Nanocarriers

Nanocarriers, which can accommodate a large number of hyperpolarized atoms in the tissue, will be combined with improvements in the production of hyperpolarized xenon and associated MR imaging techniques in this project to allow the imaging of previously MR-invisible target molecules.

The image displays two molecular structures. On the left, a complex molecule with a labeled xenon atom (Xe), showing its arrangement. On the right, a dense arrangement of molecules with spheres indicating atoms. Both structures are rendered in a 3D style, highlighting their intricate formations.

By introducing xenon hosts, the sensitivity of the Hyper-CEST method could be increased around 100-fold. The liposomes can then be provided with components that selectively bind to certain markers such as cell surface glycans of tumors. These sugar structures were visualized with MRI for the first time using the techniques developed here.

Diagram illustrating the relationship between CrA cages and POPC-based liposomes, highlighting variations in loading. An accompanying graph on the right shows the CEST performance related to chemical shifts, indicating the analysis of liposome behavior in a research context.
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