Publications with contributions of the GPCF
Co-authorships of GPCF staff are indicated in bold.
- Schmidt T. T., Sharma S., Reyes G. X., Kolodziejczak A., Wagner T., Luke B., Hofer A., Chabes A., Hombauer H., (2020) Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio. Nucleic Acids Res, 48:264-277
link to online source - Bermejo J. L., Huang G., Manoochehri M., Mesa K. G., Schick M., Silos R. G., Ko Y. D., Bruning T., Brauch H., Lo W. Y., Hoheisel J. D., Hamann U., (2019) Long intergenic noncoding RNA 299 methylation in peripheral blood is a biomarker for triple-negative breast cancer. Epigenomics, 11:81-93
link to online source - Christians A., Poisel E., Hartmann C., von Deimling A., Pusch S., (2019) Characterization of the epithelial membrane protein 3 interaction network reveals a potential functional link to mitogenic signal transduction regulation. Int J Cancer, 145:461-473
link to online source - Erkek S., Johann P. D., Finetti M. A., Drosos Y., Chou H. C., Zapatka M., Sturm D., Jones D. T. W., Korshunov A., Rhyzova M., Wolf S., Mallm J. P., Beck K., Witt O., Kulozik A. E., Fruhwald M. C., Northcott P. A., Korbel J. O., Lichter P., Eils R., Gajjar A., Roberts C. W. M., Williamson D., Hasselblatt M., Chavez L., Pfister S. M., Kool M., (2019) Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation. Cancer Cell, 35:95-110 e8
link to online source - Goeppert B., Truckenmueller F., Ori A., Fritz V., Albrecht T., Fraas A., Scherer D., Silos R. G., Sticht C., Gretz N., Mehrabi A., Bewerunge-Hudler M., Pusch S., Bermejo J. L., Dietrich P., Schirmacher P., Renner M., Roessler S., (2019) Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p. Sci Rep, 9:4796
link to online source - Haller F., Bieg M., Will R., Korner C., Weichenhan D., Bott A., Ishaque N., Lutsik P., Moskalev E. A., Mueller S. K., Bahr M., Woerner A., Kaiser B., Scherl C., Haderlein M., Kleinheinz K., Fietkau R., Iro H., Eils R., Hartmann A., Plass C., Wiemann S, Agaimy A., (2019) Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands. Nat Commun, 10:368
link to online source - Jia M., Zhang Y., Jansen L., Walter V., Edelmann D., Gundert M., Tagscherer K. E., Roth W., Bewerunge-Hudler M., Herpel E., Kloor M., Ulrich A., Burwinkel B., Blaker H., Chang-Claude J., Brenner H., Hoffmeister M., (2019) A prognostic CpG score derived from epigenome-wide profiling of tumor tissue was independently associated with colorectal cancer survival. Clin Epigenetics, 11:109
link to online source - Koelsche C., Stichel D., Griewank K. G., Schrimpf D., Reuss D. E., Bewerunge-Hudler M., Vokuhl C., Dinjens W. N. M., Petersen I., Mittelbronn M., Cuevas-Bourdier A., Buslei R., Pfister S. M., Flucke U., Mechtersheimer G., Mentzel T., von Deimling A., (2019) Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype. Clin Sarcoma Res, 9:2
link to online source - Korshunov A., Casalini B., Chavez L., Hielscher T., Sill M., Ryzhova M., Sharma T., Schrimpf D., Stichel D., Capper D., Reuss D. E., Sturm D., Absalyamova O., Golanov A., Lambo S., Bewerunge-Hudler M, Lichter P., Herold-Mende C., Wick W., Pfister S. M., Kool M., Jones D. T. W., von Deimling A., Sahm F., (2019) Integrated molecular characterization of IDH-mutant glioblastomas. Neuropathol Appl Neurobiol, 45:108-118
link to online source - Paramasivam N., Hubschmann D., Toprak U. H., Ishaque N., Neidert M., Schrimpf D., Stichel D., Reuss D., Sievers P., Reinhardt A., Wefers A. K., Jones D. T. W., Gu Z., Werner J., Uhrig S., Wirsching H. G., Schick M., Bewerunge-Hudler M., Beck K., Brehmer S., Urbschat S., Seiz-Rosenhagen M., Hanggi D., Herold-Mende C., Ketter R., Eils R., Ram Z., Pfister S. M., Wick W., Weller M., Grossmann R., von Deimling A., Schlesner M., Sahm F., (2019) Mutational patterns and regulatory networks in epigenetic subgroups of meningioma. Acta Neuropathol, 138:295-308
link to online source - Barenz F., Kschonsak Y. T., Meyer A., Jafarpour A., Lorenz H., Hoffmann I., (2018) Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry. Mol Biol Cell, :mbcE18020115
link to online source - Bunse L., Pusch S., Bunse T., Sahm F., Sanghvi K., Friedrich M., Alansary D., Sonner J. K., Green E., Deumelandt K., Kilian M., Neftel C., Uhlig S., Kessler T., von Landenberg A., Berghoff A. S., Marsh K., Steadman M., Zhu D., Nicolay B., Wiestler B., Breckwoldt M. O., Al-Ali R., Karcher-Bausch S., Bozza M., Oezen I., Kramer M., Meyer J., Habel A., Eisel J., Poschet G., Weller M., Preusser M., Nadji-Ohl M., Thon N., Burger M. C., Harter P. N., Ratliff M., Harbottle R., Benner A., Schrimpf D., Okun J., Herold-Mende C., Turcan S., Kaulfuss S., Hess-Stumpp H., Bieback K., Cahill D. P., Plate K. H., Hanggi D., Dorsch M., Suva M. L., Niemeyer B. A., von Deimling A., Wick W., Platten M., (2018) Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. Nat Med, 24:1192-1203
link to online source - Bure I., Geer S., Knopf J., Roas M., Henze S., Strobel P., Agaimy A., Wiemann S., Hoheisel J. D., Hartmann A., Haller F., Moskalev E. A., (2018) Long noncoding RNA HOTAIR is upregulated in an aggressive subgroup of gastrointestinal stromal tumors (GIST) and mediates the establishment of gene-specific DNA methylation patterns. Genes Chromosomes Cancer, 57:584-597
link to online source - Capper D., Jones D. T. W., Sill M., Hovestadt V., Schrimpf D., Sturm D., Koelsche C., Sahm F., Chavez L., Reuss D. E., Kratz A., Wefers A. K., Huang K., Pajtler K. W., Schweizer L., Stichel D., Olar A., Engel N. W., Lindenberg K., Harter P. N., Braczynski A. K., Plate K. H., Dohmen H., Garvalov B. K., Coras R., Holsken A., Hewer E., Bewerunge-Hudler M., Schick M., Fischer R., Beschorner R., Schittenhelm J., Staszewski O., Wani K., Varlet P., Pages M., Temming P., Lohmann D., Selt F., Witt H., Milde T., Witt O., Aronica E., Giangaspero F., Rushing E., Scheurlen W., Geisenberger C., Rodriguez F. J., Becker A., Preusser M., Haberler C., Bjerkvig R., Cryan J., Farrell M., Deckert M., Hench J., Frank S., Serrano J., Kannan K., Tsirigos A., Bruck W., Hofer S., Brehmer S., Seiz-Rosenhagen M., Hanggi D., Hans V., Rozsnoki S., Hansford J. R., Kohlhof P., Kristensen B. W., Lechner M., Lopes B., Mawrin C., Ketter R., Kulozik A., Khatib Z., Heppner F., Koch A., Jouvet A., Keohane C., Muhleisen H., Mueller W., Pohl U., Prinz M., Benner A., Zapatka M., Gottardo N. G., Driever P. H., Kramm C. M., Muller H. L., Rutkowski S., von Hoff K., Fruhwald M. C., Gnekow A., Fleischhack G., Tippelt S., Calaminus G., Monoranu C. M., Perry A., Jones C., Jacques T. S., Radlwimmer B., Gessi M., Pietsch T., Schramm J., Schackert G., Westphal M., Reifenberger G., Wesseling P., Weller M., Collins V. P., Blumcke I., Bendszus M., Debus J., Huang A., Jabado N., Northcott P. A., Paulus W., Gajjar A., Robinson G. W., Taylor M. D., Jaunmuktane Z., Ryzhova M., Platten M., Unterberg A., Wick W., Karajannis M. A., Mittelbronn M., Acker T., Hartmann C., Aldape K., Schuller U., Buslei R., Lichter P., Kool M., Herold-Mende C., Ellison D. W., Hasselblatt M., Snuderl M., Brandner S., Korshunov A., von Deimling A., Pfister S. M., (2018) DNA methylation-based classification of central nervous system tumours. Nature, 555:469-474
link to online source - Capper D., Stichel D., Sahm F., Jones D. T. W., Schrimpf D., Sill M., Schmid S., Hovestadt V., Reuss D. E., Koelsche C., Reinhardt A., Wefers A. K., Huang K., Sievers P., Ebrahimi A., Scholer A., Teichmann D., Koch A., Hanggi D., Unterberg A., Platten M., Wick W., Witt O., Milde T., Korshunov A., Pfister S. M., von Deimling A., (2018) Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience. Acta Neuropathol, 136:181-210
link to online source - Chudasama P., Mughal S. S., Sanders M. A., Hubschmann D., Chung I., Deeg K. I., Wong S. H., Rabe S., Hlevnjak M., Zapatka M., Ernst A., Kleinheinz K., Schlesner M., Sieverling L., Klink B., Schrock E., Hoogenboezem R. M., Kasper B., Heilig C. E., Egerer G., Wolf S., von Kalle C., Eils R., Stenzinger A., Weichert W., Glimm H., Groschel S., Kopp H. G., Omlor G., Lehner B., Bauer S., Schimmack S., Ulrich A., Mechtersheimer G., Rippe K., Brors B., Hutter B., Renner M., Hohenberger P., Scholl C., Frohling S., (2018) Integrative genomic and transcriptomic analysis of leiomyosarcoma. Nat Commun, 9:144
link to online source - Dimitrov B., Himmelreich N., Hipgrave Ederveen A. L., Luchtenborg C., Okun J. G., Breuer M., Hutter A. M., Carl M., Guglielmi L., Hellwig A., Thiemann K. C., Jost M., Peters V., Staufner C., Hoffmann G. F., Hackenberg A., Paramasivam N., Wiemann S., Eils R., Schlesner M., Strahl S., Brugger B., Wuhrer M., Christoph Korenke G., Thiel C., (2018) Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. Mol Genet Metab, 123:364-374
link to online source - Forget A., Martignetti L., Puget S., Calzone L., Brabetz S., Picard D., Montagud A., Liva S., Sta A., Dingli F., Arras G., Rivera J., Loew D., Besnard A., Lacombe J., Pages M., Varlet P., Dufour C., Yu H., Mercier A. L., Indersie E., Chivet A., Leboucher S., Sieber L., Beccaria K., Gombert M., Meyer F. D., Qin N., Bartl J., Chavez L., Okonechnikov K., Sharma T., Thatikonda V., Bourdeaut F., Pouponnot C., Ramaswamy V., Korshunov A., Borkhardt A., Reifenberger G., Poullet P., Taylor M. D., Kool M., Pfister S. M., Kawauchi D., Barillot E., Remke M., Ayrault O., (2018) Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling. Cancer Cell, 34:379-395 e7
link to online source - Grasse S., Lienhard M., Frese S., Kerick M., Steinbach A., Grimm C., Hussong M., Rolff J., Becker M., Dreher F., Schirmer U., Boerno S., Ramisch A., Leschber G., Timmermann B., Grohe C., Luders H., Vingron M., Fichtner I., Klein S., Odenthal M., Buttner R., Lehrach H., Sultmann H., Herwig R., Schweiger M. R., (2018) Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance. Genome Med, 10:55
link to online source - Grobner S. N., Worst B. C., Weischenfeldt J., Buchhalter I., Kleinheinz K., Rudneva V. A., Johann P. D., Balasubramanian G. P., Segura-Wang M., Brabetz S., Bender S., Hutter B., Sturm D., Pfaff E., Hubschmann D., Zipprich G., Heinold M., Eils J., Lawerenz C., Erkek S., Lambo S., Waszak S., Blattmann C., Borkhardt A., Kuhlen M., Eggert A., Fulda S., Gessler M., Wegert J., Kappler R., Baumhoer D., Burdach S., Kirschner-Schwabe R., Kontny U., Kulozik A. E., Lohmann D., Hettmer S., Eckert C., Bielack S., Nathrath M., Niemeyer C., Richter G. H., Schulte J., Siebert R., Westermann F., Molenaar J. J., Vassal G., Witt H., Icgc PedBrain-Seq Project, Icgc Mmml- Seq Project, Burkhardt B., Kratz C. P., Witt O., van Tilburg C. M., Kramm C. M., Fleischhack G., Dirksen U., Rutkowski S., Fruhwald M., von Hoff K., Wolf S, Klingebiel T., Koscielniak E., Landgraf P., Koster J., Resnick A. C., Zhang J., Liu Y., Zhou X., Waanders A. J., Zwijnenburg D. A., Raman P., Brors B., Weber U. D., Northcott P. A., Pajtler K. W., Kool M., Piro R. M., Korbel J. O., Schlesner M., Eils R., Jones D. T. W., Lichter P., Chavez L., Zapatka M., Pfister S. M., (2018) The landscape of genomic alterations across childhood cancers. Nature, :
link to online source - Gutekunst J., Andriantsoa R., Falckenhayn C., Hanna K., Stein W., Rasamy J., Lyko F., (2018) Clonal genome evolution and rapid invasive spread of the marbled crayfish. Nat Ecol Evol, 2:567-573
link to online source - Insua-Rodriguez J., Pein M., Hongu T., Meier J., Descot A., Lowy C. M., De Braekeleer E., Sinn H. P., Spaich S., Sutterlin M., Schneeweiss A., Oskarsson T., (2018) Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis. EMBO Mol Med, :
link to online source - Junge K. M., Leppert B., Jahreis S., Wissenbach D. K., Feltens R., Grutzmann K., Thurmann L., Bauer T., Ishaque N., Schick M., Bewerunge-Hudler M., Roder S., Bauer M., Schulz A., Borte M., Landgraf K., Korner A., Kiess W., von Bergen M., Stangl G. I., Trump S., Eils R., Polte T., Lehmann I., (2018) MEST mediates the impact of prenatal bisphenol A exposure on long-term body weight development. Clin Epigenetics, 10:58
link to online source - Kessler T., Sahm F., Sadik A., Stichel D., Hertenstein A., Reifenberger G., Zacher A., Sabel M., Tabatabai G., Steinbach J., Sure U., Krex D., Grosu A. L., Bewerunge-Hudler M., Jones D., Pfister S. M., Weller M., Opitz C., Bendszus M., von Deimling A., Platten M., Wick W., (2018) Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation. Neuro Oncol, 20:367-379
link to online source - Klett H., Balavarca Y., Toth R., Gigic B., Habermann N., Scherer D., Schrotz-King P., Ulrich A., Schirmacher P., Herpel E., Brenner H., Ulrich C. M., Michels K. B., Busch H., Boerries M., (2018) Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles. Epigenetics, 13:386-397
link to online source - Klett H., Fuellgraf H., Levit-Zerdoun E., Hussung S., Kowar S., Kusters S., Bronsert P., Werner M., Wittel U., Fritsch R., Busch H., Boerries M., (2018) Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma. Front Genet, 9:108
link to online source - Koelsche C., Hartmann W., Schrimpf D., Stichel D., Jabar S., Ranft A., Reuss D. E., Sahm F., Jones D. T. W., Bewerunge-Hudler M., Trautmann M., Klingebiel T., Vokuhl C., Gessler M., Wardelmann E., Petersen I., Baumhoer D., Flucke U., Antonescu C., Esteller M., Frohling S., Kool M., Pfister S. M., Mechtersheimer G., Dirksen U., von Deimling A., (2018) Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information. Mod Pathol, 31:1246-1256
link to online source - Mack S. C., Pajtler K. W., Chavez L., Okonechnikov K., Bertrand K. C., Wang X., Erkek S., Federation A., Song A., Lee C., Wang X., McDonald L., Morrow J. J., Saiakhova A., Sin-Chan P., Wu Q., Michaelraj K. A., Miller T. E., Hubert C. G., Ryzhova M., Garzia L., Donovan L., Dombrowski S., Factor D. C., Luu B., Valentim C. L. L., Gimple R. C., Morton A., Kim L., Prager B. C., Lee J. J. Y., Wu X., Zuccaro J., Thompson Y., Holgado B. L., Reimand J., Ke S. Q., Tropper A., Lai S., Vijayarajah S., Doan S., Mahadev V., Minan A. F., Grobner S. N., Lienhard M., Zapatka M., Huang Z., Aldape K. D., Carcaboso A. M., Houghton P. J., Keir S. T., Milde T., Witt H., Li Y., Li C. J., Bian X. W., Jones D. T. W., Scott I., Singh S. K., Huang A., Dirks P. B., Bouffet E., Bradner J. E., Ramaswamy V., Jabado N., Rutka J. T., Northcott P. A., Lupien M., Lichter P., Korshunov A., Scacheri P. C., Pfister S. M., Kool M., Taylor M. D., Rich J. N., (2018) Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. Nature, 553:101-105
link to online source - Mishra R. R., Belder N., Ansari S. A., Kayhan M., Bal H., Raza U., Ersan P. G., Tokat U. M., Eyupoglu E., Saatci O., Jandaghi P., Wiemann S., Uner A., Cekic C., Riazalhosseini Y., Sahin O., (2018) Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer. Clin Cancer Res, 24:1987-2001
link to online source - Oberacker T., Bajorat J., Ziola S., Schroeder A., Roth D., Kastl L., Edgar B. A., Wagner W., Gulow K., Krammer P. H., (2018) Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging. FEBS Lett, 592:2297-2307
link to online source - Paramasivam N., Granzow M., Evers C., Hinderhofer K., Wiemann S., Bartram C.R., Eils R., Schlesner M., (2018) Identification and prioritisation of causal variants in human genetic disorders from exome or whole genome sequencing data. OBM Genetics, 2:1-1
link to online source - Pfaff E., Kessler T., Balasubramanian G. P., Berberich A., Schrimpf D., Wick A., Debus J., Unterberg A., Bendszus M., Herold-Mende C., Capper D., Schenkel I., Eisenmenger A., Dettmer S., Brors B., Platten M., Pfister S. M., von Deimling A., Jones D. T. W., Wick W., Sahm F., (2018) Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation-the NCT Neuro Master Match (N2M2) pilot study. Neuro Oncol, 20:826-837
link to online source - Quandt J., Schlude C., Bartoschek M., Will R., Cid-Arregui A., Scholch S., Reissfelder C., Weitz J., Schneider M., Wiemann S., Momburg F., Beckhove P., (2018) Long-peptide vaccination with driver gene mutations in p53 and Kras induces cancer mutation-specific effector as well as regulatory T cell responses. Oncoimmunology, 7:e1500671
link to online source - Rodriguez-Paredes M., Bormann F., Raddatz G., Gutekunst J., Lucena-Porcel C., Kohler F., Wurzer E., Schmidt K., Gallinat S., Wenck H., Rowert-Huber J., Denisova E., Feuerbach L., Park J., Brors B., Herpel E., Nindl I., Hofmann T. G., Winnefeld M., Lyko F., (2018) Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin. Nat Commun, 9:577
link to online source - Rohrich M., Huang K., Schrimpf D., Albert N. L., Hielscher T., von Deimling A., Schuller U., Dimitrakopoulou-Strauss A., Haberkorn U., (2018) Integrated analysis of dynamic FET PET/CT parameters, histology, and methylation profiling of 44 gliomas. Eur J Nucl Med Mol Imaging, 45:1573-1584
link to online source - Saatci O., Borgoni S., Akbulut O., Durmus S., Raza U., Eyupoglu E., Alkan C., Akyol A., Kutuk O., Wiemann S, Sahin O., (2018) Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer. Oncogene, 37:2251-2269
link to online source - Schmidt N., Haydn T., Schneider I., Busch H., Boerries M., Fulda S., (2018) Smac mimetic induces an early wave of gene expression via NF-kappaB and AP-1 and a second wave via TNFR1 signaling. Cancer Lett, 421:170-185
link to online source - Shirahata M., Ono T., Stichel D., Schrimpf D., Reuss D. E., Sahm F., Koelsche C., Wefers A., Reinhardt A., Huang K., Sievers P., Shimizu H., Nanjo H., Kobayashi Y., Miyake Y., Suzuki T., Adachi J. I., Mishima K., Sasaki A., Nishikawa R., Bewerunge-Hudler M., Ryzhova M., Absalyamova O., Golanov A., Sinn P., Platten M., Jungk C., Winkler F., Wick A., Hanggi D., Unterberg A., Pfister S. M., Jones D. T. W., van den Bent M., Hegi M., French P., Baumert B. G., Stupp R., Gorlia T., Weller M., Capper D., Korshunov A., Herold-Mende C., Wick W., Louis D. N., von Deimling A., (2018) Novel, improved grading system(s) for IDH-mutant astrocytic gliomas. Acta Neuropathol, 136:153-166
link to online source - Simm F., Griesbeck A., Choukair D., Weiss B., Paramasivam N., Klammt J., Schlesner M., Wiemann S., Martinez C., Hoffmann G. F., Pfaffle R. W., Bettendorf M., Rappold G. A., (2018) Identification of SLC20A1 and SLC15A4 among other genes as potential risk factors for combined pituitary hormone deficiency. Genet Med, 20:728-736
link to online source - Singhal M., Liu X., Inverso D., Jiang K., Dai J., He H., Bartels S., Li W., Abdul Pari A. A., Gengenbacher N., Besemfelder E., Hui L., Augustin H. G., Hu J., (2018) Endothelial cell fitness dictates the source of regenerating liver vasculature. J Exp Med, :
link to online source - Thurmann L., Grutzmann K., Klos M., Bieg M., Winter M., Polte T., Bauer T., Schick M., Bewerunge-Hudler M., Roder S., Bauer M., Wissenbach D. K., Sack U., Weichenhan D., Mucke O., Plass C., Borte M., von Bergen M., Lehmann I., Eils R., Trump S., (2018) Early-onset childhood atopic dermatitis is related to NLRP2 repression. J Allergy Clin Immunol, 141:1482-1485 e16
link to online source - Waszak S. M., Northcott P. A., Buchhalter I., Robinson G. W., Sutter C., Groebner S., Grund K. B., Brugieres L., Jones D. T. W., Pajtler K. W., Morrissy A. S., Kool M., Sturm D., Chavez L., Ernst A., Brabetz S., Hain M., Zichner T., Segura-Wang M., Weischenfeldt J., Rausch T., Mardin B. R., Zhou X., Baciu C., Lawerenz C., Chan J. A., Varlet P., Guerrini-Rousseau L., Fults D. W., Grajkowska W., Hauser P., Jabado N., Ra Y. S., Zitterbart K., Shringarpure S. S., De La Vega F. M., Bustamante C. D., Ng H. K., Perry A., MacDonald T. J., Hernaiz Driever P., Bendel A. E., Bowers D. C., McCowage G., Chintagumpala M. M., Cohn R., Hassall T., Fleischhack G., Eggen T., Wesenberg F., Feychting M., Lannering B., Schuz J., Johansen C., Andersen T. V., Roosli M., Kuehni C. E., Grotzer M., Kjaerheim K., Monoranu C. M., Archer T. C., Duke E., Pomeroy S. L., Shelagh R., Frank S., Sumerauer D., Scheurlen W., Ryzhova M. V., Milde T., Kratz C. P., Samuel D., Zhang J., Solomon D. A., Marra M., Eils R., Bartram C. R., von Hoff K., Rutkowski S., Ramaswamy V., Gilbertson R. J., Korshunov A., Taylor M. D., Lichter P., Malkin D., Gajjar A., Korbel J. O., Pfister S. M., (2018) Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort. Lancet Oncol, 19:785-798
link to online source - Agaimy A., Bieg M., Michal M., Geddert H., Markl B., Seitz J., Moskalev E. A., Schlesner M., Metzler M., Hartmann A., Wiemann S, Michal M., Mentzel T., Haller F., (2017) Recurrent Somatic PDGFRB Mutations in Sporadic Infantile/Solitary Adult Myofibromas But Not in Angioleiomyomas and Myopericytomas. Am J Surg Pathol, 41:195-203
link to online source - Aram R., Dotan I., Hotz-Wagenblatt A., Canaani D., (2017) Identification of a novel metastasis inducing lncRNA which suppresses the KAI1/CD82 metastasis suppressor gene and is upregulated in triple-negative breast cancer. Oncotarget, :
link to online source - Bott A., Erdem N., Lerrer S., Hotz-Wagenblatt A., Breunig C., Abnaof K., Worner A., Wilhelm H., Munstermann E., Ben-Baruch A., Wiemann S., (2017) miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A. Oncotarget, :
link to online source - Brocks D., Schmidt C. R., Daskalakis M., Jang H. S., Shah N. M., Li D., Li J., Zhang B., Hou Y., Laudato S., Lipka D. B., Schott J., Bierhoff H., Assenov Y., Helf M., Ressnerova A., Islam M. S., Lindroth A. M., Haas S., Essers M., Imbusch C. D., Brors B., Oehme I., Witt O., Lubbert M., Mallm J. P., Rippe K., Will R., Weichenhan D., Stoecklin G., Gerhauser C., Oakes C. C., Wang T., Plass C., (2017) DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nat Genet, 49:1052-1060
link to online source - Bure I., Braun A., Kayser C., Geddert H., Schaefer I. M., Cameron S., Ghadimi M. B., Strobel P., Werner M., Hartmann A., Wiemann S., Agaimy A., Haller F., Moskalev E. A., (2017) The expression of hematopoietic progenitor cell antigen CD34 is regulated by DNA methylation in a site-dependent manner in gastrointestinal stromal tumours. Int J Cancer, 141:2296-2304
link to online source - Delacher M., Imbusch C. D., Weichenhan D., Breiling A., Hotz-Wagenblatt A., Trager U., Hofer A. C., Kagebein D., Wang Q., Frauhammer F., Mallm J. P., Bauer K., Herrmann C., Lang P. A., Brors B., Plass C., Feuerer M., (2017) Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues. Nat Immunol, :
link to online source - Dietrich S., Oles M., Lu J., Sellner L., Anders S., Velten B., Wu B., Hullein J., da Silva Liberio M., Walther T., Wagner L., Rabe S., Ghidelli-Disse S., Bantscheff M., Oles A. K., Slabicki M., Mock A., Oakes C. C., Wang S., Oppermann S., Lukas M., Kim V., Sill M., Benner A., Jauch A., Sutton L. A., Young E., Rosenquist R., Liu X., Jethwa A., Lee K. S., Lewis J., Putzker K., Lutz C., Rossi D., Mokhir A., Oellerich T., Zirlik K., Herling M., Nguyen-Khac F., Plass C., Andersson E., Mustjoki S., von Kalle C., Ho A. D., Hensel M., Durig J., Ringshausen I., Zapatka M., Huber W., Zenz T., (2017) Drug-perturbation-based stratification of blood cancer. J Clin Invest, :
link to online source - Evers C., Staufner C., Granzow M., Paramasivam N., Hinderhofer K., Kaufmann L., Fischer C., Thiel C., Opladen T., Kotzaeridou U., Wiemann S., Schlesner M., Eils R., Kolker S., Bartram C. R., Hoffmann G. F., Moog U., (2017) Impact of clinical exomes in neurodevelopmental and neurometabolic disorders. Mol Genet Metab, 121:297-307
link to online source - Gundert M., Edelmann D., Benner A., Jansen L., Jia M., Walter V., Knebel P., Herpel E., Chang-Claude J., Hoffmeister M., Brenner H., Burwinkel B., (2017) Genome-wide DNA methylation analysis reveals a prognostic classifier for non-metastatic colorectal cancer (ProMCol classifier). Gut, :
link to online source - Heilmann K., Toth R., Bossmann C., Klimo K., Plass C., Gerhauser C., (2017) Genome-wide screen for differentially methylated long noncoding RNAs identifies Esrp2 and lncRNA Esrp2-as regulated by enhancer DNA methylation with prognostic relevance for human breast cancer. Oncogene, 36:6446-6461
link to online source - Hong C., Cao J., Wu C. F., Kadioglu O., Schuffler A., Kauhl U., Klauck S. M., Opatz T., Thines E., Paul N. W., Efferth T., (2017) The Chinese herbal formula Free and Easy Wanderer ameliorates oxidative stress through KEAP1-NRF2/HO-1 pathway. Sci Rep, 7:11551
link to online source - Horak P., Klink B., Heining C., Groschel S., Hutter B., Frohlich M., Uhrig S., Hubschmann D., Schlesner M., Eils R., Richter D., Pfutze K., Georg C., Meissburger B., Wolf S., Schulz A., Penzel R., Herpel E., Kirchner M., Lier A., Endris V., Singer S., Schirmacher P., Weichert W., Stenzinger A., Schlenk R. F., Schrock E., Brors B., von Kalle C., Glimm H., Frohling S., (2017) Precision oncology based on omics data: The NCT Heidelberg experience. Int J Cancer, 141:877-886
link to online source - Jakel C., Bergmann F., Toth R., Assenov Y., van der Duin D., Strobel O., Hank T., Kloppel G., Dorrell C., Grompe M., Moss J., Dor Y., Schirmacher P., Plass C., Popanda O., Schmezer P., (2017) Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability. Nat Commun, 8:1323
link to online source - Jung E., Osswald M., Blaes J., Wiestler B., Sahm F., Schmenger T., Solecki G., Deumelandt K., Kurz F. T., Xie R., Weil S., Heil O., Thome C., Gommel M., Syed M., Haring P., Huber P. E., Heiland S., Platten M., von Deimling A., Wick W., Winkler F., (2017) Tweety-homologue 1 drives brain colonization of gliomas. J Neurosci, :
link to online source - Kessler T., Sahm F., Sadik A., Stichel D., Hertenstein A., Reifenberger G., Zacher A., Sabel M., Tabatabai G., Steinbach J., Sure U., Krex D., Grosu A. L., Bewerunge-Hudler M., Jones D., Pfister S. M., Weller M., Opitz C., Bendszus M., von Deimling A., Platten M., Wick W., (2017) Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation. Neuro Oncol, :
link to online source - Koelsche C., Schrimpf D., Tharun L., Roth E., Sturm D., Jones D. T. W., Renker E. K., Sill M., Baude A., Sahm F., Capper D., Bewerunge-Hudler M., Hartmann W., Kulozik A. E., Petersen I., Flucke U., Schreuder H. W. B., Buttner R., Weber M. A., Schirmacher P., Plass C., Pfister S. M., von Deimling A., Mechtersheimer G., (2017) Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases. Clin Sarcoma Res, 7:9
link to online source - Korshunov A., Chavez L., Sharma T., Ryzhova M., Schrimpf D., Stichel D., Capper D., Sturm D., Kool M., Habel A., Kleinschmidt-DeMasters B. K., Rosenblum M., Absalyamova O., Golanov A., Lichter P., Pfister S. M., Jones D. T. W., Perry A., von Deimling A., (2017) Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis. Brain Pathol, :
link to online source - Lipka D. B., Witte T., Toth R., Yang J., Wiesenfarth M., Nollke P., Fischer A., Brocks D., Gu Z., Park J., Strahm B., Wlodarski M., Yoshimi A., Claus R., Lubbert M., Busch H., Boerries M., Hartmann M., Schonung M., Kilik U., Langstein J., Wierzbinska J. A., Pabst C., Garg S., Catala A., De Moerloose B., Dworzak M., Hasle H., Locatelli F., Masetti R., Schmugge M., Smith O., Stary J., Ussowicz M., van den Heuvel-Eibrink M. M., Assenov Y., Schlesner M., Niemeyer C., Flotho C., Plass C., (2017) RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia. Nat Commun, 8:2126
link to online source - Mamlouk S., Childs L. H., Aust D., Heim D., Melching F., Oliveira C., Wolf T., Durek P., Schumacher D., Blaker H., von Winterfeld M., Gastl B., Mohr K., Menne A., Zeugner S., Redmer T., Lenze D., Tierling S., Mobs M., Weichert W., Folprecht G., Blanc E., Beule D., Schafer R., Morkel M., Klauschen F., Leser U., Sers C., (2017) DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer. Nat Commun, 8:14093
link to online source - Northcott P. A., Buchhalter I., Morrissy A. S., Hovestadt V., Weischenfeldt J., Ehrenberger T., Grobner S., Segura-Wang M., Zichner T., Rudneva V. A., Warnatz H. J., Sidiropoulos N., Phillips A. H., Schumacher S., Kleinheinz K., Waszak S. M., Erkek S., Jones D. T. W., Worst B. C., Kool M., Zapatka M., Jager N., Chavez L., Hutter B., Bieg M., Paramasivam N., Heinold M., Gu Z., Ishaque N., Jager-Schmidt C., Imbusch C. D., Jugold A., Hubschmann D., Risch T., Amstislavskiy V., Gonzalez F. G. R., Weber U. D., Wolf S., Robinson G. W., Zhou X., Wu G., Finkelstein D., Liu Y., Cavalli F. M. G., Luu B., Ramaswamy V., Wu X., Koster J., Ryzhova M., Cho Y. J., Pomeroy S. L., Herold-Mende C., Schuhmann M., Ebinger M., Liau L. M., Mora J., McLendon R. E., Jabado N., Kumabe T., Chuah E., Ma Y., Moore R. A., Mungall A. J., Mungall K. L., Thiessen N., Tse K., Wong T., Jones S. J. M., Witt O., Milde T., Von Deimling A., Capper D., Korshunov A., Yaspo M. L., Kriwacki R., Gajjar A., Zhang J., Beroukhim R., Fraenkel E., Korbel J. O., Brors B., Schlesner M., Eils R., Marra M. A., Pfister S. M., Taylor M. D., Lichter P., (2017) The whole-genome landscape of medulloblastoma subtypes. Nature, 547:311-317
link to online source - Northcott P. A., Buchhalter I., Morrissy A. S., Hovestadt V., Weischenfeldt J., Ehrenberger T., Grobner S., Segura-Wang M., Zichner T., Rudneva V. A., Warnatz H. J., Sidiropoulos N., Phillips A. H., Schumacher S., Kleinheinz K., Waszak S. M., Erkek S., Jones D. T. W., Worst B. C., Kool M., Zapatka M., Jager N., Chavez L., Hutter B., Bieg M., Paramasivam N., Heinold M., Gu Z., Ishaque N., Jager-Schmidt C., Imbusch C. D., Jugold A., Hubschmann D., Risch T., Amstislavskiy V., Gonzalez F. G. R., Weber U. D., Wolf S., Robinson G. W., Zhou X., Wu G., Finkelstein D., Liu Y., Cavalli F. M. G., Luu B., Ramaswamy V., Wu X., Koster J., Ryzhova M., Cho Y. J., Pomeroy S. L., Herold-Mende C., Schuhmann M., Ebinger M., Liau L. M., Mora J., McLendon R. E., Jabado N., Kumabe T., Chuah E., Ma Y., Moore R. A., Mungall A. J., Mungall K. L., Thiessen N., Tse K., Wong T., Jones S. J. M., Witt O., Milde T., Von Deimling A., Capper D., Korshunov A., Yaspo M. L., Kriwacki R., Gajjar A., Zhang J., Beroukhim R., Fraenkel E., Korbel J. O., Brors B., Schlesner M., Eils R., Marra M. A., Pfister S. M., Taylor M. D., Lichter P., (2017) The whole-genome landscape of medulloblastoma subtypes. Nature, 547:311-317
link to online source - Pei W., Feyerabend T. B., Rossler J., Wang X., Postrach D., Busch K., Rode I., Klapproth K., Dietlein N., Quedenau C., Chen W., Sauer S., Wolf S., Hofer T., Rodewald H. R., (2017) Polylox barcoding reveals haematopoietic stem cell fates realized in vivo. Nature, 548:456-460
link to online source - Raffel S., Falcone M., Kneisel N., Hansson J., Wang W., Lutz C., Bullinger L., Poschet G., Nonnenmacher Y., Barnert A., Bahr C., Zeisberger P., Przybylla A., Sohn M., Tonjes M., Erez A., Adler L., Jensen P., Scholl C., Frohling S., Cocciardi S., Wuchter P., Thiede C., Florcken A., Westermann J., Ehninger G., Lichter P., Hiller K., Hell R., Herrmann C., Ho A. D., Krijgsveld J., Radlwimmer B., Trumpp A., (2017) BCAT1 restricts alphaKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation. Nature, 551:384-388
link to online source - Rafiullah R., Long A. B., Ivanova A. A., Ali H., Berkel S., Mustafa G., Paramasivam N., Schlesner M., Wiemann S., Wade R. C., Bolthauser E., Blum M., Kahn R. A., Caspary T., Rappold G. A., (2017) A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity. Eur J Hum Genet, 25:1324-1334
link to online source - Ratnaparkhe M., Hlevnjak M., Kolb T., Jauch A., Maass K. K., Devens F., Rode A., Hovestadt V., Korshunov A., Pastorczak A., Mlynarski W., Sungalee S., Korbel J., Hoell J., Fischer U., Milde T., Kramm C., Nathrath M., Chrzanowska K., Tausch E., Takagi M., Taga T., Constantini S., Loeffen J., Meijerink J., Zielen S., Gohring G., Schlegelberger B., Maass E., Siebert R., Kunz J., Kulozik A. E., Worst B., Jones D. T., Pfister S. M., Zapatka M., Lichter P., Ernst A., (2017) Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis. Leukemia, :
link to online source - Ratz L., Laible M., Kacprzyk L. A., Wittig-Blaich S. M., Tolstov Y., Duensing S., Altevogt P., Klauck S. M., Sultmann H., (2017) TMPRSS2:ERG gene fusion variants induce TGF-beta signaling and epithelial to mesenchymal transition in human prostate cancer cells. Oncotarget, 8:25115-25130
link to online source - Sahm F., Korshunov A., Schrimpf D., Stichel D., Jones D. T., Capper D., Koelsche C., Reuss D., Kratz A., Huang K., Wefers A. K., Schick M., Bewerunge-Hudler M, Mittelbronn M., Platten M., Hanggi D., Jeibmann A., Unterberg A., Herold-Mende C., Pfister S. M., Brandner S., Wick W., von Deimling A., (2017) Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas. Acta Neuropathol, 133:325-327
link to online source - Sahm F., Schrimpf D., Stichel D., Jones D. T. W., Hielscher T., Schefzyk S., Okonechnikov K., Koelsche C., Reuss D. E., Capper D., Sturm D., Wirsching H. G., Berghoff A. S., Baumgarten P., Kratz A., Huang K., Wefers A. K., Hovestadt V., Sill M., Ellis H. P., Kurian K. M., Okuducu A. F., Jungk C., Drueschler K., Schick M., Bewerunge-Hudler M., Mawrin C., Seiz-Rosenhagen M., Ketter R., Simon M., Westphal M., Lamszus K., Becker A., Koch A., Schittenhelm J., Rushing E. J., Collins V. P., Brehmer S., Chavez L., Platten M., Hanggi D., Unterberg A., Paulus W., Wick W., Pfister S. M., Mittelbronn M., Preusser M., Herold-Mende C., Weller M., von Deimling A., (2017) DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis. Lancet Oncol, 18:682-694
link to online source - Sahm F., Toprak U. H., Hubschmann D., Kleinheinz K., Buchhalter I., Sill M., Stichel D., Schick M., Bewerunge-Hudler M., Schrimpf D., Zadeh G., Aldape K., Herold-Mende C., Beck K., Staszewski O., Prinz M., Harosh C. B., Eils R., Sturm D., Jones D. T. W., Pfister S. M., Paulus W., Ram Z., Schlesner M., Grossman R., von Deimling A., (2017) Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature. Acta Neuropathol, 134:155-158
link to online source - Song C., Hotz-Wagenblatt A., Voit R., Grummt I., (2017) SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability. Genes Dev, :
link to online source - Uhlmann S., Mracsko E., Javidi E., Lamble S., Teixeira A., Hotz-Wagenblatt A., Glatting K. H., Veltkamp R., (2017) Genome-Wide Analysis of the Circulating miRNome After Cerebral Ischemia Reveals a Reperfusion-Induced MicroRNA Cluster. Stroke, 48:762-769
link to online source - Wittig-Blaich S., Wittig R., Schmidt S., Lyer S., Bewerunge-Hudler M., Gronert-Sum S., Strobel-Freidekind O., Muller C., List M., Jaskot A., Christiansen H., Hafner M., Schadendorf D., Block I., Mollenhauer J., (2017) Systematic screening of isogenic cancer cells identifies DUSP6 as context-specific synthetic lethal target in melanoma. Oncotarget, 8:23760-23774
link to online source - Eden M., Meder B., Volkers M., Poomvanicha M., Domes K., Branchereau M., Marck P., Will R., Bernt A., Rangrez A., Busch M., Hrabe de Angelis M., Heymes C., Rottbauer W., Most P., Hofmann F., Frey N., (2016) Erratum: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. Nat Commun, 7:11835
link to online source - Florath I., Butterbach K., Heiss J., Bewerunge-Hudler M., Zhang Y., Schottker B., Brenner H., (2016) Type 2 diabetes and leucocyte DNA methylation: an epigenome-wide association study in over 1,500 older adults. Diabetologia, 59:130-8
link to online source - Florath I., Schottker B., Butterbach K., Bewerunge-Hudler M., Brenner H., (2016) Epigenome-wide search for association of serum 25-hydroxyvitamin D concentration with leukocyte DNA methylation in a large cohort of older men. Epigenomics, 8:487-99
link to online source - Goeppert B., Ernst C., Baer C., Roessler S., Renner M., Mehrabi A., Hafezi M., Pathil A., Warth A., Stenzinger A., Weichert W., Bahr M., Will R., Schirmacher P., Plass C., Weichenhan D., (2016) Cadherin-6 is a putative tumor suppressor and target of epigenetically dysregulated miR-429 in cholangiocarcinoma. Epigenetics, 11:780-790
link to online source - Haller F., Knopf J., Ackermann A., Bieg M., Kleinheinz K., Schlesner M., Moskalev E. A., Will R., Satir A. A., Abdelmagid I. E., Giedl J., Carbon R., Rompel O., Hartmann A., Wiemann S., Metzler M., Agaimy A., (2016) Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern. J Pathol, 238:700-10
link to online source - Lin C. Y., Erkek S., Tong Y., Yin L., Federation A. J., Zapatka M., Haldipur P., Kawauchi D., Risch T., Warnatz H. J., Worst B. C., Ju B., Orr B. A., Zeid R., Polaski D. R., Segura-Wang M., Waszak S. M., Jones D. T., Kool M., Hovestadt V., Buchhalter I., Sieber L., Johann P., Chavez L., Groschel S., Ryzhova M., Korshunov A., Chen W., Chizhikov V. V., Millen K. J., Amstislavskiy V., Lehrach H., Yaspo M. L., Eils R., Lichter P., Korbel J. O., Pfister S. M., Bradner J. E., Northcott P. A., (2016) Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature, 530:57-62
link to online source - Oakes C. C., Seifert M., Assenov Y., Gu L., Przekopowitz M., Ruppert A. S., Wang Q., Imbusch C. D., Serva A., Koser S. D., Brocks D., Lipka D. B., Bogatyrova O., Weichenhan D., Brors B., Rassenti L., Kipps T. J., Mertens D., Zapatka M., Lichter P., Dohner H., Kuppers R., Zenz T., Stilgenbauer S., Byrd J. C., Plass C., (2016) DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia. Nat Genet, 48:253-64
link to online source - Rafiullah R., Aslamkhan M., Paramasivam N., Thiel C., Mustafa G., Wiemann S., Schlesner M., Wade R. C., Rappold G. A., Berkel S., (2016) Homozygous missense mutation in the LMAN2L gene segregates with intellectual disability in a large consanguineous Pakistani family. J Med Genet, 53:138-44
link to online source - Rohrich M., Koelsche C., Schrimpf D., Capper D., Sahm F., Kratz A., Reuss J., Hovestadt V., Jones D. T., Bewerunge-Hudler M., Becker A., Weis J., Mawrin C., Mittelbronn M., Perry A., Mautner V. F., Mechtersheimer G., Hartmann C., Okuducu A. F., Arp M., Seiz-Rosenhagen M., Hanggi D., Heim S., Paulus W., Schittenhelm J., Ahmadi R., Herold-Mende C., Unterberg A., Pfister S. M., von Deimling A., Reuss D. E., (2016) Methylation-based classification of benign and malignant peripheral nerve sheath tumors. Acta Neuropathol, 131:877-87
link to online source - Sahm F., Schrimpf D., Jones D. T., Meyer J., Kratz A., Reuss D., Capper D., Koelsche C., Korshunov A., Wiestler B., Buchhalter I., Milde T., Selt F., Sturm D., Kool M., Hummel M., Bewerunge-Hudler M., Mawrin C., Schuller U., Jungk C., Wick A., Witt O., Platten M., Herold-Mende C., Unterberg A., Pfister S. M., Wick W., von Deimling A., (2016) Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets. Acta Neuropathol, 131:903-10
link to online source - Salvermoser M., Chotewutmontri S., Braspenning-Wesch I., Hasche D., Rosl F., Vinzon S. E., (2016) Transcriptome analysis of Mastomys natalensis papillomavirus in productive lesions after natural infection. J Gen Virol, :
link to online source - Sturm D., Orr B. A., Toprak U. H., Hovestadt V., Jones D. T. W., Capper D., Sill M., Buchhalter I., Northcott P. A., Leis I., Ryzhova M., Koelsche C., Pfaff E., Allen S. J., Balasubramanian G., Worst B. C., Pajtler K. W., Brabetz S., Johann P. D., Sahm F., Reimand J., Mackay A., Carvalho D. M., Remke M., Phillips J. J., Perry A., Cowdrey C., Drissi R., Fouladi M., Giangaspero F., Lastowska M., Grajkowska W., Scheurlen W., Pietsch T., Hagel C., Gojo J., Lotsch D., Berger W., Slavc I., Haberler C., Jouvet A., Holm S., Hofer S., Prinz M., Keohane C., Fried I., Mawrin C., Scheie D., Mobley B. C., Schniederjan M. J., Santi M., Buccoliero A. M., Dahiya S., Kramm C. M., von Bueren A. O., von Hoff K., Rutkowski S., Herold-Mende C., Fruhwald M. C., Milde T., Hasselblatt M., Wesseling P., Rossler J., Schuller U., Ebinger M., Schittenhelm J., Frank S., Grobholz R., Vajtai I., Hans V., Schneppenheim R., Zitterbart K., Collins V. P., Aronica E., Varlet P., Puget S., Dufour C., Grill J., Figarella-Branger D., Wolter M., Schuhmann M. U., Shalaby T., Grotzer M., van Meter T., Monoranu C. M., Felsberg J., Reifenberger G., Snuderl M., Forrester L. A., Koster J., Versteeg R., Volckmann R., van Sluis P., Wolf S., Mikkelsen T., Gajjar A., Aldape K., Moore A. S., Taylor M. D., Jones C., Jabado N., Karajannis M. A., Eils R., Schlesner M., Lichter P., von Deimling A., Pfister S. M., Ellison D. W., Korshunov A., Kool M., (2016) New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. Cell, 164:1060-1072
link to online source - Tang Q., Holland-Letz T., Slynko A., Cuk K., Marme F., Schott S., Heil J., Qu B., Golatta M., Bewerunge-Hudler M, Sutter C., Surowy H., Wappenschmidt B., Schmutzler R., Hoth M., Bugert P., Bartram C. R., Sohn C., Schneeweiss A., Yang R., Burwinkel B., (2016) DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA. Oncotarget, 7:64191-64202
link to online source - The ORFeome Collaboration, Wiemann S., Pennacchio C., Hu Y., Hunter P., Harbers M., Amiet A., Bethel G., Busse M., Carninci P., Dunham I., Hao T., Harper J. W., Hayashizaki Y., Heil O., Hennig S., Hotz-Wagenblatt A., Jang W., JĂścker A., Kawai J., Koenig C., Korn B., Lambert C., LeBeau A., Lu S., Maurer J., Moore T., Ohara O., Park J., Rolfs A., Salehi-Ashtiani K., Seiler C., Simmons B., van Brabant Smith A., Steel J., Wagner L., Weaver T., Wellenreuther R., Yang S., Vidal M., Gerhard D. S., LaBaer J., Temple G., Hill D. E., (2016) The ORFeome Collaboration: a genome-scale human ORF-clone resource. Nat Methods, 13:191-192
link to online source - Thomas C., Sill M., Ruland V., Witten A., Hartung S., Kordes U., Jeibmann A., Beschorner R., Keyvani K., Bergmann M., Mittelbronn M., Pietsch T., Felsberg J., Monoranu C. M., Varlet P., Hauser P., Olar A., Grundy R. G., Wolff J. E., Korshunov A., Jones D. T., Bewerunge-Hudler M., Hovestadt V., von Deimling A., Pfister S. M., Paulus W., Capper D., Hasselblatt M., (2016) Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro Oncol, 18:790-6
link to online source - Worst B. C., van Tilburg C. M., Balasubramanian G. P., Fiesel P., Witt R., Freitag A., Boudalil M., Previti C., Wolf S., Schmidt S., Chotewutmontri S., Bewerunge-Hudler M., Schick M., Schlesner M., Hutter B., Taylor L., Borst T., Sutter C., Bartram C. R., Milde T., Pfaff E., Kulozik A. E., von Stackelberg A., Meisel R., Borkhardt A., Reinhardt D., Klusmann J. H., Fleischhack G., Tippelt S., Dirksen U., Jurgens H., Kramm C. M., von Bueren A. O., Westermann F., Fischer M., Burkhardt B., Wossmann W., Nathrath M., Bielack S. S., Fruhwald M. C., Fulda S., Klingebiel T., Koscielniak E., Schwab M., Tremmel R., Driever P. H., Schulte J. H., Brors B., von Deimling A., Lichter P., Eggert A., Capper D., Pfister S. M., Jones D. T., Witt O., (2016) Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study. Eur J Cancer, 65:91-101
link to online source - Wu C. F., Klauck S. M., Efferth T., (2016) Anticancer activity of cryptotanshinone on acute lymphoblastic leukemia cells. Arch Toxicol, 90:2275-86
link to online source - Wu C. F., Seo E. J., Klauck S. M., Efferth T., (2016) Cryptotanshinone deregulates unfolded protein response and eukaryotic initiation factor signaling in acute lymphoblastic leukemia cells. Phytomedicine, 23:174-80
link to online source - Abba M., Benner A., Patil N., Heil O., Allgayer H., (2015) Differentially expressed microRNAs in colorectal cancer metastasis. Genom Data, 6:33-5
link to online source - Alioto T. S., Buchhalter I., Derdak S., Hutter B., Eldridge M. D., Hovig E., Heisler L. E., Beck T. A., Simpson J. T., Tonon L., Sertier A. S., Patch A. M., Jager N., Ginsbach P., Drews R., Paramasivam N., Kabbe R., Chotewutmontri S., Diessl N., Previti C., Schmidt S., Brors B., Feuerbach L., Heinold M., Grobner S., Korshunov A., Tarpey P. S., Butler A. P., Hinton J., Jones D., Menzies A., Raine K., Shepherd R., Stebbings L., Teague J. W., Ribeca P., Giner F. C., Beltran S., Raineri E., Dabad M., Heath S. C., Gut M., Denroche R. E., Harding N. J., Yamaguchi T. N., Fujimoto A., Nakagawa H., Quesada V., Valdes-Mas R., Nakken S., Vodak D., Bower L., Lynch A. G., Anderson C. L., Waddell N., Pearson J. V., Grimmond S. M., Peto M., Spellman P., He M., Kandoth C., Lee S., Zhang J., Letourneau L., Ma S., Seth S., Torrents D., Xi L., Wheeler D. A., Lopez-Otin C., Campo E., Campbell P. J., Boutros P. C., Puente X. S., Gerhard D. S., Pfister S. M., McPherson J. D., Hudson T. J., Schlesner M., Lichter P., Eils R., Jones D. T., Gut I. G., (2015) A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. Nat Commun, 6:10001
link to online source - Bar S., Rommelaere J., Nuesch J. P., (2015) PKCeta/Rdx-driven phosphorylation of PDK1: a novel mechanism promoting cancer cell survival and permissiveness for parvovirus-induced lysis. PLoS Pathog, 11:e1004703
link to online source - Barrangou R., Birmingham A., Wiemann S., Beijersbergen R. L., Hornung V., Smith Av, (2015) Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference. Nucleic Acids Res, 43:3407-19
link to online source - Blume C. J., Hotz-Wagenblatt A., Hullein J., Sellner L., Jethwa A., Stolz T., Slabicki M., Lee K., Sharathchandra A., Benner A., Dietrich S., Oakes C. C., Dreger P., te Raa D., Kater A. P., Jauch A., Merkel O., Oren M., Hielscher T., Zenz T., (2015) p53-dependent non-coding RNA networks in chronic lymphocytic leukemia. Leukemia, 29:2015-23
link to online source - Cohen-Dvashi H., Ben-Chetrit N., Russell R., Carvalho S., Lauriola M., Nisani S., Mancini M., Nataraj N., Kedmi M., Roth L., Kostler W., Zeisel A., Yitzhaky A., Zylberg J., Tarcic G., Eilam R., Wigelman Y., Will R., Lavi S., Porat Z., Wiemann S., Ricardo S., Schmitt F., Caldas C., Yarden Y., (2015) Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression. EMBO Mol Med, 7:299-314
link to online source - Gu L., Frommel S. C., Oakes C. C., Simon R., Grupp K., Gerig C. Y., Bar D., Robinson M. D., Baer C., Weiss M., Gu Z., Schapira M., Kuner R., Sultmann H., Provenzano M., Icgc Project on Early Onset Prostate Cancer, Yaspo M. L., Brors B., Korbel J., Schlomm T., Sauter G., Eils R., Plass C., Santoro R., (2015) BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence. Nat Genet, 47:22-30
link to online source - Haller F., Bieg M., Moskalev E. A., Barthelmess S., Geddert H., Boltze C., Diessl N., Braumandl K., Brors B., Iro H., Hartmann A., Wiemann S., Agaimy A., (2015) Recurrent mutations within the amino-terminal region of beta-catenin are probable key molecular driver events in sinonasal hemangiopericytoma. Am J Pathol, 185:563-71
link to online source - Haller F., Zhang J. D., Moskalev E. A., Braun A., Otto C., Geddert H., Riazalhosseini Y., Ward A., Balwierz A., Schaefer I. M., Cameron S., Ghadimi B. M., Agaimy A., Fletcher J. A., Hoheisel J., Hartmann A., Werner M., Wiemann S., Sahin O., (2015) Combined DNA methylation and gene expression profiling in gastrointestinal stromal tumors reveals hypomethylation of SPP1 as an independent prognostic factor. Int J Cancer, 136:1013-23
link to online source - Keklikoglou I., Hosaka K., Bender C., Bott A., Koerner C., Mitra D., Will R., Woerner A., Muenstermann E., Wilhelm H., Cao Y., Wiemann S., (2015) MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes. Oncogene, 34:4867-78
link to online source - Koelsche C., Hovestadt V., Jones D. T., Capper D., Sturm D., Sahm F., Schrimpf D., Adeberg S., Bohmer K., Hagenlocher C., Mechtersheimer G., Kohlhof P., Muhleisen H., Beschorner R., Hartmann C., Braczynski A. K., Mittelbronn M., Buslei R., Becker A., Grote A., Urbach H., Staszewski O., Prinz M., Hewer E., Pfister S. M., von Deimling A., Reuss D. E., (2015) Melanotic tumors of the nervous system are characterized by distinct mutational, chromosomal and epigenomic profiles. Brain Pathol, 25:202-8
link to online source - Lei J., Osen W., Gardyan A., Hotz-Wagenblatt A., Wei G., Gissmann L., Eichmuller S., Lochelt M., (2015) Replication-Competent Foamy Virus Vaccine Vectors as Novel Epitope Scaffolds for Immunotherapy. PLoS One, 10:e0138458
link to online source - Pajtler K. W., Witt H., Sill M., Jones D. T., Hovestadt V., Kratochwil F., Wani K., Tatevossian R., Punchihewa C., Johann P., Reimand J., Warnatz H. J., Ryzhova M., Mack S., Ramaswamy V., Capper D., Schweizer L., Sieber L., Wittmann A., Huang Z., van Sluis P., Volckmann R., Koster J., Versteeg R., Fults D., Toledano H., Avigad S., Hoffman L. M., Donson A. M., Foreman N., Hewer E., Zitterbart K., Gilbert M., Armstrong T. S., Gupta N., Allen J. C., Karajannis M. A., Zagzag D., Hasselblatt M., Kulozik A. E., Witt O., Collins V. P., von Hoff K., Rutkowski S., Pietsch T., Bader G., Yaspo M. L., von Deimling A., Lichter P., Taylor M. D., Gilbertson R., Ellison D. W., Aldape K., Korshunov A., Kool M., Pfister S. M., (2015) Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups. Cancer Cell, 27:728-43
link to online source - Rattay K., Claude J., Rezavandy E., Matt S., Hofmann T. G., Kyewski B., Derbinski J., (2015) Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells. J Immunol, 194:921-8
link to online source - Reuss D. E., Sahm F., Schrimpf D., Wiestler B., Capper D., Koelsche C., Schweizer L., Korshunov A., Jones D. T., Hovestadt V., Mittelbronn M., Schittenhelm J., Herold-Mende C., Unterberg A., Platten M., Weller M., Wick W., Pfister S. M., von Deimling A., (2015) ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma. Acta Neuropathol, 129:133-46
link to online source - Rode I., Martins V. C., Kublbeck G., Maltry N., Tessmer C, Rodewald H. R., (2015) Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus. J Immunol, 195:5678-87
link to online source - Savant S., La Porta S., Budnik A., Busch K., Hu J., Tisch N., Korn C., Valls A. F., Benest A. V., Terhardt D., Qu X., Adams R. H., Baldwin H. S., Ruiz de Almodovar C., Rodewald H. R., Augustin H. G., (2015) The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell Rep, 12:1761-73
link to online source - Wegert J., Ishaque N., Vardapour R., Georg C., Gu Z., Bieg M., Ziegler B., Bausenwein S., Nourkami N., Ludwig N., Keller A., Grimm C., Kneitz S., Williams R. D., Chagtai T., Pritchard-Jones K., van Sluis P., Volckmann R., Koster J., Versteeg R., Acha T., O'Sullivan M. J., Bode P. K., Niggli F., Tytgat G. A., van Tinteren H., van den Heuvel-Eibrink M. M., Meese E., Vokuhl C., Leuschner I., Graf N., Eils R., Pfister S. M., Kool M., Gessler M., (2015) Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors. Cancer Cell, 27:298-311
link to online source - Wu C. F., Hong C., Klauck S. M., Lin Y. L., Efferth T., (2015) Molecular mechanisms of rosmarinic acid from Salvia miltiorrhiza in acute lymphoblastic leukemia cells. J Ethnopharmacol, 176:55-68
link to online source - Zhao Q., Assimopoulou A. N., Klauck S. M., Damianakos H., Chinou I., Kretschmer N., Rios J. L., Papageorgiou V. P., Bauer R., Efferth T., (2015) Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells. Oncotarget, 6:38934-51
link to online source - Zuckermann M., Hovestadt V., Knobbe-Thomsen C. B., Zapatka M., Northcott P. A., Schramm K., Belic J., Jones D. T., Tschida B., Moriarity B., Largaespada D., Roussel M. F., Korshunov A., Reifenberger G., Pfister S. M., Lichter P., Kawauchi D., Gronych J., (2015) Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling. Nat Commun, 6:7391
link to online source - Bergmann F., Aulmann S., Sipos B., Kloor M., von Heydebreck A., Schweipert J., Harjung A., Mayer P., Hartwig W., Moldenhauer G., Capper D., Dyckhoff G., Freier K., Herpel E., Schleider A., Schirmacher P., Mechtersheimer G., Kloppel G., Blaker H., (2014) Acinar cell carcinomas of the pancreas: a molecular analysis in a series of 57 cases. Virchows Arch, :
link to online source - Bretz N. P., Salnikov A. V., Doberstein K., Garbi N., Kloess V., Joumaa S., Naumov I., Boon L., Moldenhauer G., Arber N., Altevogt P., (2014) Lack of CD24 expression in mice reduces the number of leukocytes in the colon. Immunol Lett, 161:140-8
link to online source - Brocks D., Assenov Y., Minner S., Bogatyrova O., Simon R., Koop C., Oakes C., Zucknick M., Lipka D. B., Weischenfeldt J., Feuerbach L., Cowper-Sal Lari R., Lupien M., Brors B., Korbel J., Schlomm T., Tanay A., Sauter G., Gerhauser C., Plass C., Icgc Early Onset Prostate Cancer Project, (2014) Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer. Cell Rep, 8:798-806
link to online source - Diebolder P., Keller A., Haase S., Schlegelmilch A., Kiefer J. D., Karimi T., Weber T., Moldenhauer G., Kehm R., Eis-Hubinger A. M., Jager D., Federspil P. A., Herold-Mende C., Dyckhoff G., Kontermann R. E., Arndt M. A., Krauss J., (2014) Generation of "LYmph Node Derived Antibody Libraries" (LYNDAL) for selecting fully human antibody fragments with therapeutic potential. MAbs, 6:130-42
link to online source - Doberstein K., Harter P. N., Haberkorn U., Bretz N. P., Arnold B., Carretero R., Moldenhauer G., Mittelbronn M., Altevogt P., (2014) Antibody therapy to human L1CAM in a transgenic mouse model blocks local tumor growth but induces EMT. Int J Cancer, :
link to online source - Florath I., Butterbach K., Muller H., Bewerunge-Hudler M, Brenner H., (2014) Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites. Hum Mol Genet, 23:1186-201
link to online source - Fogel M., Harari A., Muller-Holzner E., Zeimet A. G., Moldenhauer G., Altevogt P., (2014) A standardized staining protocol for L1CAM on formalin-fixed, paraffin-embedded tissues using automated platforms. Int J Biol Markers, 29:e180-3
link to online source - Haberle V., Li N., Hadzhiev Y., Plessy C., Previti C, Nepal C., Gehrig J., Dong X., Akalin A., Suzuki A. M., van IJcken W. F., Armant O., Ferg M., Strahle U., Carninci P., Muller F., Lenhard B., (2014) Two independent transcription initiation codes overlap on vertebrate core promoters. Nature, 507:381-5
link to online source - Han J., Ono T., Uekusa H., Klika K. D., Soloshonok V. A., (2014) Substituent-controlled preference of carbonyl group-metal coordination in d(8) metal complexes with non-symmetric pentadentate ligands. Structural and stereochemical aspects. Dalton Trans, 43:5375-81
link to online source - Hauser R., Ceol A., Rajagopala S. V., Mosca R., Siszler G., Wermke N., Sikorski P., Schwarz F., Schick M., Wuchty S., Aloy P., Uetz P., (2014) A Second-generation Protein-Protein Interaction Network of Helicobacter pylori. Mol Cell Proteomics, :
link to online source - Heckmann D., Maier P., Laufs S., Li L., Sleeman J. P., Trunk M. J., Leupold J. H., Wenz F., Zeller W. J., Fruehauf S., Allgayer H., (2014) The disparate twins: a comparative study of CXCR4 and CXCR7 in SDF-1alpha-induced gene expression, invasion and chemosensitivity of colon cancer. Clin Cancer Res, 20:604-16
link to online source - Hein Z., Uchtenhagen H., Abualrous E. T., Saini S. K., Janssen L., Van Hateren A., Wiek C., Hanenberg H., Momburg F., Achour A., Elliott T., Springer S., Boulanger D., (2014) Peptide-independent stabilization of MHC class I molecules breaches cellular quality control. J Cell Sci, 127:2885-97
link to online source - Hovestadt V., Jones D. T., Picelli S., Wang W., Kool M., Northcott P. A., Sultan M., Stachurski K., Ryzhova M., Warnatz H. J., Ralser M., Brun S., Bunt J., Jager N., Kleinheinz K., Erkek S., Weber U. D., Bartholomae C. C., von Kalle C., Lawerenz C., Eils J., Koster J., Versteeg R., Milde T., Witt O., Schmidt S., Wolf S., Pietsch T., Rutkowski S., Scheurlen W., Taylor M. D., Brors B., Felsberg J., Reifenberger G., Borkhardt A., Lehrach H., Wechsler-Reya R. J., Eils R., Yaspo M. L., Landgraf P., Korshunov A., Zapatka M., Radlwimmer B., Pfister S. M., Lichter P., (2014) Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature, 510:537-41
link to online source - Kool M., Jones D. T., Jager N., Northcott P. A., Pugh T. J., Hovestadt V., Piro R. M., Esparza L. A., Markant S. L., Remke M., Milde T., Bourdeaut F., Ryzhova M., Sturm D., Pfaff E., Stark S., Hutter S., Seker-Cin H., Johann P., Bender S., Schmidt C., Rausch T., Shih D., Reimand J., Sieber L., Wittmann A., Linke L., Witt H., Weber U. D., Zapatka M., Konig R., Beroukhim R., Bergthold G., van Sluis P., Volckmann R., Koster J., Versteeg R., Schmidt S, Wolf S, Lawerenz C., Bartholomae C. C., von Kalle C., Unterberg A., Herold-Mende C., Hofer S., Kulozik A. E., von Deimling A., Scheurlen W., Felsberg J., Reifenberger G., Hasselblatt M., Crawford J. R., Grant G. A., Jabado N., Perry A., Cowdrey C., Croul S., Zadeh G., Korbel J. O., Doz F., Delattre O., Bader G. D., McCabe M. G., Collins V. P., Kieran M. W., Cho Y. J., Pomeroy S. L., Witt O., Brors B., Taylor M. D., Schuller U., Korshunov A., Eils R., Wechsler-Reya R. J., Lichter P., Pfister S. M., Icgc PedBrain Tumor Project, (2014) Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition. Cancer Cell, 25:393-405
link to online source - Mack S. C., Witt H., Piro R. M., Gu L., Zuyderduyn S., Stutz A. M., Wang X., Gallo M., Garzia L., Zayne K., Zhang X., Ramaswamy V., Jager N., Jones D. T., Sill M., Pugh T. J., Ryzhova M., Wani K. M., Shih D. J., Head R., Remke M., Bailey S. D., Zichner T., Faria C. C., Barszczyk M., Stark S., Seker-Cin H., Hutter S., Johann P., Bender S., Hovestadt V., Tzaridis T., Dubuc A. M., Northcott P. A., Peacock J., Bertrand K. C., Agnihotri S., Cavalli F. M., Clarke I., Nethery-Brokx K., Creasy C. L., Verma S. K., Koster J., Wu X., Yao Y., Milde T., Sin-Chan P., Zuccaro J., Lau L., Pereira S., Castelo-Branco P., Hirst M., Marra M. A., Roberts S. S., Fults D., Massimi L., Cho Y. J., Van Meter T., Grajkowska W., Lach B., Kulozik A. E., von Deimling A., Witt O., Scherer S. W., Fan X., Muraszko K. M., Kool M., Pomeroy S. L., Gupta N., Phillips J., Huang A., Tabori U., Hawkins C., Malkin D., Kongkham P. N., Weiss W. A., Jabado N., Rutka J. T., Bouffet E., Korbel J. O., Lupien M., Aldape K. D., Bader G. D., Eils R., Lichter P., Dirks P. B., Pfister S. M., Korshunov A., Taylor M. D., (2014) Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature, 506:445-50
link to online source - Neumann J., Boerries M., Kohler R., Giaisi M., Krammer P. H., Busch H., Li-Weber M., (2014) The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints. Int J Cancer, 134:1991-2002
link to online source - Northcott P. A., Lee C., Zichner T., Stutz A. M., Erkek S., Kawauchi D., Shih D. J., Hovestadt V., Zapatka M., Sturm D., Jones D. T., Kool M., Remke M., Cavalli F. M., Zuyderduyn S., Bader G. D., VandenBerg S., Esparza L. A., Ryzhova M., Wang W., Wittmann A., Stark S., Sieber L., Seker-Cin H., Linke L., Kratochwil F., Jager N., Buchhalter I., Imbusch C. D., Zipprich G., Raeder B., Schmidt S., Diessl N., Wolf S., Wiemann S., Brors B., Lawerenz C., Eils J., Warnatz H. J., Risch T., Yaspo M. L., Weber U. D., Bartholomae C. C., von Kalle C., Turanyi E., Hauser P., Sanden E., Darabi A., Siesjo P., Sterba J., Zitterbart K., Sumerauer D., van Sluis P., Versteeg R., Volckmann R., Koster J., Schuhmann M. U., Ebinger M., Grimes H. L., Robinson G. W., Gajjar A., Mynarek M., von Hoff K., Rutkowski S., Pietsch T., Scheurlen W., Felsberg J., Reifenberger G., Kulozik A. E., von Deimling A., Witt O., Eils R., Gilbertson R. J., Korshunov A., Taylor M. D., Lichter P., Korbel J. O., Wechsler-Reya R. J., Pfister S. M., (2014) Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature, 511:428-34
link to online source - Oakes C. C., Claus R., Gu L., Assenov Y., Hullein J., Zucknick M., Bieg M., Brocks D., Bogatyrova O., Schmidt C. R., Rassenti L., Kipps T. J., Mertens D., Lichter P., Dohner H., Stilgenbauer S., Byrd J. C., Zenz T., Plass C., (2014) Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia. Cancer Discov, 4:348-61
link to online source - Olins Ada L., Ishaque Naveed, Chotewutmontri Sasithorn, Langowski JĂśrg, Olins Donald E., (2014) Retrotransposon Alu is enriched in the epichromatin of HL-60 cells. Nucleus, 5:0-9
link to online source - Panjideh H., Muller G., Koch M., Wilde F., Scheu S., Moldenhauer G., Lipp M., (2014) Immunotherapy of B-cell non-Hodgkin lymphoma by targeting the chemokine receptor CXCR5 in a preclinical mouse model. Int J Cancer, 135:2623-32
link to online source - Rajagopala S. V., Sikorski P., Kumar A., Mosca R., Vlasblom J., Arnold R., Franca-Koh J., Pakala S. B., Phanse S., Ceol A., Hauser R., Siszler G., Wuchty S., Emili A., Babu M., Aloy P., Pieper R., Uetz P., (2014) The binary protein-protein interaction landscape of Escherichia coli. Nat Biotechnol, :
link to online source - Rappe U., Schlechter T., Aschoff M., Hotz-Wagenblatt A., Hofmann I., (2014) Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing. J Biol Chem, 289:12421-34
link to online source - Reuss D. E., Habel A., Hagenlocher C., Mucha J., Ackermann U., Tessmer C., Meyer J., Capper D., Moldenhauer G, Mautner V., Frappart P. O., Schittenhelm J., Hartmann C., Hagel C., Katenkamp K., Petersen I., Mechtersheimer G., von Deimling A., (2014) Neurofibromin specific antibody differentiates malignant peripheral nerve sheath tumors (MPNST) from other spindle cell neoplasms. Acta Neuropathol, 127:565-72
link to online source - Sahm F., Reuss D., Koelsche C., Capper D., Schittenhelm J., Heim S., Jones D. T., Pfister S. M., Herold-Mende C., Wick W., Mueller W., Hartmann C., Paulus W., von Deimling A., (2014) Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. Acta Neuropathol, 128:551-9
link to online source - Schlecker E., Fiegler N., Arnold A., Altevogt P., Rose-John S., Moldenhauer G., Sucker A., Paschen A., von Strandmann E. P., Textor S., Cerwenka A., (2014) Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30. Cancer Res, 74:3429-40
link to online source - Sturm D., Bender S., Jones D. T., Lichter P., Grill J., Becher O., Hawkins C., Majewski J., Jones C., Costello J. F., Iavarone A., Aldape K., Brennan C. W., Jabado N., Pfister S. M., (2014) Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nat Rev Cancer, 14:92-107
link to online source - Teif V. B., Beshnova D. A., Vainshtein Y., Marth C., Mallm J. P., Hofer T., Rippe K., (2014) Nucleosome repositioning links DNA (de)methylation and differential CTCF binding during stem cell development. Genome Res, :
link to online source - Weiler M., Blaes J., Pusch S., Sahm F., Czabanka M., Luger S., Bunse L., Solecki G., Eichwald V., Jugold M., Hodecker S., Osswald M., Meisner C., Hielscher T., Rubmann P., Pfenning P. N., Ronellenfitsch M., Kempf T., Schnolzer M., Abdollahi A., Lang F., Bendszus M., von Deimling A., Winkler F., Weller M., Vajkoczy P., Platten M., Wick W., (2014) mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy. Proc Natl Acad Sci U S A, 111:409-14
link to online source - Wick W., Fricke H., Junge K., Kobyakov G., Martens T., Heese O., Wiestler B., Schliesser M. G., von Deimling A., Pichler J., Vetlova E., Harting I., Debus J., Hartmann C., Kunz C., Platten M., Bendszus M., Combs S. E., (2014) A phase II, randomized, study of weekly APG101+reirradiation versus reirradiation in progressive glioblastoma. Clin Cancer Res, 20:6304-13
link to online source - Wiestler B., Capper D., Hovestadt V., Sill M., Jones D. T., Hartmann C., Felsberg J., Platten M., Feiden W., Keyvani K., Pfister S. M., Wiestler O. D., Meyermann R., Reifenberger G., Pietsch T., von Deimling A., Weller M., Wick W., (2014) Assessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial. Neuro Oncol, 16:1630-8
link to online source - Wiestler B., Capper D., Sill M., Jones D. T., Hovestadt V., Sturm D., Koelsche C., Bertoni A., Schweizer L., Korshunov A., Weiss E. K., Schliesser M. G., Radbruch A., Herold-Mende C., Roth P., Unterberg A., Hartmann C., Pietsch T., Reifenberger G., Lichter P., Radlwimmer B., Platten M., Pfister S. M., von Deimling A., Weller M., Wick W., (2014) Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma. Acta Neuropathol, 128:561-71
link to online source - Wojtalewicz N., Sadeqzadeh E., Weiss J. V., Tehrani M. M., Klein-Scory S., Hahn S., Schmiegel W., Warnken U., Schnolzer M., de Bock C. E., Thorne R. F., Schwarte-Waldhoff I., (2014) A Soluble Form of the Giant Cadherin Fat1 Is Released from Pancreatic Cancer Cells by ADAM10 Mediated Ectodomain Shedding. PLoS One, 9:e90461
link to online source - Ameta S., Winz M. L., Previti C., Jaschke A., (2013) Next-generation sequencing reveals how RNA catalysts evolve from random space. Nucleic Acids Res, :
link to online source - Aretz S., Krohne T. U., Kammerer K., Warnken U., Hotz-Wagenblatt A., Bergmann M., Stanzel B. V., Kempf T, Holz F. G., Schnolzer M., Kopitz J., (2013) In-depth mass spectrometric mapping of the human vitreous proteome. Proteome Sci, 11:22
link to online source - Bender S., Tang Y., Lindroth A. M., Hovestadt V., Jones D. T., Kool M., Zapatka M., Northcott P. A., Sturm D., Wang W., Radlwimmer B., Hojfeldt J. W., Truffaux N., Castel D., Schubert S., Ryzhova M., Seker-Cin H., Gronych J., Johann P. D., Stark S., Meyer J., Milde T., Schuhmann M., Ebinger M., Monoranu C. M., Ponnuswami A., Chen S., Jones C., Witt O., Collins V. P., von Deimling A., Jabado N., Puget S., Grill J., Helin K., Korshunov A., Lichter P., Monje M., Plass C., Cho Y. J., Pfister S. M., (2013) Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell, 24:660-72
link to online source - Beutler N., Hauka S., Niepel A., Kowalewski D. J., Uhlmann J., Ghanem E., Erkelenz S., Wiek C., Hanenberg H., Schaal H., Stevanovic S., Springer S., Momburg F., Hengel H., Halenius A., (2013) A natural tapasin isoform lacking exon 3 modifies peptide loading complex function. Eur J Immunol, 43:1459-69
link to online source - Blasche S., Koegl M., (2013) Analysis of Protein-Protein Interactions Using LUMIER Assays. Methods Mol Biol, 1064:17-27
link to online source - Blasche S., Mortl M., Steuber H., Siszler G., Nisa S., Schwarz F., Lavrik I., Gronewold T. M., Maskos K., Donnenberg M. S., Ullmann D., Uetz P., Kogl M., (2013) The E. coli effector protein NleF is a caspase inhibitor. PLoS One, 8:e58937
link to online source - Campbell K. L., Foster-Schubert K. E., Makar K. W., Kratz M., Hagman D., Schur E. A., Habermann N., Horton M., Abbenhardt C., Kuan L. Y., Xiao L., Davison J., Morgan M., Wang C. Y., Duggan C., McTiernan A., Ulrich C. M., (2013) Gene expression changes in adipose tissue with diet- and/or exercise-induced weight loss. Cancer Prev Res (Phila), 6:217-31
link to online source - Castro F., Dirks W. G., Fahnrich S., Hotz-Wagenblatt A., Pawlita M., Schmitt M., (2013) High-throughput SNP-based authentication of human cell lines. Int J Cancer, 132:308-14
link to online source - Dawlaty M. M., Breiling A., Le T., Raddatz G., Barrasa M. I., Cheng A. W., Gao Q., Powell B. E., Li Z., Xu M., Faull K. F., Lyko F., Jaenisch R., (2013) Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell, 24:310-23
link to online source - Djuika C. F., Fiedler S., Schnolzer M., Sanchez C., Lanzer M., Deponte M., (2013) Plasmodium falciparum antioxidant protein as a model enzyme for a special class of glutaredoxin/glutathione-dependent peroxiredoxins. Biochim Biophys Acta, 1830:4073-90
link to online source - Franke W. W., Heid H., Zimbelmann R., Kuhn C., Winter-Simanowski S., Dorflinger Y., Grund C., Rickelt S., (2013) Transmembrane protein PERP is a component of tessellate junctions and of other junctional and non-junctional plasma membrane regions in diverse epithelial and epithelium-derived cells. Cell Tissue Res, 353:99-115
link to online source - Haderk F., Hanna B., Richter K., Schnolzer M., Zenz T., Stilgenbauer S., Lichter P., Seiffert M., (2013) Extracellular vesicles in chronic lymphocytic leukemia. Leuk Lymphoma, 54:1826-30
link to online source - Heid H., Rickelt S., Zimbelmann R., Winter S., Schumacher H., Dorflinger Y., (2013) Lipid droplets, perilipins and cytokeratins--unravelled liaisons in epithelium-derived cells. PLoS One, 8:e63061
link to online source - Hovestadt V., Remke M., Kool M., Pietsch T., Northcott P. A., Fischer R., Cavalli F. M., Ramaswamy V., Zapatka M., Reifenberger G., Rutkowski S., Schick M., Bewerunge-Hudler M., Korshunov A., Lichter P., Taylor M. D., Pfister S. M., Jones D. T., (2013) Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays. Acta Neuropathol, 125:913-916
link to online source - Issa A., Gill J. W., Heideman M. R., Sahin O., Wiemann S., Dey J. H., Hynes N. E., (2013) Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models. Breast Cancer Res, 15:R8
link to online source - Jager N., Schlesner M., Jones D. T., Raffel S., Mallm J. P., Junge K. M., Weichenhan D., Bauer T., Ishaque N., Kool M., Northcott P. A., Korshunov A., Drews R. M., Koster J., Versteeg R., Richter J., Hummel M., Mack S. C., Taylor M. D., Witt H., Swartman B., Schulte-Bockholt D., Sultan M., Yaspo M. L., Lehrach H., Hutter B., Brors B., Wolf S., Plass C., Siebert R., Trumpp A., Rippe K., Lehmann I., Lichter P., Pfister S. M., Eils R., (2013) Hypermutation of the inactive X chromosome is a frequent event in cancer. Cell, 155:567-81
link to online source - Jones D. T., Hutter B., Jager N., Korshunov A., Kool M., Warnatz H. J., Zichner T., Lambert S. R., Ryzhova M., Quang D. A., Fontebasso A. M., Stutz A. M., Hutter S., Zuckermann M., Sturm D., Gronych J., Lasitschka B., Schmidt S., Seker-Cin H., Witt H., Sultan M., Ralser M., Northcott P. A., Hovestadt V., Bender S., Pfaff E., Stark S., Faury D., Schwartzentruber J., Majewski J., Weber U. D., Zapatka M., Raeder B., Schlesner M., Worth C. L., Bartholomae C. C., von Kalle C., Imbusch C. D., Radomski S., Lawerenz C., van Sluis P., Koster J., Volckmann R., Versteeg R., Lehrach H., Monoranu C., Winkler B., Unterberg A., Herold-Mende C., Milde T., Kulozik A. E., Ebinger M., Schuhmann M. U., Cho Y. J., Pomeroy S. L., von Deimling A., Witt O., Taylor M. D., Wolf S., Karajannis M. A., Eberhart C. G., Scheurlen W., Hasselblatt M., Ligon K. L., Kieran M. W., Korbel J. O., Yaspo M. L., Brors B., Felsberg J., Reifenberger G., Collins V. P., Jabado N., Eils R., Lichter P., Pfister S. M., International Cancer Genome Consortium PedBrain Tumor Project, (2013) Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet, 45:927-32
link to online source - Kaeppel C., Beattie S. G., Fronza R., van Logtenstein R., Salmon F., Schmidt S., Wolf S., Nowrouzi A., Glimm H., von Kalle C., Petry H., Gaudet D., Schmidt M., (2013) A largely random AAV integration profile after LPLD gene therapy. Nat Med, 19:889-91
link to online source - Klika K. D., (2013) Chiral Solid Solutions for the NMR Analysis of Enantiomers: A Potential New Approach to Chiral Analysis. Journal of Spectroscopy, 2013:
- Kuhns S., Schmidt K. N., Reymann J., Gilbert D. F., Neuner A., Hub B., Carvalho R., Wiedemann P., Zentgraf H., Erfle H., Klingmuller U., Boutros M., Pereira G., (2013) The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. J Cell Biol, 200:505-22
link to online source - Kuner R., Falth M., Pressinotti N. C., Brase J. C., Puig S. B., Metzger J., Gade S., Schafer G., Bartsch G., Steiner E., Klocker H., Sultmann H., (2013) The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer. J Mol Med (Berl), 91:237-48
link to online source - Li J., Bonifati S., Hristov G., Marttila T., Valmary-Degano S., Stanzel S., Schnolzer M., Mougin C., Aprahamian M., Grekova S. P., Raykov Z., Rommelaere J., Marchini A., (2013) Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas. EMBO Mol Med, 5:1537-55
link to online source - Luo C., Tetteh P. W., Merz P. R., Dickes E., Abukiwan A., Hotz-Wagenblatt A., Holland-Cunz S., Sinnberg T., Schittek B., Schadendorf D., Diederichs S., Eichmuller S. B., (2013) miR-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes. J Invest Dermatol, 133:768-75
link to online source - Mahmutefendic H., Zagorac G. B., Tomas M. I., Groettrup M., Momburg F., Lucin P., (2013) Endosomal trafficking of open Major Histocompatibility Class I conformers--implications for presentation of endocytosed antigens. Mol Immunol, 55:149-52
link to online source - Maier B., Kirsch M., Anderhub S., Zentgraf H., Kramer A., (2013) The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. Cell Cycle, 12:1457-71
link to online source - Mier W., Kramer S., Zitzmann S., Altmann A., Leotta K., Schierbaum U., Schnolzer M., Eisenhut M., Haberkorn U., (2013) PEGylation enables the specific tumor accumulation of a peptide identified by phage display. Org Biomol Chem, 11:2706-11
link to online source - Momburg F., Watzl C., Cerwenka A., (2013) NK cells--versatile tools for viral defense and cancer treatment. Eur J Immunol, 43:860-3
link to online source - Nepal C., Hadzhiev Y., Previti C., Haberle V., Li N., Takahashi H., Suzuki A. M., Sheng Y., Abdelhamid R. F., Anand S., Gehrig J., Akalin A., Kockx C. E., van der Sloot A. A., van Ijcken W. F., Armant O., Rastegar S., Watson C., Strahle U., Stupka E., Carninci P., Lenhard B., Muller F., (2013) Dynamic regulation of the transcription initiation landscape at single nucleotide resolution during vertebrate embryogenesis. Genome Res, 23:1938-50
link to online source - Popanda O., Seibold P., Nikolov I., Oakes C. C., Burwinkel B., Hausmann S., Flesch-Janys D., Plass C., Chang-Claude J., Schmezer P., (2013) Germline variants of base excision repair genes and breast cancer: A polymorphism in DNA polymerase gamma modifies gene expression and breast cancer risk. Int J Cancer, 132:55-62
link to online source - Renner M., Wolf T., Meyer H., Hartmann W., Penzel R., Ulrich A., Lehner B., Hovestadt V., Czwan E., Egerer G., Schmitt T., Alldinger I., Renker E. K., Ehemann V., Eils R., Wardelmann E., Buttner R., Lichter P., Brors B., Schirmacher P., Mechtersheimer G., (2013) Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas. Genome Biol, 14:r137
link to online source - Rieber N., Zapatka M., Lasitschka B., Jones D., Northcott P., Hutter B., Jager N., Kool M., Taylor M., Lichter P., Pfister S., Wolf S., Brors B., Eils R., (2013) Coverage bias and sensitivity of variant calling for four whole-genome sequencing technologies. PLoS One, 8:e66621
link to online source - Schroder S., Herker E., Itzen F., He D., Thomas S., Gilchrist D. A., Kaehlcke K., Cho S., Pollard K. S., Capra J. A., Schnolzer M., Cole P. A., Geyer M., Bruneau B. G., Adelman K., Ott M., (2013) Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell, 52:314-24
link to online source - Slavkovic Lukic D., Hotz-Wagenblatt A., Lei J., Rathe A. M., Muhle M., Denner J., Munk C., Lochelt M., (2013) Identification of the feline foamy virus Bet domain essential for APOBEC3 counteraction. Retrovirology, 10:76
link to online source - Swiersy A., Wiek C., Zentgraf H., Lindemann D., (2013) Characterization and manipulation of foamy virus membrane interactions. Cell Microbiol, 15:227-36
link to online source - Ucar O., Tykocinski L. O., Dooley J., Liston A., Kyewski B., (2013) An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression. Eur J Immunol, 43:1769-78
link to online source - Waldeck W., Mueller G., Glatting K. H., Hotz-Wagenblatt A., Diessl N., Chotewutmonti S., Langowski J., Semmler W., Wiessler M., Braun K., (2013) Spatial Localization of Genes Determined by Intranuclear DNA Fragmentation with the Fusion Proteins Lamin KRED and Histone KRED und Visible Light. Int J Med Sci, 10:1136-48
link to online source - Walluscheck D., Poehlmann A., Hartig R., Lendeckel U., Schonfeld P., Hotz-Wagenblatt A., Reissig K., Bajbouj K., Roessner A., Schneider-Stock R., (2013) ATF2 knockdown reinforces oxidative stress-induced apoptosis in TE7 cancer cells. J Cell Mol Med, :
link to online source - Wang Q., Gu L., Adey A., Radlwimmer B., Wang W., Hovestadt V., Bahr M., Wolf S., Shendure J., Eils R., Plass C., Weichenhan D., (2013) Tagmentation-based whole-genome bisulfite sequencing. Nat Protoc, 8:2022-32
link to online source - Ward A., Balwierz A., Zhang J. D., Kublbeck M., Pawitan Y., Hielscher T., Wiemann S., Sahin O., (2013) Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene, 32:1173-82
link to online source - Weischenfeldt J., Simon R., Feuerbach L., Schlangen K., Weichenhan D., Minner S., Wuttig D., Warnatz H. J., Stehr H., Rausch T., Jager N., Gu L., Bogatyrova O., Stutz A. M., Claus R., Eils J., Eils R., Gerhauser C., Huang P. H., Hutter B., Kabbe R., Lawerenz C., Radomski S., Bartholomae C. C., Falth M., Gade S., Schmidt M., Amschler N., Hass T., Galal R., Gjoni J., Kuner R., Baer C., Masser S., von Kalle C., Zichner T., Benes V., Raeder B., Mader M., Amstislavskiy V., Avci M., Lehrach H., Parkhomchuk D., Sultan M., Burkhardt L., Graefen M., Huland H., Kluth M., Krohn A., Sirma H., Stumm L., Steurer S., Grupp K., Sultmann H., Sauter G., Plass C., Brors B., Yaspo M. L., Korbel J. O., Schlomm T., (2013) Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell, 23:159-70
link to online source - Weyd H., Abeler-Dorner L., Linke B., Mahr A., Jahndel V., Pfrang S., Schnolzer M., Falk C. S., Krammer P. H., (2013) Annexin A1 on the surface of early apoptotic cells suppresses CD8+ T cell immunity. PLoS One, 8:e62449
link to online source - Winter J., Link S., Witzigmann D., Hildenbrand C., Previti C., Diederichs S., (2013) Loop-miRs: active microRNAs generated from single-stranded loop regions. Nucleic Acids Res, 41:5503-12
link to online source - Xu B., Chotewutmontri S., Wolf S., Klos U., Schmitz M., Durst M., Schwarz E., (2013) Multiplex Identification of Human Papillomavirus 16 DNA Integration Sites in Cervical Carcinomas. PLoS One, 8:e66693
link to online source - Zeisel A., Yitzhaky A., Koerner C., Lauriola M., Cohen-Dvashi H., Kostler W. J., Yarden Y., Wiemann S., Domany E., (2013) qCMA: a desktop application for quantitative collective cell migration analysis. J Biomol Screen, 18:356-60
link to online source - Zhu Z. L., Yan B. Y., Zhang Y., Yang Y. H., Wang M. W., Zentgraf H., Zhang X. H., Sun X. F., (2013) Overexpression of FXYD-3 is involved in the tumorigenesis and development of esophageal squamous cell carcinoma. Dis Markers, 35:195-202
link to online source - von Bauer R., Oikonomou D., Sulaj A., Mohammed S., Hotz-Wagenblatt A, Grone H. J., Arnold B., Falk C., Luethje D., Erhardt A., Stern D. M., Bierhaus A., Nawroth P. P., (2013) CD166/ALCAM Mediates Proinflammatory Effects of S100B in Delayed Type Hypersensitivity. J Immunol, 191:369-77
link to online source - Abba M., Laufs S., Aghajany M., Korn B., Benner A., Allgayer H., (2012) Look who's talking: deregulated signaling in colorectal cancer. Cancer Genomics Proteomics, 9:15-25
link to online source - Adelmann K., Frey D., Riedl E., Koeppel H., Pfister F., Peters V., Schmitt C. P., Sternik P., Hofmann S., Zentgraf H. W., Navis G., van den Born J., Bakker S. J., Kramer B. K., Yard B. A., Hauske S. J., (2012) Different conformational forms of serum carnosinase detected by a newly developed sandwich ELISA for the measurements of carnosinase concentrations. Amino Acids, 43:143-51
link to online source - Bahtz R., Seidler J., Arnold M., Haselmann-Weiss U., Antony C., Lehmann W. D., Hoffmann I., (2012) GCP6 is a substrate of Plk4 and required for centriole duplication. J Cell Sci, 125:486-96
link to online source - Balasubramanian P. G., Beckmann A., Warnken U., Schnolzer M., Schuler A., Bornberg-Bauer E., Holstein T. W., Ozbek S., (2012) Proteome of Hydra nematocyst. J Biol Chem, 287:9672-81
link to online source - Batra R., Harder N., Gogolin S., Diessl N., Soons Z., Jager-Schmidt C., Lawerenz C., Eils R., Rohr K., Westermann F., Konig R., (2012) Time-lapse imaging of neuroblastoma cells to determine cell fate upon gene knockdown. PLoS One, 7:e50988
link to online source - Bierhaus A., Fleming T., Stoyanov S., Leffler A., Babes A., Neacsu C., Sauer S. K., Eberhardt M., Schnolzer M., Lasitschka F., Neuhuber W. L., Kichko T. I., Konrade I., Elvert R., Mier W., Pirags V., Lukic I. K., Morcos M., Dehmer T., Rabbani N., Thornalley P. J., Edelstein D., Nau C., Forbes J., Humpert P. M., Schwaninger M., Ziegler D., Stern D. M., Cooper M. E., Haberkorn U., Brownlee M., Reeh P. W., Nawroth P. P., (2012) Methylglyoxal modification of Na(v)1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nat Med, 18:926-33
link to online source - Blauenburg B., Metsä-Ketelä M., Klika K. D., (2012) Formation of 5-Hydroxy-3-methoxy-1,4-naphthoquinone and 8-Hydroxy-4-methoxy-1,2-naphthoquinone from Juglone. ISRN Organic Chemistry, 2012:Article ID 274980
- Bocker M. T., Tuorto F., Raddatz G., Musch T., Yang F. C., Xu M., Lyko F., Breiling A., (2012) Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster. Nat Commun, 3:818
link to online source - Bretz N. P., Salnikov A. V., Perne C., Keller S., Wang X., Mierke C. T., Fogel M., Erbe-Hofmann N., Schlange T., Moldenhauer G., Altevogt P., (2012) CD24 controls Src/STAT3 activity in human tumors. Cell Mol Life Sci, 69:3863-79
link to online source - Bretz N., Noske A., Keller S., Erbe-Hofmann N., Schlange T., Salnikov A. V., Moldenhauer G., Kristiansen G., Altevogt P., (2012) CD24 promotes tumor cell invasion by suppressing tissue factor pathway inhibitor-2 (TFPI-2) in a c-Src-dependent fashion. Clin Exp Metastasis, 29:27-38
link to online source - Brodde A., Teigler A., Brugger B., Lehmann W. D., Wieland F., Berger J., Just W. W., (2012) Impaired neurotransmission in ether lipid-deficient nerve terminals. Hum Mol Genet, 21:2713-24
link to online source - Bronneke S., Bruckner B., Peters N., Bosch T. C., Stab F., Wenck H., Hagemann S., Winnefeld M., (2012) DNA methylation regulates lineage-specifying genes in primary lymphatic and blood endothelial cells. Angiogenesis, 15:317-29
link to online source - Campa D., Butterbach K., Slager S. L., Skibola C. F., de Sanjose S., Benavente Y., Becker N., Foretova L., Maynadie M., Cocco P., Staines A., Kaaks R., Boffetta P., Brennan P., Conde L., Bracci P. M., Caporaso N. E., Strom S. S., Camp N. J., Cerhan J. R., Consortium G., Canzian F., Nieters A., (2012) A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk. Int J Cancer, 131:803-12
link to online source - Dolnik A., Engelmann J. C., Scharfenberger-Schmeer M., Mauch J., Kelkenberg-Schade S., Haldemann B., Fries T., Kronke J., Kuhn M. W., Paschka P., Kayser S., Wolf S., Gaidzik V. I., Schlenk R. F., Rucker F. G., Dohner H., Lottaz C., Dohner K., Bullinger L., (2012) Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing. Blood, 120:e83-92
link to online source - Eichhorn T., Schloissnig S., Hahn B., Wendler A., Mertens R., Lehmann W. D., Krauth-Siegel R. L., Efferth T., (2012) Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells. Mol Biosyst, 8:1311-8
link to online source - Forster F., Beisser D., Grohme M. A., Liang C., Mali B., Siegl A. M., Engelmann J. C., Shkumatov A. V., Schokraie E., Muller T., Schnolzer M., Schill R. O., Frohme M., Dandekar T., (2012) Transcriptome analysis in tardigrade species reveals specific molecular pathways for stress adaptations. Bioinform Biol Insights, 6:69-96
link to online source - Fredebohm J., Boettcher M., Eisen C., Gaida M. M., Heller A., Keleg S., Tost J., Greulich-Bode K. M., Hotz-Wagenblatt A., Lathrop M., Giese N. A., Hoheisel J. D., (2012) Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system. PLoS One, 7:e48503
link to online source - Groth A., Salnikov A. V., Ottinger S., Gladkich J., Liu L., Kallifatidis G., Salnikova O., Ryschich E., Giese N., Giese T., Momburg F., Buchler M. W., Moldenhauer G., Herr I., (2012) New gene-immunotherapy combining TRAIL-lymphocytes and EpCAMxCD3 Bispecific antibody for tumor targeting. Clin Cancer Res, 18:1028-38
link to online source - Hagemann S., Kuck D., Stresemann C., Prinz F., Brueckner B., Mund C., Mumberg D., Sommer A., (2012) Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation. PLoS One, 7:e36125
link to online source - Hauser R., Pech M., Kijek J., Yamamoto H., Titz B., Naeve F., Tovchigrechko A., Yamamoto K., Szaflarski W., Takeuchi N., Stellberger T., Diefenbacher M. E., Nierhaus K. H., Uetz P., (2012) RsfA (YbeB) proteins are conserved ribosomal silencing factors. PLoS Genet, 8:e1002815
link to online source - Herr I., Groth A., Salnikov A. V., Buchler M. W., Moldenhauer G., (2012) Combining forces to hit cancer stem cells: TRAIL-lymphocytes and EpCAMxCD3 bispecific antibody show efficacy against pancreatic cancer. Oncoimmunology, 1:741-743
link to online source - Jones D. T., Jager N., Kool M., Zichner T., Hutter B., Sultan M., Cho Y. J., Pugh T. J., Hovestadt V., Stutz A. M., Rausch T., Warnatz H. J., Ryzhova M., Bender S., Sturm D., Pleier S., Cin H., Pfaff E., Sieber L., Wittmann A., Remke M., Witt H., Hutter S., Tzaridis T., Weischenfeldt J., Raeder B., Avci M., Amstislavskiy V., Zapatka M., Weber U. D., Wang Q., Lasitschka B., Bartholomae C. C., Schmidt M., von Kalle C., Ast V., Lawerenz C., Eils J., Kabbe R., Benes V., van Sluis P., Koster J., Volckmann R., Shih D., Betts M. J., Russell R. B., Coco S., Tonini G. P., Schuller U., Hans V., Graf N., Kim Y. J., Monoranu C., Roggendorf W., Unterberg A., Herold-Mende C., Milde T., Kulozik A. E., von Deimling A., Witt O., Maass E., Rossler J., Ebinger M., Schuhmann M. U., Fruhwald M. C., Hasselblatt M., Jabado N., Rutkowski S., von Bueren A. O., Williamson D., Clifford S. C., McCabe M. G., Collins V. P., Wolf S., Wiemann S., Lehrach H., Brors B., Scheurlen W., Felsberg J., Reifenberger G., Northcott P. A., Taylor M. D., Meyerson M., Pomeroy S. L., Yaspo M. L., Korbel J. O., Korshunov A., Eils R., Pfister S. M., Lichter P., (2012) Dissecting the genomic complexity underlying medulloblastoma. Nature, 488:100-5
link to online source - Jurmeister S., Baumann M., Balwierz A., Keklikoglou I., Ward A., Uhlmann S., Zhang J. D., Wiemann S., Sahin O., (2012) MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F. Mol Cell Biol, 32:633-51
link to online source - Keklikoglou I., Koerner C., Schmidt C., Zhang J. D., Heckmann D., Shavinskaya A., Allgayer H., Guckel B., Fehm T., Schneeweiss A., Sahin O., Wiemann S., Tschulena U., (2012) MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-kappaB and TGF-beta signaling pathways. Oncogene, 31:4150-63
link to online source - Klika K. D., (2012) Application of the PROJECT concept for suppression of J modulation to DEPT for 13C-multilabeled analytes. Org Lett, 14:524-7
link to online source - Klika K. D., (2012) Suggested New Terms for Describing Chiral States and the State-Dependent Behavior of Chiral Systems. International Journal of Organic Chemistry, 2:224-32
- Klika K. D., (2012) Differentiation Between 6- and 7-Membered Rings Based on Theoretical Calculation of NMR Parameters. ISRN Spectroscopy, 2012:Article 697156
- Klika K. D., Tähtinen P., Mäntsälä P., Niemi J., Metsä-Ketelä M., (2012) The potential of VCD to resolve the epimer vs. inverse epimer quandary. Computational and Theoretical Chemistry, 992:156-163
- Koch C. M., Joussen S., Schellenberg A., Lin Q., Zenke M., Wagner W., (2012) Monitoring of cellular senescence by DNA-methylation at specific CpG sites. Aging Cell, 11:366-9
link to online source - Koch C. M., Reck K., Shao K., Lin Q., Joussen S., Ziegler P., Walenda G., Drescher W., Opalka B., May T., Brummendorf T. H., Zenke M., Saric T., Wagner W., (2012) Pluripotent stem cells escape from senescence-associated DNA methylation changes. Genome Res, 23:248-59
link to online source - Kwon H. S., Lim H. W., Wu J., Schnolzer M., Verdin E., Ott M., (2012) Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol, 188:2712-21
link to online source - Lemke D., Pfenning P. N., Sahm F., Klein A. C., Kempf T., Warnken U., Schnolzer M., Tudoran R., Weller M., Platten M., Wick W., (2012) Costimulatory protein 4IgB7H3 drives the malignant phenotype of glioblastoma by mediating immune escape and invasiveness. Clin Cancer Res, 18:105-17
link to online source - Marme F., Werft W., Walter A., Keller S., Wang X., Benner A., Burwinkel B., Sinn P., Hug S., Sohn C., Bretz N., Moldenhauer G., Rupp C., Rupp A. K., Biakhov M. Y., Bottini A., Friedrichs K., Khailenko V. A., Manikhas G. M., Ruiz A., Sanchez-Rovira P., Santoro A., Segui M. A., Villena C., Lichter P., Kristiansen G., Altevogt P., Schneeweiss A., (2012) CD24 Ala57Val polymorphism predicts pathologic complete response to sequential anthracycline- and taxane-based neoadjuvant chemotherapy for primary breast cancer. Breast Cancer Res Treat, 132:819-31
link to online source - Mohr K., Koegl M., (2012) High-throughput yeast two-hybrid screening of complex cDNA libraries. Methods Mol Biol, 812:89-102
link to online source - Moldenhauer G., Salnikov A. V., Luttgau S., Herr I., Anderl J., Faulstich H., (2012) Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule monoclonal antibody against pancreatic carcinoma. J Natl Cancer Inst, 104:622-34
link to online source - Oja T., Tähtinen P., Dreiack N., Mäntsälä P., Niemi J., Metsä-Ketelä M., Klika K. D., (2012) Alnumycins A2 and A3: new inverse-epimeric pairs stereoisomeric to alnumycin A1. Tetrahedron-Asymmetry, 23:670-682
- Ott M. G., Marme F., Moldenhauer G., Lindhofer H., Hennig M., Spannagl R., Essing M. M., Linke R., Seimetz D., (2012) Humoral response to catumaxomab correlates with clinical outcome: results of the pivotal phase II/III study in patients with malignant ascites. Int J Cancer, 130:2195-203
link to online source - Palani S., Meitinger F., Boehm M. E., Lehmann W. D., Pereira G., (2012) Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation. J Cell Sci, 125:3091-6
link to online source - Patrikainen P., Kallio P., Fan K., Klika K. D., Shaaban K. A., Mäntsälä P., Rohr J., Yang K., Niemi J., Metsä-Ketelä M., (2012) Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities. Chem Biol, 19:647-55
link to online source - Pieperhoff S., Rickelt S., Heid H., Claycomb W. C., Zimbelmann R., Kuhn C., Winter-Simanowski S., Kuhn C., Frey N., Franke W. W., (2012) The plaque protein myozap identified as a novel major component of adhering junctions in endothelia of the blood and the lymph vascular systems. J Cell Mol Med, 16:1709-19
link to online source - Pipkorn R., Wiessler M., Waldeck W., Hennrich U., Nokihara K., Beining M., Braun K., (2012) Improved synthesis strategy for peptide nucleic acids (PNA) appropriate for cell-specific fluorescence imaging. Int J Med Sci, 9:1-10
link to online source - Raddatz G., Gao Q., Bender S., Jaenisch R., Lyko F., (2012) Dnmt3a protects active chromosome domains against cancer-associated hypomethylation. PLoS Genet, 8:e1003146
link to online source - Rausch V., Liu L., Apel A., Rettig T., Gladkich J., Labsch S., Kallifatidis G., Kaczorowski A., Groth A., Gross W., Gebhard M. M., Schemmer P., Werner J., Salnikov A. V., Zentgraf H., Buchler M. W., Herr I., (2012) Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment. J Pathol, 227:325-35
link to online source - Salnikov A. V., Liu L., Platen M., Gladkich J., Salnikova O., Ryschich E., Mattern J., Moldenhauer G., Werner J., Schemmer P., Buchler M. W., Herr I., (2012) Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential. PLoS One, 7:e46391
link to online source - Schafer H., Geismann C., Heneweer C., Egberts J. H., Korniienko O., Kiefel H., Moldenhauer G., Bachem M. G., Kalthoff H., Altevogt P., Sebens S., (2012) Myofibroblast-induced tumorigenicity of pancreatic ductal epithelial cells is L1CAM dependent. Carcinogenesis, 33:84-93
link to online source - Schleich K., Warnken U., Fricker N., Ozturk S., Richter P., Kammerer K., Schnolzer M., Krammer P. H., Lavrik I. N., (2012) Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model. Mol Cell, 47:306-19
link to online source - Schmetzer O., Moldenhauer G., Nicolaou A., Schlag P., Riesenberg R., Pezzutto A., (2012) Detection of circulating tumor-associated antigen depends on the domains recognized by the monoclonal antibodies used: N-terminal trimmed EpCAM-levels are much higher than untrimmed forms. Immunol Lett, 143:184-92
link to online source - Schmidt K. N., Kuhns S., Neuner A., Hub B., Zentgraf H, Pereira G., (2012) Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis. J Cell Biol, 199:1083-101
link to online source - Schokraie E., Warnken U., Hotz-Wagenblatt A., Grohme M. A., Hengherr S., Forster F., Schill R. O., Frohme M., Dandekar T., Schnolzer M., (2012) Comparative proteome analysis of Milnesium tardigradum in early embryonic state versus adults in active and anhydrobiotic state. PLoS One, 7:e45682
link to online source - Schroder S., Cho S., Zeng L., Zhang Q., Kaehlcke K., Mak L., Lau J., Bisgrove D., Schnolzer M., Verdin E., Zhou M. M., Ott M., (2012) Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem, 287:1090-9
link to online source - Shamu C. E., Wiemann S., Boutros M., (2012) On target: a public repository for large-scale RNAi experiments. Nat Cell Biol, 14:115
link to online source - Shao K., Koch C., Gupta M. K., Lin Q., Lenz M., Laufs S., Denecke B., Schmidt M., Linke M., Hennies H. C., Hescheler J., Zenke M., Zechner U., Saric T., Wagner W., (2012) Induced Pluripotent Mesenchymal Stromal Cell Clones Retain Donor-derived Differences in DNA Methylation Profiles. Mol Ther, 21:240-50
link to online source - Simpson J. C., Joggerst B., Laketa V., Verissimo F., Cetin C., Erfle H., Bexiga M. G., Singan V. R., Heriche J. K., Neumann B., Mateos A., Blake J., Bechtel S., Benes V., Wiemann S., Ellenberg J., Pepperkok R., (2012) Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Nat Cell Biol, 14:764-74
link to online source - Spaich S., Will R. D., Just S., Spaich S., Kuhn C., Frank D., Berger I.M., Wiemann S., Korn B., Koegl M., Backs J., Katus H. A., Rottbauer W., Frey N., (2012) Fbxl22, A Cardiac-Enriched F-Box Protein, Regulates Sarcomeric Protein Turnover and is Essential for Maintenance of Contractile Function In Vivo. Circ Res, 111:Epub ahead of print
link to online source - Sturm D., Witt H., Hovestadt V., Khuong-Quang D. A., Jones D. T., Konermann C., Pfaff E., Tonjes M., Sill M., Bender S., Kool M., Zapatka M., Becker N., Zucknick M., Hielscher T., Liu X. Y., Fontebasso A. M., Ryzhova M., Albrecht S., Jacob K., Wolter M., Ebinger M., Schuhmann M. U., van Meter T., Fruhwald M. C., Hauch H., Pekrun A., Radlwimmer B., Niehues T., von Komorowski G., Durken M., Kulozik A. E., Madden J., Donson A., Foreman N. K., Drissi R., Fouladi M., Scheurlen W., von Deimling A., Monoranu C., Roggendorf W., Herold-Mende C., Unterberg A., Kramm C. M., Felsberg J., Hartmann C., Wiestler B., Wick W., Milde T., Witt O., Lindroth A. M., Schwartzentruber J., Faury D., Fleming A., Zakrzewska M., Liberski P. P., Zakrzewski K., Hauser P., Garami M., Klekner A., Bognar L., Morrissy S., Cavalli F., Taylor M. D., van Sluis P., Koster J., Versteeg R., Volckmann R., Mikkelsen T., Aldape K., Reifenberger G., Collins V. P., Majewski J., Korshunov A., Lichter P., Plass C., Jabado N., Pfister S. M., (2012) Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell, 22:425-37
link to online source - Teif V. B., Vainshtein Y., Caudron-Herger M., Mallm J. P., Marth C., Hofer T., Rippe K., (2012) Genome-wide nucleosome positioning during embryonic stem cell development. Nat Struct Mol Biol, 19:1185-92
link to online source - Tähtinen P., Oja T., Dreiack N., Mäntsälä P., Niemi J., Metsä-Ketelä M., Klika K. D., (2012) Epimers vs. inverse epimers: the C-1 configuration in alnumycin A1. Rsc Advances, 2:5098-5100
- Uhlmann S., Mannsperger H., Zhang J. D., Horvat E. A., Schmidt C., Kublbeck M., Henjes F., Ward A., Tschulena U., Zweig K., Korf U., Wiemann S., Sahin O., (2012) Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer. Mol Syst Biol, 8:570
link to online source - Vulprecht J., David A., Tibelius A., Castiel A., Konotop G., Liu F., Bestvater F., Raab M. S., Zentgraf H., Izraeli S., Kramer A., (2012) STIL is required for centriole duplication in human cells. J Cell Sci, 125:1353-62
link to online source - Winnefeld M., Brueckner B., Gronniger E., Stab F., Wenck H., Lyko F., (2012) Stable ethnic variations in DNA methylation patterns of human skin. J Invest Dermatol, 132:466-8
link to online source - Adamczyk K. A., Klein-Scory S., Tehrani M. M., Warnken U., Schmiegel W., Schnolzer M., Schwarte-Waldhoff I., (2011) Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells. Life Sci, 89:304-12
link to online source - Amann P. M., Schadendorf D., Owen R. W., Korn B., Eichmuller S. B., Bazhin A. V., (2011) Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT. Exp Dermatol, 20:373-5
link to online source - Bachmann J., Raue A., Schilling M., Bohm M. E., Kreutz C., Kaschek D., Busch H., Gretz N., Lehmann W. D., Timmer J., Klingmuller U., (2011) Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Mol Syst Biol, 7:516
link to online source - Bai S.W., Herrera-Abreu M.T., Rohn J., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J., (2011) A novel strategy to identify and characterize a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. BMC Biology, 9:54
link to online source - Bartholomae C. C., Arens A., Balaggan K. S., Yanez-Munoz R. J., Montini E., Howe S. J., Paruzynski A., Korn B., Appelt J. U., Macneil A., Cesana D., Abel U., Glimm H., Naldini L., Ali R. R., Thrasher A. J., von Kalle C., Schmidt M., (2011) Lentiviral vector integration profiles differ in rodent postmitotic tissues. Mol Ther, 19:703-10
link to online source - Bender C., Heyde S., Henjes F., Wiemann S., Korf U., Beissbarth T., (2011) Inferring signalling networks from longitudinal data using sampling based approaches in the R-package 'ddepn'. BMC Bioinformatics, 12:291
link to online source - Blomberg J., Sheikholvaezin A., Elfaitouri A., Blomberg F., Sjosten A., Mattson Ulfstedt J., Pipkorn R., Kallander C., Ohrmalm C., Sperber G., (2011) Phylogeny-directed search for murine leukemia virus-like retroviruses in vertebrate genomes and in patients suffering from myalgic encephalomyelitis/chronic fatigue syndrome and prostate cancer. Adv Virol, 2011:341294
link to online source - Bocker M. T., Hellwig I., Breiling A., Eckstein V., Ho A. D., Lyko F., (2011) Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging. Blood, 117:e182-9
link to online source - Breitling L. P., Yang R., Korn B., Burwinkel B., Brenner H., (2011) Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet, 88:450-7
link to online source - Campa D., Husing A., Stein A., Dostal L., Boeing H., Pischon T., Tjonneland A., Roswall N., Overvad K., Ostergaard J. N., Rodriguez L., Sala N., Sanchez M. J., Larranaga N., Huerta J. M., Barricarte A., Khaw K. T., Wareham N., Travis R. C., Allen N. E., Lagiou P., Trichopoulou A., Trichopoulos D., Palli D., Sieri S., Tumino R., Sacerdote C., van Kranen H., Bueno-de-Mesquita H. B., Hallmans G., Johansson M., Romieu I., Jenab M., Cox D. G., Siddiq A., Riboli E., Canzian F., Kaaks R., (2011) Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). PLoS One, 6:e16914
link to online source - Capper D., Preusser M., Habel A., Sahm F., Ackermann U., Schindler G., Pusch S., Mechtersheimer G., Zentgraf H., von Deimling A., (2011) Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol, 122:11-9
link to online source - Chiocchetti A., Pakalapati G., Duketis E., Wiemann S., Poustka A., Poustka F., Klauck S. M., (2011) Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder. Am J Med Genet A, 155A:1472-5
link to online source - Dafinger C., Liebau M. C., Elsayed S. M., Hellenbroich Y., Boltshauser E., Korenke G. C., Fabretti F., Janecke A. R., Ebermann I., Nurnberg G., Nurnberg P., Zentgraf H., Koerber F., Addicks K., Elsobky E., Benzing T., Schermer B., Bolz H. J., (2011) Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics. J Clin Invest, 121:2662-7
link to online source - Edelson-Averbukh M., Shevchenko A., Pipkorn R., Lehmann W. D., (2011) Discrimination between peptide O-sulfo- and O-phosphotyrosine residues by negative ion mode electrospray tandem mass spectrometry. J Am Soc Mass Spectrom, 22:2256-68
link to online source - Faber K., Glatting K. H., Mueller P. J., Risch A., Hotz-Wagenblatt A., (2011) Genome-wide prediction of splice-modifying SNPs in human genes using a new analysis pipeline called AASsites. BMC Bioinformatics, 12 Suppl 4:S2
link to online source - Felix K., Fakelman F., Hartmann D., Giese N. A., Gaida M. M., Schnolzer M., Flad T., Buchler M. W., Werner J., (2011) Identification of serum proteins involved in pancreatic cancer cachexia. Life Sci, 88:218-25
link to online source - Feyerabend T. B., Weiser A., Tietz A., Stassen M., Harris N., Kopf M., Radermacher P., Moller P., Benoist C., Mathis D., Fehling H. J., Rodewald H. R., (2011) Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity. Immunity, 35:832-44
link to online source - Gabriel R., Lombardo A., Arens A., Miller J. C., Genovese P., Kaeppel C., Nowrouzi A., Bartholomae C. C., Wang J., Friedman G., Holmes M. C., Gregory P. D., Glimm H., Schmidt M., Naldini L., von Kalle C., (2011) An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat Biotechnol, 29:816-23
link to online source - Giordano F. A., Sorg U. R., Appelt J. U., Lachmann N., Bleier S., Roeder I., Kleff V., Flasshove M., Zeller W. J., Allgayer H., von Kalle C., Fruehauf S., Moritz T., Laufs S., (2011) Clonal inventory screens uncover monoclonality following serial transplantation of MGMT P140K-transduced stem cells and dose-intense chemotherapy. Hum Gene Ther, 22:697-710
link to online source - Hagemann S., Heil O., Lyko F., Brueckner B., (2011) Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines. PLoS One, 6:e17388
link to online source - Hahn B., Bohm M., Raia V., Zinn N., Moller P., Klingmuller U., Lehmann W. D., (2011) One-source peptide/phosphopeptide standards for accurate phosphorylation degree determination. Proteomics, 11:490-4
link to online source - Hoffmann S. C., Wabnitz G. H., Samstag Y., Moldenhauer G., Ludwig T., (2011) Functional analysis of bispecific antibody (EpCAMxCD3)-mediated T-lymphocyte and cancer cell interaction by single-cell force spectroscopy. Int J Cancer, 128:2096-104
link to online source - Hotz-Wagenblatt A., Kats I. , Scharfenberger-Schmeer M., Haldemann B., Glatting K., (2011) Ontarget: A tool for analysing enrichment data derived from next generation sequencing.. IEEE Explore, 11th International Conference on Intelligent Systems Design and Applications (ISDA):873-876
link to online source - Kalay E., Yigit G., Aslan Y., Brown K. E., Pohl E., Bicknell L. S., Kayserili H., Li Y., Tuysuz B., Nurnberg G., Kiess W., Koegl M., Baessmann I., Buruk K., Toraman B., Kayipmaz S., Kul S., Ikbal M., Turner D. J., Taylor M. S., Aerts J., Scott C., Milstein K., Dollfus H., Wieczorek D., Brunner H. G., Hurles M., Jackson A. P., Rauch A., Nurnberg P., Karaguzel A., Wollnik B., (2011) CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Nat Genet, 43:23-6
link to online source - Kallifatidis G., Labsch S., Rausch V., Mattern J., Gladkich J., Moldenhauer G., Buchler M. W., Salnikov A. V., Herr I., (2011) Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate. Mol Ther, 19:188-95
link to online source - Kaltner H., Kubler D., Lopez-Merino L., Lohr M., Manning J. C., Lensch M., Seidler J., Lehmann W. D., Andre S., Solis D., Gabius H. J., (2011) Toward comprehensive analysis of the galectin network in chicken: unique diversity of galectin-3 and comparison of its localization profile in organs of adult animals to the other four members of this lectin family. Anat Rec (Hoboken), 294:427-44
link to online source - Karskela T., Klika K. D., Lonnberg H., (2011) SYNTHESIS OF 7-SUBSTITUTED 3-beta-D-RIBOFURANOSYL-3H-IMIDAZO[2,1-i]PURINES. Collection of Czechoslovak Chemical Communications, 76:1043-1054
- Klika K. D., (2011) Proposed Extension to the Natta Projection Notation System for Enabling an Indication of Relative Stereochemistry and the Stereochemical State. International Journal of Organic Chemistry, 1:215-7
- Koskela S., Soderholm P. P., Ainasoja M., Wennberg T., Klika K. D., Ovcharenko V. V., Kylanlahti I., Auerma T., Yli-Kauhaluoma J., Pihlaja K., Vuorela P. M., Teeri T. H., (2011) Polyketide derivatives active against Botrytis cinerea in Gerbera hybrida. Planta, 233:37-48
link to online source - Liebau M. C., Hopker K., Muller R. U., Schmedding I., Zank S., Schairer B., Fabretti F., Hohne M., Bartram M. P., Dafinger C., Hackl M., Burst V., Habbig S., Zentgraf H., Blaukat A., Walz G., Benzing T., Schermer B., (2011) Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia. J Biol Chem, 286:14237-45
link to online source - Lossner C., Meier J., Warnken U., Rogers M. A., Lichter P., Pscherer A., Schnolzer M., (2011) Quantitative proteomics identify novel miR-155 target proteins. PLoS One, 6:e22146
link to online source - Lossner C., Warnken U., Pscherer A., Schnolzer M., (2011) Preventing arginine-to-proline conversion in a cell-line-independent manner during cell cultivation under stable isotope labeling by amino acids in cell culture (SILAC) conditions. Anal Biochem, 412:123-5
link to online source - Meder B., Haas J., Keller A., Heid C., Just S., Borries A., Boisguerin V., Scharfenberger-Schmeer M., Stahler P., Beier M., Weichenhan D., Strom T. M., Pfeufer A., Korn B., Katus H. A., Rottbauer W., (2011) Targeted next-generation sequencing for the molecular genetic diagnostics of cardiomyopathies. Circ Cardiovasc Genet, 4:110-22
link to online source - Meitinger F., Boehm M. E., Hofmann A., Hub B., Zentgraf H., Lehmann W. D., Pereira G., (2011) Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis. Genes Dev, 25:875-88
link to online source - Merveille A. C., Davis E. E., Becker-Heck A., Legendre M., Amirav I., Bataille G., Belmont J., Beydon N., Billen F., Clement A., Clercx C., Coste A., Crosbie R., de Blic J., Deleuze S., Duquesnoy P., Escalier D., Escudier E., Fliegauf M., Horvath J., Hill K., Jorissen M., Just J., Kispert A., Lathrop M., Loges N. T., Marthin J. K., Momozawa Y., Montantin G., Nielsen K. G., Olbrich H., Papon J. F., Rayet I., Roger G., Schmidts M., Tenreiro H., Towbin J. A., Zelenika D., Zentgraf H., Georges M., Lequarre A. S., Katsanis N., Omran H., Amselem S., (2011) CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs. Nat Genet, 43:72-8
link to online source - Mullers E., Uhlig T., Stirnnagel K., Fiebig U., Zentgraf H., Lindemann D., (2011) Novel functions of prototype foamy virus Gag glycine- arginine-rich boxes in reverse transcription and particle morphogenesis. J Virol, 85:1452-63
link to online source - Naumann P., Fortunato F., Zentgraf H., Buchler M. W., Herr I., Werner J., (2011) Autophagy and cell death signaling following dietary sulforaphane act independently of each other and require oxidative stress in pancreatic cancer. Int J Oncol, 39:101-9
link to online source - Olins A. L., Langhans M., Monestier M., Schlotterer A., Robinson D. G., Viotti C., Zentgraf H., Zwerger M., Olins D. E., (2011) An epichromatin epitope: persistence in the cell cycle and conservation in evolution. Nucleus, 2:47-60
link to online source - Pagans S., Sakane N., Schnolzer M., Ott M., (2011) Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies. Methods, 53:91-6
link to online source - Pietrosiuk A., Lenherr E. D., Falk S., Bonemann G., Kopp J., Zentgraf H., Sinning I., Mogk A., (2011) Molecular basis for the unique role of the AAA+ chaperone ClpV in type VI protein secretion. J Biol Chem, 286:30010-21
link to online source - Pipkorn , Wiessler M., Waldeck W., Lorenz P., Muehlhausen U., Fleischhacker H., Koch M., Braun K., (2011) Enhancement of the click chemistry for the inverse Diels Alder technology by functionalization of amide-based monomers. Int J Med Sci, 8:387-96
link to online source - Raia V., Schilling M., Bohm M., Hahn B., Kowarsch A., Raue A., Sticht C., Bohl S., Saile M., Moller P., Gretz N., Timmer J., Theis F., Lehmann W. D., Lichter P., Klingmuller U., (2011) Dynamic mathematical modeling of IL13-induced signaling in Hodgkin and primary mediastinal B-cell lymphoma allows prediction of therapeutic targets. Cancer Res, 71:693-704
link to online source - Rupp A. K., Rupp C., Keller S., Brase J. C., Ehehalt R., Fogel M., Moldenhauer G., Marme F., Sultmann H., Altevogt P., (2011) Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage. Gynecol Oncol, 122:437-46
link to online source - Seibold P., Hein R., Schmezer P., Hall P., Liu J., Dahmen N., Flesch-Janys D., Popanda O., Chang-Claude J., (2011) Polymorphisms in oxidative stress-related genes and postmenopausal breast cancer risk. Int J Cancer, 129:1467-76
link to online source - Seidler J., Zinn N., Haaf E., Boehm M. E., Winter D., Schlosser A., Lehmann W. D., (2011) Metal ion-mobilizing additives for comprehensive detection of femtomole amounts of phosphopeptides by reversed phase LC-MS. Amino Acids, 41:311-20
link to online source - Swiersy A., Wiek C., Reh J., Zentgraf H., Lindemann D., (2011) Orthoretroviral-like prototype foamy virus Gag-Pol expression is compatible with viral replication. Retrovirology, 8:66
link to online source - Tahoun A., Siszler G., Spears K., McAteer S., Tree J., Paxton E., Gillespie T. L., Martinez-Argudo I., Jepson M. A., Shaw D. J., Koegl M., Haas J., Gally D. L., Mahajan A., (2011) Comparative analysis of EspF variants in inhibition of Escherichia coli phagocytosis by macrophages and inhibition of E. coli translocation through human- and bovine-derived M cells. Infect Immun, 79:4716-29
link to online source - Wiessler M., Hennrich U., Pipkorn R., Waldeck W., Cao L., Peter J., Ehemann V., Semmler W., Lammers T., Braun K., (2011) Theranostic cRGD-BioShuttle Constructs Containing Temozolomide- and Cy7 For NIR-Imaging and Therapy. Theranostics, 1:381-94
link to online source - Zhang J. D., Koerner C., Bechtel S., Bender C., Keklikoglou I., Schmidt C., Irsigler A., Ernst U., Sahin O., Wiemann S., Tschulena U., (2011) Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation. PLoS One, 6:e22176
link to online source - Andrulis M., Capper D., Luft T., Hartmann C., Zentgraf H., von Deimling A., (2010) Detection of isocitrate dehydrogenase 1 mutation R132H in myelodysplastic syndrome by mutation-specific antibody and direct sequencing. Leuk Res, 34:1091-3
link to online source - Andrulis M., Capper D., Meyer J., Penzel R., Hartmann C., Zentgraf H., von Deimling A., (2010) IDH1 R132H mutation is a rare event in myeloproliferative neoplasms as determined by a mutation specific antibody. Haematologica, 95:1797-8
link to online source - Barbosa S., Pratte D., Schwarz H., Pipkorn R., Singer-Kruger B., (2010) Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex. Traffic, 11:1092-106
link to online source - Beckhove P., Warta R., Lemke B., Stoycheva D., Momburg F., Schnolzer M., Warnken U., Schmitz-Winnenthal H., Ahmadi R., Dyckhoff G., Bucur M., Junger S., Schueler T., Lennerz V., Woelfel T., Unterberg A., Herold-Mende C., (2010) Rapid T cell-based identification of human tumor tissue antigens by automated two-dimensional protein fractionation. J Clin Invest, 120:2230-42
link to online source - Bedlovicova Z., Imrich J., Kristian P., Danihel I., Bohm S., Sabolova D., Kozurkova M., Paulikova H., Klika K. D., (2010) Novel Carbohydrazide and Hydrazone Biomarkers Based on 9-Substituted Acridine and Anthracene Fluorogens. Heterocycles, 80:1047-1066
- Bentmann A., Kawelke N., Moss D., Zentgraf H., Bala Y., Berger I., Gasser J. A., Nakchbandi I. A., (2010) Circulating fibronectin affects bone matrix, whereas osteoblast fibronectin modulates osteoblast function. J Bone Miner Res, 25:706-15
link to online source - Bock B. C., Tagscherer K. E., Fassl A., Kramer A., Oehme I., Zentgraf H. W., Keith M., Roth W., (2010) The PEA-15 protein regulates autophagy via activation of JNK. J Biol Chem, 285:21644-54
link to online source - Bork S., Pfister S., Witt H., Horn P., Korn B., Ho A. D., Wagner W., (2010) DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells. Aging Cell, 9:54-63
link to online source - Bourbeillon J., Orchard S., Benhar I., Borrebaeck C., de Daruvar A., Dubel S., Frank R., Gibson F., Gloriam D., Haslam N., Hiltker T., Humphrey-Smith I., Hust M., Juncker D., Koegl M., Konthur Z., Korn B., Krobitsch S., Muyldermans S., Nygren P. A., Palcy S., Polic B., Rodriguez H., Sawyer A., Schlapshy M., Snyder M., Stoevesandt O., Taussig M. J., Templin M., Uhlen M., van der Maarel S., Wingren C., Hermjakob H., Sherman D., (2010) Minimum information about a protein affinity reagent (MIAPAR). Nat Biotechnol, 28:650-3
link to online source - Braun K., Dunsch L., Pipkorn R., Bock M., Baeuerle T., Yang S., Waldeck W., Wiessler M., (2010) Gain of a 500-fold sensitivity on an intravital MR contrast agent based on an endohedral gadolinium-cluster-fullerene-conjugate: a new chance in cancer diagnostics. Int J Med Sci, 7:136-46
link to online source - Braun K., Wiessler M., Pipkorn R., Ehemann V., Bauerle T., Fleischhacker H., Muller G., Lorenz P., Waldeck W., (2010) A cyclic-RGD-BioShuttle functionalized with TMZ by DARinv "Click Chemistry" targeted to alphavbeta3 integrin for therapy. Int J Med Sci, 7:326-39
link to online source - Busse C., Feederle R., Schnolzer M., Behrends U., Mautner J., Delecluse H. J., (2010) Epstein-Barr viruses that express a CD21 antibody provide evidence that gp350's functions extend beyond B-cell surface binding. J Virol, 84:1139-47
link to online source - Capper D., Weissert S., Balss J., Habel A., Meyer J., Jager D., Ackermann U., Tessmer C., Korshunov A., Zentgraf H., Hartmann C., von Deimling A., (2010) Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol, 20:245-54
link to online source - Chin R., Nachbur U., Earnest-Silveira L., Bankovacki A., Koeberlein B., Zentgraf H., Bock C. T., Silke J., Torresi J., (2010) Dysregulation of hepatocyte cell cycle and cell viability by hepatitis B virus. Virus Res, 147:7-16
link to online source - Dani D., Shimokawa I., Komatsu T., Higami Y., Warnken U., Schokraie E., Schnolzer M., Krause F., Sugawa M. D., Dencher N. A., (2010) Modulation of oxidative phosphorylation machinery signifies a prime mode of anti-ageing mechanism of calorie restriction in male rat liver mitochondria. Biogerontology, 11:321-34
link to online source - Derrer B., Windeisen V., Guedez Rodriguez G., Seidler J., Gengenbacher M., Lehmann W. D., Rippe K., Sinning I., Tews I., Kappes B., (2010) Defining the structural requirements for ribose 5-phosphate-binding and intersubunit cross-talk of the malarial pyridoxal 5-phosphate synthase. FEBS Lett, 584:4169-74
link to online source - Dietz L., Esser P. R., Schmucker S. S., Goette I., Richter A., Schnolzer M., Martin S. F., Thierse H. J., (2010) Tracking human contact allergens: from mass spectrometric identification of peptide-bound reactive small chemicals to chemical-specific naive human T-cell priming. Toxicol Sci, 117:336-47
link to online source - Eck W., Nicholson A. I., Zentgraf H., Semmler W., Bartling S., (2010) Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice. Nano Lett, 10:2318-22
link to online source - Emerson V., Holtkotte D., Pfeiffer T., Wang I. H., Schnolzer M., Kempf T., Bosch V., (2010) Identification of the cellular prohibitin 1/prohibitin 2 heterodimer as an interaction partner of the C-terminal cytoplasmic domain of the HIV-1 glycoprotein. J Virol, 84:1355-65
link to online source - Erlbruch A., Hung C. W., Seidler J., Borrmann K., Gesellchen F., Konig N., Kubler D., Herberg F. W., Lehmann W. D., Bossemeyer D., (2010) Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit. Proteomics, 10:2890-900
link to online source - Gdynia G., Keith M., Kopitz J., Bergmann M., Fassl A., Weber A. N., George J., Kees T., Zentgraf H. W., Wiestler O. D., Schirmacher P., Roth W., (2010) Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria. Cancer Res, 70:8558-68
link to online source - Gloriam D. E., Orchard S., Bertinetti D., Bjorling E., Bongcam-Rudloff E., Borrebaeck C. A., Bourbeillon J., Bradbury A. R., de Daruvar A., Dubel S., Frank R., Gibson T. J., Gold L., Haslam N., Herberg F. W., Hiltke T., Hoheisel J. D., Kerrien S., Koegl M., Konthur Z., Korn B., Landegren U., Montecchi-Palazzi L., Palcy S., Rodriguez H., Schweinsberg S., Sievert V., Stoevesandt O., Taussig M. J., Ueffing M., Uhlen M., van der Maarel S., Wingren C., Woollard P., Sherman D. J., Hermjakob H., (2010) A community standard format for the representation of protein affinity reagents. Mol Cell Proteomics, 9:1-10
link to online source - Gronniger E., Weber B., Heil O, Peters N., Stab F., Wenck H., Korn B., Winnefeld M., Lyko F., (2010) Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet, 6:e1000971
link to online source - Hristov G., Kramer M., Li J., El-Andaloussi N., Mora R., Daeffler L., Zentgraf H., Rommelaere J., Marchini A., (2010) Through its nonstructural protein NS1, parvovirus H-1 induces apoptosis via accumulation of reactive oxygen species. J Virol, 84:5909-22
link to online source - Imrich J., Tomascikova J., Danihel I., Kristian P., Bohm S., Klika K. D., (2010) Selective Formation of 5-or 6-Membered Rings, 1,3-Thiazolidin-4-One Vs. 1,3-Thiazin-4-One, from Acridine Thiosemicarbazides by the Use of Ethyne Acid Esters. Heterocycles, 80:489-503
- Klika K. D., (2010) Direct detection of non-proton-bearing 15N nuclei by long-range couplings using polarization transfer. Magn Reson Chem, 48:818-22
link to online source - Klika K. D., Budovska M., Kutschy P., (2010) NMR spectral enantioresolution of spirobrassinin and 1-methoxyspirobrassinin enantiomers using (S)-(-)-ethyl lactate and modeling of spirobrassinin self-association for rationalization of its self-induced diastereomeric anisochromism (SIDA) and enantiomer self-disproportionation on achiral-phase chromatography (ESDAC) phenomena. Journal of Fluorine Chemistry, 131:467-476
- Klika K. D., Budoyska M., Kutschy P., (2010) Enantiodifferentiation of phytoalexin spirobrassinin derivatives using the chiral solvating agent (R)-(+)-1,1 '-bi-2-naphthol in conjunction with molecular modeling. Tetrahedron-Asymmetry, 21:647-658
- Koeberlein B., zur Hausen A., Bektas N., Zentgraf H., Chin R., Nguyen L. T., Kandolf R., Torresi J., Bock C. T., (2010) Hepatitis B virus overexpresses suppressor of cytokine signaling-3 (SOCS3) thereby contributing to severity of inflammation in the liver. Virus Res, 148:51-9
link to online source - Kogenaru S. , del Val C., Hotz-Wagenblatt A., Glatting K., (2010) TissueDistributionDBs: a repository of organism-specific tissue-distribution profiles.. Theoretical Chemistry Accounts, 125:651-658
link to online source - Lohr J. M., Faissner R., Koczan D., Bewerunge P., Bassi C., Brors B., Eils R., Frulloni L., Funk A., Halangk W., Jesenofsky R., Kaderali L., Kleeff J., Kruger B., Lerch M. M., Losel R., Magnani M., Neumaier M., Nittka S., Sahin-Toth M., Sanger J., Serafini S., Schnolzer M., Thierse H. J., Wandschneider S., Zamboni G., Kloppel G., (2010) Autoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression profiling and immunoassays identify pancreatic enzymes as a major target of the inflammatory process. Am J Gastroenterol, 105:2060-71
link to online source - Lyko F., Foret S., Kucharski R., Wolf S., Falckenhayn C., Maleszka R., (2010) The honey bee epigenomes: differential methylation of brain DNA in queens and workers. PLoS Biol, 8:e1000506
link to online source - Mali B., Grohme M. A., Forster F., Dandekar T., Schnolzer M., Reuter D., Welnicz W., Schill R. O., Frohme M., (2010) Transcriptome survey of the anhydrobiotic tardigrade Milnesium tardigradum in comparison with Hypsibius dujardini and Richtersius coronifer. BMC Genomics, 11:168
link to online source - Meitinger F., Petrova B., Lombardi I. M., Bertazzi D. T., Hub B., Zentgraf H., Pereira G., (2010) Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast. J Cell Sci, 123:1851-61
link to online source - Moosmeier M. A., Bulkescher J., Reed J., Schnolzer M., Heid H., Hoppe-Seyler K., Hoppe-Seyler F., (2010) Transtactin: a universal transmembrane delivery system for Strep-tag II-fused cargos. J Cell Mol Med, 14:1935-45
link to online source - Mora R., Dokic I., Kees T., Huber C. M., Keitel D., Geibig R., Brugge B., Zentgraf H., Brady N. R., Regnier-Vigouroux A., (2010) Sphingolipid rheostat alterations related to transformation can be exploited for specific induction of lysosomal cell death in murine and human glioma. Glia, 58:1364-83
link to online source - Pagans S., Kauder S. E., Kaehlcke K., Sakane N., Schroeder S., Dormeyer W., Trievel R. C., Verdin E., Schnolzer M., Ott M., (2010) The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe, 7:234-44
link to online source - Paruzynski A., Arens A., Gabriel R., Bartholomae C. C., Scholz S., Wang W., Wolf S., Glimm H., Schmidt M., von Kalle C., (2010) Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing. Nat Protoc, 5:1379-95
link to online source - Potocnak I., Imrich J., Danihel I., Koaeisek J., Klika K. D., (2010) 4-(9,10-Dihydroacridin-9-ylidene)thiosemicarbazide and its five-membered thiazole and six-membered thiazine derivatives. Acta Crystallogr C, 66:o87-92
link to online source - Reinartz A., Ehling J., Franz S., Simon V., Bravo I. G., Tessmer C., Zentgraf H., Lyer S., Schneider U., Koster J., Raupach K., Kammerer E., Klaus C., Tischendorf J. J., Kopitz J., Alonso A., Gassler N., (2010) Small intestinal mucosa expression of putative chaperone fls485. BMC Gastroenterol, 10:27
link to online source - Rickelt S., Rizzo S., Doerflinger Y., Zentgraf H., Basso C., Gerosa G., Thiene G., Moll R., Franke W. W., (2010) A novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomata. Mod Pathol, 23:1429-37
link to online source - Riedl E., Koeppel H., Pfister F., Peters V., Sauerhoefer S., Sternik P., Brinkkoetter P., Zentgraf H., Navis G., Henning R. H., Van Den Born J., Bakker S. J., Janssen B., van der Woude F. J., Yard B. A., (2010) N-glycosylation of carnosinase influences protein secretion and enzyme activity: implications for hyperglycemia. Diabetes, 59:1984-90
link to online source - Roesch-Ely M., Schnolzer M., Nees M., Plinkert P. K., Bosch F. X., (2010) Reference spectra from squamous epithelium and connective tissue allow whole section proteomics analysis. Arch Physiol Biochem, 116:218-26
link to online source - Schokraie E., Hotz-Wagenblatt A, Warnken U., Mali B., Frohme M., Forster F., Dandekar T., Hengherr S., Schill R. O., Schnolzer M, (2010) Proteomic analysis of tardigrades: towards a better understanding of molecular mechanisms by anhydrobiotic organisms. PLoS One, 5:e9502
link to online source - Seeger T. S., Frank D., Rohr C., Will R., Just S., Grund C., Lyon R., Luedde M., Koegl M., Sheikh F., Rottbauer W., Franke W. W., Katus H. A., Olson E. N., Frey N., (2010) Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo. Circ Res, 106:880-90
link to online source - Seidler J., Zinn N., Boehm M. E., Lehmann W. D., (2010) De novo sequencing of peptides by MS/MS. Proteomics, 10:634-49
link to online source - Sela N., Mersch B., Hotz-Wagenblatt A., Ast G., (2010) Characteristics of transposable element exonization within human and mouse. PLoS One, 5:e10907
link to online source - Soza-Ried J., Hotz-Wagenblatt A., Glatting K. H., del Val C., Fellenberg K., Bode H. R., Frank U., Hoheisel J. D., Frohme M., (2010) The transcriptome of the colonial marine hydroid Hydractinia echinata. FEBS J, 277:197-209
link to online source - Stirnnagel K., Luftenegger D., Stange A., Swiersy A., Mullers E., Reh J., Stanke N., Grosse A., Chiantia S., Keller H., Schwille P., Hanenberg H., Zentgraf H., Lindemann D., (2010) Analysis of prototype foamy virus particle-host cell interaction with autofluorescent retroviral particles. Retrovirology, 7:45
link to online source - Uhlmann S., Zhang J. D., Schwager A., Mannsperger H., Riazalhosseini Y., Burmester S., Ward A., Korf U., Wiemann S., Sahin O., (2010) miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. Oncogene, 29:4297-306
link to online source - Volkmann M., Luithle D., Zentgraf H., Schnolzer M., Fiedler S., Heid H., Schulze-Bergkamen A., Strassburg C. P., Gehrke S. G., Manns M. P., (2010) SLA/LP/tRNP((Ser)Sec) antigen in autoimmune hepatitis: identification of the native protein in human hepatic cell extract. J Autoimmun, 34:59-65
link to online source - Wiessler M., Waldeck W., Pipkorn R., Kliem C., Lorenz P., Fleischhacker H., Hafner M., Braun K., (2010) Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry. Int J Med Sci, 7:213-23
link to online source - Will R. D., Eden M., Just S., Hansen A., Eder A., Frank D., Kuhn C., Seeger T. S., Oehl U., Wiemann S., Korn B., Koegl M., Rottbauer W., Eschenhagen T., Katus H. A., Frey N., (2010) Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing. Circ Res, 107:1253-64
link to online source - Winter D., Seidler J., Hahn B., Lehmann W. D., (2010) Structural and mechanistic Information on c(1) ion formation in collision-induced fragmentation of peptides. J Am Soc Mass Spectrom, 21:1814-20
link to online source - Winter D., Seidler J., Kugelstadt D., Derrer B., Kappes B., Lehmann W. D., (2010) Minimally permutated peptide analogs as internal standards for relative and absolute quantification of peptides and proteins. Proteomics, 10:1510-4
link to online source - Zinn N., Winter D., Lehmann W. D., (2010) Recombinant isotope labeled and selenium quantified proteins for absolute protein quantification. Anal Chem, 82:2334-40
link to online source - de Souza Rocha Simonini P., Breiling A., Gupta N., Malekpour M., Youns M., Omranipour R., Malekpour F., Volinia S., Croce C. M., Najmabadi H., Diederichs S., Sahin O., Mayer D., Lyko F., Hoheisel J. D., Riazalhosseini Y., (2010) Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells. Cancer Res, 70:9175-84
link to online source - del Val C., Pelz O., Glatting K., Barta E., Hotz-Wagenblatt A., (2010) PromoterSweep: a tool for identification of transcription factor binding sites.. Theoretical Chemistry Accounts, 125:583-591
link to online source - Apel A., Zentgraf H., Buchler M. W., Herr I., (2009) Autophagy-A double-edged sword in oncology. Int J Cancer, 125:991-5
link to online source - Appelt J. U., Giordano F. A., Ecker M., Roeder I., Grund N., Hotz-Wagenblatt A., Opelz G., Zeller W. J., Allgayer H., Fruehauf S., Laufs S., (2009) QuickMap: a public tool for large-scale gene therapy vector insertion site mapping and analysis. Gene Ther, 16:885-93
link to online source - Bar H., Sharma S., Kleiner H., Mucke N., Zentgraf H., Katus H. A., Aebi U., Herrmann H., (2009) Interference of amino-terminal desmin fragments with desmin filament formation. Cell Motil Cytoskeleton, 66:986-99
link to online source - Bonemann G., Pietrosiuk A., Diemand A., Zentgraf H., Mogk A., (2009) Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion. EMBO J, 28:315-25
link to online source - Borner A., Warnken U., Schnolzer M., Hagen J., Giese N., Bauer A., Hoheisel J., (2009) Subcellular protein extraction from human pancreatic cancer tissues. Biotechniques, 46:297-304
link to online source - Braun A., Treede I., Gotthardt D., Tietje A., Zahn A., Ruhwald R., Schoenfeld U., Welsch T., Kienle P., Erben G., Lehmann W. D., Fuellekrug J., Stremmel W., Ehehalt R., (2009) Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: a clue to pathogenesis. Inflamm Bowel Dis, 15:1705-20
link to online source - Braun K., Ehemann V., Wiessler M., Pipkorn R, Didinger B., Mueller G., Waldeck W., (2009) High-resolution flow cytometry: a suitable tool for monitoring aneuploid prostate cancer cells after TMZ and TMZ-BioShuttle treatment. Int J Med Sci, 6:338-47
link to online source - Braun K., Wiessler M., Ehemann V., Pipkorn R, Spring H., Debus J., Didinger B., Koch M., Muller G., Waldeck W., (2009) Treatment of glioblastoma multiforme cells with temozolomide-BioShuttle ligated by the inverse Diels-Alder ligation chemistry. Drug Des Devel Ther, 2:289-301
link to online source - Brenner D., Brechmann M., Rohling S., Tapernoux M., Mock T., Winter D., Lehmann W. D., Kiefer F., Thome M., Krammer P. H., Arnold R., (2009) Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells. Proc Natl Acad Sci U S A, 106:14508-13
link to online source - Capper D., Zentgraf H., Balss J., Hartmann C., von Deimling A., (2009) Monoclonal antibody specific for IDH1 R132H mutation. Acta Neuropathol, 118:599-601
link to online source - Dietz L., Bosque A., Pankert P., Ohnesorge S., Merz P., Anel A., Schnolzer M., Thierse H. J., (2009) Quantitative DY-maleimide-based proteomic 2-DE-labeling strategies using human skin proteins. Proteomics, 9:4298-308
link to online source - Dittami S. M., Scornet D., Petit J. L., Segurens B., Da Silva C., Corre E., Dondrup M., Glatting K. H., Konig R., Sterck L., Rouze P., Van de Peer Y., Cock J. M., Boyen C., Tonon T., (2009) Global expression analysis of the brown alga Ectocarpus siliculosus (Phaeophyceae) reveals large-scale reprogramming of the transcriptome in response to abiotic stress. Genome Biol, 10:R66
link to online source - Edelson-Averbukh M., Shevchenko A., Pipkorn R., Lehmann W. D., (2009) Gas-phase intramolecular phosphate shift in phosphotyrosine-containing peptide monoanions. Anal Chem, 81:4369-81
link to online source - Forster F., Liang C., Shkumatov A., Beisser D., Engelmann J. C., Schnolzer M., Frohme M., Muller T., Schill R. O., Dandekar T., (2009) Tardigrade workbench: comparing stress-related proteins, sequence-similar and functional protein clusters as well as RNA elements in tardigrades. BMC Genomics, 10:469
link to online source - Fossum E., Friedel C. C., Rajagopala S. V., Titz B., Baiker A., Schmidt T., Kraus T., Stellberger T., Rutenberg C., Suthram S., Bandyopadhyay S., Rose D., von Brunn A., Uhlmann M., Zeretzke C., Dong Y. A., Boulet H., Koegl M., Bailer S. M., Koszinowski U., Ideker T., Uetz P., Zimmer R., Haas J., (2009) Evolutionarily conserved herpesviral protein interaction networks. PLoS Pathog, 5:e1000570
link to online source - Francis R. J., Chatterjee B., Loges N. T., Zentgraf H., Omran H., Lo C. W., (2009) Initiation and maturation of cilia-generated flow in newborn and postnatal mouse airway. Am J Physiol Lung Cell Mol Physiol, 296:L1067-75
link to online source - Kiessling F., Huppert J., Zhang C., Jayapaul J., Zwick S., Woenne E. C., Mueller M. M., Zentgraf H., Eisenhut M., Addadi Y., Neeman M., Semmler W., (2009) RGD-labeled USPIO inhibits adhesion and endocytotic activity of alpha v beta3-integrin-expressing glioma cells and only accumulates in the vascular tumor compartment. Radiology, 253:462-9
link to online source - Kruger R., Zinn N., Lehmann W. D., (2009) Quantification of protein phosphorylation by microLC-ICP-MS. Methods Mol Biol, 527:201-18, ix
link to online source - Loftas P., Onnesjo S., Widegren E., Adell G., Kayed H., Kleeff J., Zentgraf H., Sun X. F., (2009) Expression of FXYD-3 is an independent prognostic factor in rectal cancer patients with preoperative radiotherapy. Int J Radiat Oncol Biol Phys, 75:137-42
link to online source - Loges N. T., Olbrich H., Becker-Heck A., Haffner K., Heer A., Reinhard C., Schmidts M., Kispert A., Zariwala M. A., Leigh M. W., Knowles M. R., Zentgraf H., Seithe H., Nurnberg G., Nurnberg P., Reinhardt R., Omran H., (2009) Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects. Am J Hum Genet, 85:883-9
link to online source - Ludwig S., Mannherz H. G., Schmitt S., Schaffer M., Zentgraf H., Napirei M., (2009) Murine serum deoxyribonuclease 1 (Dnase1) activity partly originates from the liver. Int J Biochem Cell Biol, 41:1079-93
link to online source - Mayer U., Kuller A., Daiber P. C., Neudorf I., Warnken U., Schnolzer M., Frings S., Mohrlen F., (2009) The proteome of rat olfactory sensory cilia. Proteomics, 9:322-34
link to online source - Mora R., Abschuetz A., Kees T., Dokic I., Joschko N., Kleber S., Geibig R., Mosconi E., Zentgraf H., Martin-Villalba A., Regnier-Vigouroux A., (2009) TNF-alpha- and TRAIL-resistant glioma cells undergo autophagy-dependent cell death induced by activated microglia. Glia, 57:561-81
link to online source - Olins A. L., Hoang T. V., Zwerger M., Herrmann H., Zentgraf H., Noegel A. A., Karakesisoglou I., Hodzic D., Olins D. E., (2009) The LINC-less granulocyte nucleus. Eur J Cell Biol, 88:203-14
link to online source - Pipkorn R., Waldeck W., Didinger B., Braun K., (2009) BioShuttle mediated plasmid transfer--a way to new genetic intervention. Adv Exp Med Biol, 611:285-6
link to online source - Pipkorn R., Waldeck W., Didinger B., Koch M., Mueller G., Wiessler M., Braun K., (2009) Inverse-electron-demand Diels-Alder reaction as a highly efficient chemoselective ligation procedure: synthesis and function of a BioShuttle for temozolomide transport into prostate cancer cells. J Pept Sci, 15:235-41
link to online source - Schaefer M., Pollex T., Hanna K., Lyko F., (2009) RNA cytosine methylation analysis by bisulfite sequencing. Nucleic Acids Res, 37:e12
link to online source - Schill R. O., Mali B., Dandekar T., Schnolzer M., Reuter D., Frohme M., (2009) Molecular mechanisms of tolerance in tardigrades: new perspectives for preservation and stabilization of biological material. Biotechnol Adv, 27:348-52
link to online source - Schilling M., Maiwald T., Hengl S., Winter D., Kreutz C., Kolch W., Lehmann W. D., Timmer J., Klingmuller U., (2009) Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions. Mol Syst Biol, 5:334
link to online source - Schmitt M., Pawlita M., (2009) High-throughput detection and multiplex identification of cell contaminations. Nucleic Acids Res, 37:e119
link to online source - Seidler J., Adal M., Kubler D., Bossemeyer D., Lehmann W. D., (2009) Analysis of autophosphorylation sites in the recombinant catalytic subunit alpha of cAMP-dependent kinase by nano-UPLC-ESI-MS/MS. Anal Bioanal Chem, 395:1713-20
link to online source - Wang M. W., Gu P., Zhang Z. Y., Zhu Z. L., Geng Y., Kayed H., Zentgraf H., Sun X. F., (2009) FXYD3 expression in gliomas and its clinicopathological significance. Oncol Res, 18:133-9
link to online source - Widegren E., Onnesjo S., Arbman G., Kayed H., Zentgraf H., Kleeff J., Zhang H., Sun X. F., (2009) Expression of FXYD3 protein in relation to biological and clinicopathological variables in colorectal cancers. Chemotherapy, 55:407-13
link to online source - Wiessler M., Waldeck W., Kliem C., Pipkorn R., Braun K., (2009) The Diels-Alder-reaction with inverse-electron-demand, a very efficient versatile click-reaction concept for proper ligation of variable molecular partners. Int J Med Sci, 7:19-28
link to online source - Winter D., Kugelstadt D., Seidler J., Kappes B., Lehmann W. D., (2009) Protein phosphorylation influences proteolytic cleavage and kinase substrate properties exemplified by analysis of in vitro phosphorylated Plasmodium falciparum glideosome-associated protein 45 by nano-ultra performance liquid chromatography-tandem mass spectrometry. Anal Biochem, 393:41-7
link to online source - Winter D., Lehmann W. D., (2009) Individual b2 ion fragmentation profiles combined with AspN digestion improve N-terminal peptide sequencing. Anal Bioanal Chem, 393:1587-91
link to online source - Winter D., Lehmann W. D., (2009) Sequencing of the thirteen structurally isomeric quartets of N-terminal dipeptide motifs in peptides by collision-induced dissociation. Proteomics, 9:2076-84
link to online source - Winter D., Pipkorn R., Lehmann W. D., (2009) Separation of peptide isomers and conformers by ultra performance liquid chromatography. J Sep Sci, 32:1111-9
link to online source - Winter D., Seidler J., Ziv Y., Shiloh Y., Lehmann W. D., (2009) Citrate boosts the performance of phosphopeptide analysis by UPLC-ESI-MS/MS. J Proteome Res, 8:418-24
link to online source - Winter D., Seidler J., Ziv-Lehrman S., Shiloh Y., Lehmann W. D., (2009) Simultaneous identification and quantification of proteins by differential (16)O/(18)O labeling and UPLC-MS/MS applied to mouse cerebellar phosphoproteome following irradiation. Anticancer Res, 29:4949-58
link to online source - Zinn N., Hahn B., Pipkorn R., Schwarzer D., Lehmann W. D., (2009) Phosphorus-based absolutely quantified standard peptides for quantitative proteomics. J Proteome Res, 8:4870-5
link to online source - Afanasyeva E. A., Hotz-Wagenblatt A., Glatting K. H., Westermann F., (2008) New miRNAs cloned from neuroblastoma. BMC Genomics, 9:52
link to online source - Braun K., Frank M., Pipkorn R., Reed J., Spring H., Debus J., Didinger B., von der Lieth C. W., Wiessler M., Waldeck W., (2008) HIV-1 capsid assembly inhibitor (CAI) peptide: structural preferences and delivery into human embryonic lung cells and lymphocytes. Int J Med Sci, 5:230-9
link to online source - Huber A., Thongphasuk P., Erben G., Lehmann W. D., Tuma S., Stremmel W., Chamulitrat W., (2008) Significantly greater antioxidant anticancer activities of 2,3-dehydrosilybin than silybin. Biochim Biophys Acta, 1780:837-47
link to online source - Jaskolla T. W., Lehmann W. D., Karas M., (2008) 4-Chloro-alpha-cyanocinnamic acid is an advanced, rationally designed MALDI matrix. Proc Natl Acad Sci U S A, 105:12200-5
link to online source - Kaltner H., Solis D., Kopitz J., Lensch M., Lohr M., Manning J. C., Murnseer M., Schnolzer M., Andre S., Saiz J. L., Gabius H. J., (2008) Prototype chicken galectins revisited: characterization of a third protein with distinctive hydrodynamic behaviour and expression pattern in organs of adult animals. Biochem J, 409:591-9
link to online source - Klimmeck D., Mayer U., Ungerer N., Warnken U., Schnolzer M., Frings S., Mohrlen F., (2008) Calcium-signaling networks in olfactory receptor neurons. Neuroscience, 151:901-12
link to online source - Korf U., Derdak S., Tresch A., Henjes F., Schumacher S., Schmidt C., Hahn B., Lehmann W. D., Poustka A., Beissbarth T., Klingmuller U., (2008) Quantitative protein microarrays for time-resolved measurements of protein phosphorylation. Proteomics, 8:4603-12
link to online source - Kubler D., Hung C. W., Dam T. K., Kopitz J., Andre S., Kaltner H., Lohr M., Manning J. C., He L., Wang H., Middelberg A., Brewer C. F., Reed J., Lehmann W. D., Gabius H. J., (2008) Phosphorylated human galectin-3: facile large-scale preparation of active lectin and detection of structural changes by CD spectroscopy. Biochim Biophys Acta, 1780:716-22
link to online source - Kwon H. S., Brent M. M., Getachew R., Jayakumar P., Chen L. F., Schnolzer M., McBurney M. W., Marmorstein R., Greene W. C., Ott M., (2008) Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe, 3:158-67
link to online source - Marme A., Zimmermann H. P., Moldenhauer G., Schorpp-Kistner M., Muller C., Keberlein O., Giersch A., Kretschmer J., Seib B., Spiess E., Hunziker A., Merchan F., Moller P., Hahn U., Kurek R., Marme F., Bastert G., Wallwiener D., Ponstingl H., (2008) Loss of Drop1 expression already at early tumor stages in a wide range of human carcinomas. Int J Cancer, 123:2048-56
link to online source - Mayer U., Ungerer N., Klimmeck D., Warnken U., Schnolzer M., Frings S., Mohrlen F., (2008) Proteomic analysis of a membrane preparation from rat olfactory sensory cilia. Chem Senses, 33:145-62
link to online source - Mersch B., Gepperth A., Suhai S., Hotz-Wagenblatt A., (2008) Automatic detection of exonic splicing enhancers (ESEs) using SVMs. BMC Bioinformatics, 9:369
link to online source - Munk C., Beck T., Zielonka J., Hotz-Wagenblatt A., Chareza S., Battenberg M., Thielebein J., Cichutek K., Bravo I. G., O'Brien S. J., Lochelt M., Yuhki N., (2008) Functions, structure, and read-through alternative splicing of feline APOBEC3 genes. Genome Biol, 9:R48
link to online source - Singer-Kruger B., Lasic M., Burger A. M., Hausser A., Pipkorn R, Wang Y., (2008) Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution. EMBO J, 27:1423-35
link to online source - Stadler V., Felgenhauer T., Beyer M., Fernandez S., Leibe K., Guttler S., Groning M., Konig K., Torralba G., Hausmann M., Lindenstruth V., Nesterov A., Block I., Pipkorn R., Poustka A., Bischoff F. R., Breitling F., (2008) Combinatorial synthesis of peptide arrays with a laser printer. Angew Chem Int Ed Engl, 47:7132-5
link to online source - Tschuch C., Schulz A., Pscherer A., Werft W., Benner A., Hotz-Wagenblatt A., Barrionuevo L. S., Lichter P., Mertens D., (2008) Off-target effects of siRNA specific for GFP. BMC Mol Biol, 9:60
link to online source - Waldeck W., Wiessler M., Ehemann V., Pipkorn R, Spring H., Debus J., Didinger B., Mueller G., Langowski J., Braun K., (2008) TMZ-BioShuttle--a reformulated temozolomide. Int J Med Sci, 5:273-84
link to online source - Wangler C., Moldenhauer G., Saffrich R., Knapp E. M., Beijer B., Schnolzer M., Wangler B., Eisenhut M., Haberkorn U., Mier W., (2008) PAMAM structure-based multifunctional fluorescent conjugates for improved fluorescent labelling of biomacromolecules. Chemistry, 14:8116-30
link to online source - Bazhin A. V., Wiedemann N., Schnolzer M., Schadendorf D., Eichmuller S. B., (2007) Expression of GAGE family proteins in malignant melanoma. Cancer Lett, 251:258-67
link to online source - Braun K., von Brasch L., Pipkorn R, Ehemann V., Jenne J., Spring H., Debus J., Didinger B., Rittgen W., Waldeck W., (2007) BioShuttle-mediated plasmid transfer. Int J Med Sci, 4:267-77
link to online source - Di Bartolo V., Montagne B., Salek M., Jungwirth B., Carrette F., Fourtane J., Sol-Foulon N., Michel F., Schwartz O., Lehmann W. D., Acuto O., (2007) A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. J Exp Med, 204:681-91
link to online source - Edelson-Averbukh M., Pipkorn R., Lehmann W. D., (2007) Analysis of protein phosphorylation in the regions of consecutive serine/threonine residues by negative ion electrospray collision-induced dissociation. Approach to pinpointing of phosphorylation sites. Anal Chem, 79:3476-86
link to online source - Giordano F. A., Hotz-Wagenblatt A., Lauterborn D., Appelt J. U., Fellenberg K., Nagy K. Z., Zeller W. J., Suhai S., Fruehauf S., Laufs S., (2007) New bioinformatic strategies to rapidly characterize retroviral integration sites of gene therapy vectors. Methods Inf Med, 46:542-7
link to online source - Hung C. W., Kubler D., Lehmann W. D., (2007) pI-based phosphopeptide enrichment combined with nanoESI-MS. Electrophoresis, 28:2044-52
link to online source - Hung C. W., Schlosser A., Wei J., Lehmann W. D., (2007) Collision-induced reporter fragmentations for identification of covalently modified peptides. Anal Bioanal Chem, 389:1003-16
link to online source - Jesnowski R., Zubakov D., Faissner R., Ringel J., Hoheisel J. D., Losel R., Schnolzer M., Lohr M., (2007) Genes and proteins differentially expressed during in vitro malignant transformation of bovine pancreatic duct cells. Neoplasia, 9:136-46
link to online source - Kenzelmann M., Maertens S., Hergenhahn M., Kueffer S., Hotz-Wagenblatt A., Li L., Wang S., Ittrich C., Lemberger T., Arribas R., Jonnakuty S., Hollstein M. C., Schmid W., Gretz N., Grone H. J., Schutz G., (2007) Microarray analysis of newly synthesized RNA in cells and animals. Proc Natl Acad Sci U S A, 104:6164-9
link to online source - Koegl M., Uetz P., (2007) Improving yeast two-hybrid screening systems. Brief Funct Genomic Proteomic, 6:302-12
link to online source - Kremoser C., Albers M., Burris T. P., Deuschle U., Koegl M., (2007) Panning for SNuRMs: using cofactor profiling for the rational discovery of selective nuclear receptor modulators. Drug Discov Today, 12:860-9
link to online source - Kruger R., Wolschin F., Weckwerth W., Bettmer J., Lehmann W. D., (2007) Plant protein phosphorylation monitored by capillary liquid chromatography--element mass spectrometry. Biochem Biophys Res Commun, 355:89-96
link to online source - Kubler D., Gosenca D., Wind M., Heid H., Friedberg I., Jahnen-Dechent W., Lehmann W. D., (2007) Proteolytic processing by matrix metalloproteinases and phosphorylation by protein kinase CK2 of fetuin-A, the major globulin of fetal calf serum. Biochimie, 89:410-8
link to online source - Kugelstadt D., Winter D., Pluckhahn K., Lehmann W. D., Kappes B., (2007) Raf kinase inhibitor protein affects activity of Plasmodium falciparum calcium-dependent protein kinase 1. Mol Biochem Parasitol, 151:111-7
link to online source - Lehmann W. D., Kruger R., Salek M., Hung C. W., Wolschin F., Weckwerth W., (2007) Neutral loss-based phosphopeptide recognition: a collection of caveats. J Proteome Res, 6:2866-73
link to online source - Mersch B., Sela N., Ast G., Suhai S., Hotz-Wagenblatt A., (2007) SERpredict: detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements. BMC Genet, 8:78
link to online source - Munter L. M., Voigt P., Harmeier A., Kaden D., Gottschalk K. E., Weise C., Pipkorn R., Schaefer M., Langosch D., Multhaup G., (2007) GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. EMBO J, 26:1702-12
link to online source - Pipkorn R., Waldeck W., Jenne J. W., Didinger B., Braun K., (2007) Generation, application and quantification of clamp-BioShuttle carriers for plasmid delivery into nuclei of prostate cancer cells. Biochem Soc Trans, 35:829-32
link to online source - Roesch-Ely M., Nees M., Karsai S., Ruess A., Bogumil R., Warnken U., Schnolzer M., Dietz A., Plinkert P. K., Hofele C., Bosch F. X., (2007) Proteomic analysis reveals successive aberrations in protein expression from healthy mucosa to invasive head and neck cancer. Oncogene, 26:54-64
link to online source - Sela N., Mersch B., Gal-Mark N., Lev-Maor G., Hotz-Wagenblatt A., Ast G., (2007) Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome. Genome Biol, 8:R127
link to online source - Treiber C., Pipkorn R, Weise C., Holland G., Multhaup G., (2007) Copper is required for prion protein-associated superoxide dismutase-I activity in Pichia pastoris. FEBS J, 274:1304-11
link to online source - Treiber C., Thompsett A. R., Pipkorn R., Brown D. R., Multhaup G., (2007) Real-time kinetics of discontinuous and highly conformational metal-ion binding sites of prion protein. J Biol Inorg Chem, 12:711-20
link to online source - Vasiljevic N., Hazard K., Eliasson L., Ly H., Hunziker A., de Villiers E. M., Norrild B., Dillner J., Forslund O., (2007) Characterization of two novel cutaneous human papillomaviruses, HPV93 and HPV96. J Gen Virol, 88:1479-83
link to online source - Vernaleken A., Veyhl M., Gorboulev V., Kottra G., Palm D., Burckhardt B. C., Burckhardt G., Pipkorn R, Beier N., van Amsterdam C., Koepsell H., (2007) Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity. J Biol Chem, 282:28501-13
link to online source - Waldeck W., Strunz A. M., Muller G., Hotz-Wagenblatt A., Wijenne J., Langowski J., Didinger B., Debus J., Braun K., (2007) Induced and repressed genes after irradiation sensitizing by pentoxyphylline. Int J Cancer, 120:1198-207
link to online source - Yan J., Kim Y. S., Yang X. P., Albers M., Koegl M., Jetten A. M., (2007) Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha. Nucleic Acids Res, 35:1673-86
link to online source - del Val C., Ernst P., Falkenhahn M., Fladerer C., Glatting K. H., Suhai S., Hotz-Wagenblatt A., (2007) ProtSweep, 2Dsweep and DomainSweep: protein analysis suite at DKFZ. Nucleic Acids Res, 35:W444-50
link to online source - Albers M., Blume B., Schlueter T., Wright M. B., Kober I., Kremoser C., Deuschle U., Koegl M., (2006) A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors. J Biol Chem, 281:4920-30
link to online source - Edelson-Averbukh M., Pipkorn R., Lehmann W. D., (2006) Phosphate group-driven fragmentation of multiply charged phosphopeptide anions. Improved recognition of peptides phosphorylated at serine, threonine, or tyrosine by negative ion electrospray tandem mass spectrometry. Anal Chem, 78:1249-56
link to online source - Engelke M., Mills K., Seitz S., Simon P., Gripon P., Schnolzer M., Urban S., (2006) Characterization of a hepatitis B and hepatitis delta virus receptor binding site. Hepatology, 43:750-60
link to online source - Fliegauf M., Horvath J., von Schnakenburg C., Olbrich H., Muller D., Thumfart J., Schermer B., Pazour G. J., Neumann H. P., Zentgraf H., Benzing T., Omran H., (2006) Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia. J Am Soc Nephrol, 17:2424-33
link to online source - Hofmann I., Casella M., Schnolzer M., Schlechter T., Spring H., Franke W. W., (2006) Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules. Mol Biol Cell, 17:1388-98
link to online source - Knoess M., Kurz A. K., Goreva O., Bektas N., Breuhahn K., Odenthal M., Schirmacher P., Dienes H. P., Bock C. T., Zentgraf H., zur Hausen A., (2006) Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases. World J Gastroenterol, 12:5870-4
link to online source - Kruger R., Kubler D., Pallisse R., Burkovski A., Lehmann W. D., (2006) Protein and proteome phosphorylation stoichiometry analysis by element mass spectrometry. Anal Chem, 78:1987-94
link to online source - Lehmann W. D., Wei J., Hung C. W., Gabius H. J., Kirsch D., Spengler B., Kubler D., (2006) Effective solvation of alkaline earth ions by proline-rich proteolytic peptides of galectin-3 upon electrospray ionisation. Rapid Commun Mass Spectrom, 20:2404-10
link to online source - Leykauf K., Salek M., Bomke J., Frech M., Lehmann W. D., Durst M., Alonso A., (2006) Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process. J Cell Sci, 119:3634-42
link to online source - Marchini A., Daeffler L., Marttila T., Schneider K. U., Blaschke R. J., Schnolzer M., Rommelaere J., Rappold G., (2006) Phosphorylation on Ser106 modulates the cellular functions of the SHOX homeodomain protein. J Mol Biol, 355:590-603
link to online source - Michel A., Kopp-Schneider A., Zentgraf H., Gruber A. D., de Villiers E. M., (2006) E6/E7 expression of human papillomavirus type 20 (HPV-20) and HPV-27 influences proliferation and differentiation of the skin in UV-irradiated SKH-hr1 transgenic mice. J Virol, 80:11153-64
link to online source - Muller M., Meyer M., Schilling T., Ulsperger E., Lehnert T., Zentgraf H., Stremmel W., Volkmann M., Galle P. R., (2006) Testing for anti-p53 antibodies increases the diagnostic sensitivity of conventional tumor markers. Int J Oncol, 29:973-80
link to online source - Muller-Decker K., Furstenberger G., Neumann M., Schnolzer M., (2006) Differential protein expression in the epidermis of wild-type and COX-2 transgenic mice. Skin Pharmacol Physiol, 19:89-94
link to online source - Pipkorn R., Waldeck W., Spring H., Jenne J. W., Braun K., (2006) Delivery of substances and their target-specific topical activation. Biochim Biophys Acta, 1758:606-10
link to online source - Schermer B., Ghenoiu C., Bartram M., Muller R. U., Kotsis F., Hohne M., Kuhn W., Rapka M., Nitschke R., Zentgraf H., Fliegauf M., Omran H., Walz G., Benzing T., (2006) The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol, 175:547-54
link to online source - Winnefeld M., Grewenig A., Schnolzer M., Spring H., Knoch T. A., Gan E. C., Rommelaere J., Cziepluch C., (2006) Human SGT interacts with Bag-6/Bat-3/Scythe and cells with reduced levels of either protein display persistence of few misaligned chromosomes and mitotic arrest. Exp Cell Res, 312:2500-14
link to online source - Wolf M., Bauder-Wust U., Pipkorn R., Eskerski H., Eisenhut M., (2006) Fluorophor-labeled spermidine derivatives as fluorescent markers in optical tumor imaging. Bioorg Med Chem Lett, 16:3193-6
link to online source - Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M., (2005) Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics, 4:205-13
link to online source - Braun K., Pipkorn R., Waldeck W., (2005) Development and characterization of drug delivery systems for targeting mammalian cells and tissues: a review. Curr Med Chem, 12:1841-58
link to online source - Gareiss M., Eberhardt K., Kruger E., Kandert S., Bohm C., Zentgraf H., Muller C. R., Dabauvalle M. C., (2005) Emerin expression in early development of Xenopus laevis. Eur J Cell Biol, 84:295-309
link to online source - Gerke P., Sellin L., Kretz O., Petraschka D., Zentgraf H., Benzing T., Walz G., (2005) NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. J Am Soc Nephrol, 16:1693-702
link to online source - Gombert M., Dieu-Nosjean M. C., Winterberg F., Bunemann E., Kubitza R. C., Da Cunha L., Haahtela A., Lehtimaki S., Muller A., Rieker J., Meller S., Pivarcsi A., Koreck A., Fridman W. H., Zentgraf H. W., Pavenstadt H., Amara A., Caux C., Kemeny L., Alenius H., Lauerma A., Ruzicka T., Zlotnik A., Homey B., (2005) CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation. J Immunol, 174:5082-91
link to online source - Schermer B., Hopker K., Omran H., Ghenoiu C., Fliegauf M., Fekete A., Horvath J., Kottgen M., Hackl M., Zschiedrich S., Huber T. B., Kramer-Zucker A., Zentgraf H., Blaukat A., Walz G., Benzing T., (2005) Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. EMBO J, 24:4415-24
link to online source - Schlieker C., Zentgraf H., Dersch P., Mogk A., (2005) ClpV, a unique Hsp100/Clp member of pathogenic proteobacteria. Biol Chem, 386:1115-27
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last update:
22/03/2019