MR Thermometry

CEST is an MR method that uses many RF pulses to record molecular information. In this project, we are quantifying for the first time the possible temperature changes in the samples that can occur with typical measurement parameters. The extent to which different RF pulse shapes provide meaningful CEST spectra with minimal heating is also important here.

A graph displays temperature change in degrees Celsius over time in minutes, with lines representing power levels of 20 mW (black), 40 mW (red), 60 mW (blue), 80 mW (green), and 100 mW (purple). The temperature change increases gradually with time for each power level.
Schematic diagram illustrating a setup for magnetic resonance thermometry. It shows components like a gas inlet, PFA tubing, a sensor, and an NMR tube, all connected to facilitate temperature measurements in an optical fiber context. Labels indicate specific parts and their functions.

Temperature changes can be measured directly in the strong magnetic field of the sample using an optical sensor. A comparison with the changes in the chemical shift of temperature-sensitive signals allows cores such as 129Xe to be used as absolute MR temperature probes. Necessary corrections for the drift of the magnet are also taken into account.

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