vokuhl C., Gessler M., Wardelmann E., Petersen I., Baumhoer D., Flucke U., Antonescu C., Esteller M., Frohling S., Kool M., Pfister S. M., Mechtersheimer G., Dirksen U., von Deimling A., (2018) Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information. Mod Pathol, 31:1246-1256
link to online source - Mack S. C., Pajtler K. W., Chavez L., Okonechnikov K., Bertrand K. C., Wang X., Erkek S., Federation A., Song A., Lee C., Wang X., McDonald L., Morrow J. J., Saiakhova A., Sin-Chan P., Wu Q., Michaelraj K. A., Miller T. E., Hubert C. G., Ryzhova M., Garzia L., Donovan L., Dombrowski S., Factor D. C., Luu B., Valentim C. L. L., Gimple R. C., Morton A., Kim L., Prager B. C., Lee J. J. Y., Wu X., Zuccaro J., Thompson Y., Holgado B. L., Reimand J., Ke S. Q., Tropper A., Lai S., Vijayarajah S., Doan S., Mahadev V., Minan A. F., Grobner S. N., Lienhard M., Zapatka M., Huang Z., Aldape K. D., Carcaboso A. M., Houghton P. J., Keir S. T., Milde T., Witt H., Li Y., Li C. J., Bian X. W., Jones D. T. W., Scott I., Singh S. K., Huang A., Dirks P. B., Bouffet E., Bradner J. E., Ramaswamy V., Jabado N., Rutka J. T., Northcott P. A., Lupien M., Lichter P., Korshunov A., Scacheri P. C., Pfister S. M., Kool M., Taylor M. D., Rich J. N., (2018) Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. Nature, 553:101-105
link to online source - Mishra R. R., Belder N., Ansari S. A., Kayhan M., Bal H., Raza U., Ersan P. G., Tokat U. M., Eyupoglu E., Saatci O., Jandaghi P., Wiemann S., Uner A., Cekic C., Riazalhosseini Y., Sahin O., (2018) Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer. Clin Cancer Res, 24:1987-2001
link to online source - Oberacker T., Bajorat J., Ziola S., Schroeder A., Roth D., Kastl L., Edgar B. A., Wagner W., Gulow K., Krammer P. H., (2018) Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging. FEBS Lett, 592:2297-2307
link to online source - Paramasivam N., Granzow M., Evers C., Hinderhofer K., Wiemann S., Bartram C.R., Eils R., Schlesner M., (2018) Identification and prioritisation of causal variants in human genetic disorders from exome or whole genome sequencing data. OBM Genetics, 2:1-1
link to online source - Pfaff E., Kessler T., Balasubramanian G. P., Berberich A., Schrimpf D., Wick A., Debus J., Unterberg A., Bendszus M., Herold-Mende C., Capper D., Schenkel I., Eisenmenger A., Dettmer S., Brors B., Platten M., Pfister S. M., von Deimling A., Jones D. T. W., Wick W., Sahm F., (2018) Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation-the NCT Neuro Master Match (N2M2) pilot study. Neuro Oncol, 20:826-837
link to online source - Quandt J., Schlude C., Bartoschek M., Will R., Cid-Arregui A., Scholch S., Reissfelder C., Weitz J., Schneider M., Wiemann S., Momburg F., Beckhove P., (2018) Long-peptide vaccination with driver gene mutations in p53 and Kras induces cancer mutation-specific effector as well as regulatory T cell responses. Oncoimmunology, 7:e1500671
link to online source - Rodriguez-Paredes M., Bormann F., Raddatz G., Gutekunst J., Lucena-Porcel C., Kohler F., Wurzer E., Schmidt K., Gallinat S., Wenck H., Rowert-Huber J., Denisova E., Feuerbach L., Park J., Brors B., Herpel E., Nindl I., Hofmann T. G., Winnefeld M., Lyko F., (2018) Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin. Nat Commun, 9:577
link to online source - Rohrich M., Huang K., Schrimpf D., Albert N. L., Hielscher T., von Deimling A., Schuller U., Dimitrakopoulou-Strauss A., Haberkorn U., (2018) Integrated analysis of dynamic FET PET/CT parameters, histology, and methylation profiling of 44 gliomas. Eur J Nucl Med Mol Imaging, 45:1573-1584
link to online source - Saatci O., Borgoni S., Akbulut O., Durmus S., Raza U., Eyupoglu E., Alkan C., Akyol A., Kutuk O., Wiemann S, Sahin O., (2018) Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer. Oncogene, 37:2251-2269
link to online source - Schmidt N., Haydn T., Schneider I., Busch H., Boerries M., Fulda S., (2018) Smac mimetic induces an early wave of gene expression via NF-kappaB and AP-1 and a second wave via TNFR1 signaling. Cancer Lett, 421:170-185
link to online source - Shirahata M., Ono T., Stichel D., Schrimpf D., Reuss D. E., Sahm F., Koelsche C., Wefers A., Reinhardt A., Huang K., Sievers P., Shimizu H., Nanjo H., Kobayashi Y., Miyake Y., Suzuki T., Adachi J. I., Mishima K., Sasaki A., Nishikawa R., Bewerunge-Hudler M., Ryzhova M., Absalyamova O., Golanov A., Sinn P., Platten M., Jungk C., Winkler F., Wick A., Hanggi D., Unterberg A., Pfister S. M., Jones D. T. W., van den Bent M., Hegi M., French P., Baumert B. G., Stupp R., Gorlia T., Weller M., Capper D., Korshunov A., Herold-Mende C., Wick W., Louis D. N., von Deimling A., (2018) Novel, improved grading system(s) for IDH-mutant astrocytic gliomas. Acta Neuropathol, 136:153-166
link to online source - Simm F., Griesbeck A., Choukair D., Weiss B., Paramasivam N., Klammt J., Schlesner M., Wiemann S., Martinez C., Hoffmann G. F., Pfaffle R. W., Bettendorf M., Rappold G. A., (2018) Identification of SLC20A1 and SLC15A4 among other genes as potential risk factors for combined pituitary hormone deficiency. Genet Med, 20:728-736
link to online source - Singhal M., Liu X., Inverso D., Jiang K., Dai J., He H., Bartels S., Li W., Abdul Pari A. A., Gengenbacher N., Besemfelder E., Hui L., Augustin H. G., Hu J., (2018) Endothelial cell fitness dictates the source of regenerating liver vasculature. J Exp Med, :
link to online source - Thurmann L., Grutzmann K., Klos M., Bieg M., Winter M., Polte T., Bauer T., Schick M., Bewerunge-Hudler M., Roder S., Bauer M., Wissenbach D. K., Sack U., Weichenhan D., Mucke O., Plass C., Borte M., von Bergen M., Lehmann I., Eils R., Trump S., (2018) Early-onset childhood atopic dermatitis is related to NLRP2 repression. J Allergy Clin Immunol, 141:1482-1485 e16
link to online source - Waszak S. M., Northcott P. A., Buchhalter I., Robinson G. W., Sutter C., Groebner S., Grund K. B., Brugieres L., Jones D. T. W., Pajtler K. W., Morrissy A. S., Kool M., Sturm D., Chavez L., Ernst A., Brabetz S., Hain M., Zichner T., Segura-Wang M., Weischenfeldt J., Rausch T., Mardin B. R., Zhou X., Baciu C., Lawerenz C., Chan J. A., Varlet P., Guerrini-Rousseau L., Fults D. W., Grajkowska W., Hauser P., Jabado N., Ra Y. S., Zitterbart K., Shringarpure S. S., De La Vega F. M., Bustamante C. D., Ng H. K., Perry A., MacDonald T. J., Hernaiz Driever P., Bendel A. E., Bowers D. C., McCowage G., Chintagumpala M. M., Cohn R., Hassall T., Fleischhack G., Eggen T., Wesenberg F., Feychting M., Lannering B., Schuz J., Johansen C., Andersen T. V., Roosli M., Kuehni C. E., Grotzer M., Kjaerheim K., Monoranu C. M., Archer T. C., Duke E., Pomeroy S. L., Shelagh R., Frank S., Sumerauer D., Scheurlen W., Ryzhova M. V., Milde T., Kratz C. P., Samuel D., Zhang J., Solomon D. A., Marra M., Eils R., Bartram C. R., von Hoff K., Rutkowski S., Ramaswamy V., Gilbertson R. J., Korshunov A., Taylor M. D., Lichter P., Malkin D., Gajjar A., Korbel J. O., Pfister S. M., (2018) Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort. Lancet Oncol, 19:785-798
link to online source - Agaimy A., Bieg M., Michal M., Geddert H., Markl B., Seitz J., Moskalev E. A., Schlesner M., Metzler M., Hartmann A., Wiemann S, Michal M., Mentzel T., Haller F., (2017) Recurrent Somatic PDGFRB Mutations in Sporadic Infantile/Solitary Adult Myofibromas But Not in Angioleiomyomas and Myopericytomas. Am J Surg Pathol, 41:195-203
link to online source - Aram R., Dotan I., Hotz-Wagenblatt A., Canaani D., (2017) Identification of a novel metastasis inducing lncRNA which suppresses the KAI1/CD82 metastasis suppressor gene and is upregulated in triple-negative breast cancer. Oncotarget, :
link to online source - Bott A., Erdem N., Lerrer S., Hotz-Wagenblatt A., Breunig C., Abnaof K., Worner A., Wilhelm H., Munstermann E., Ben-Baruch A., Wiemann S., (2017) miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A. Oncotarget, :
link to online source - Brocks D., Schmidt C. R., Daskalakis M., Jang H. S., Shah N. M., Li D., Li J., Zhang B., Hou Y., Laudato S., Lipka D. B., Schott J., Bierhoff H., Assenov Y., Helf M., Ressnerova A., Islam M. S., Lindroth A. M., Haas S., Essers M., Imbusch C. D., Brors B., Oehme I., Witt O., Lubbert M., Mallm J. P., Rippe K., Will R., Weichenhan D., Stoecklin G., Gerhauser C., Oakes C. C., Wang T., Plass C., (2017) DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nat Genet, 49:1052-1060
link to online source - Bure I., Braun A., Kayser C., Geddert H., Schaefer I. M., Cameron S., Ghadimi M. B., Strobel P., Werner M., Hartmann A., Wiemann S., Agaimy A., Haller F., Moskalev E. A., (2017) The expression of hematopoietic progenitor cell antigen CD34 is regulated by DNA methylation in a site-dependent manner in gastrointestinal stromal tumours. Int J Cancer, 141:2296-2304
link to online source - Delacher M., Imbusch C. D., Weichenhan D., Breiling A., Hotz-Wagenblatt A., Trager U., Hofer A. C., Kagebein D., Wang Q., Frauhammer F., Mallm J. P., Bauer K., Herrmann C., Lang P. A., Brors B., Plass C., Feuerer M., (2017) Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues. Nat Immunol, :
link to online source - Dietrich S., Oles M., Lu J., Sellner L., Anders S., Velten B., Wu B., Hullein J., da Silva Liberio M., Walther T., Wagner L., Rabe S., Ghidelli-Disse S., Bantscheff M., Oles A. K., Slabicki M., Mock A., Oakes C. C., Wang S., Oppermann S., Lukas M., Kim V., Sill M., Benner A., Jauch A., Sutton L. A., Young E., Rosenquist R., Liu X., Jethwa A., Lee K. S., Lewis J., Putzker K., Lutz C., Rossi D., Mokhir A., Oellerich T., Zirlik K., Herling M., Nguyen-Khac F., Plass C., Andersson E., Mustjoki S., von Kalle C., Ho A. D., Hensel M., Durig J., Ringshausen I., Zapatka M., Huber W., Zenz T., (2017) Drug-perturbation-based stratification of blood cancer. J Clin Invest, :
link to online source - Evers C., Staufner C., Granzow M., Paramasivam N., Hinderhofer K., Kaufmann L., Fischer C., Thiel C., Opladen T., Kotzaeridou U., Wiemann S., Schlesner M., Eils R., Kolker S., Bartram C. R., Hoffmann G. F., Moog U., (2017) Impact of clinical exomes in neurodevelopmental and neurometabolic disorders. Mol Genet Metab, 121:297-307
link to online source - Gundert M., Edelmann D., Benner A., Jansen L., Jia M., Walter V., Knebel P., Herpel E., Chang-Claude J., Hoffmeister M., Brenner H., Burwinkel B., (2017) Genome-wide DNA methylation analysis reveals a prognostic classifier for non-metastatic colorectal cancer (ProMCol classifier). Gut, :
link to online source - Heilmann K., Toth R., Bossmann C., Klimo K., Plass C., Gerhauser C., (2017) Genome-wide screen for differentially methylated long noncoding RNAs identifies Esrp2 and lncRNA Esrp2-as regulated by enhancer DNA methylation with prognostic relevance for human breast cancer. Oncogene, 36:6446-6461
link to online source - Hong C., Cao J., Wu C. F., Kadioglu O., Schuffler A., Kauhl U., Klauck S. M., Opatz T., Thines E., Paul N. W., Efferth T., (2017) The Chinese herbal formula Free and Easy Wanderer ameliorates oxidative stress through KEAP1-NRF2/HO-1 pathway. Sci Rep, 7:11551
link to online source - Horak P., Klink B., Heining C., Groschel S., Hutter B., Frohlich M., Uhrig S., Hubschmann D., Schlesner M., Eils R., Richter D., Pfutze K., Georg C., Meissburger B., Wolf S., Schulz A., Penzel R., Herpel E., Kirchner M., Lier A., Endris V., Singer S., Schirmacher P., Weichert W., Stenzinger A., Schlenk R. F., Schrock E., Brors B., von Kalle C., Glimm H., Frohling S., (2017) Precision oncology based on omics data: The NCT Heidelberg experience. Int J Cancer, 141:877-886
link to online source - Jakel C., Bergmann F., Toth R., Assenov Y., van der Duin D., Strobel O., Hank T., Kloppel G., Dorrell C., Grompe M., Moss J., Dor Y., Schirmacher P., Plass C., Popanda O., Schmezer P., (2017) Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability. Nat Commun, 8:1323
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link to online source - Derrer B., Windeisen V., Guedez Rodriguez G., Seidler J., Gengenbacher M., Lehmann W. D., Rippe K., Sinning I., Tews I., Kappes B., (2010) Defining the structural requirements for ribose 5-phosphate-binding and intersubunit cross-talk of the malarial pyridoxal 5-phosphate synthase. FEBS Lett, 584:4169-74
link to online source - Dietz L., Esser P. R., Schmucker S. S., Goette I., Richter A., Schnolzer M., Martin S. F., Thierse H. J., (2010) Tracking human contact allergens: from mass spectrometric identification of peptide-bound reactive small chemicals to chemical-specific naive human T-cell priming. Toxicol Sci, 117:336-47
link to online source - Eck W., Nicholson A. I., Zentgraf H., Semmler W., Bartling S., (2010) Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice. Nano Lett, 10:2318-22
link to online source - Emerson V., Holtkotte D., Pfeiffer T., Wang I. H., Schnolzer M., Kempf T., Bosch V., (2010) Identification of the cellular prohibitin 1/prohibitin 2 heterodimer as an interaction partner of the C-terminal cytoplasmic domain of the HIV-1 glycoprotein. J Virol, 84:1355-65
link to online source - Erlbruch A., Hung C. W., Seidler J., Borrmann K., Gesellchen F., Konig N., Kubler D., Herberg F. W., Lehmann W. D., Bossemeyer D., (2010) Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit. Proteomics, 10:2890-900
link to online source - Gdynia G., Keith M., Kopitz J., Bergmann M., Fassl A., Weber A. N., George J., Kees T., Zentgraf H. W., Wiestler O. D., Schirmacher P., Roth W., (2010) Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria. Cancer Res, 70:8558-68
link to online source - Gloriam D. E., Orchard S., Bertinetti D., Bjorling E., Bongcam-Rudloff E., Borrebaeck C. A., Bourbeillon J., Bradbury A. R., de Daruvar A., Dubel S., Frank R., Gibson T. J., Gold L., Haslam N., Herberg F. W., Hiltke T., Hoheisel J. D., Kerrien S., Koegl M., Konthur Z., Korn B., Landegren U., Montecchi-Palazzi L., Palcy S., Rodriguez H., Schweinsberg S., Sievert V., Stoevesandt O., Taussig M. J., Ueffing M., Uhlen M., van der Maarel S., Wingren C., Woollard P., Sherman D. J., Hermjakob H., (2010) A community standard format for the representation of protein affinity reagents. Mol Cell Proteomics, 9:1-10
link to online source - Gronniger E., Weber B., Heil O, Peters N., Stab F., Wenck H., Korn B., Winnefeld M., Lyko F., (2010) Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet, 6:e1000971
link to online source - Hristov G., Kramer M., Li J., El-Andaloussi N., Mora R., Daeffler L., Zentgraf H., Rommelaere J., Marchini A., (2010) Through its nonstructural protein NS1, parvovirus H-1 induces apoptosis via accumulation of reactive oxygen species. J Virol, 84:5909-22
link to online source - Imrich J., Tomascikova J., Danihel I., Kristian P., Bohm S., Klika K. D., (2010) Selective Formation of 5-or 6-Membered Rings, 1,3-Thiazolidin-4-One Vs. 1,3-Thiazin-4-One, from Acridine Thiosemicarbazides by the Use of Ethyne Acid Esters. Heterocycles, 80:489-503
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link to online source - Klika K. D., Budovska M., Kutschy P., (2010) NMR spectral enantioresolution of spirobrassinin and 1-methoxyspirobrassinin enantiomers using (S)-(-)-ethyl lactate and modeling of spirobrassinin self-association for rationalization of its self-induced diastereomeric anisochromism (SIDA) and enantiomer self-disproportionation on achiral-phase chromatography (ESDAC) phenomena. Journal of Fluorine Chemistry, 131:467-476
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link to online source - Meitinger F., Petrova B., Lombardi I. M., Bertazzi D. T., Hub B., Zentgraf H., Pereira G., (2010) Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast. J Cell Sci, 123:1851-61
link to online source - Moosmeier M. A., Bulkescher J., Reed J., Schnolzer M., Heid H., Hoppe-Seyler K., Hoppe-Seyler F., (2010) Transtactin: a universal transmembrane delivery system for Strep-tag II-fused cargos. J Cell Mol Med, 14:1935-45
link to online source - Mora R., Dokic I., Kees T., Huber C. M., Keitel D., Geibig R., Brugge B., Zentgraf H., Brady N. R., Regnier-Vigouroux A., (2010) Sphingolipid rheostat alterations related to transformation can be exploited for specific induction of lysosomal cell death in murine and human glioma. Glia, 58:1364-83
link to online source - Pagans S., Kauder S. E., Kaehlcke K., Sakane N., Schroeder S., Dormeyer W., Trievel R. C., Verdin E., Schnolzer M., Ott M., (2010) The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe, 7:234-44
link to online source - Paruzynski A., Arens A., Gabriel R., Bartholomae C. C., Scholz S., Wang W., Wolf S., Glimm H., Schmidt M., von Kalle C., (2010) Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing. Nat Protoc, 5:1379-95
link to online source - Potocnak I., Imrich J., Danihel I., Koaeisek J., Klika K. D., (2010) 4-(9,10-Dihydroacridin-9-ylidene)thiosemicarbazide and its five-membered thiazole and six-membered thiazine derivatives. Acta Crystallogr C, 66:o87-92
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link to online source - Rickelt S., Rizzo S., Doerflinger Y., Zentgraf H., Basso C., Gerosa G., Thiene G., Moll R., Franke W. W., (2010) A novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomata. Mod Pathol, 23:1429-37
link to online source - Riedl E., Koeppel H., Pfister F., Peters V., Sauerhoefer S., Sternik P., Brinkkoetter P., Zentgraf H., Navis G., Henning R. H., Van Den Born J., Bakker S. J., Janssen B., van der Woude F. J., Yard B. A., (2010) N-glycosylation of carnosinase influences protein secretion and enzyme activity: implications for hyperglycemia. Diabetes, 59:1984-90
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link to online source - Schokraie E., Hotz-Wagenblatt A, Warnken U., Mali B., Frohme M., Forster F., Dandekar T., Hengherr S., Schill R. O., Schnolzer M, (2010) Proteomic analysis of tardigrades: towards a better understanding of molecular mechanisms by anhydrobiotic organisms. PLoS One, 5:e9502
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link to online source - Soza-Ried J., Hotz-Wagenblatt A., Glatting K. H., del Val C., Fellenberg K., Bode H. R., Frank U., Hoheisel J. D., Frohme M., (2010) The transcriptome of the colonial marine hydroid Hydractinia echinata. FEBS J, 277:197-209
link to online source - Stirnnagel K., Luftenegger D., Stange A., Swiersy A., Mullers E., Reh J., Stanke N., Grosse A., Chiantia S., Keller H., Schwille P., Hanenberg H., Zentgraf H., Lindemann D., (2010) Analysis of prototype foamy virus particle-host cell interaction with autofluorescent retroviral particles. Retrovirology, 7:45
link to online source - Uhlmann S., Zhang J. D., Schwager A., Mannsperger H., Riazalhosseini Y., Burmester S., Ward A., Korf U., Wiemann S., Sahin O., (2010) miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. Oncogene, 29:4297-306
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link to online source - Winter D., Seidler J., Kugelstadt D., Derrer B., Kappes B., Lehmann W. D., (2010) Minimally permutated peptide analogs as internal standards for relative and absolute quantification of peptides and proteins. Proteomics, 10:1510-4
link to online source - Zinn N., Winter D., Lehmann W. D., (2010) Recombinant isotope labeled and selenium quantified proteins for absolute protein quantification. Anal Chem, 82:2334-40
link to online source - de Souza Rocha Simonini P., Breiling A., Gupta N., Malekpour M., Youns M., Omranipour R., Malekpour F., Volinia S., Croce C. M., Najmabadi H., Diederichs S., Sahin O., Mayer D., Lyko F., Hoheisel J. D., Riazalhosseini Y., (2010) Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells. Cancer Res, 70:9175-84
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link to online source - Apel A., Zentgraf H., Buchler M. W., Herr I., (2009) Autophagy-A double-edged sword in oncology. Int J Cancer, 125:991-5
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link to online source - Bonemann G., Pietrosiuk A., Diemand A., Zentgraf H., Mogk A., (2009) Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion. EMBO J, 28:315-25
link to online source - Borner A., Warnken U., Schnolzer M., Hagen J., Giese N., Bauer A., Hoheisel J., (2009) Subcellular protein extraction from human pancreatic cancer tissues. Biotechniques, 46:297-304
link to online source - Braun A., Treede I., Gotthardt D., Tietje A., Zahn A., Ruhwald R., Schoenfeld U., Welsch T., Kienle P., Erben G., Lehmann W. D., Fuellekrug J., Stremmel W., Ehehalt R., (2009) Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: a clue to pathogenesis. Inflamm Bowel Dis, 15:1705-20
link to online source - Braun K., Ehemann V., Wiessler M., Pipkorn R, Didinger B., Mueller G., Waldeck W., (2009) High-resolution flow cytometry: a suitable tool for monitoring aneuploid prostate cancer cells after TMZ and TMZ-BioShuttle treatment. Int J Med Sci, 6:338-47
link to online source - Braun K., Wiessler M., Ehemann V., Pipkorn R, Spring H., Debus J., Didinger B., Koch M., Muller G., Waldeck W., (2009) Treatment of glioblastoma multiforme cells with temozolomide-BioShuttle ligated by the inverse Diels-Alder ligation chemistry. Drug Des Devel Ther, 2:289-301
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link to online source - Pipkorn R., Waldeck W., Didinger B., Braun K., (2009) BioShuttle mediated plasmid transfer--a way to new genetic intervention. Adv Exp Med Biol, 611:285-6
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last update:
22/03/2019