GECCO - Genetics and Epidemiology of Colorectal Cancer Consortium

In the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) researchers from North America, Europe and Australia combine their efforts to identify colorectal-cancer-risk and prognosis-related genetic variants and to investigate how these variants interact with environmental factors. The coordinating center at the Fred Hutchinson Cancer Research Center harmonizes data from several epidemiological studies on colorectal cancer, comprising in total about 40,000 participants.

Our group takes part in this consortium by providing data and DNA samples from the DACHS study. Using the rich data source made available by GECCO, we lead several studies that mainly focus on how the use of menopausal hormone therapy interplays with the genetic susceptibility towards colorectal cancer. To investigate this, a genome-wide analysis of gene-environment interaction with menopausal hormone therapy will b carried out as well as a pathway analysis including hormone-metabolism pathways.

Funding: National Cancer Institute, NIH, U.S. Department of Health and Human Services (U01 CA137088)

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